폴리이미드 박막의 전기적 특성에 관한 연구

김유경,박귀남,김지균,이헌용 明知大學校 産業技術硏究所 2003 産業技術硏究所論文集 Vol.22 No.-

Abstract - in this study, Polymide(PI) Thin-films of MIS structure and MIM structure is deposited on Si wafer and AI Thin-films based on spincoating method. Using material is SE5291(PAA) of NISSAN CHEMICAL. Spincoating velocity is 4000[rpm] for 5[min] The uniform thin films of PI formed by curing at 150[℃] for 30[min](Soft baking) and 350[℃] for 60[min](Hard baking). Thickness of PI Thin-films is 150-170 [nm]. For Electrical characteristics of PI Thin-films measured Ⅰ-Ⅴ properties, C-V properties and f-C properties. The result analysis is like below: Ⅰ-Ⅴ characteristic using HP 4156A, C-V is HP 4280A f-C is HP 4294A

Benzodiazepinone과 1,5-Benzodiazepine 유도체의 합성 연구

정대일,이용균,박유미,최태원,정일수,김인식,김윤영 東亞大學校 1997 東亞論叢 Vol.34 No.-

The reaction of o-phenylenediamine 5 with acrylic acid 11 in the presencce of P₂O5+H₃PO₄afforded benzodiazepinone 13 and pyridobenzodiazepinono 17. The reactions of o-phenylenediamine 5 with acrylic acid 11 in the presence of PPA or SiO₂afforded only benzodiazepinone 13. But the reaction of O-phenylenediamine 5 with acrylic acid 11 in the presence of acetonedicarboxylic acid 18 or acetonedicarboxylic acid 18 and PPA or acetonedicarboxylic acid 18 and SiO₂was respectively synthesized 2,4,4,-trimethyI-3H-5-hydro-1.5-benzodi-azepine 23 as new cyclic imine compound. We propose that formation of 2-(2`-imine)propyI-N-isopropylidene aniline proceed though 2-amino, N-isopropylidene aniline intermediate C and 2-(N-a-methylethyI) amino, N-isopropylidene aniline intermediate G. The reaction of o-phenylenediamine 5 with acetonedicarboxylic acid 18 in the presence of PPA or SiO₂or HCI gave 2,4,4-trimethyI-3H-5-hydro-1,5-benzodiazepine 23. Using acetone 19 instead of acetonedicarboxylic acid 18, the reaction of o-phenylenediamine 5 in the presence of PPA or SiO₂or acrylic acid 11 was synthesized 2,4,4-trimethyI-3H-5-hydro-1,5-benzodiazepine 23 as same product. And also the reaction of o-phenylenediamine 5 with acetone 19 and acrylic 11 in the presence of PPA or SiO₂was obtained 2,4,4-trimethyI-3H-5-hydro-1,5-benzodiazepine 23. In case of acetophenone 21 in stead of acceton 19, the reaction of o-phenylenediamine 5 in presence of PPA or SiO₂at 40~45℃ were obtained 2,4-diphenyI-4methyI-3H-5-hydro-1,5-benzodiazepine 24. The reaction of o-phenylenediamine 5 with crotonic acid 25 in the presence of PPA or P₂O5+H₃PO₄or SiO₂at 100~110℃ afforded respectively 4-methybenzodiazepinone 26 as 1:1 cycloadduct.

TiO₂를 이용한 프로필렌 가스의 광촉매 산화반응

정대일,이동희,김용환,김현숙,이용균,박유미,최순규,김동현 동아대학교 환경문제연구소 2001 硏究報告 Vol.24 No.1

Photocatalyzed degradation of propylene gas was carried out over precoated titanium dioxide(anatase) illuminated W light in a flow reactor. photocatalytic oxidation of propylene gas indicated high conversion rates (78.0%) to CO₂ gas. And photocatalytic oxidation of gas according to a fold, twofold, and threefold of titanium dioxide(anatase) respectively gave high conversion rate. The longer reaction time was, the higher conversion rate to CO₂ gas showed.

TiO₂를 이용한 아세틸렌 가스의 광촉매 산화반응

정대일,김성엽,이도훈,이용균,박유미,최순규,김동현 동아대학교 환경문제연구소 2000 硏究報告 Vol.23 No.1

Photocatalyzed degradation of acetylene gas was carried out over precoated titanium dioxide(anatase) illuminated UV light in a flow reactor. photocatalytic oxidation of acetylene gas indicated high conversion rates (78.0%) to CO₂gas. And photocatalytic oxidation of gas according to a fold, twofold, and threefold of titanium dioxide(anatase) respectively gave high conversion rates. The longer reaction time was, the higher conversion rate to CO₂ gas showed.

