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정상 자궁 동맥 Doppler 파형을 보이는 자궁내 성장지연 임신에서 양수내 Nitric Oxide 및 제대혈액 내 태아 성장인자의 농도 측정
김소라 ( So Ra Kim ),김종수 ( Jong Soo Kim ),정지윤 ( Ji Youn Chung ),원혜성 ( Hye Sung Won ),이필량 ( Pil Ryang Lee ),이인식 ( In Sik Lee ),김암 ( Ahm Kim ) 대한주산의학회 2002 大韓周産醫學會雜誌 Vol.13 No.2
목적:정상자궁동맥 Doppler 파형을 보이는 자궁내 성장지연 임신에서 양수 내 nitric oxide(NO) 농도 및 제대혈액 내 태아 성장인자와의 연관성을 알아보고자 하였다. 연구방법:1999년 7월부터 2000년 3월까지 임신 32주에서 40주 사이의 임신부를 대상으로 초음파상 측정을 통해 추정 태아 체중이 10 percentile 미만인 경우를 자궁내 성장지연으로 정의하고 연구대상군으로 선정하였다. 이들 중 태반부전으로 인한 자궁내 성장지연을 배제하기 위하여 초음파 검사를 시행하여 정상자궁태반 혈류를 보이는 군만을 대상으로 하였다. 정상대조군은 추정 태아 체중 25 percentile 이상인 산모들을 대상으로 하였다. 두 군에는 각각 18명 씩의 산모들이 포함되었고, 이들의 양수 내 NO의 값과 제대혈 내 IGF-Ⅰ, IGFBP-1, cortisol의 농도를 측정하였다. 결과:NO는 자궁내 성장지연군에서 대조군보다 낮게 측정되었으나 두군간의 통계적인 의의는 없었다(p=0.14). 자궁내 성장지연을 보인 태아에서는 태아 성장에 관여하는 IGF-Ⅰ 값이 정상임신군에 비해 유의하게 낮게 측정되었고, cortisol과 IGF-Ⅰ의 bioavailability를 조절하는 IGFBP-1의 경우 자궁내 성장지연군에서 대조군에 비해 유의하게 높았다(p<0.05). 결론:본 연구의 결과, 자궁동맥이 정상 Doppler 파형을 보이는 자궁내 성장지연의 경우, 양수 내 NO의 값은 정상군과 유의한 차이를 보이지 않았으나, 제대혈 내 태아성장인자들은 유의한 차이를 보이는 것으로 나타나 IUGR 환아의 예후 및 처치에 대한 연구의 기초적 자료를 제공할 수 있을 것으로 판단된다. Objective:Our purpose was to evaluate the relationship between amniotic fluid nitric oxide(NO) and fetal blood IGF-I, IGFBP-1, and cortisol in pregnancies complicated by intrauterine growth restriction(IUGR), but showing normal uterine artery doppler waveform. Methods:From July 1999 to March 2000, 18 pregnant women with IUGR and 18 normal pregnancies were studied. Both group showed normal uterine artery doppler waveform. Amniotic fluid samples were collected to measure NO, and fetal blood samples were collected from umbilical vein to measure fetal growth factors. The definition used to identify cases of IUGR depended on three criteria: clinical evidence of suboptimal growth, ultrasonographic evidence of deviation from an appropriate growth percentile, and individualized birth weight ratios <10th percentile. Results:Overall median NO values in amniotic fluid were lower in IUGRs than in controls, but there was no statistical significance. However, IUGR newborns showed significantly lower(p<0.05) concentrations of IGF-I, and greater(p<0.05) concentrations of IGFBP-1 and cortisol than did controls. Conclusion:These result suggest that cord blood IGF-I, IGFBP-1, and cortisol, but not amniotic fluid NO may act major regulating factor in idiopathic IUGR without placental insufficiency.
