Metabolic Syndrome in Psychiatric Patients Treated with Antipsychotic Drugs in Thailand

Pichet Udomratn 대한정신약물학회 2010 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.8 No.2

Recently, Thai psychiatrists have increased their attention to metabolic abnormalities among patients receiving antipsychotics,especially a condition called metabolic syndrome (MetS). Therefore, the objectives of this paper were to review the rate of MetS associated with antipsychotics, to compare the prevalence of MetS between those receiving first and second generation antipsychotics (FGAs, SGAs) and to find the associated factors of MetS in Thai patients. Reviewing of the PUBMED database and two Thai journals was conducted. Authors interested in this topic were also contacted. The inclusion and exclusion criteria were defined and finally, 4 papers that fulfilled the criteria were reviewed. It was found that the prevalence rate of MetS in Thai patients varied from 15.4% to 23.9% by the IDF criteria and it was higher, between 20.5% to 30.5%, by the updated ATP III criteria. The incidence rate, by the IDF criteria, in patients who took any type of antipsychotic for one year was 20%. The prevalence rate of MetS, by the IDF criteria, among those receiving FGAs and SGAs was 9.4% to 27.1% and 20% to 20.3%, respectively. Difference in rates of MetS was found in different regions of Thailand. The factors associated with MetS were the use of SGAs and a family history of hypertension. The prevalence rate of MetS in Thai psychiatric patients was rather lower than that from a study in Taiwan. The definition of MetS according to IDF is less likely to identify metabolically abnormal but non-obese individuals. Perhaps, the modified or updated ATP III criteria is more appropriate to detect MetS in Asian patients, particularly those in Thailand.

복합 해양치유 프로그램이 근골격계 및 대사성 질환자의 대사증후군 위험인자 및 CRP에 미치는 영향

김현준 ( Kim Hyunjun ),신재숙 ( Shin Jaesuk ) 대한통합의학회 2020 대한통합의학회지 Vol.8 No.1

Purpose : The purpose of this study is to verify the effectiveness of combined marine healing programs by analyzing the physical composition of elderly musculoskeletal and metabolic patients, the risk factors of metabolic syndrome and the effects of the inflammatory factors, the C -reactive protein (CRP). Methods : Individuals with musculoskeletal and metabolic diseases were identified, and marine healing programs were conducted for f our hours each day for two weeks with 11 elderly participants. A one-way RM ANOVA was conducted to determine the differences due to treatment with composite marine healing systems. The results are as follows. Results : After a two-week ocean healing program, weight decreased the most, while BMI also decreased and muscle mass increased. Waist circumference, a risk factor for metabolic syndrome and CRP, decreased, and CRP demonstrated a decreasing trend. Conclusion : The above results show that the two-week marine healing program has a positive effect on the body composition and inflammatory factors of elderly musculoskeletal and metabolic patients.

인터벌 트레이닝과 유산소 운동이 대사증후군 환자의 심폐체력과 동맥경직도에 미치는 영향

정성림,김병로,강설중 대한운동사협회 2011 아시아 운동학 학술지 Vol.13 No.3

[INTRODUCTION] The purpose of this study was to investigate the effects of interval training and aerobic exercise on the cardiovascular fitness and arterial stiffness in metabolic syndrome. [METHOD] Participants were randomly assigned an interval training group(n=10) or a aerobic exercise group(n=10). Interval training(80-90% of HRR or 60% of HRR, 40min) and aerobic exercise(60% of HRR, 50min) have performed 5times a week for 12weeks. Metabolic risk factor, cardiorespiratory and arterial stiffness were measured at before and after 12 weeks from each group. [RESULT] The metabolic syndrome risk factors(weight, %fat, waist circumference, systolic blood pressure, diastolic blood pressure, triglyceride, and HDL-Cholesterol) were significantly improvement than those after treatment in both interval training and aerobic exercise groups before treatment, with no significant group difference. The VO2max were significantly increased than those after treatment in both interval training and aerobic exercise groups before treatment, with no significant group difference. The Pulse Wave Velocity were significantly increased than those after treatment in both interval training and aerobic exercise groups before treatment, with no significant group difference. [CONCLUSION] Interval training and aerobic exercise had improvement effects on cardiovascular fitness and arterial stiffness in metabolic syndrome patients. [서론] 본 연구는 인터벌 트레이닝과 유산소 운동이 대사증후군 환자의 심폐체력과 동맥경직도에 미치는 영향을 규명하였다. [방법] 연구대상자는 대사증후군으로 진단된 중년여성을 선정하여 인터벌 트레이닝 집단(n=10)과 유산소 운동 집단(n=10)으로 구분하였다. 12주간 인터벌 트레이닝(여유심박수의 80~90%와 60%, 40분)과 유산소 운동(여유심박수의 60%, 50분)을 주 5회 실시하였으며 대사증후군 위험인자, 심폐체력 및 동맥경직도를 분석하였다. [결과] 인터벌 트레이닝과 유산소 운동은 대사증후군 위험인자(체중, 체지방율, 허리둘레, 공복 혈당, 수축기와 이완기 혈압, 중성지방 및 HDL-콜레스테롤)를 유의하게 개선시키는 것으로 나타났지만 집단 간 유의한 차이는 없었다. 인터벌 트레이닝과 유산소 운동은 심폐체력 지표(O2max)를 유의하게 증가시키는 것으로 나타났지만 집단 간 유의한 차이는 없는 것으로 나타났다. 또한 인터벌 트레이닝과 유산소 운동은 동맥경직도 지표(맥파 속도)를 유의하게 감소시키는 것으로 나타났지만 집단 간 유의한 차이는 없었다. [결론] 인터벌 트레이닝과 유산소 운동은 대사증후군 환자의 심폐체력과 동맥경직도 개선에 효과적인 것으로 생각된다.

