Competition and Coordination for the Dual-channel Supply Chain with Channel Preference

ZHOU Yong-wei,FAN He-hua,LI Yan-chao 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.2

Aiming at the dual-channel supply chain system with the manufacturer owned direct channel and retail channel simultaneously, the consumers are divided into retail channel loyalty and brand loyalty two parts, under the condition of market demand are depend on the consumers’ channel preference, we studied to the pricing game and coordination between the manufacturer and retailer. The research result showed that the Nash equilibrium of price exists in centralized and decentralized supply chain system, the channel preference degree of consumers, the number of brand loyalty consumers are all have certain influence on supply chain’s optimal pricing strategy, and the price markup contract can realize the coordination of supply chain. The numerical experiment has showed the effectiveness of the conclusions.

Electrochemical micro-couple mechanism based on Si and Mn segregations revealing the initiation of grain boundary dissolution for Q235 carbon steel

Yong Zhou,Fuan Yan 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.120 No.-

The purpose of this work was to reveal the initiation mechanism of grain boundary dissolution (GBD) forcarbon steels in acidic electrolytes containing NO2 – . For Q235 carbon steel in a HNO3-NaNO2 solution withpH 4, the electrochemical methods of potentiodynamic polarization and scanning Kelvin probe forcemicroscope (SKPFM) were applied to explore electrochemical behavior, and the surface methods of scanningelectron microscope (SEM), electron back-scatter diffraction (EBSD) and scanning tunneling microscope(STM) were applied to explore surface microstructure and composition. Q235 carbon steelpresented the electrochemical behavior of activation-passivation-transpassivation in pH 4 HNO3-NaNO2 solution, GBD occurred on steel surface during anodic polarization. GBD initiation, which showeda selective characteristic, was found at the grain boundaries of relatively high Si and Mn contents (highSi-Mn grain boundary) when Q235 carbon steel was polarized to active–passive transition potential. Thegrain boundary segregations of Si and Mn played a critical role in the initiation of GBD, and an electrochemicalmicro-couple (EMC) mechanism based on the Si and Mn segregations was proposed to revealGBD initiation. EMC potential difference between high Si-Mn grain boundary and grain interior wasgreater than that between low Si-Mn grain boundary and grain interior, resulting in that GBD initiatedat high Si-Mn grain boundary. The detailed EMC mechanism of GBD initiation was discussed in this work.

Experimental Study of Molecular Immune Mechanism of TGCO Anti-Adjurant Arthritis

Zhou, Yong,Li, Jianmin,Wang, Xudan 경희대학교 2001 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.2001 No.1

The total glycosides of cornus officinal (TGCO) is effective part of cornus officinals, TGCO suppress immune reactions has been reported in vivo or in vitro. In this paper, we researched effect of TGCO on rat adjuvant arthritis and its molecular immune mechanism. The results showed that TGCO had better action of curing to rat AA, suppressing joint swell of primary and secondary recreation to adjuvant, improving of pathological changes of joints and alleviating spain. On above basis, we forward investigated the molecular immune mechanism TGCO anti-AA, the main results showed such as: 1. TGCO could suppress T lymphocytes proliferation stimulated with ConA and DTH reaction induced by PPO in AA rats. 2. TGCO suppress production of IL-1, IL-6 and TNFα of peritoneal macrophages from AA rats, and PEG2 in plasma of AA rats.3. TGCO could suppress expression of iNOS mRNA gene and IL-lra mRNA gone of peritoneal macrophage of AA rats. 4. Cell-ELISA method was used to detect adhesion molecules(ICAM-1, CD44) and integrin (α4 β7) on ECV 304(It is an important endothelial cell line derived from HUVEC), TGCO could inhibit ECV304 expressing adhesion molecules (ICAM-1, CD44) and integrin(α4β7), with TNF-α and IL-1 stimulate in vitro. Summarizing above results, we infer that TGCO can cure rat AA is in relation to suppressing cell-mediated immune, anti inflammation cytokine(IL-1. IL-6 and TNF-α), and inhibiting adhesion molecule expression.

Control over the Preferred Orientation of CIGS Films Deposited by Magnetron Sputtering Using a Wetting Layer

Yong Yan,Fan Jiang,Lian Liu,Zhou Yu,Yong Zhang,Yong Zhao 대한금속·재료학회 2016 ELECTRONIC MATERIALS LETTERS Vol.12 No.1

A growth method is presented to control the preferred orientation inchalcopyrite CuInxGa1-xSe2 (CIGS) thin films grown by magnetronsputtering. Films with (220/204) and (112) preferred orientation aswell as randomly oriented films were prepared. The effects of anIn2Se3 wetting layer and the working pressure on the texture transitionphenomena were examined. A large-grained CIGS film with (220/204) texture was formed at 400°C with the inclusion of a thin (80 nm)In2Se3 layer and liquid phase (excess copper selenide phase)formation, and the reaction mechanism is proposed. The devicedeposited at 2.0 Pa on an In2Se3 layer exhibited the optimal electricalproperties.

