http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Yuya Yoshimitsu,Kiwamu Tanaka,Takashi Tagawa,Yasushi Nakamura,Tomoaki Matsuo,Shigehisa Okamoto 한국식물학회 2009 Journal of Plant Biology Vol.52 No.6
Tungsten particles have long been used as microcarriers in biolistic bombardment because of their cost-effectiveness compared to alternative gold particles— even if the former have several drawbacks, including their DNA-degrading activity. We characterized tungsteninduced DNA degradation to assess the value of this metal particle and to improve tungsten-based biolistic bombardment. Alkaline pH, low temperature, and high salt concentration were found to diminish tungsten-induced DNA breakdown. The pH was the most influential factor in this phenomenon, both in aqueous solutions and on the particles. Furthermore, alkaline pH greater than 9.4 of an adsorption mixture was found to be essential for DNA binding to metal particles. Based on these findings, we propose a new formula of DNA/tungsten adsorption by using TE buffers that keep alkaline pH (>9.4) of the mixture, in which tungsten-bound plasmid DNA cleavage was suppressed to half the level of that in the conventional DNA-binding condition.
Shiro Nakamura,Teita Asano,Hiroaki Tsuchiya,Kanami Sugimoto,Yuya Imai,Seiji Yokoyama,Yasuo Suzuki 대한장연구학회 2022 Intestinal Research Vol.20 No.3
Background/Aims: Golimumab (GLM) is an anti-tumor necrosis factor-α drug approved for treating moderate-to-severe active ulcerative colitis (UC). A 52-week post-marketing surveillance (PMS) was initiated to evaluate its safety and effectiveness in patients with UC in Japan. We present an interim report of the ongoing PMS.Methods: Patients received 200 mg of subcutaneous GLM at week 0, 100 mg at week 2, and 100 mg 4 weekly thereafter. The safety analysis set included 392 patients with UC, and the effectiveness analysis set 387 patients. Safety and effectiveness were assessed at week 6.Results: Adverse drug reactions (ADRs) were reported in 8.2% (32/392) and serious ADRs in 4.6% (18/392). The most frequent ADRs were infection and infestation (3.3%), with herpes zoster being the most common. ADRs were significantly higher in patients with concomitant corticosteroid use (odds ratio [OR], 3.45; 95% confidence interval [CI], 1.40–9.68). No significant difference in ADR incidence was observed between patients aged ≥65 and <65 years (OR, 1.23; 95% CI, 0.35–3.47). Six-week effectiveness of GLM was confirmed by a decrease in the partial Mayo score (–2.3; 95% CI, –2.6 to –2.1) and C-reactive protein levels (–0.64; 95% CI, –0.92 to –0.36), including in the biologics-experienced population.Conclusions: The safety and effectiveness of GLM at week 6 in a real-world setting were demonstrated in patients with UC in Japan. ADR patterns were consistent with previous reports with no new safety signals. Concomitant corticosteroid use may be associated with increased ADR incidence. The final results of the ongoing PMS are necessary for further evaluation.
Characteristics of Self-Leveling Behavior of Debris Beds in a Series of Experiments
Songbai Cheng,Hidemasa Yamano,Tohru Suzuki,Yoshiharu Tobita,Yuya Nakamura,Bin Zhang,Tatsuya Matsumoto,Koju Morita 한국원자력학회 2013 Nuclear Engineering and Technology Vol.45 No.3
During a hypothetical core-disruptive accident (CDA) in a sodium-cooled fast reactor (SFR), degraded core materials can form roughly conically-shaped debris beds over the core-support structure and/or in the lower inlet plenum of the reactor vessel from rapid quenching and fragmentation of the core material pool. However, coolant boiling may ultimately lead to leveling of the debris bed, which is crucial to the relocation of the molten core and heat-removal capability of the debris bed. To clarify the mechanisms underlying this self-leveling behavior, a large number of experiments were performed within a variety of conditions in recent years, under the constructive collaboration between the Japan Atomic Energy Agency (JAEA)and Kyushu University (Japan). The present contribution synthesizes and gives detailed comparative analyses of those experiments. Effects of various experimental parameters that may have potential influence on the leveling process, such as boiling mode, particle size, particle density, particle shape, bubbling rate, water depth and column geometry, were investigated, thus giving a large palette of favorable data for the better understanding of CDAs, and improved verifications of computer models developed in advanced fast reactor safety analysis codes.