일회성 유산소 운동이 대사증후군 환자의 용적맥파 분석시 혈관 탄성과 혈관 저항 지수에 미치는 영향

백운효(Un-Hyo, Back),강설중(Seol-Jung Kang) 한국엔터테인먼트산업학회 2013 한국엔터테인먼트산업학회 학술대회 논문집 Vol.2013 No.5

The purpose of this study was to effects of acute aerobic exercise on vascular elastic and vascular resistance index by pulse wave velocity analysis in the metabolism patients. The subjects of this study consist of metabolism syndrome 22 female by Adults Treatment Panel(ATP Ⅲ) criteria on National Cholesterol Education Program. We have performed on a treadmill walking at HRmax 60% exercise intensity for 40 minutes. Plethysmogram waveform analysis wave were measures to Digital Arterial Pulse Wave Velocity. The results were follow: The Elastic Index, Ejection Elastic Index, and Dicrotic Elastic Index were significantly increase pre exercise compared to after exercise, Dicrotic Dilation Index were significantly decrease pre exercise compared to after exercise. These results suggested that acute aerobic exercise was effects on vascular function in metabolic syndrome patients.

필라테스 운동이 뇌졸중 편마비 여성 환자의 대사호르몬과 동맥경화지수 및 관상동맥질환 위험인자에 미치는 영향

권호준(Ho Jun Kwon),김남정(Nam Jung Kim),최용철(Yong Chul Choi),허선(Sun Hur) 한국사회체육학회 2013 한국사회체육학회지 Vol.0 No.53

The purpose of this study was to investigate the effect of Pilates exercise on blood metabolic hormone, atherosclerosis indices and coronary artery disease risk factors in women hemiplegia stroke patients. Thirty women stroke patients (exercise group, n=15; control group, n=15) volunteered for this study. The subjects of exercise group were required to performed Pilates exercise for 12 weeks (3 days a week, warm-up 15 minutes, exercise 40 minutes, and cool-down 15 minutes). After exercise training, percent of body fat (p<.05), insulin (p<.01), total cholesterol (p<.05), low density lipoprotein cholesterol (p<.05) levels, TC/HDL-C (p<.01), LDL-C/HDL-C (p<.05) were significantly decreased in exercise group. High density lipoprotein cholesterol (p<.05) level was significantly increased after exercise training. Also, blood leptin concentration was a significant negative correlation with body mass index (r=-.767, p<.01) and high density lipoprotein cholesterol(r=-.712, p<.01). Taken together, the Pilates exercise program was effect on the reduction of coronary artery disease risk factors and the prevent of recurrent stroke.

Systematic Evaluation of Extraction and Simulation Methods for Development of High-Quality Cancer Patient-Specific Metabolic Models

Sang Mi LEE,GaRyoung LEE,Hyun Uk KIM 한국생물공학회 2022 한국생물공학회 학술대회 Vol.2022 No.9

복합운동이 당뇨병환자의 대사증후군 요인에 미치는 영향

장채욱(Jang, Chae-Ouk),서재명(Suh, Jae-Myeong),강소형(Kang, So-Hyung) 한국체육과학회 2018 한국체육과학회지 Vol.27 No.6

The purpose of this study was to investigate the effect of combined exercise on body composition and metabolic syndrome in diabetic patients. The combined exercise program was designed to suggest exercise program and exercise program effect in daily life through aerobic exercise and resistance exercise. For this purpose, we applied 60 minutes of aerobic exercise and resistance exercise three times a week for 12 weeks in diabetic patients. The following conclusions were obtained through this objective and experimental procedure. First, there was a significant interaction effect between skeletal muscle and fat mass. Also, BMI and body fat percentage showed significant effects only in repetitive factors. Second, significant interaction effects were observed in blood glucose and LDL, and in the sagittal, diastolic and blood glucose levels. In the main effect group, only HDL was significant.

