[PB-0095] Genome-Wide Association Study and Transcriptome Analysis of Salinity Tolerance in Peanuts(Arachis hypogaea L.)

Kunyan Zou(Kunyan Zou),Seung-Ah Han(Seung-Ah Han),Min-jae Choi(Min-jae Choi),Min-jeong Lee(Min-jeong Lee),Da-Hye Jeon(Da-Hye Jeon),Tae-Hwan Jun(Tae-Hwan Jun) 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-

[PB-0094] Genome-Wide Association Study of Leaf Chlorophyll Content Using High-Density 50K SNP Array in Peanut Accessions

Kunyan Zou(Kunyan Zou),Nayoung Kwon(Nayoung Kwon),Tae-Hwan Jun(Tae-Hwan Jun) 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-

Dynamic response characteristics of an innovative turretless low motion FPSO hull in central GoM ultra-deep waters

Zou, Jun Techno-Press 2022 Ocean systems engineering Vol.12 No.2

In oil and gas industry, FPSO concept is the most popular hull form and ship shaped hull form dominants the FPSO market. Only a non-ship-shaped hull in operations with minor market shares is the cylindrical FPSO hull with medium to small storage capability. To add contracting options and competitions to reduce field development costs, an innovative turretless low motion hull, eco-FPSO, with 1MM bbls oil storage capacity and suitable for installing topsides modulars and equipping with regular SCRs, was first introduced in Zou (2020a). Dynamic characteristic responses of the eco-FPSO compared to the traditional SS-FPSO hull and DD-Semi platform are presented and discussed in this paper, suitability and feasibility of the proposed hull have been demonstrated and validated through extensive analyses in 10-yrp, 100-yrp and 1,000-yrp hurricanes in ultra-deepwater central GoM.

자기 공명 영상을 이용한 안면비대칭환자의 측두하악관절 원반의 형태와 위치에 관한 연구

Bingshuang Zou,김태우,최순철 대한치과교정학회 2005 대한치과교정학회지 Vol.35 No.5

본 연구는 안면비대칭이 있는 환자의 측두하악관절원반 형태와 위치를 평가하고 악관절내장증과 안명비대칭 간의 관계를 규명하기 위하여 시행되었다. 남자 10명 및 여자 27명으로 구성된 안명비대칭 환자 37명의 74개의 TMJ MRI를 사용하였으며, 대상 집단의 연령은 12세에서 44세까지의 범위로 평균 21.4세였다. 시상 및 두정 TMJ MRI를 최대감합위 및 최대개구위에서 채득한 후 부분전방변위, 전방변위, 회전 또는 측방 원반변위 등 원반변위의 종류를 기록하였으며, 원반의 모양, 위치, 그리고 원반의 변위 및 회전을 MRI tracing 상에서 판독하였다. 악관절내장증의 증상은 정상, 정복성 전방원반변위 (ADDR). 그리고 비정복성 전방원반변위(ADDNR)집단으로 분류하였으며, 환자는 양측성 정상. 편측 혹은 양측 내장증 집단으로 분류하였다. 약 70%의 환자에서 편측성 또는 양측성 내장증을 보였으며, 통계분석 결과 ADD. 특히 회전성 ADD가 변위측에서 더 높은 빈도로 나타났으나 반대측에서는 원반의 위치가 정상인 경우가 많았다 (p<0.01).변위측의 원반은 모양의 변형 및 하전방 변위를 유의하게 더 나타냈다. 그러나 반대쪽은 개구시 원반이 수직방향으로 과운동성이 관찰되었다. 이 연구는 안면비대칭 환자에서 ADD의 종류가 원반의 모양,경사,변위 각도,변위의 수직거리 및 회전각도와 연관이 있다는 것을 제시한다. The present study was conducted to examine the morphometrics and function of the disk on both sides among patients with facial asymmetry (FA) and to elucidate plausible correlations between internal derangement (ID) and FA. The sample was composed of 10 males and 27 females with FA. The disk status of all subjects was evaluated by biateral high resolution magnetic resonance scans in the sagittal (closed and open) and coronal (closed) planes. Five types of disk displacement were identified accordingly. The disk function was diagnosed as normal disk function, disk displacement with reduction, and disk displacement without reduction. The disk shape on sagittal MRI in closed position was classified as bi-concave, biplanar, funnel/hemiconvex, and deformed. The disk position, translation and rotation were also measured. The difference between the shifted side and non-shifted side was analyzed by statistical analysis. Approximately 70% of the patients in the present study showed unilateral or bilateral ID. It was found that anterior disk displacements (ADD), especially rotational ADD, occurred more frequently in the shifted side, while normal disk position was observed mainly in the non-shifted side(p<0.01). The disk of the shifted side showed significantly deformed configuration and inferior-anterior disk position. However, the disk of the non-deviated side showed hyper-mobility during jaw opening movement. These results demonstrate that in FA patients, the disks status of the shifted side is different from that of the non-shifted side, a phenomenon that could be correlated to facial asymmetry.

