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폐경후 여성에서 Ipriflavone 의 골밀도 및 골대사에 미치는 영향에 관한 연구
김정구(JK Kim),이미리(ML Lee),박창수(CS Park),김석현(SH Kim),최영민(YM Choi),신창재(CJ Shin),문신용(SY Moon),장윤석(YS Chang),이진용(JY Lee) 대한산부인과학회 1995 Obstetrics & Gynecology Science Vol.38 No.7
Ipriflavone, a synthetic isoflavone derived flavonoid, is known to have inhibitory effect on bone resportion by inhibiting osteoclastic activity. Becasue Ipriflavone does not possess any estrogenic activity, it has no risk of breast or endometrial cancer. The purposes of this study were to evaluate the effect of ipriflavone on the bone mineral density, bone metabolism, and low risk pain in the postmenopausal women, and to compare the effect of Ipriflavone alone with those of premarin or premarin plus Ipriflavone, Sixty postmenopausal women were randomly submitted to the 4 groups of treatment with; 600mg of Ipriflavone divided in 3 does daily by oral administration(group I), placebo(group II), 0.625 mg of premarin once a day (group III), and 0.625 mg of premarin once a day plus 600mg of Ipriflavone divided in 3 doses daily by oral administration(group IV) All women were given with 1g/day of calcium supplementation. In all subjects, bone mineral density(BMD) of lunmar spine and femur neck, urinary calcium/creatinine ratio. And the symptom scores for low back pain were measured before treatment and after 3 and 6 months of treatment . BMD of femur neck in group I, group III and group IV increased significantly (p
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생체 외에서 시행한 정량적 자기공명영상, 단일 에너지 정량적 전산화단층촬영술, 그리고 이중엑스선 골밀도측정기 사이의 연관성
고지호,허진도,정규식,오경승,이승룡,조영덕 고신대학교 의학부 2004 高神大學校 醫學部 論文集 Vol.19 No.1
This study was performed to examine the correlation among quantitative magnetic resonance (QMR), single energy quantitative computed tomography (SE-QCT). and dual energy X-ray absorptiometry (DXA), and to examine the relation with bone mineral density (BMD) through in vitro experiment with pig lumbar vertebrae. The correlation among 1/T2 of QMR, SE-QCT, and DXA was investigated by measuring the pig lumbar vertebrae BMD five times each method. It was examined whether there is a significant difference in the values of 1/T2, SE-QCT, and DXA measured by changing the height (11㎝, 20㎝, 29㎝) of water in water bath in order to make the soft tissues different in quantity. The lumbar vertebrae were placed in 0.1N sodium hydroxide (NaOH) solution for 24 hours to remove the residual soft tissue. Each values of SE-QCT before and after removal of the soft tissue were compared. Real BMD, measured after burning only the body of lumbar vertebrae for e hours at 1200℃, was compared to BMD with three methods. Based on the correlation analysis of 1/T2 and SE-QCT (correlation coefficient, r= -0.729 to 0.737), 1/T2 and DXA (r= -0.709 to o.929) and SE-QCT and DXA (r= -0.878 to 0.862) after measuring BMD within the water bath, no significant correlation was observed among three methods. Also, there was no correlation between 1/T2 and SE-QCT (r= -0.587 to 0.447) xeasured in the outside of water bath. SE-QCT (p=0.094) and 1/T2 (P=0.012 to 0.094) measured in the inside and the outside, respectively, of the water bath significantly different. When the height of water in the water bath was different, the change value of the BMD showed a significant different in 1/T2 (p=0.012 to 0.403) and SE-QCT (p=0.012 to 0.527), but not in DXA (P=0.012). The values of SE-QCT measured before and after placing limbar vertebrae in 0.1N NaOH for 24 hours were not significantly different (P=0.3177). The BMD showed the different changing aspect (p<0.05). There was no correlation among QMR, SE-QCT, and DXA, however the significant relation was observed between the BMD and QMR. The value of the BMD was measured differently depending on the height of water in the water bath. Therefore, although QMR is influenced by the height of the water bath in some degree, it reflects the BMD very well.
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