CLASSIFICATION AND EXISTENCE OF NONOSCILLATORY SOLUTIONS OF HIGHER ORDER NONLINEAR NEUTRAL DIFFERENCE EQUATIONS

ZHOU, YONG,LI, C. F. 한국전산응용수학회 2005 Journal of applied mathematics & informatics Vol.18 No.1

In this paper, we consider the higher order nonlinear neutral delay difference equation of the form $\Delta^{\gamma}(x_{n}+px_{n-\gamma})+f(n, x_{n-\sigma_1(n)}, x_{n-\sigma_2(n)}, \ldots, x_{n-\sigma{_m}(n)})=0$. We give an integrated classification of nonoscillatory solutions of the above equation according to their asymptotic behaviours. Necessary and sufficient conditions for the existence of nonoscillatory solutions with designated asymptotic properties are also established.

Knockdown of LncRNAZFAS1 suppresses cell proliferation and metastasis in nonsmall cell lung cancer

Yong Zhou,Xiao-Wei Hu,Si-Jia Yang,Zhe Yu 한국통합생물학회 2020 Animal cells and systems Vol.24 No.2

To evaluate the effects of LncRNAZFAS1 on cell proliferation and tumor metastasis in non-small cell lung cancer (NSCLC), we detected the expression level of LncRNAZFAS1 in NSCLC-related tissues and cells. qRT-PCR results revealed that LncRNAZFAS1 in tumor tissues was significantly higher than that in normal lung tissue, especially significantly up-regulated in stage III / IV and in metastatic NSCLC tissues. LncRNAZFAS1 expression was dramatically up-regulated in 4 NSCLCrelated cells (A549, SPC-A1, SK-MES-1, and NCI-H1299), with having the highest expression level in A549 cells. Furthermore, we implemented a knockdown of LncRNAZFAS1 in A549 cells, and the results of CCK8 and Transwell assays suggested that knockdown of LncRNAZFAS1 significantly inhibited NSCLC cell proliferation and metastasis. Next, we constructed a tumor xenograft model to evaluate the effect of LncRNAZFAS1 on the NSCLC cell proliferation in vivo. The results indicated that knockdown of LncRNAZFAS1 dramatically inhibited A549 cells proliferation and repressed tumor growth. Additionally, knockdown of LncRNAZFAS1 drastically weakened the expressions of MMP2, MMP9 and Bcl-2 proteins, whereas noticeably strengthened the expression of BAX protein. Our results altogether suggest that knockdown of LncRNAZFAS1 has a negative effect on the proliferation and metastasis of NSCLC cell, which implying LncRNAZFAS1 is a potential unfavorable biomarker in patients with NSCLC.

One Metal-Organic Framework Showing Two-Dimensional Sheet Structure: Synthesis, Structure, and Magnetic Property

Yong Hong Zhou,Zhe Yu Wang 대한화학회 2015 Bulletin of the Korean Chemical Society Vol.36 No.2

Under hydrothermal condition, the reaction of 2,4-dichlorophenoxyacetic acid (2,4-DH) and 1,3-bis(4-pyridyl)propane with MnCl2·2H2O gave a novel metal-organic framework (MOF), [Mn(2,4-D)2 (H2O)2] n (1). This complex was characterized by IR, elemental analysis, powder X-ray diffraction, and thermogravimetry analysis. X-Ray single-crystal diffraction shows that the Mn(II) ions are bidendate bridged by carboxyl groups in the syn–anti mode, giving a two-dimensional (2D) network. Temperature-dependent magnetic studies reveal that there are weak antiferromagnetic exchange interactions between the Mn(II) ions transmitted by carboxyl groups.

