Using Queue Model to Evaluate the Reliability in Cloud Platforms

Zhichao Liu,Ze Xiao 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.10

In recent years, cloud platforms have been widely applied in various areas to provide flexible service for users. However, how to evaluate the reliability of cloud platforms still remains a challenging issue because of its complexity and dynamical characteristic. In this paper, we present a novel reliability evaluation model which is aiming at providing a technique to accurately evaluate the reliability of virtualized cloud platforms. The proposed model is deprived from the classical tree-structure based reliability model and incorporates some new mechanisms to overcome the shortcomings of previous models. Extensive experiments are conducted to investigate the effectiveness of the proposed model. The results shown that, comparing with the existing approaches, the proposed model can significantly improve the accuracy of reliability evaluation, especially when the target cloud platform is in presence of intensive workloads.

Study on Preparation of Core-Spun Yarn Surgical Sutures by Compositing Drug-Loaded Nanofiber Membrane with PLA and Its Controllable Drug Release Performance

Zhichao Yang,Shuqiang Liu,Jingjing Li,Gaihong Wu,Man Zhang,Fu Li,Lu Jia,Yujing Zhang,Huimin Li,Xia Liu,Jingjing Zhao,Huiqin Zhang,Shiyu Li 한국섬유공학회 2023 Fibers and polymers Vol.24 No.12

Polylactic acid (PLA) surgical suture is considered to be one of the most ideal materials for tissue closure due to its rich raw materials and excellent biological properties. However, surgical sutures face great challenges due to problems such as wound infection and tissue reaction in practical applications. In order to improve the clinical applicability of surgical sutures, we constructed a new drug-loading system for core-spun surgical sutures. The shell was composed of nanofibrous membranes composed of polyglycolic acid (PGA) and polycaprolactone (PCL) and ciprofloxacin (CIP) antibacterial drugs, and the core layer adopts PLA filament. By adjusting the composition ratio of PGA and PCL in the shell, a new mode of regulating the release rate and release cycle of the suture was constructed. According to different wound healing time, different drug release cycles of surgical suture were selected. In the study, the structure of the core-spun yarn can be clearly observed by scanning electron microscope, the higher the shell PGA content and drug loading, the faster the drug release rate. When the carrier ratio PGA/PCL was 80/20 and the drug loading was 3%, the drug release rate was the fastest and the drug release was high; finally, antibacterial experiments showed that the suture had excellent antibacterial effect and could effectively kill Staphylococcus aureus and Escherichia coli. The successful preparation of core-spun yarn surgical suture provides a new idea for the study of new antibacterial surgical suture.

TiO2 Nanotubes/Nanoparticles Composite Film with Higher Light Harvesting and Electron Transfer for Dye-Sensitized Solar Cells

Chengcheng Liu,Zhifeng Liu,Lei E,Yabin Li,Jianhua Han,Yun Wang,Zhichao Liu,Jing Ya,Xuhuang Chen 대한금속·재료학회 2012 ELECTRONIC MATERIALS LETTERS Vol.8 No.5

TiO2 nanotubes with an inner diameter of 4-6 nm were synthesized by hydrothermal treatment method. TiO2nanotubes/nanoparticles composite films were fabricated as a dye-sensitized solar cells work electrode using TiO2 nanotubes and TiO2 nanoparticles as precursor. The structure of composite films has a remarkable influence on the final performance of the cell due to high surface area, fast electron transfer, enhanced light-scattering and light-harvesting, simultaneously. I-V characteristic measurement indicates an enhanced efficiency by 27%as compared to TiO2 nanotubes film.

Effects of Aspect Ratio on the Microwave Properties of Fe-Si-Al Alloy Flakes

Kaihuang Liu,Deren Li,Tiancheng Liu,Zhichao Lu,Shaoxiong Zhou 한국자기학회 2010 한국자기학회 학술연구발표회 논문개요집 Vol.2010 No.12

Folic acid supplementation regulates key immunity-associated genes and pathways during the periparturient period in dairy cows

Khan Muhammad Zahoor,Zhang Zhichao,Liu Lei,Wang Di,Mi Siyuan,Liu Xueqin,Liu Gang,Guo Gang,Li Xizhi,Wang Yachun,Yu Ying 아세아·태평양축산학회 2020 Animal Bioscience Vol.33 No.9