Substituting oat hay or maize silage for portion of alfalfa hay affects growth performance, ruminal fermentation, and nutrient digestibility of weaned calves

Yang Zou,XinPing Zou,XiZhi Li,Gang Guo,Peng Ji,Yan Wang,ShengLi Li,YaJing Wang,ZhiJun Cao 아세아·태평양축산학회 2018 Animal Bioscience Vol.31 No.3

Objective: The impact of forage feeding strategy on growth performance, ruminal fermentation and nutrient digestibility in post-weaning calves was investigated. Methods: Forty-five female Holstein calves (body weight [BW] = 79.79±0.38 kg) were enrolled in the 35-d study at one week after weaning and randomly assigned to one of three dietary treatments. All diets were fed as total mixed ration containing 60% (dry matter [DM] basis) of basal starter feed and 40% (DM basis) of forage, but varied in composition of forage source including i) alfalfa (40% DM, AH); ii) alfalfa hay (26.7% DM)+oat hay (13.3% DM; OH); iii) alfalfa hay (26.7% DM)+corn silage (13.3% DM; WS). Results: Dry matter intake was not different among treatment groups (p>0.05). However, BW (p<0.05) and average daily gain (p<0.05) of calves fed AH and OH were greater than WS-fed calves, whereas heart girth was greater in OH-fed calves than those fed AH and WS (p<0.05). Ruminal fermentation parameters including proportion of butyric acid, acetated-to-propionate ratio, concentration of total volatile fatty acid, protozoal protein, bacterial protein, and microbial protein in rumen were the highest in OH (p<0.05) and the lowest in WS. Compared with the AH and WS, feeding oat hay to postweaning calves increased crude protein digestibility (p<0.05), and decreased duration of diarrhea (p<0.05) and fecal index (p<0.05). Conclusion: Our results suggested that partially replacing alfalfa hay with oat hay improved ruminal fermentation, nitrogen utilization, and reduced incidence of diarrhea in post-weaning dairy calves.

Asymmetric Virtual Impedance for Improving Transient Stability of Grid-Forming Inverters Based on Virtual Reluctance Torque

Zhaoyue Zou,Chao Wu,Yong Wang,Yu Lu,Qiang Zou,Nannan Wang 전력전자학회 2023 ICPE(ISPE)논문집 Vol.2023 No.-

The grid-forming inverters have received much attention due to the great voltage and frequency support ability. However, a lot of transient instability phenomena have been reported to the grid-forming inverters. In order to improve the transient stability of grid-forming inverters, an asymmetric virtual impedance is proposed to simulate the reluctance torque of synchronous generator to increase to power transfer ability. Furthermore, the design of virtual impedance is considered from the dimensions of d axis and q axis respectively, and the effect of reluctance torque on the transient stability is shown from the perspectives of increasing power transfer margin and providing larger deceleration area. Finally, the simulation results are presented to validate the effectiveness of the proposed method.

SIRT3-Mediated Dimerization of IDH2 Directs Cancer Cell Metabolism and Tumor Growth

Zou, Xianghui,Zhu, Yueming,Park, Seong-Hoon,Liu, Guoxiang,O'Brien, Joseph,Jiang, Haiyan,Gius, David American Association for Cancer Research 2017 Cancer research Vol.77 No.15

<P>These findings identify SIRT3 as a potential tumor suppressor, mediating its effects by limiting the ability of IDH2 to drive cancer cell metabolism and malignant progression.</P><P>The isocitrate dehydrogenase IDH2 produces α-ketoglutarate by oxidizing isocitrate, linking glucose metabolism to oxidative phosphorylation. In this study, we report that loss of SIRT3 increases acetylation of IDH2 at lysine 413 (IDH2-K413-Ac), thereby decreasing its enzymatic activity by reducing IDH2 dimer formation. Expressing a genetic acetylation mimetic IDH2 mutant (IDH2<SUP>K413Q</SUP>) in cancer cells decreased IDH2 dimerization and enzymatic activity and increased cellular reactive oxygen species and glycolysis, suggesting a shift in mitochondrial metabolism. Concurrently, overexpression of IDH2<SUP>K413Q</SUP> promoted cell transformation and tumorigenesis in nude mice, resulting in a tumor-permissive phenotype. IHC staining showed that IDH2 acetylation was elevated in high-risk luminal B patients relative to low-risk luminal A patients. Overall, these results suggest a potential relationship between SIRT3 enzymatic activity, IDH2-K413 acetylation-determined dimerization, and a cancer-permissive phenotype. <I>Cancer Res; 77(15); 3990–9. ©2017 AACR</I>.</P>