( Yoshiki Hirooka ),( Akihiro Itoh ),( Hiroki Kawashima ),( Eizaburo Ohno ),( Yuya Itoh ),( Yosuke Nakamura ),( Takeshi Hiramatsu ),( Hiroyuki Sugimoto ),( Hajime Sumi ),( Daijiro Hayashi ),( Naoki Oh 대한소화기학회 2013 Gut and Liver Vol.7 No.4
Background/Aims: To confirm the feasibility of using newly developed endoscopic ultrasound (EUS) with Zone sonographyTM technology (ZST; Fujifilm Corp.). Methods: Seventy-five patients with pancreatic disorders were enrolled: 45 with intraductal papillary mucinous neoplasm; 15 with ductal carcinoma; five with neuroendocrine tumors; three with serous cystic neoplasms; and seven with simple cysts. The endoscopes used were EG-530UR2 and EG-530UT2 (Fujifilm Corp.). Two items were evaluated: visualization depth among four frequencies and image quality after automatic adjustment of sound speed (AASS), assessed using a 5-scale Likert scale by two endosonographers blinded to disease status. Because sound speed could be manually controlled, besides AASS, image quality at sound speeds of 1,440 and 1,600 m/sec were also assessed. Results: In all cases, sufficient images were obtained in the range of 3 cm from the EUS probe. Judgments of image quality before AASS were 3.49 0.50, 3.65±0.48, respectively. After AASS, A and B scored 4.36±0.48 and 4.40±0.49 (p<0.0001). There were significant differences in the data before and after AASS and plus 60 m/sec, but no significant difference between the datasets were seen after AASS and at sound speeds manually set for minus 100 m/sec. Conclusions: EUS with ZST was shown to be feasible in this preliminary experiment. Further evaluation of this novel technology is necessary and awaited. (Gut Liver 2013; 7:486-491)
CHARACTERISTICS OF SELF-LEVELING BEHAVIOR OF DEBRIS BEDS IN A SERIES OF EXPERIMENTS
Cheng, Songbai,Yamano, Hidemasa,Suzuki, TYohru,Tobita, Yoshiharu,Nakamura, Yuya,Zhang, Bin,Matsumoto, Tatsuya,Morita, Koji Korean Nuclear Society 2013 Nuclear Engineering and Technology Vol.45 No.3
During a hypothetical core-disruptive accident (CDA) in a sodium-cooled fast reactor (SFR), degraded core materials can form roughly conically-shaped debris beds over the core-support structure and/or in the lower inlet plenum of the reactor vessel from rapid quenching and fragmentation of the core material pool. However, coolant boiling may ultimately lead to leveling of the debris bed, which is crucial to the relocation of the molten core and heat-removal capability of the debris bed. To clarify the mechanisms underlying this self-leveling behavior, a large number of experiments were performed within a variety of conditions in recent years, under the constructive collaboration between the Japan Atomic Energy Agency (JAEA) and Kyushu University (Japan). The present contribution synthesizes and gives detailed comparative analyses of those experiments. Effects of various experimental parameters that may have potential influence on the leveling process, such as boiling mode, particle size, particle density, particle shape, bubbling rate, water depth and column geometry, were investigated, thus giving a large palette of favorable data for the better understanding of CDAs, and improved verifications of computer models developed in advanced fast reactor safety analysis codes.
Synchrotron-radiation-based <SUP>174</SUP>Yb Mossbauer Spectroscopy of the 1/1 Au-Al-Yb Approximant
Yumi Kinoshita,Hisao Kobayashi,Nobumoto Nagasawa,Yoshitaka Yoda,Ryo Masuda,Yuki Nakamura,Yuya Sakakibara,Kazuhiko Deguchi 한국물리학회 2023 새물리 Vol.73 No.12
The Yb-based valence-uctuating Au-Al-Yb quasicrystal exhibits unconventional quantum critical phenomena with unusual critical indices at low temperatures at ambient pressure. Furthermore, the quantum criticality of the Au-Al-Yb quasicrystal remains robust even under hydrostatic pressure. In contrast, the Au-Al-Yb 1/1 approximant does not display quantum criticality at ambient pressure and quantum criticality appears at approximately 2.0 GPa with the same critical indices as the quasicrystal. In this study, we conducted synchrotron-radiation (SR) -based <SUP>174</SUP>Yb Mossbauer spectroscopy on both the quasicrystal and 1/1 approximant, allowing us to observe di_erences in the 4f electronic states of Yb ions between the quasicrystal and 1/1 approximant.
Ultrasound Measurements on the Skutterudite Compound SmOs4P12
Yoshiki Nakanishi,Gen Koseki,Dai Tamura,Kohei Kurita,Takeshi Saito,Minoru Koseki,Mitsuteru Nakamura,Masahito Yoshizawa,Yuya Koyota,Chihiro Sekine,Takehiko Yagi 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.62 No.12
We have investigated the elastic properties of the Sm-based filled skutterudite compoundSmOs4P12 for the first time. The measurements were performed on polycrystalline samples preparedat high temperatures and high pressures by using a wedge-type, cubic anvil, high-pressureapparatus. A clear and steep decrease was observed at an antiferromagnetic transition temperatureof 4.5 K in the temperature dependence of both the longitudinal and the transverse elastic constants. Absence of a precursor behavior reminds us of the multipolar ordering, possibly octupolarordering, observed in the isostructural system SmRu4P12. The transition is robust against an externalmagnetic field. We argue that the low-lying degenerate levels derived from the 4f-multipletground state of the Sm ion is split by the crystalline electric field in SmOs4P12. Furthermore, wediscuss the phononic properties, which include the ionic degrees of freedom for the rattling motion,and compare them with the values for other isostructural systems.