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Luteolin induces apoptotic cell death via antioxidant activity in human colon cancer cells
Kang, Kyoung Ah,Piao, Mei Jing,Ryu, Yea Seong,Hyun, Yu Jae,Park, Jeong Eon,Shilnikova, Kristina,Zhen, Ao Xuan,Kang, Hee Kyoung,Koh, Young Sang,Jeong, Yong Joo,Hyun, Jin Won Spandidos Publications 2017 International journal of oncology Vol.51 No.4
<P>The present study determined whether luteolin induces HT-29 colon cancer cell death through an antioxidant effect such as the activation of antioxidant enzymes. Luteolin decreased cell viability in human colon cancer cells (HT-29), whereas it had no effect on normal colon cells (FHC). Luteolin induced apoptosis by activating the mitochondria-mediated caspase pathway in HT-29 cells. Luteolin caused loss of the mitochondrial membrane action potential, increased mitochondrial Ca2+ level, upregulated Bax, downregulated Bcl-2, induced the release of cytochrome c from mitochondria to the cytosol, and increased the levels of the active forms of caspase-9 and caspase-3. Luteolin-induced apoptosis was accompanied by the activation of intracellular and mitochondrial reactive oxygen species scavenging through the activation of antioxidant enzymes, such as superoxide dismutase and catalase in HT-29 cells. Luteolin increased the level of reduced glutathione (GSH) and the expression of GSH synthetase, which catalyzes the second step of GSH biosynthesis. The apoptotic effect of luteolin was mediated by the activation of the mitogen-activated protein kinase signaling pathway. The present results indicate that luteolin induces apoptosis by promoting antioxidant activity and activating MAPK signaling in human colon cancer cells.</P>
A Comparative Study of DEA-SFA for Industry-level in China
Zhen-Nan Kang,Tae-Hwang Kim 한국무역연구원 2018 貿易 硏究 Vol.14 No.3
This paper aims to make a comparative analysis between Data Envelopment Analysis (DEA) and Stochastic Frontier Analysis (SFA) based efficiency scores and decomposed TFP (Total Factor Productivity) index, which are estimated from constructed industry-level data in China from 1985 to 2014. On one hand, the results are that DEA and SFA efficiency scores appear positively correlated and estimated TFP growth is in similar shape. On the other hand, for industry-level productivity in China, we found that according to the SFA, the estimation of TFP change and all decomposed elements showed a less noisy and much smoother shape when compared to DEA. The paper concludes that for an analysis of TFP of Chinese industry, the methodology of an SFA is more effective in explaining the changes and impacts as compared to the DEA. Since most of China’s industry level productivity studies have been done using DEA, we expect different and more practically significant results for future inter-industry studies. In this context, this paper would contribute to develop analytic methodology of China’s industry level productivity studies.
A General Distributed Computer Simulation System GDCSS
Zhen, Kang Nai,You, Chang Hui,Xian, Liang Yong 대한전자공학회 1992 HICEC:Harbin International Conference on Electroni Vol.1 No.1
This paper introduces the function, realization and use of a general distributed computer simulation system (GDCSS). It can be used as an aided tool to design and simulate various distributed computer systems or distributed algorithms.