Positive Association Between miR-499A>G and Hepatocellular Carcinoma Risk in a Chinese Population

Zou, Hong-Zhi,Zhao, Yan-Qiu Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3

A case-control study of the association of miR-499A>G rs3746444 with risk of hepatocellular carcinoma (HCC)was conducted. Patients with HCC and healthy control subjects were recruited for genotyping of miR-499A>G using duplex polymerase-chain-reaction with confronting-two-pair primer(PCR-RFLP) analysis. The MiR-499 GG genotype was associated with a decreased risk of HCC as compared with the miR-499 AA genotype (adjusted OR=0.74, 95%CI=0.24-0.96). Similarly, the GG genotype showed a 0.45-fold decreased HCC risk in a recessive model. The MiR-499 G allele was significantly associated with decreased risk of HCC among patients infected with HBV in a dominant model (OR=0.09, 95%CI= 0.02-0.29). In conclusion, the MiR-499A>G rs3746444 polymorphism is associated with HCC risk in the Chinese population, and may be useful predictive marker for CAD susceptibility.

Direct current exerts electricidal and bioelectric effects on Porphyromonas gingivalis biofilms partially via promoting oxidative stress and antibiotic transport

Zou Peihui,Li Peng,Liu Jia,Cao Pei,Luan Qingxian 한국미생물학회 2022 The journal of microbiology Vol.60 No.1

Low electric current can inhibit certain microbial biofilms and enhance the efficacy of antimicrobials against them. This study investigated the electricidal and bioelectric effects of direct current (DC) against Porphyromonas gingivalis biofilms as well as the underlying mechanisms. Here, we firstly showed that DC significantly suppressed biofilm formation of P. gingivalis in time- and intensity-dependent manners, and markedly inhibited preformed P. gingivalis biofilms. Moreover, DC enhanced the killing efficacy of metronidazole (MTZ) and amoxicillin with clavulanate potassium (AMC) against the biofilms. Notably, DC-treated biofilms displayed upregulated intracellular ROS and expression of ROS related genes (sod, feoB, and oxyR) as well as porin gene. Interestingly, DC-induced killing of biofilms was partially reversed by ROS scavenger N-dimethylthiourea (DMTU), and the synergistic effect of DC with MTZ/AMC was weakened by small interfering RNA of porin gene (si-Porin). In conclusion, DC can exert electricidal and bioelectric effects against P. gingivalis biofilms partially via promotion of oxidative stress and antibiotic transport, which offers a promising approach for effective management of periodontitis.

Prognostic Threshold of Neuroendocrine Differentiation in Gastric Carcinoma: a Clinicopathological Study of 945 Cases

Zou, Yi,Chen, Linying,Wang, Xingfu,Chen, Yupeng,Hu, Liwen,Zeng, Saifan,Wang, Pengcheng,Li, Guoping,Huang, Ming,Wang, Liting,He, Shi,Li, Sanyan,Jian, Lihui,Zhang, Sheng The Korean Gastric Cancer Association 2019 Journal of gastric cancer Vol.19 No.1

Purpose: The significance of neuroendocrine differentiation (NED) in gastric carcinoma (GC) is controversial, leading to ambiguous concepts in traditional classifications. This study aimed to determine the prognostic threshold of meaningful NED in GC and clarify its unclear features in existing classifications. Materials and Methods: Immunohistochemical staining for synaptophysin, chromogranin A, and neural cell adhesion molecule was performed for 945 GC specimens. Survival analysis was performed using the log-rank test and univariate/multivariate models with percentages of NED ($P_{NED}$) and demographic and clinicopathological parameters. Results: In total, 275 (29.1%) cases were immunoreactive to at least 1 neuroendocrine (NE) marker. GC-NED was more common in the upper third of the stomach. $P_{NED}$, and Borrmann's classification and tumor, lymph node, metastasis stages were independent prognostic factors. The cutoff $P_{NED}$ was 10%, beyond which patients had significantly worse outcomes, although the risk did not increase with higher $P_{NED}$. Tumors with ${\geq}10%$ NED tended to manifest as Borrmann type III lesion with mixed/diffuse morphology and poorer histological differentiation; the NE components in this population mainly grew in insulae/nests, which differed from the predominant growth pattern (glandular/acinar) in GC with <10% NED. Conclusions: GC with ${\geq}10%$ NED should be classified as a distinct subtype because of its worse prognosis, and more attention should be paid to the necessity of additional therapeutics for NE components.