탄광부 진폐증의 운동지수

조영선,김세곤,문우기,유재인,정치경 가톨릭대학 산업의학 센타 산업의학연구소 1984 韓國의 産業醫學 Vol.23 No.3

Exercise index(EI) was measured on 933 pneumoconiosis patients (865 patients with small rounded opacities and 68 patients with large opacities) and 176 suspected pneumoconiosis patients from Korean anthracitic mines, in order to evaluate the ventilatory impairment of pulmonary function according to the chest radiographic findings of pneumoconiosis. Exercise index was obtained from the maximum breathing capacity (MBC) and the exercise ventilation volume(EV) which were measured by spirometer and two step-test. Classification of pneumoconiosis was based on the international classification of ILO U/C. The results were as follows: 1. The mean value of E1 was significantly increased in pneumoconiosis patients with large opacities(46.0%) than in patients with small rounded opacities(26.5%) and with suspected pneumoconiosis(25.0%). The number of jpatients in substandard EI was 97.1% in patients with large opacities but 49.4% in patients with small rounded opacities and 40.3% in patients with suspected pneumoconiosis. 2. The mean values of EI and the number of patients in substandard EI were markedly increased in pneumoconiosis patients with small rounded opacities and suspected over 50 years of age. However, the number of patients in substandard EI showed no association with age in pneumoconiosis patients with large opacitis. 3. In pneumoconiosis patients with small rounded opacities, the mean values of EI and the number of patients in substandard EI showed significant association with the profusion (category) but no significant association with the type of small rounded opacities. 4. In pneumoconiosis patients with large opacities, the mean values of EI and the number of patients in substandard EI showed no significant difference between patients complicated with and without pulmonary tuberculosis. 5. No significant association of EI and the number of patients in substandard EI with the size of large opacities was observed in pneumoconiosis patients with large opacities, however, the mean values of EI showed increasing tendenccy in category B and C compared to category A.

Characteristics and outcomes of public bath-related out-of-hospital cardiac arrests in South Korea

Yung Jae Yoo,김기운,Choung Ah Lee,박용진,Kyoung Mi Lee,Jin-Seong Cho,Won Jung Jeong,Hyuk Joong Choi,Han Joo Choi,Nam Hun Heo,Hyung Jun Moon 대한응급의학회 2020 Clinical and Experimental Emergency Medicine Vol.7 No.3

Objective To analyze the differences in characteristics and outcomes between public bath (PB)-related and non-PB-related out-of-hospital cardiac arrest (OHCA) patients in South Korea. Methods We performed a retrospective observational analysis of collected data from the Smart Advanced Cardiac Life Support (SALS) registry between September 2015 and December 2018. We included adult OHCA patients (aged >18 years) with presumed OHCA of non-traumatic etiology who were attended by dispatched emergency medical services. SALS is a field advanced life support with smartphone-based direct medical direction. The primary outcome was the survival to discharge rate measured at the time of discharge. Results Of 38,995 cardiac arrest patients enrolled in the SALS registry, 11,889 were included in the final analysis. In total, 263 OHCAs occurred in PBs. Male sex and bystander cardiopulmonary resuscitation proportions appeared to be higher among PB patients than among non-PB patients. Percentages for shockable rhythm, witnessed rate, and number of underlying disease were lower in the PB group than in the non-PB group. Prehospital return of spontaneous circulation (11.4% vs. 19.5%, P=0.001), survival to discharge (2.3% vs. 9.9%, P<0.001), and favorable neurologic outcome (1.9% vs. 5.8%, P=0.007) in PB patients were significantly poorer than those in non-PB patients. Conclusion Patient characteristics and emergency medical services factors differed between PB and non-PB patients. All outcomes of PB-related OHCA were poorer than those of non-PB-related OHCA. Further treatment strategies should be developed to improve the outcomes of PB-related cardiac arrest.

Adiponectin promotes angiogenesis via CXCL1 in ovarian cancer

( Yung-taek Ouh ),( Na Young Bae ),( Yoo Jin Lee ),( Sung Eun Kim ),( Hyun Woong Cho ),( Jae-kwan Lee ),( Jin Hwa Hong ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-