Xin, Zhen Xiang,Zhang, Zhen Xiu,Pal, Kaushik,Kang, Dong Jin,Lee, Sung Hyo,Kim, Jin Kuk Wiley Subscription Services, Inc., A Wiley Company 2009 Journal of Vinyl and Additive Technology Vol.15 No.4
<P>Microcellular polypropylene (PP)/WGRT blends, a new outlet for the recycling of waste tire rubber, were prepared in an injection-molding process by using a chemical blowing agent. The effects of WGRT content and chemical blowing agent content on the density, cell morphology, and physicomechanical properties of the foamed PP/WGRT blends were investigated. The foam morphologies were characterized in terms of void fraction, average cell size, and cell density. The results indicated that both the WGRT and the blowing agent content had huge effects on the cell morphology and tensile properties of the PP/WGRT foams. J. VINYL ADDIT. TECHNOL., 2009. © 2009 Society of Plastics Engineers</P>
Xin, Zhen Xiang,Zhang, Zhen Xiu,Pal, Kaushik,Kim, Kwang-Jea,Kang, Dong Jin,Kim, Jin Kuk,Bang, Dae-Suk SAGE Publications 2009 Journal of cellular plastics Vol.45 No.6
<P>A new approach towards the recycling of waste ground rubber tire (WGRT) powder was demonstrated in this study by introducing the polypropylene/ waste ground rubber tire (PP/WGRT) foaming method by using CO<SUB>2</SUB> as the foaming agent in an extrusion foaming process. The regression models were constructed to study the relationships between the foam structure (i.e., void fraction, average cell size, and cell density) of foamed PP/WGRT blends, the processing parameters (extruder’s die temperature and CO<SUB>2</SUB> concentration), and WGRT content by applying a three-factor central composite design (CCD) statistical approach. The response surface plots generated using the regression models allow the rapid selection of the proper process parameters to obtain microcellular PP/WGRT blends with the desired density and morphology.</P>
Jin, Zhen,Nguyen, Kim Tien,Go, Gwangjun,Kang, Byungjeon,Min, Hyun-Ki,Kim, Seok-Jae,Kim, Yun,Li, Hao,Kim, Chang-Sei,Lee, Seonmin,Park, Sukho,Kim, Kyu-Pyo,Huh, Kang Moo,Song, Jihwan,Park, Jong-Oh,Choi, American Chemical Society 2019 NANO LETTERS Vol.19 No.12
<P>Nanorobots are safe and exhibit powerful functionalities, including delivery, therapy, and diagnosis. Therefore, they are in high demand for the development of new cancer therapies. Although many studies have contributed to the progressive development of the nanorobot system for anticancer drug delivery, these systems still face some critical limitations, such as potentially toxic materials in the nanorobots, unreasonable sizes for passive targeting, and the lack of several essential functions of the nanorobot for anticancer drug delivery including sensing, active targeting, controlling drug release, and sufficient drug loading capacity. Here, we developed a multifunctional nanorobot system capable of precise magnetic control, sufficient drug loading for chemotherapy, light-triggered controlled drug release, light absorption for photothermal therapy, enhanced magnetic resonance imaging, and tumor sensing. The developed nanorobot system exhibits an <I>in vitro</I> synergetic antitumor effect of photothermal therapy and chemotherapy and outstanding tumor-targeting efficiency in both <I>in vitro</I> and <I>in vivo</I> environments. The results of this study encourage further explorations of an efficient active drug delivery system for cancer treatment and the development of nanorobot systems for other biomedical applications.</P> [FIG OMISSION]</BR>
( Ao Xuan Zhen ),( Mei Jing Piao ),( Yu Jae Hyun ),( Kyoung Ah Kang ),( Yea Seong Ryu ),( Suk Ju Cho ),( Hee Kyoung Kang ),( Young Sang Koh ),( Mee Jung Ahn ),( Tae Hoon Kim ),( Jin Won Hyun ) 한국응용약물학회 2019 Biomolecules & Therapeutics(구 응용약물학회지) Vol.27 No.4
Purpurogallin, a natural phenol obtained from oak nutgalls, has been shown to possess antioxidant, anticancer, and anti-inflammatory effects. Recently, in addition to ultraviolet B (UVB) radiation that induces cell apoptosis via oxidative stress, particulate matter 2.5 (PM<sub>2.5</sub>) was shown to trigger excessive production of reactive oxygen species. In this study, we observed that UVB radiation and PM<sub>2.5</sub> severely damaged human HaCaT keratinocytes, disrupting cellular DNA, lipids, and proteins and causing mitochondrial depolarization. Purpurogallin protected HaCaT cells from apoptosis induced by UVB radiation and/or PM<sub>2.5</sub>. Furthermore, purpurogallin effectively modulates the pro-apoptotic and anti-apoptotic proteins under UVB irradiation via caspase signaling pathways. Additionally, purpurogallin reduced apoptosis via MAPK signaling pathways, as demonstrated using MAPK-p38, ERK, and JNK inhibitors. These results indicate that purpurogallin possesses antioxidant effects and protects cells from damage and apoptosis induced by UVB radiation and PM<sub>2.5</sub>.
