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민경업 대한알레르기학회 1999 천식 및 알레르기 Vol.19 No.5
첨단 과학의 발전에 따른 질병 발생에 관한 병태생리의 이해와 새로운 치료약제의 도입에도 불구하도 알레르기 질환은 최근 20년 사이에 전세계적으로 증가하고 있는 추세이다. 국내에서도 암, 만성 성인병과 더불어 국민의 3대 만성 질환의 하나이고 소아에서는 이제 가장 흔한 만성 질환으로 알려져 있다. 1972년 대한알레르기학회가 창립되고 1981년 '알레르기' 학회 잡지가 발간되면서 알레르기 질환의 발생, 진단, 치료, 예방 등에 대한 관심이 증가하여 알레르기 여러 분야에서 논문들이 활발하게 보고되기 시작하였으며 여러 가지 학술활동 및 환자와 가족들을 위한 알레르기 교육이 시작되었다. 그러나 이러한 활동은 주로 알레르기 전문 클리닉이 설치되어 있는 병원들에 내원한 환자들을 대상으로 시행되었기 때문에 알레르기 질환의 증가 추세와 비교할 때 부족한 감이 있었다. 이에 대책으로 대한 천식 및 알레르기학회는 대한 소아알레르기 및 호흡기학회와 공동으로 1999년 5월 15일부터 21일까지 1주간을 제1회 알레르기주간으로 제정하고 다가오는 21세기에는 알레르기 질환의 발병을 줄이기 위하여 알레르기 예방을 위한 "7대 권장사항"을 채택하였다 (Table.1). 이는 알레르기질환의 발볍에 영향응 미치는 인자들 중 학문적으로 그 중요성이 널리 인정된 것들을 국내의 상황에 맞게 채택하였다. 이에 이러한 캠페인의 전체적인 필요성과 각 항목의 선정 배경을 밝히고자 한다.
김윤근,장윤석,정재원,이병재,김희연,손지웅,이상록,조상헌,박해심,이명현,민경업,김유영 ( Yoon Keon Kim,Yoon Suk Jang,Jae Won Jung,Byung Jae Lee,Hee Yeon Kim,Jee Wong Son,Sang Rok Lee,Sang Heon Cho,Hae Sim Park,Myung Hyun Lee,Kyung Up Min,Y 대한천식알레르기학회 1998 천식 및 알레르기 Vol.18 No.3
Backpwnd: Prevalence of bee venom allergy in Korea is unknown, Objective'. We performed a cross-sectional study to evaluate the prevalence of bee venom allergy and importance of risk factors, such as age, sex, and atopy, in the development of the allergic reaction in children and adults living in rural area of Cheju Island. Swbject and method: The prevalence was investigated in subjects with 1,054 children and 370 adults (701 male, 723 female), aged 7-87 years, living in rural area of Cheju Island. A history particularly focused on the systemic reactions after the bee stings was taken in all subjects. Skin prick test,s to common inhalant allergens, including house dust mites, fungi, tree, grass, mugwort and ragweed pollen, cockroach, animal epithelium, Japanese cedar pollen, and citrus red mite were performed. Result: The prevalence of bee venom allergy was 5.8% (mild systemic reactions 5.0%, severe systemic reactions 0.8% ). The prevalence was higher in adults than in children (10.2% vs. 5.0%, g = 12.0, p<0.01). Among t,he child!'en, the prevalerlce wB.S Signifcant,ly higher ill male than in female (8.6% vs. 1.3%, x=28.7, p<0.01), but no significant diffecence was noted between male and female in adults (10.0% vs. 10.3%, p>0.05). The prevalence of bee venom allergy was not significantly different between subjects with positive skin reaction and those with negative skin reaction to inhalant allergens (6.4% vs. 5.4% ), Conclasion'. The prevlence of bee venom allergy in inhabitants of rural area of Cheju Island is 5.8% (mild systemic,' 5.0%, severe systemic reaction. 0.8%), and bee venom allergy was more common in adults than in children, and in male children than in female children.
