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- 주제어 : SH90 (검색결과 3 건)
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SPIN90 Modulates Long-Term Depression and Behavioral Flexibility in the Hippocampus
Kim, Dae Hwan,Kang, Minkyung,Kim, Chong-Hyun,Huh, Yun Hyun,Cho, In Ha,Ryu, Hyun-Hee,Chung, Kyung Hwun,Park, Chul-Seung,Rhee, Sangmyung,Lee, Yong-Seok,Song, Woo Keun Frontiers Media S.A. 2017 Frontiers in molecular neuroscience Vol.10 No.-
<P>The importance of actin-binding proteins (ABPs) in the regulation of synapse morphology and plasticity has been well established. SH3 protein interacting with Nck, 90 kDa (SPIN90), an Nck-interacting protein highly expressed in synapses, is essential for actin remodeling and dendritic spine morphology. Synaptic targeting of SPIN90 to spine heads or dendritic shafts depends on its phosphorylation state, leading to blockage of cofilin-mediated actin depolymerization and spine shrinkage. However, the physiological role of SPIN90 in long-term plasticity, learning and memory are largely unknown. In this study, we demonstrate that <I>Spin90</I>-knockout (KO) mice exhibit substantial deficits in synaptic plasticity and behavioral flexibility. We found that loss of SPIN90 disrupted dendritic spine density in CA1 neurons of the hippocampus and significantly impaired long-term depression (LTD), leaving basal synaptic transmission and long-term potentiation (LTP) intact. These impairments were due in part to deficits in AMPA receptor endocytosis and its pre-requisites, GluA1 dephosphorylation and postsynaptic density (PSD) 95 phosphorylation, but also by an intrinsic activation of Akt-GSK3β signaling as a result of <I>Spin90</I>-KO. In accordance with these defects, mice lacking SPIN90 were found to carry significant deficits in object-recognition and behavioral flexibility, while learning ability was largely unaffected. Collectively, these findings demonstrate a novel modulatory role for SPIN90 in hippocampal LTD and behavioral flexibility.</P>
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수산자원전용조사선 탐구 21호에 탑재된 최첨단 음향장비 소개와첫 시험조사
황강석,이정훈,박정호,차형기,최정화,이형빈,박준성,강명희 한국수산과학회 2016 한국수산과학회지 Vol.49 No.4
At the first time in South Korea, the state of the art acoustic systems were mounted on the R/V Tamgu 21. The acoustic systems are an EK80 broadband echosounder (18, 38, 70, 120, 200 and 333 kHz) which has two beam modes such as continuous wave (narrowband) and frequency modulation (FM, broadband), an ME70 multibeam echosounder (70-120 kHz), and a SH90 sonar (111.5-115.5 kHz). Acoustic data from FM mode have a very short range resolution, a large detection range, a high signal to noise ratio, and a wide and consecutive frequency response. In ME70, each individual beam consisted in a multibeam plays a role as a spilt beam. The first trial of the cutting edge acoustic system installed on the R/V Tamgu 21 was conducted from 15 Feb to 29 Feb 2016 in East Sea, South Sea and East China Sea. The properties of the acoustic systems were elucidated and exploratory results from three systems were exhibited. Lastly, issues which should be considered and future research plan are mentioned.
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강정호,김영학,장효준,정원상,김혁,박문향 대한흉부외과학회 2007 Journal of Chest Surgery (J Chest Surg) Vol.40 No.7
기관지성 낭종은 일반적으로 폐실질 내 혹은 종격동 내에 발생하는 것으로 알려져 있다. 종격동 내에 위치하는 경우 기관지와 식도 부근에 위치하나 식도에 함몰되어 있는 경우는 매우 드물다. 수술 전에 기관지성 낭종과 식도 낭종을 구분하는 것은 매우 어려워 식도 양성 종양으로 의심하고 수술을 시행하게 된다. 저자들은 우연히 발견된 식도 내 종양이 수술 절제를 통해 기관지성 낭종으로 밝혀져 보고하는 바이다.
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