인간 황체화과립막세포에서 변형성장인자-α가 인슐린유사성장인자-2와 인슐린유사성장인자 결합단백질-1, 3의 분비 및 표피성장인자 수용체의 발현에 미치는 영향
강은희 ( Eun Hee Kang ),홍석호 ( Seok Ho Hong ),조준식 ( Jun Sik Cho ),김성훈 ( Sung Hoon Kim ),채희동 ( Hee Dong Chae ),김정훈 ( Chung Hoon Kim ),강병문 ( Byung Moon Kang ),남주현 ( Joo Hyun Nam ) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.12
Objective : To investigate the effects of transforming growth factor (TGF)-α on insulin-like growth factor (IGF)-α, insulin-like growth factor binding protein (IGFBP)-1, and 3 secretion and epidermal growth factor (EGF) receptor expression in cultured hum
운동형태가 초등학생의 뇌유래신경성장인자와 성장관련호르몬에 미치는 영향
권지영 한국스포츠학회 2019 한국스포츠학회지 Vol.17 No.2
본 연구는 초등학교에 재학중인 5학년 남학생을 대상으로 12주 동안 유산소운동과 복합운동 프로그램이 뇌유 래신경성장인자(BDNF)와 성장관련호르몬인 IGF-1, 성장호르몬(GH)에 어떠한 변화가 나타나는지를 규명하고자 하 였다. 이를 위하여 Y시에 소재한 초등학교 방과후 체육활동에 참여하고 있는 아동 12명을 대상으로 유산소운동군 6명, 복합운동군 6명으로 나누어 12주 동안 주당 2회, 1일 80분으로 구성된 유산소운동 및 복합운동 프로그램을 시행하였고 다음과 같은 결론을 얻었다. 12주 동안 규칙적인 유산소운동과 복합운동 프로그램은 BDNF, IGF-1, GH 수준 모두를 운동 시작 전보다 통계적으로 유의하게 증가시켰다. 세 가지 모든 변인에서 시간과 집단에 따른 상호작용효과와 두 집단 간 차이는 나타나지 않았다(p≤.05). 위의 결과를 종합해 볼 때, 12주 동안의 유산소운동과 복합운동 프로그램은 초등 남학생의 BDNF, IGF-1, GH를 유의하게 증가시키는 것으로 나타났다. 추후 연구에서는 보다 세분화된 연령과 운동 강도에 따른 연구, 복합운동의 경우 성장관련인자의 효율적인 개선을 위한 유산소와 무산소운동의 비율에 대한 연구, 적정심박수 유지가 용이한 다양한 형태의 유산소운동프로그램 개발과 관련된 연구가 필요할 것으로 생각한다. This research, which targets fifth-grade elementary school male students for 12 weeks ,tries to establish certain changes in BDNF, IGF-1, and GH that aerobic exercise and multiple exercise program affect. For this, aerobic exercise and multiple exercise program, which targets 12 children who participate in after school physical activity of elementary school in Y city, were operated . 6 children participated in aerobic exercise program and other 6 children participated in multiple exercise program. The programs operated twice a week and 80 minutes a day for 12 weeks. As a result, we got the following conclusions. Regular aerobic exercise and multiple exercise program for 12 weeks increase all levels of BDNF, IGF-1 and GH before they started to exercise. These change are meaningful statistically. In all three parameters, there are no differences that are caused by effects of interaction and time between two groups(p≤.05). Given all above results, aerobic exercise and multiple exercise program for 12 weeks increase all levels of BDNF, IGF-1 and GH of elementary school male students meaningfully. In further research, we seem to need more segmentalized age of subjects, studies about intensity of exercise, studies, in the case of multiple exercise, about proportion of aerobic and anaerobic exercise for effective improvement of factors related to growth, and studies about development of various types of aerobic exercise programs that help to keep appropriate hear rate.
임신 중기 양수내 인슐린유사성장인자-I, II 및 인슐린 유사성장인자결합단백질-3과 신생아 출생 체중과의 연관성
김지영(Ji Young Kim),양순하(Soon Ha Yang),이인식(In Sik Lee) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.4
Objective:To determine the correlation between birth weight and the level of insulin-like growth factor(IGF)-I, -II and insulin-like growth factor binding protein(IGFBP)-3 in amniotic fluid at second trimester and to evaluate possibility whether the levels of IGF-I, II and IGFBP-3 could predict birth weight. Methods:Sixty-seven samples of amniotic fluid in second trimester were analyzed for IGF-I, IGF-II, and IGFBP-3 by radioimmunoassay. Newborn birth weights were stratified arbitrarily as <25th percentile, 25-75th percentile, and >75th percentile. Linear regression analysis and Kruskal-Wallis test were used in well appropriately for statistical analysis. Results:The level of IGF-I showed positive correlation with birth weight. However, the levels of IGF-II and IGFBP-3 showed no significant correlation with birth weight. The level of IGF-I were significantly different among these groups. However, the levels of IGF-II and IGFBP-3 were not significantly different among these groups divided by the birth weight percentile. Conclusion:The levels of IGF-I in amniotic fluid at second trimester may be useful marker in predicting birth weight.
