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HOXC10 suppresses browning of white adipose tissues
Yvonne Ng,Shi-Xiong Tan,Sook Yoong Chia,Hwee Yim Angeline Tan,Sin Yee Gun,Lei Sun,Wanjin Hong,Weiping Han 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Given that increased thermogenesis in white adipose tissue, also known as browning, promotes energy expenditure, significant efforts have been invested to determine the molecular factors involved in this process. Here we show that HOXC10, a homeobox domain-containing transcription factor expressed in subcutaneous white adipose tissue, is a suppressor of genes involved in browning white adipose tissue. Ectopic expression of HOXC10 in adipocytes suppresses brown fat genes, whereas the depletion of HOXC10 in adipocytes and myoblasts increases the expression of brown fat genes. The protein level of HOXC10 inversely correlates with brown fat genes in subcutaneous white adipose tissue of cold-exposed mice. Expression of HOXC10 in mice suppresses cold-induced browning in subcutaneous white adipose tissue and abolishes the beneficial effect of cold exposure on glucose clearance. HOXC10 exerts its effect, at least in part, by suppressing PRDM16 expression. The results support that HOXC10 is a key negative regulator of the process of browning in white adipose tissue.
Income Inequality in the South-South Integration
( Yvonne Sperlich ),( Stefan Sperlich ) 세종대학교 경제통합연구소 2014 Journal of Economic Integration Vol.29 No.4
Some of the findings from new trade and economic geography theory are quite critical concerning the South-South agreements. This study contributes to the discussion by means of different empirical analyses of a representative set of South-South integrations. The income developments of its member states are studied with a special focus on income dispersion between and within member states. The results show that income dispersion has slightly decreased, within and between member states. The findings are placed in relation to growth models and beta convergence as other studies have found ambivalent results for growth and convergence in South-South integration areas.
Hepatocellular carcinoma surveillance: Eastern and Western perspectives
Yvonne Purcell,Pauline Copin,Luisa Paulatto,Romain Pommier,Valérie Vilgrain,Maxime Ronot 대한초음파의학회 2019 ULTRASONOGRAPHY Vol.38 No.3
Eastern and Western guidelines for the management of hepatocellular carcinoma (HCC) are known to significantly differ on many points, because they reflect different diagnostic and therapeutic approaches to this cancer. Importantly, these guidelines are primarily consensusdriven when it comes to surveillance, both in term of the tests used and surveillance program design. The main difference between East and West lies in clinical practice, as several Eastern countries implement coordinated and systematic surveillance programs, while most Western countries rely on individual adherence to surveillance recommendations. This review article presents an overview of the evidence supporting surveillance programs for HCC, with a particular focus on the efficacy, cost-effectiveness, and consequences of this approach for patient survival. Western and Eastern guideline recommendations are discussed.
Yvonne Iradukunda,Elizabeth Mkoba,Silas Mirau 대한전자공학회 2022 IEIE Transactions on Smart Processing & Computing Vol.11 No.3
Poor monitoring of levels in juice tanks is among the challenges that beverage industries face when pumping liquid from one tank to another. This leads to spilling fluids, faulty juice tests, and industrial accidents. To keep track of the liquid level in a tank, various approaches have been used. Existing technologies are costly and not interactive, and the majority do not benefit individuals with physical disabilities when manual monitoring is needed. The purpose of this paper is to present an optimal smart tank juice-level monitoring system that can be used in beverage industries. The system is able to monitor the juice level within a tank and regulate a pump using voice commands via Alexa and the Amazon Echo Dot. The proposed system was tested and validated, with key findings being that the developed prototype prevented overflowing, accidents, and changes in juice flavor during the dilution process. This paper contributes to the body of knowledge for food and beverage industries in that engineers and operators of beverage industries can monitor the level of juice in a tank, as well as enhance communication when pumping juice from one tank to another in real time.