Objective: Adiponectin is a cytokine secreted from adipose tissue with regulating energy homeostasis, inflammation, and cell proliferation. Obesity is associated with the risk of various cancer including ovarian cancer. Adipokines, including adiponectin, have been implicated as a factor linking obesity and carcinogenesis. The oncogenic role of adiponectin has been controversial in several cancer types. We sought to determine the association of adiponectin with angiogenesis in ovarian cancer. Methods: To identify independent angiogenic role of adiponectin on ovarian cancer, vascular endothelial growth factor (VEGF) small interfering RNA (siRNA) was transfected into SKOV3 cells. VEGF-knockdown SKOV3 cell lines were treated with adiponectin for 48 hours. The cytokines involved in adiponectin-mediated angiogenesis were explored by using human angiogenesis cytokine array and were verified with enzyme-linked immunosorbent assay (ELISA). The angiogenic effect of adiponectin was identified by tube formation assay in human umbilical vein endothelial cells (HUVEC). Results: The number of tubes formed by HUVEC significantly decreased following transfection with VEGF siRNA, but treatment of adiponectin conversely increased the number of tubes. To determine which cytokine or chemokine is affected by adiponectin, we conducted angiogenesis-related cytokine array and found that CXC chemokine ligand 1 (CXCL1) was overexpressed after adiponectin treatment, which were further confirmed with ELISA. The secretion of CXCL1 was increased by adiponectin in both SKOV3 cells and VEGF-knockdown SKOV3 cells. Conclusion: Adiponectin treatment of the ovarian cancer cell induced angiogenesis via CXCL1 independently of VEGF, suggesting that adiponectin may serve as a therapeutic target for ovarian cancer.

Inhibitory effe t of irradiated LPS on L PS-induced endotoxemia

YOO Yung-Choon,BYUN Myung-Woo,LEE Ju-Woon,KIM Jae-Hoon,SUNG Nak-Yoon 大韓藥學會 2005 大韓藥學會 總會 및 學術大會 Vol.2005 No.2

Skin necrosis complicated by severe traumatic vulva hematoma in teenage girl

( Yoo Jin Lee ),( Yung-taek Ouh ),( Hyun Woong Cho ),( Jin Hwa Hong ),( Jae-kwan Lee ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-

Nonobstetric vulvar hematomas are relatively uncommon compared with obstetric. They are often caused by traumatic vascular injury such as in cases of fall, coitus and sexual assault. There are no consensus guidelines for the appropriate initial treatment of conservative or surgical management. A 10-year-old premenarchal girl was admitted to emergency room for painful large vulvar hematoma. It was caused by a straddle bicycle accidents. An ultrasound and abdomen and pelvic computed tomography were done and a huge hematoma measuring in the vulva, labium, and perineum was shown, which was 11 x 9.7 x 7.7 cm sized hematoma with enhanced vessel meaning active arterial bleeding. Conservative management was recommended and ice packs were applied to the perineum. On admission day 5, necrotic change of left perineum was found. Surgical debridement with incision and drainage under general anesthesia was underwent. She subsequently showed no sign of complication and discharged on operation day 7. Conservative management is preferred for traumatic perineal hematoma in teenage girls, however, if the hematoma continues to grow or skin shows necrotic change surgical intervention may be required.

Preoperative total cholesterol is predictive of prognosis in epithelial ovarian cancer

( Yung-taek Ouh ),( Na Young Bae ),( Yoo Jin Lee ),( Sung Eun Kim ),( Hyun Woong Cho ),( Jin Hwa Hong ),( Jae-kwan Lee ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-

Objective: To investigate the prognostic implication of preoperative total cholesterol (TC) level in patients with epithelial ovarian carcinoma (EOC). Methods: Medical records of patients who underwent primary debulking surgery and adjuvant platinum-based chemotherapy from January 2002 and December 2015 were reviewed. The association among preoperative TC level, clinical prognostic factors, and outcome as progression free survival (PFS) and overall survival (OS) was analyzed by univariate analysis. To explore independent prognostic factors for PFS and OS, multivariate Cox proportional hazard regression was used. Results: Of total 121 patients, 99 (81.8%) had lower TC (<200 mg/dL) and 22 (18.2%) had higher TC (200 mg/dL). Higher preoperative TC was significantly associated with lower histologic grade (grade 1 or 2) and histology of mucinous and endometrioid. The patients with lower TC showed higher mortality rate (P=0.018). Patients with higher preoperative TC had a longer PFS (P=0.012) and OS (P=0.021). In multivariate analysis, preoperative TC showed a significant association with OS (HR, 0.111; 95% confidence interval [CI], 0.015-0.827, P = 0.032). Conclusion: Higher TC most likely leads to better overall survival in patients with EOC. These results suggest that the level of preoperative cholesterol could assist the identification of patients with poor prognosis in patients with EOC.