체외수정시술시 예후 예측에 관한 혈중 인슐린유사 성장인자 및 결합단백질의 임상적 효용성
김석현 ( Seok Hyun Kim ),구승엽 ( Seung Yup Ku ),지병철 ( Byung Chul Jee ),서창석 ( Chang Suk Suh ),최영민 ( Young Min Choi ),김정구 ( Jung Gu Kim ),문신용 ( Shin Yong Moon ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.4
Objective : To evaluate the clinical efficacy of serum insulin-like growth factor-Ⅰ (IGF-Ⅰ), IGF-Ⅰ, and IGF binding protein-3 (IGFBP-3) levels in predicting the prognosis of in vitro fertilization and embryo transfer (IVF-ET). Materials and Methods : In 8
체외수정시술을 시행하는 환자의 난포액 내 인슐린유사성장인자-2, 인슐린유사성장인자 결합단백질-1, 3과 누적배아지수와의 상관관계
권혜은 ( Kwon Hye Eun ),홍석호 ( Hong Seog Ho ),박정열 ( Park Jeong Yeol ),김성훈 ( Kim Seong Hun ),채희동 ( Chae Hui Dong ),김정훈 ( Kim Jeong Hun ),강병문 ( Kang Byeong Mun ),남주현 ( Nam Ju Hyeon ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.5
Objective : To investigate the correlation between the concentrations of insuline-like growth factor-Ⅱ (IGF-Ⅱ), insuline-like growth factor binding protein-Ⅰ, 3 (IGFBP-1, 3) in the follicular fluid and the cumulative embryo score (CES) in the patient who underwent in vitro fertilization and embryo transfer (IVF-ET). Materials and Methods : A total of 21 cycles of 18 patients which underwent IVF-ET cycle after controlled ovarian hyperstimulation (COH) were included in this study. Using immunoradiometric assay (IRMA), we measured the concentrations of IGF-Ⅱ, IGFBP-1, 3 in the follicular fluid. The patients were grouped into the pregnant and non-pregnant group. The concentrations of IGF-Ⅱ, IGFBP-1, 3 in the follicular fluid were compared between the two groups and the correlations of the follicular concentrations of IGF-Ⅱ, IGFBP-1, 3 and cumulative embryo score were evaluated. Results were analyzed with Mann-Whitney U test and Spearman`s rank correlation coefficient and statistical significance was defined as p<0.05. Results : There were no statistical significance in the follicular concentrations of IGF-Ⅱ, IGFBP-1, 3 between the pregnant group and non-pregnant group. There were signifiant correlation between the follicular concentration of IGF-Ⅱ and cumulative embryo score (p=0.001). There might be correlations between the follicular concentration of IGFBP-3, and free IGF-Ⅱ and cumulative embryo score (p=0.053, p=0.056, respectively). Conclusion : The follicular IGF-Ⅱ and free IGF-Ⅱ might have an influence to development of good-quality embryos in patients undergoing IVF-ET.