Niacinamide Protects Skin Cells from Oxidative Stress Induced by Particulate Matter
( Ao Xuan Zhen ),( Mei Jing Piao ),( Kyoung Ah Kang ),( Pincha Devage Sameera Madushan Fernando ),( Hee Kyoung Kang ),( Young Sang Koh ),( Joo Mi Yi ),( Jin Won Hyun ) 한국응용약물학회 2019 Biomolecules & Therapeutics(구 응용약물학회지) Vol.27 No.6
Niacinamide (NIA) is a water-soluble vitamin that is widely used in the treatment of skin diseases. Moreover, NIA displays antioxidant effects and helps repair damaged DNA. Recent studies showed that particulate matter 2.5 (PM<sub>2.5</sub>) induced reactive oxygen species (ROS), causing disruption of DNA, lipids, and protein, mitochondrial depolarization, and apoptosis of skin keratinocytes. Here, we investigated the protective effects of NIA on PM<sub>2.5</sub>-induced oxidative stress in human HaCaT keratinocytes. We found that NIA could inhibit the ROS generation induced by PM<sub>2.5</sub>, as well block the PM<sub>2.5</sub>-induced oxidation of molecules, such as lipids, proteins, and DNA. Furthermore, NIA alleviated PM<sub>2.5</sub>-induced accumulation of cellular Ca<sup>2+</sup>, which caused cell membrane depolarization and apoptosis, and reduced the number of apoptotic cells. Collectively, the findings show that NIA can protect keratinocytes from PM<sub>2.5</sub>-induced oxidative stress and cell damage.
Kang, Kyoung Ah,Piao, Mei Jing,Hyun, Yu Jae,Zhen, Ao Xuan,Cho, Suk Ju,Ahn, Mee Jung,Yi, Joo Mi,Hyun, Jin Won Nature Publishing Group UK 2019 Experimental and molecular medicine Vol.51 No.4
<▼1><P>Luteolin, a dietary flavone, modulates various signaling pathways involved in carcinogenesis. In this study, we investigated the molecular mechanism that underlies the apoptotic effects of luteolin mediated by DNA demethylation of the nuclear factor erythroid 2-related factor 2 (Nrf2) promoter and the interaction of Nrf2 and p53, a tumor suppressor, in human colon cancer cells. Luteolin increased the expression of apoptosis-related proteins and antioxidant enzymes. In DNA methylation, luteolin inhibited the expression of DNA methyltransferases, a transcription repressor, and increased the expression and activity of ten-eleven translocation (TET) DNA demethylases, a transcription activator. Methyl-specific polymerase chain reaction and bisulfite genomic sequencing indicated that luteolin decreased the methylation of the Nrf2 promoter region, which corresponded to the increased mRNA expression of Nrf2. In addition, luteolin increased TET1 binding to the Nrf2 promoter, as determined using a chromatin immunoprecipitation (ChIP) assay. TET1 knockdown decreased the percentages of luteolin-treated cells in sub-G<SUB>1</SUB> phase and cells with fragmented nuclei. Furthermore, complex formation between p53 and Nrf2 was involved in the apoptotic effects of luteolin. These results provide insight into the mechanism that underlies the anticancer effects of luteolin on colon cancer, which involve the upregulation of Nrf2 and its interaction with the tumor suppressor.</P></▼1><▼2><P><B>Cancer: Cell-killing plant compound exerts antioxidant effects</B></P><P>A molecule found in fruits, vegetables and herbs helps kill colon cancer cells by activating a master regulator of detoxifying enzymes. Jin Won Hyun from Jeju National University School of Medicine in South Korea and colleagues treated human colon cancer cells with luteolin, a molecule that occurs naturally in many food plants. They showed that luteolin increased the levels of proteins involved in cell death and antioxidant responses by causing DNA-modifying enzymes to strip suppressive chemical markers off the gene encoding Nrf2, a protein that regulates antioxidant effects. Nrf2 levels subsequently increased and the protein interacted with the tumor suppressor p53 to facilitate destruction of the colon cancer cells. The findings offer a mechanistic basis for using luteolin to help prevent and treat cancer.</P></▼2>