Effect of gamma irradiated phytic acid on the function of immune cells

YOO Yung-Choon,BYUN Myung-Woo,LEE Ju -Woon,KIM Jae-Hoon,SUNG Nak-Yoon 大韓藥學會 2005 大韓藥學會 總會 및 學術大會 Vol.2005 No.2

토양으로 부터 분리한 방선균 KYR 26균주가 생산하는 항생물질의 분리 정제

유진철,방희재,심정보,이은하,김형근,김성준,김영호,이정준 조선대학교 부설 유전생물공학연구소 1993 유전생물공학연구지 Vol.3 No.-

1. 작용 범위가 넓고 부작용이 적은 의약용 항생물질을 screening하기 위한 목적으로 전남 지역 토양시료로 부터 방선균을 분리하여 항균활성이 우수한 방선균을 선별하여 KYR 26이라 명명 하였다. 2. KYR 26균주의 최적 배양배지는 Modified SMM배지 이었으며, 항생물질 생산은 배양 3일째에 최대의 수율을 나타내었다. 3. KYR 26균주가 생산하는 항생 물질은 Ion exchange chromatography, Adsorption chromatography, LH-20 coluom chromatography, Precipitation과 Silica column chromatography 과정을 통하여 항생물질 A, B를 분리정제 하였다. 4. 분리 정제된 항생 물질 A와 B는 TLC에서 각각 Rf치 0.53, 0.48에서 단일 spot로 나타났고,HPLC에서 항생물질 A와B는 각각 2.94, 7.66의 retention time을 보였으며 모두 98%의 순도를 보였다. 5. 분리 정제된 항생 물질 A와 B의 UV spectrum을 조사한 결과 항생물질 A,B는 모두 270nm에서 최대흡수 파장을 나타내었다. 현재 최종 분리 정재된 항생물질 A와 B의 구조 규명을 위하여 IR, ^1H-NMR, ^3C-NMR, Mass spectroscopy에 관한 실험이 진행중에 있다. Soil Actinomycetes were isolated from soil samples which were collected from the 100 sites of Cheon-nam areas. Isolated strains were tested for the production of antibiotics in various fermentation media using 4 strains of antibiotic sensitive test microorganisms. One strain which has excellent antibacterial activities was selected, and named to KYR 26. From culture broth of KYR 26 strain, two antibiotics were obtained through Ion Exchange Chromatography, Adsorption Chromatography, Gel Filtration Chromatography, Silica gel column chromatography and Crystalization. The finally purified two antibiotics exhibited single spot on the TLC chromatogram,and about 98 % purity on the profile of HPLC Chromatogram. Two antibiotics exhibited Rf 0.53 and 0.48 each on TLC with developing solvent system (MeOH:CHCl_3). The UV spectrum of isolated antibiotics exhibited a characteristic absorption maximum at 270nm.

Effect of gamma-irradiated ovalbum in (OVA ) on OVA -induced allergy in mice

YOO Yung Choon,BYUN Myung Woo,JEONG Jae Hoon,LEE Joo Eun,SEO Ji Hyun 대한약학회 2006 大韓藥學會 總會 및 學術大會 Vol.2006 No.2

Clinical outcomes and characteristics of acute myocardial infarction patients with developing fever after percutaneous coronary intervention

Jae-Geun Lee,Yeekyoung Ko,Joon Hyouk Choi,Jeong Rae Yoo,Misun Kim,Ki Yung Boo,Jong Wook Beom,Song-Yi Kim,Seung-Jae Joo 제주대학교 의과학연구소 2022 The Journal of Medicine and Life Science Vol.19 No.2

The incidence of fever complicating percutaneous coronary intervention (PCI) is rare. However, little is known regarding the cause of fever after PCI. Therefore, this study aimed to determine the clinical characteristics of patients with acute myocardial infarction (AMI), with or without fever, after PCI. We enrolled a total of 926 AMI patients who underwent PCI. Body temperature (BT) was measured every 4 hours or 8 hours for 5 days after PCI. Patients were divided into two groups according to BT as follows: BT<37.7°C (nofever group) and BT ≥37.7°C (fever group). The 2 years clinical outcomes were compared subsequently. Fever after PCI was associated with higher incidence of major adverse cardiac events (MACE) (hazard ratio [HR], 1.56; 95% confidence interval [CI], 1.07-2.28; P=0.021), all-cause death (HR, 2.32; 95% CI, 1.18-4.45; P=0.014), cardiac death (CD) (HR, 2.57; 95% CI, 1.02-6.76; P=0.049), and any revascularization (HR, 1.69; 95% CI, 1.02-2.81; P=0.044) than without fever. In women, prior chronic kidney disease, lower left ventricular (LV) ejection fraction, higher LV wall motion score index, white blood cell count, peak creatine kinasemyocardial band level, and longer PCI duration were associated with fever after PCI. Procedures such as an intra-aortic balloon pump, extracorporeal membrane oxygenation, continuous renal replacement therapy, central and arterial line insertion, and cardiopulmonary resuscitation were related to fever after PCI. Fever after PCI in patients with AMI was associated with a higher incidence of MACE, all-cause death, CD, and any revascularization at the 2 years mark than in those without fever.