배양된 생쥐의 과립막 세포에서 activin과 follistatin이 인슐린유사성장인자-1, 2, 인슐린유사성장인자 결합단백질-1, 2, 3의 mRNA 발현에 미치는 영향
채희동 ( Hee Dong Chae ),홍석호 ( Seok Ho Hong ),조윤현 ( Yun Hyun Cho ),오영미 ( Young Mi Oh ),이방현 ( Bang Hyun Lee ),김성훈 ( Sung Hoon Kim ),김정훈 ( Chung Hoon Kim ),강병문 ( Byung Moon Kang ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.3
Objective : To investigate the influence of activin and follistatin on the expression of IGF (insulin-like growth factor)-I, Ⅱ, IGFBP (insulin-like growth factor binding protein)-1, 2, and 3 mRNA in cultured mouse granulosa cells Materials and Methods : T
종양괴사인자-α가 배양된 인간 황체화과립막세포의 에스트라디올, 프로게스테론, 인슐린유사성장인자-II, 인슐린유사성장인자 결합단백질-1, 2, 3의 분비에 미치는 영향
채희동(Hee Dong Chae),강은희(Eun Hee Kang),박은주(Eun Ju Park),김성훈(Sung Hoon Kim),홍석호(Seok Ho Hong),김정훈(Chung Hoon Kim),강병문(Byung Moon Kang),장윤석(Yoon Seok Chang),김정구(Jung Gu Kim),이진용(Jing Yong Lee) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.4
Objectives : To investigate the influence of TNF-α on the secretion of estradiol (E2), progesterone (P4), insulin-like growth factor (IGF)-II, insulin-like growth factor binding protein (IGFBP)-1, 2, and 3 in cultured human luteinized granulosa cells. Materials and Methods : Human luteinized granulosa cells were obtained from the follicular fluid by transvaginal oocyte aspiration from infertile patients undergoing controlled ovarian hyperstimulation (COH) for in vitro fertilization (IVF). The cells were grouped into the control, 1.0, 10.0, and 100.0 ng/ml of TNF-α group according to the concentrations of TNF-α. The cells were cultured for 72 hours with the different concentrations of TNF-α as descibed above. The cells not treated with TNF-α served as control. The concentrations of E2, P4, IGF-I, IGFBP-1, 2, and 3 were determined in conditioned culture media by immunoradiometric assay (IRMA) or radioimmunoassay (RIA). Results : The cell number in 100.0 ng/ml of TNF-α group was significantly higher than those in other groups, although the cell viabilities were similar in all groups. There were no statistically significant differences in the concentrations of E2 in all groups. However, the concentrations of P4 were seemed to be decreased as the concentrations of TNF-α were increased and the concentration of P4 in 100.0 ng/ml of TNF-α group was significantly lower than those in the control and other TNF-α groups. The concentrations of IGF-II, IGFBP-1, 2, and 3 were not different among the control and each TNF-α group. The secretion of E2 and P4 was not affected by IGF type I receptor antibody pretreatment. Conclusion : TNF-α might play a role as a regulator of ovarian physiology by modulating luteinized granulosa cellular proliferation and P4 secretion, and this mechanism might not be related to IGF system.
인슐린유사 성장인자가 자궁내막증환자 및 자궁내막증이 없는 환자의 자궁내막 기질세포 증식에 미치는 영향
김명희(Myung Hee Kim),이규화(Gue Wha Lee),이용희(Yong Hee Lee),김정구(Jung Gu Kim) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.2
Objectives: To test the hypothesis that the endometrial stromal cells from patients with endometriosis responds differently to the insulin-like growth factor (IGF) compared with those from patients without endometriosis. Methods: IGFs in peritoneal fluid (PF) from patients with endometriosis(n=18) and without endometriosis(n=12;control patients) were measured by radioimmunoassay. Endometrial stromal cells from patients with endometriosis and control patients were cultured in serum free media(SFM) in the presence or absence of PF or IGF-I(0.25-25 ng/ml) or IGF-II(5-50 ng/ml) and the proliferation of endometrial stromal cells were evaluated by [3H] thymidine incorporation test. All statistics were performed by ANOVA test and student's t-test. Results: When added to SFM, IGF-I(1-25 ng/ml) increased thymidine incorporation in both endometrial stromal cells from patients with endometriosis and control patients in dose dependent manner and IGF-II(5-25 ng/ml) gave similar response in latter cells but not in former cells. Within low IGF-I(less than 100 ng/ml) PF group or high IGF-I(more than 100ng/ml) PF group, the type of endometrial stromal cells did not result in any difference in thymidine incorporation. However, regardless of the source of stromal cells, high IGF-I PF group produced a greater extent of thymidine incorporation than low IGF-I PF group in patients with endometriosis but not in control patients. Also, thymidine incorporation was higher in high IGF-I PF group of former patients than in the same group of latter patients. PF induced higher thymidine incorporation in endometrial stromal cells than the same levels(0.25-2.5 ng/ml) of IGF-I directly added to SFM. Conclusions: The effects of IGF-I in PF on endometrial stromal cells are similar regardless of their source and IGF-I is one of several growth factors that may participate in the growth of endometrial stromal cells in pelvic endometriosis.