Expression and Immunogenicity of SARSCoV-2 Virus-Like Particles based on Recombinant Truncated HEV-3 ORF2 Capsid Protein

( Yong-fei Zhou ),( Jiao-jiao Nie ),( Chao Shi ),( Ke Ning ),( Yu-feng Cao ),( Yanbo Xie ),( Hongyu Xiang ),( Qiuhong Xie ) 한국미생물생명공학회 2022 Journal of microbiology and biotechnology Vol.32 No.10

COVID-19 is an emerging disease that poses a severe threat to global public health. As such, there is an urgent demand for vaccines against SARS-CoV-2, the virus that causes COVID-19. Here, we describe a virus-like nanoparticle candidate vaccine against SARS-CoV-2 produced by an E. coli expression system. The fusion protein of a truncated ORF2-encoded protein of aa 439~608 (p170) from hepatitis E virus CCJD-517 and the receptor-binding domain of the spike protein from SARSCoV-2 were expressed, purified and characterized. The antigenicity and immunogenicity of p170-RBD were evaluated in vitro and in Kunming mice. Our investigation revealed that p170-RBD selfassembled into approximately 24 nm virus-like particles, which could bind to serum from vaccinated people (p < 0.001) and receptors on cells. Immunization with p170-RBD induced the titer of IgG antibody vaccine increased from 14 days post-immunization and was significantly enhanced after a booster immunization at 28 dpi, ultimately reaching a peak level on 42 dpi with a titer of 4.97 log10. Pseudovirus neutralization tests showed that the candidate vaccine induced a strong neutralizing antibody response in mice. In this research, we demonstrated that p170-RBD possesses strong antigenicity and immunogenicity and could be a potential candidate for use in future SARS-CoV-2 vaccine development.

Design, performance analysis, and testing of a GFRP racetrack ring for a high-temperature superconducting motor with a flexible support rotor

Yong Zhou,Feng Xie,Hai-Yuan Jia,Wei Chen 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.10

A conceptual 20 MW high-temperature superconducting (HTS) motor (HTSM) with a novel glass-fiber reinforced plastic (GFRP) racetrack ring in the flexible support rotor was explored in this study. To support the cold mass at operating conditions, the high-strength, lowleakage GFRP racetrack ring was designed as follows. First, conceptual design of the 20 MW HTSM was conducted, and the torque transmitted by the GFRP racetrack rings was obtained through electromagnetic analysis. Second, a GFRP racetrack ring was designed, and its total cross-sectional area was obtained through theoretical analysis. Third, thermal leakage and stress were calculated and examined through theoretical and finite element analyses, respectively. The GFRP racetrack ring with the “D” ring was selected based on the results. The thickness and width of the GFRP ring were set to 16 and 10 mm, respectively, and the thickness of the “D” ring was 3 mm. Then, a full-scaled GFRP ring was fabricated, and its strength and stiffness were tested via room-temperature and low-temperature tensile tests. The average tensile strength and average Young’s modulus of the GFRP ring at room temperature were 1131.5 MPa and 49.9 GPa, respectively. The strength of the GFRP ring at 193.4 K was 1243.9 MPa, and the Young's modulus of the GFRP ring at 141.3 K was 69 GPa. Lastly, a new 200 kW HTS generator was assembled using a scaled rotor with the same structure as the 20 MW HTSM and the original stator of an existing 200 kW generator. The test system was built to evaluate the feasibility of the GFRP ring before manufacturing the 20 MW HTSM. Test results showed that the GFRP ring is feasible, the design method of the GFRP ring is credible. The GFRP ring is suitable for the cold mass support of HTSMs and other low-temperature devices.

A Pole Pair Segment of Oil-cooling Air-Core Stator for a 2 MW Direct-Drive High Temperature Superconducting Wind Power Generator

Zhou Yong,Dong Qi,Niu Xiao-Jun,Xu Hong,Xiong Qi,Su Hao,Zheng Jun 대한전기학회 2021 Journal of Electrical Engineering & Technology Vol.16 No.6

A 2 MW direct-drive (DD) high temperature superconducting (HTS) wind power generator with HTS wires in the rotor fi eld windings and copper transposed conductor in the stator coils was explored for the wind turbine application in this study. An oil-cooling air-core stator with non-magnetic teeth of the 2 MW DD HTS generator was designed because the high fl ux density generated by the HTS wires wound result in larger dissipation in iron teeth, and the process of that could be summarized as follows. First, a 2 MW DD HTS wind power generator was designed, and the electromagnetic (EM), loss, EM force, and insulation of the DD HTS generator were analyzed and developed, respectively. Second, the thermal and mechanical of the one pole pair oil-cooling air-gap armature was analyzed by the fi nite element analysis. Then, a pole pair segment of the oil-cooling air-core stator with the same structure as the 2 MW generator was designed and manufactured to identify potential challenges, obtain practical knowledge before production, and then reduce the development risk of the 2 MW DD HTS generator. Furthermore, a test system with converter, oil-cooling system, and data acquisition equipment was developed simultaneously to test the temperature distribution of the slotless stator. The performance test results show that the maximum temperature rise of the one pole pair oil-cooling stator under rated conditions is about 81.4 K, which satisfi es the design requirements of the 2 MW DD HTS generator.