췌장 추출물 흡입에 의한 병원근무자의 직업성 알레르기에서 주요 알레르겐 규명
김상하 ( Sang Ha Kim ),예영민 ( Young Min Ye ),김현미 ( Hyun Mi Kim ),이명규 ( Myoung Kyu Lee ),서창희 ( Chang Hee Suh ),남동호 ( Dong Ho Nahm ),박해심 ( Hae Sim Park ) 대한천식알레르기학회 2007 천식 및 알레르기 Vol.27 No.1
Background: Digestive drugs, including pancreatic extracts, have been widely prescribed in this country. There have been several reports of occupational asthma and rhinitis caused by digestive enzymes in workers in pharmaceutical industries; however, there has been no epidemiologic study among the medical personnel. Objective: We evaluated the prevalence of occupational allergy and sensitization rates to digestive drugs in medical personnel and its pathogenic mechanisms. Method: Eighteen pharmacists, 135 nurses and 123 non atopic normal controls were enrolled. Skin prick tests with 12 common aeroallergens and 5 commonly exposed drugs and its ingredients were performed. Serum specific IgE, IgG1 and IgG4 to α-amylase were measured by ELISA. SDS-PAGE followed by IgE and IgG4 immunoblot analysis was performed. Result: Work-related allergy symptoms were observed in 27.8% of pharmacists and 27.4% of nurses. IgE immunoblot analysis demonstrated 3 components which of 19 and 24 kDa were more frequently identified in sera from symptomatic subjects. IgG4 immunoblot analysis demonstrated 2 components of which 19 kDa was more frequently identified in sera from asymptomatic subjects. Conclusion: Digestive drug powders could induce IgE-mediated respiratory allergy symptoms in the medical personnel. Two major allergenic components of α-amylase (19, 24 kDa) were identified. Specific IgG4 response to 19 kDa might have a role for preventing the development of work- related allergy symptoms after exposure to α-amylase powder. (Korean J Asthma Allergy Clin Immunol 2007;27:10-19)
소아천식환자에 대한 RAST 및 알레르기 피부검사의 진단적 가치 평가
이기영 대한천식알레르기학회 1987 천식 및 알레르기 Vol.7 No.2
RAST has been used frequently as a test to detect specific IgE for the diagnosis of atopic allergic diseases. But many reports have shown that RAST is correlated well with allergy skin test and not better than the latter in its significance for confirming causative allergens. The purpose of this study is to know whether RAST can detect the patients who could not be detected by allergy skin test. 108 cases who had asthma like symptoms and shown negative or equivocal reactions to D. farinae or D. pteronyssinus by allergy skin test as a screc.,'ng test were performed RAST with about 10 allergens which are frequently positive in Korean children including house dust mite allergen. In cases who were positive by RAST, allergy skin test with same allergens were performed and the results were analyzed. The results obtained from this study were as fol- lows: 1. Ninty-nine cases(91.6%) were negative to house dust mite allergen and only 9 cases(8.4%) showed equivocal or positive reactions to same allergen by RAST. 2. Seven out of 9 cases who had equivocal or positive reactions to house dust mite by RAST were per- formed allergy skin test with same allergen as a follow-up study. The result of allergy skin test on house dust mite was correlated very well with RAST. The possibility of correlation with RAST on the other 2 cases who had not performed allergy skin test were also discussed. 3. Twenty-one allergens other than house dust mite were equivocal or positive reactions by RAST. Allergy skin tests were performed with same allergens on these cases. Seven allergens (cat hair in 5 cases, house dust and ragweed in each case) were negative by allergy skin test. Therefore, it can be concluded that detection of house dust mite allergen by allergy skin test in the diagnosis of atopic respiratory diseases is reliable method because skin test is correlated very well with RAST. But it is recommendable to perform allergy skin test more than once in suspicious cases in diagnosis.
영유아 식품알레르기 예방을 위한 최신 의견: 수유와 이유식을 중심으로
송태원 ( Tae Won Song ),안강모 ( Kang Mo Ahn ),이수영 ( Soo Young Lee ) 대한천식알레르기학회(구 대한알레르기학회) 2015 Allergy Asthma & Respiratory Disease Vol.3 No.5
Food allergy is common with the prevalence of 5%-7% in Korean children. The development of food allergy is likely to reflect interactions between genetic factors and environmental exposure. To prevent food allergy, early exposure to food allergens through maternal and infant diet have been investigated. Recently, guidelines for primary prevention of food allergy have been updated, and consensus communication on early peanut introduction has been demonstrated. For the first 4-6 months after birth, exclusive breast-feeding is recommended, and if impossible, extensively or partially hydrolyzed infant formula can be recommended in high-risk infants. Introducing complementary foods is recommended between 4 and 6 months of age, even in case of potentially allergenic foods such as egg, milk, and wheat. For the prevention of peanut allergy, early peanut introduction could be better than late peanut introduction in selected high-risk infants. However, infants who developed food allergy should avoid ingestion of specific offending foods. (Allergy Asthma Respir Dis 2015;3:320-325)