성인 당뇨병 환자의 소득수준에 따른 혈당, 당화혈색소, 혈압, 및 혈중지질 지표의 변화 추이 : 국민건강영양조사 1998 ~ 2014 분석 결과

조수경,박경 한국영양학회 2019 Journal of Nutrition and Health Vol.52 No.2

Purpose: Management of the metabolic risk factors in diabetes patients is essential for preventing or delaying diabetic complications. This study compared the levels of the metabolic risk factors in diabetes patients according to the income levels, and examined the secular trends in recent decades. Methods: The data from the Korea National Health and Nutrition Examination Survey 1998 ~ 2014 were used. The diabetes patients were divided into three groups based on their household income levels. General information was obtained through self-administered questionnaires, and the blood biomarkers and blood pressure data were obtained from a health examination. Multivariable linear regression models were used to compare the metabolic biomarker levels according to the household income levels, adjusting for potential confounding factors. Results: The fasting blood glucose, hemoglobin A1c, and blood lipid (total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, and triglyceride) levels were similar in the three groups. During the survey period of 16 years, the blood pressure showed a significant decreasing trend with time in all groups (p < 0.001). In contrast, the fasting blood glucose (p = 0.004), total cholesterol (p < 0.001), and LDL-cholesterol levels (p = 0.007) decreased significantly, and the HDL-cholesterol level (p < 0.001) increased significantly in the highest-income groups. In the lowest-income group, the fasting blood glucose (p = 0.02), total cholesterol (p < 0.001), and triglyceride (p = 0.003) levels showed a significant decreasing trend over time. On the other hand, the middle-income group showed no significant change in any of the metabolic risk factors except for blood pressure. Conclusion: The level of management of metabolic risk factors according to the income level of Korean diabetes patients was similar. On the other hand, the highest- and lowest-income groups showed positive trends of management of these factors during 16 years of observation, whereas the middle-income group did not show any improvement.

복합 해양치유 프로그램이 대사성 질환자의 혈중지질 및 CRP에 미치는 영향

김의식 ( Ui-sik Kim ),김현준 ( Hyun-jun Kim ),신재숙 ( Jae-suk Shin ) 대한통합의학회 2021 대한통합의학회지 Vol.9 No.4

Purpose : The purpose of this study is to verify the effectiveness of combined marine healing programs by analyzing the physical composition of metabolic patients, blood lipids and the effects of the inflammatory factors, the C -reactive protein(CRP). Methods : the combined marine treatment program was conducted for 6 hours a day, 5 days a week on the 10 adult patients with metabolic diseases and the results of their body composition, blood lipids and CRP were analyzed before and after the subjects completed the program. For the statistical analysis, the mean and standard deviation (M±SD) of each variable were calculated using SPSS version 20 and a paired t-test was conducted in order to test for the differences before and after the combined marine treatment program. All significant levels were set to α=.05. As a result of the experiment Results : First, regarding the changes in body composition and blood pressure after the 5-day combined marine treatment program was completed, there were statistically significant differences found in weight (p<.01) and systolic blood pressure (p<.05). Second, regarding the changes in blood lipids and CRP after the program was conducted, there were statistically significant differences found in total cholesterol (p<.05) while there was no statistically significant difference found in the variables of neutral fat, low-density lipoprotein cholesterol and CRP. Conclusion : the study results were integrated, the 5-day combined marine treatment program had a positive effect on weight, blood pressure and total cholesterol in the patients with metabolic diseases. Therefore, the short-term marine treatment program was thought to be effective for them. However, considering no significant differences were found in neutral fat, low-density lipoprotein cholesterol and CRP, further development and research on combined marine treatment programs should be conducted in the long term to create an effective program for patients with metabolic diseases.

High sensitivity C-reactive protein and its relationship with impaired glucose regulation in lean patients with polycystic ovary syndrome

Kim, Ji Won,Han, Ji Eun,Kim, You Shin,Won, Hyung Jae,Yoon, Tae Ki,Lee, Woo Sik Informa Healthcare 2012 Gynecological endocrinology Vol.28 No.4

<P>The polycystic ovary syndrome (PCOS) is the most common endocrine-metabolic disorder, also associated with the metabolic syndrome. Serum high sensitivity C-reactive protein (hs-CRP), a marker of low-grade chronic inflammation is a potent predictor of cardiovascular events, closely linked to metabolic syndrome features and higher in patients with PCOS. However, hs-CRP in lean patients with PCOS has not been fully evaluated and few data are available. We aimed to investigate the relation between glucose intolerance and hs-CRP levels in lean patients with PCOS, and to evaluate the possible relationship between hs-CRP and PCOS by evaluating PCOS-related metabolic abnormalities in Korean women. We consecutively recruited 115 lean (BMI < 25kg/m<SUP>2</SUP>) patients diagnosed with PCOS and 103 lean healthy controls. The PCOS group was divided two groups: impaired glucose regulation (IGR) and normal glucose tolerance group (NGT). In lean patients with PCOS, hs-CRP level was higher in the IGR group than in the NGT group (0.60 ± 1.37 versus 0.18 ± 0.46, <I>p</I><SUB>Bonf</SUB> == 0.023) and other metabolic risk factors were also higher in the IGR group than in the NGT group. And there were close relationships between hs-CRP level and metabolic risk factor, such as 2 h postprandial insulin level in the lean patients with PCOS.</P>