( Yvonne A. B. Buunk-werkhoven ),( Jolanda J. C. Gortzak ),( Judith J. E. Sjoerts ),( Annemarie Frederiks ) 한국치위생과학회 2021 치위생과학회지 Vol.21 No.3
Background: The aim of these two (pre COVID-19 pandemic) public health studies in Amsterdam were to promote the profession of the oral hygienist and to increase oral health care awareness among (pregnant) women and young mothers, who were visitors of public consumer’s exhibitions. Methods: Two cross-sectional studies were carried out. In 2018, during the first study, 1,765 visitors of the Household Fair completed a questionnaire. In 2020, during Study 2, 304 visitors of the Nine-Month Fair completed a semi-structured online questionnaire. At both fairs a team of ‘outspoken’ oral hygienists, i.e., members of the Foundation ‘Goed Gebekt’, provided the visitors with tailored advices about general health related to adults, mothers’, and their children’ oral health, using natural routine interviewing, that was based on their own professional daily practical experience. Results: In Study 1, just over half (53.5%) of a total of 1,742 visitors, (85.7% female) was younger than 45 years old. In Study 2, 210 visitors with a mean age of 30.7 years were included. Most women reported their self-perceived oral health as ‘good’ (mean=8.0, standard deviation=1.3; range 3∼10). Qualified (self) employed oral hygienists seem to be known among the visitors, but still only visited upon referral of the dentists. Up to the age of 18 reimbursements by the basic insurance is still unknown to the public. Conclusion: The Foundation ‘Goed Gebekt’ encourages other oral hygienists to make their own initiatives and experiences public and to share it. Public awareness is needed for oral health promotion and the development of optimally targeted interventions among (pregnant) women and young mothers by oral hygienists.
Yvonne Nitschke,Yan Yan,Insa Buers,Kristina Kintziger,Kim Askew,Frank Rutsch 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Generalized arterial calcification of infancy (GACI) is associated with widespread arterial calcification and stenoses and is caused by mutations in ENPP1. ENPP1 encodes for ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), which cleaves ATP to generate inorganic pyrophosphate (PPi) and adenosine monophosphate (AMP) extracellularly. The current study was designed to define the prevalence of arterial stenoses in GACI individuals and to identify the mechanism through which ENPP1 deficiency causes intimal proliferation. Furthermore, we aimed to effectively prevent and treat neointima formation in an animal model of GACI through the systemic administration of recombinant human (rh)ENPP1-Fc protein. Based on a literature review, we report that arterial stenoses are present in at least 72.4% of GACI cases. We evaluated the effect of rhENPP1-Fc on ENPP1-silenced human vascular smooth muscle cells (VSMCs) and on induced intimal proliferation in Enpp1-deficient ttw/ttw mice treated with carotid ligation. We demonstrate that silencing ENPP1 in VSMCs resulted in a tenfold increase in proliferation relative to that of cells transfected with negative control siRNA. The addition of rhENPP1-Fc, AMP or adenosine restored the silenced ENPP1- associated proliferation. In contrast, neither PPi nor etidronate, a current off-label treatment for GACI, had an effect on VSMC proliferation. Furthermore, subcutaneous rhENPP1-Fc protein replacement was effective in preventing and treating intimal hyperplasia induced by carotid ligation in an animal model of GACI. We conclude that ENPP1 inhibits neointima formation by generating AMP. RhENPP1-Fc may serve as an approach for the effective prevention and treatment of arterial stenoses in GACI.
Strategies towards ending violence against girls and young women in Mathare informal settlement
Yvonne Bellys AKOTH 이화여자대학교 아시아여성학센터 2018 이화여자대학교 아시아여성학센터 학술대회자료집 Vol.2018 No.1
A significant number of girls and young women in informal settlements are subjected to sexual and physical violence. There is an urgent need for a renewed approach to impart knowledge and information on recognizing, preventing and ending violence targeted at the most vulnerable members of our society. Empowering young women and girls to know and exercise their rights is a step forward towards achieving gender equality. In the recent past, we have seen cases of child paedophilia which has ended in murder, the undressing of women marred with sexual harassment in open public spaces, and the chopping of women’s body parts in domestic disputes. Recent campaigns such as the ‘My Dress My Choice Campaign’ in Kenya showed how women’s freedom is curtailed. This research looks at violence against girls and young women 10 to 24 years of age in Nairobi’s Mathare informal settlement. We look at women’s freedom over their bodies as well as their personal space from childhood to young adulthood in low income neighbourhoods. Whereas the Kenyan government, international development partners and non-governmental organizations have taken an active role in ensuring the persecution of perpetrators of violence, a lot remains to be done to guarantee safety and security of women and girls in Nairobi’s second largest informal settlement.