Objective: The current research was aimed to profile the transcriptomic picture of the peripheral blood lymphocytes (PBLs) associated with immunity in Chinese Holsteins supplemented orally with coated folic acid during the periparturient period. Methods: The total of 123 perinatal cows were selected for this study and divided into three groups; group A (n = 41, 240 mg/500 kg cow/d), group B (n = 40, 120 mg/500 kg cow/d) and group C (n = 42, 0 mg/cow/d) based on the quantity of folic acid fed. Three samples of PBLs were selected from each folic acid treated group (high, low, and control) and RNA sequencing method was carried out for transcriptomic analysis. Results: The analysis revealed that a higher number of genes and pathways were regulated in response to high and low folic acid supplementation compared to the controls. We reported the novel pathways tumor necrosis factor (TNF) signaling, antigen processing and presentation, Staphylococcus aureus infection and nuclear factor (NF)-kappa B signaling pathways) and the key genes (e.g. C-X-C motif chemokine ligand 10, TNF receptor superfamily member 1A, cluster difference 4, major histocompatibility complex, class II, DQ beta, NF-kappa-B inhibitor alpha, and TNF superfamily 13) having great importance in immunity and anti-inflammation in the periparturient cows in response to coated folic acid treatment. Conclusion: Collectively, our study profiled first-time transcriptomic analysis of bovine lymphocytes and compared the involved cytokines, genes, and pathways between high vs control and low vs control. Our data suggest that the low folic acid supplementation (120 mg/500 kg) could be a good choice to boost appropriate immunity and anti-inflammation as well as might being applied to the health improvement of perinatal dairy cows.

Coffin-Siris syndrome in two chinese patients with novel pathogenic variants of ARID1A and SMARCA4

Liu Mingjie,Wan Linlin,Wang Chunrong,Yuan Hongyu,Peng Yun,Wan Na,Tang Zhichao,Yuan Xinrong,Chen Daji,Long Zhe,Shi Yuting,Qiu Rong,Tang Beisha,Tang Beisha,Chen Zhao 한국유전학회 2022 Genes & Genomics Vol.44 No.9

Background: Coffin-Siris syndrome (CSS) is a rare congenital syndrome characterized by developmental delay, intellectual disability, microcephaly, coarse face and hypoplastic nail of the fifth digits. Heterozygous variants of different BAF complex-related genes were reported to cause CSS, including ARID1A and SMARCA4. So far, no CSS patients with ARID1A and SMARCA4 variants have been reported in China. Objective: The aim of the current study was to identify the causes of two Chinese patients with congenital growth deficiency and intellectual disability. Methods: Genomic DNA was extracted from the peripheral venous blood of patients and their family members. Genetic analysis included whole-exome and Sanger sequencing. Pathogenicity assessments of variants were performed according to the guideline of the American College of Medical Genetics and Genomics. The phenotypic characteristics of all CSS subtypes were summarized through literature review. Results: We identified two Chinese CSS patients carrying novel variants of ARID1A and SMARCA4 respectively. The cases presented most core symptoms of CSS except for the digits involvement. Additionally, we performed a review of the phenotypic characteristics in CSS, highlighting phenotypic varieties and related potential causes. Conclusions: We reported the first Chinese CSS2 and CSS4 patients with novel variants of ARID1A and SMARCA4. Our study expanded the genetic and phenotypic spectrum of CSS, providing a comprehensive overview of genotype-phenotype correlations of CSS.

Optimal modulation strategy based on fundamental reactive power for dual‑active‑bridge converters

Zhichao Zhu,Fei Xiao,Jilong Liu,Peng Chen,Zhaojie Huang,Qiang Ren 전력전자학회 2021 JOURNAL OF POWER ELECTRONICS Vol.21 No.12

Dual-active-bridge (DAB) converters are widely used in bidirectional power transmission and voltage conversion. At present, phase-shift (PS) control is one of the most common and mature control methods for DAB converters. To improve the efficiency and performance of DAB converters, the soft switching and current stress are optimized by increasing the inner phaseshift ratio. However, under different PS controls, it is difficult to establish a unified mathematical model using the traditional instantaneous integral method. To solve this problem, based on the approximate equivalence of the fundamental component of a high-frequency link decomposed by Fourier series, an optimal fundamental modulation strategy is proposed, which takes the fundamental reactive power as the objective of optimization. The trajectories for each of the electrical parameters are analyzed intuitively through a vector diagram of the phasor. A practical optimal control strategy scheme for engineering is obtained. Finally, the effectiveness of the theoretical analysis and the proposed method are verified by experimental results.

