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홍현상,채영래,백인호 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.6
It has been thought that the onset of schizophrenia is limited to youth. However, many European investigators have reported the occurrence of schizophrenia in later life. They have noted that the symptoms found in late-onset schizophrenia are not different from those noted in patients with early-onset schizophrenia. With the advent of the DSM-III-R(1987), there has been a renewal of interest in schizophrenia that arise for the first time in late life. This study was designed to examine some characteristic findings on demographics, clinical features, and treatment response in late-onset schizophrenia. The subjects consisted of 36 patients with late-onset(after 40) schizophrena and 72 patients with early-onset schizophrenia(before 40) by DSM-III-R who were admitted to the Department of Neuropshcyiatry of Kangnam St. Mary's Hospital, Catholic University Medical College from March 1982 to July 1990 The results were as follows : 1) The male to female ratio of the late-onset schizohprenic patients was 1 : 5. 2) The patients with late-onset schizophrenia were more likely to have grandiose delusions and auditory hallucinations than those of early-onset schizophrenia. 3) There was no significant difference in frequenty of clinical symptoms such as loosening of association, inappropriate affect, catatonia and response to neuroleptic treatment among each group. In light of these results, it seems likely that late-onset schizophrenia is somewhat different from, or might be a subtype of, more typical schizophrenia.
CASE REPORT : Necrotizing Myositis as an Extraintestinal Manifestation of Crohn`s Disease
( Dong Hyun Kim ),( Kyu Hyun Paik ),( Hee Jun Shim ),( Su Yeon Rhie ),( Lae Ik Jung ),( Beom Jin Kim ),( Jae Gyu Kim ) 대한장연구학회 2013 Intestinal Research Vol.11 No.4
Inflammatory bowel disease is associated with extraintestinal manifestations involving almost every organ system in the body. Crohn`s disease (CD) appears to be more commonly associated with an inflammatory myopathy than ulcerative colitis. However, myopathy of the thigh in patients with CD is rare. We report an unusual site of necrotizing myositis in a patient with CD. A 23-year-old woman presented with swelling and pain at the left popliteal area that had lasted for 1 week. Twenty-two months before admission, she had presented with pyoderma gangrenosum on the left upper chest and was diagnosed with CD. A magnetic resonance imaging scan of her leg revealed diffuse swelling in the left semimembranous muscle and biceps femoris muscle that was compatible with myositis, and a cystic lesion in the distal portion of the semimembranous muscle. The findings from semimembranous muscle biopsy were also consistent with necrotizing myositis. In conclusion, myositis, although rare, can be an extraintestinal manifestation of CD. (Intest Res 2013;11:303-305)
Sequence analysis of the first B5 subgenogroup strain of enterovirus 71 isolated in Korea
Yu-Jung Won,Lae Hyung Kang,Ah Ra Lee,Bomina Paik,Hyun Kim,Sung Geun Lee,Seung Won Park,Seung Jin Hong,Soon-Young Paik 한국미생물학회 2020 The journal of microbiology Vol.58 No.5
Enterovirus A71 (EV71), the main etiological agent of handfoot- mouth disease (HFMD), circulates in many areas of the world and has caused large epidemics since 1997, especially in the Asia-Pacific region. In this study, we determined the full-genome sequence of CMC718, a newly isolated EV71 strain in Korea. The CMC718 genome was 7,415 nucleotides in length and was confirmed by whole-genome phylogenetic analysis to belong to the B5 genotype. In particular, CMC718 demonstrated maximum identity with strain M988 of the B5 genotype and numerous amino acid variants were detected in the 3D domain of the viral protein P3, which is consistent with the mutation pattern of a B5 strain isolated in 2012–2013. Comparison of the CMC718 sequence with other EV71 reference strains confirmed the relationship and genetic variation of CMC718. Our study was a full-genome sequence analysis of the first EV71 strain of the B5 genotype isolated in South Korea. This information will be a valuable reference for the development of methods for the detection of recombinant viruses, the tracking of infections, and the diagnosis of EV71.