Enhanced morphology and hydrophilicity of PVDF flat membrane with modified CaCO3@SMA additive via thermally induced phase separation method

Zhichao Zhang,Wei Wang,Xin Xu,Xi Liu,Yuanling Li,Peng Zhang 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.107 No.-

Modified CaCO3@SMA nanoparticles obtained by coordination reaction between poly(styrene-co-maleicanhydride) (SMA) and calcium carbonate (CaCO3) nanoparticles were adopted as additive to preparepolyvinylidene fluoride (PVDF) flat membrane via thermally induced phase separation (TIPS) methodwith dioctyl phthalate (DOP) and dibutyl phthalate (DBP) as mixed diluent. The CaCO3 nanoparticlesmodified by SMA effectively reduced the adverse agglomeration of nanoparticles and made the additivedisperse evenly in PVDF matrix. The presence of modified CaCO3@SMA changed the membrane morphologyfrom dispersed spherulites with large pores to fuzzy dendrite structures with uniform pore sizes. Themembrane pore sizes, pore size distribution and tensile strength were significantly improved comparedto both virgin membranes and those containing unmodified CaCO3 nanoparticles. After the CaCO3 waspickled, the porosity and the connectivity between membrane pores were greatly enhanced, resultingin a significant increase in pure water flux. At the same time, the amphiphilic SMA fixed in and on themembrane surface improved the hydrophilic and anti-fouling properties demonstrated in a three-cycletest. The present study provided a potential TIPS method for the fabrication of PVDF membrane combinedwith a simple strategy of modified inorganic particle additive.

Phase II trial of VEGFR2 inhibitor apatinib for metastatic sarcoma: focus on efficacy and safety

Zhichao Liao,Feng Li,Chao Zhang,Lei Zhu,Yehui Shi,Gang Zhao,Xu Bai,Shafat Hassan,Xinyue Liu,Ting Li,Peipei Xing,Jun Zhao,Jin Zhang,Ruwei Xing,Sheng Teng,Yun Yang,Kexin Chen,Jilong Yang 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-

Apatinib (YN968D1) is a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor 2 (VEGFR- 2). We conducted a single-arm, nonrandomized phase II study (NCT03121846) to assess the efficacy and safety of apatinib in patients with stage IV sarcoma. We recruited 64 patients with stage IV sarcoma who had failed chemotherapy. The primary endpoint was progression-free survival (PFS), and the secondary endpoints were progression-free survival rate (PFR), objective response rate (ORR), and disease control rate (DCR) at week 12. Treatment-related adverse effects (AEs) were evaluated. Fifty-nine patients were assessed for efficacy and 64 patients for AEs. The median PFS was 7.93 months. At 12 weeks, the PFR was 74%, the ORR was 16.95% (10/59), and the DCR was 86.44% (51/59). The final ORR was 15.25% (9/59) and the DCR was 57.63% (34/59). Notably, 22 patients (34.38%) who developed hypertension, hand-foot-skin reaction, or proteinuria had significantly longer OS than those without these AEs (18.20 vs. 10.73 months; P = 0.002). We conclude that apatinib is effective and well tolerated in patients with advanced sarcoma. The development of hypertension, hand-foot-skin reaction, or proteinuria may indicate a favorable prognosis, representing a novel finding in sarcoma patients.

Numerical Investigation of the Influence of Rock Characteristics on the Soil-Rock Mixture (SRM) Slopes Stability

Shiqi Liu,Huanling Wang,Weiya Xu,Zhichao Cheng,Zhipeng Xiang,Wei-Chau Xie 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.11

Soil-rock mixture is a widely distributed geological material in mountainous regions, where slope stability is an important issue. To investigate the influence of rock on slope stability, firstly, rocks in SRM are generated and then SRM slope models are simulated based on the finite difference method (FDM). The impact of various characteristics of rocks on slope factor of safety (FOS) is studied systematically by using the reduced strength method. The characteristic of rock considered include rock content, number of rock edges, aspect ratio, rock size and inclination of rock. The simulations indicate that increasing the rock content can prevent the development of high strain region and improve slope stability. However, the aspect ratio of rock has negligible impact on the mean value of FOS. For slopes with 45o slope angle, rocks with 45o angle of inclination result in smooth potential sliding surface, whereas rocks with 135o angle of inclination lead to more tortuous potential sliding surfaces. Statistical indices are utilized to analyze the results of numerical modelling.