새로운 Acetylcholinesterase inhibitors의 합성

최순규,김형민,조승환,최학기,박유미,이용균,정대일,김인식,한정태 동아대학교 부설 기초과학연구소 2004 基礎科學硏究論文集 Vol.21 No.1

노인성 치매의 일종인 alzheimer's disease의 효과적인 억제제를 합성하기 위해 우리는 분자 모델링에 의한 가장 적합한 물질인 m-[(N,N,N-trimethylammonio)phenyl]boronic acid를 합성하였다. 출발물질인 3-aminophenylboronic acid monohydrate의 경우 boronic acid의 작용기인 hydroxyl group을 protecting시킴으로써 반응의 안정성을 기하였다. Quarternary ammonium salt는 과량의 methyliodide와 염기 촉매인 potassium hydrogen carbonate를 사용하여 용매인 methanol에서 반응시켜 상당히 높은 수율을 얻을 수 있었다. 또한 과량의 methyliodide와 염기촉매인 potassium hydrogen carbonate를 사용하여 용매인 methanol에서 반응시킨 결과 boronic acid의 protection없이도 안정하게 반응이 진행되어짐을 확인할 수 있었다. In order to syntheisize a effective inhibotor for alzheimer's disease, we synthesized m-[(N,N,N-trimethylammonio)phenyl]boronic acid 4 which is designed by molecular modeling form. We protected the hydroxyl group of 3-aminophenylboronic acid monohydrate 1 with ethlyne glycol to remove the reactivity if hydroxyl group. To synthesize m-[(N,N,N-trimethylammonio)phenyl]boronic acid 4, we reacted 3-aminophenylboronic acid monohydrate 1 with ezcess methyl iodide and potassium hydrogen carbonate as a base-catalyst in methanol. but On executed reaction without protection on hydroxyl group, we found out the result that the hydroxyl group of boronic acid group at 3-aminophenylboronic acid monohydrate 1 didn't react with excess methyliodide. Synthesized m-[(N,N,N-trimethylammonio)phenyl]boronic acid 4 is in progress about biological tests as a plausible acetylcholinesterase inhibitor.

Human Spatial Cognition Using Visual and Auditory Stimulation

Yu, Mi,Piao, Yong-Jun,Kim, Yong-Yook,Kwon, Tae-Kyu,Hong, Chul-Un,Kim, Nam-Gyun Korean Society for Precision Engineering 2006 International Journal of Precision Engineering and Vol.7 No.2

This paper deals with human spatial cognition using visual and auditory stimulation. More specially, this investigation is to observe the relationship between the head and the eye motor system for the localization of visual target direction in space and to try to describe what is the role of right-side versus left-side pinna. In the experiment of visual stimulation, nineteen red LEDs (Luminescent Diodes, Brightness: $210\;cd/^2$) arrayed in the horizontal plane of the surrounding panel are used. Here the LEDs are located 10 degrees apart from each other. Physiological parameters such as EOG (Electro-Oculography), head movement, and their synergic control are measured by BIOPAC system and 3SPACE FASTRAK. In the experiment of auditory stimulation, one side of the pinna function was distorted intentionally by inserting a short tube in the ear canal. The localization error caused by right and left side pinna distortion was investigated as well. Since a laser pointer showed much less error (0.5%) in localizing target position than FASTRAK (30%) that has been generally used, a laser pointer was used for the pointing task. It was found that harmonic components were not essential for auditory target localization. However, non-harmonic nearby frequency components was found to be more important in localizing the target direction of sound. We have found that the right pinna carries out one of the most important functions in localizing target direction and pure tone with only one frequency component is confusing to be localized. It was also found that the latency time is shorter in self moved tracking (SMT) than eye alone tracking (EAT) and eye hand tracking (EHT). These results can be used in further study on the characterization of human spatial cognition.

Development of SSR Markers of Under-utilized Crops Including Some Vegetables

Yong-Jin Park,kyung-Ho Ma,Jae-Woong Yu,Anupam Dixit,Jae-Gyun Gwag,Eun-Gi Cho,Tae-San Kim 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-

Effects of Tendon Vibration During One-Legged and Two-Legged Stance in Elderly Individuals

Yu, Mi,Piao, Yong-Jun,Kim, Seong-Hyun,Kim, Dong-Wook,Kim, Nam-Gyun 한국정밀공학회 2010 International Journal of Precision Engineering and Vol.11 No.6

The purpose of this study was to analyze the effects of vibration of the tibialis anterior and Achilles tendons during one-legged and two-legged stance in young and elderly individuals. Sway in the center of pressure (COP) and plantar pressure was observed in four vibration conditions, which included single vibration, combined vibration and non-vibration applied to the tibialis anterior and/or Achilles tendons of the supporting leg. For single vibration, whole-body tilts were directed backward and forward according to the location of the vibration. In combined vibration, very small amplitude body shifts were observed. Using combined vibration of the tibialis anterior and Achilles tendons, the decrease in the COP sway may improve the ability to balance during one-legged stance in elderly individuals. In particular, the decrease in COP sway may improve the ability to balance during one-legged stance by combined vibration in elderly subjects. These findings are important for the use of somatosensory information processing to regulate postural adjustments in the elderly.

해외귀국 한국인의 뎅기 바이러스에 대한 항체 양성율

유정희,최택균,최우영,주영란,진성현,박근용 대한감염학회 2004 감염과 화학요법 Vol.36 No.4

목적 : 한국인의 해외여행이 지속적으로 증가함에 따라 해외 유행 질병의 유입 및 해외 감염 가능성이 점점 증가하고 있다. 특히 뎅기열은 동남아시아 등의 해외여행 및 거주 한국인이 증가함에 따라 감염기회가 점차 증가할 것으로 예상되고 있다. 따라서 뎅기열 유행지역의 여행 및 체류 한국인 가운데 뎅기열 의심증상을 보인 환자의 검체를 수집하여 혈청학적 및 역학적 상황을 확인함으로서 현재까지 확인되지 않았던 한국인의 뎅기 바이러스 감염 실태를 파악하여 국가의 보건지표를 확립하고자 하였다. 재료 및 방법 : 해외여행 후 뎅기열 의심증세를 보이는 환자의 혈청을 수집하여 상업용 진단 kit인 MAC-ELISA 및 ICA법을 사용하여 뎅기 바이러스에 대한 항체시험을 실시하고 성별, 연령, 방문국 등 뎅기 감염에 영향을 미치는 요인들을 분석하였다. 상업용 진단 kit에 의해 혈청학적 결과가 확인된 99건의 검체 가운데 25건의 검체에 대하여 본 실험실에서 제작한 IFA 슬라이드로 확인시험을 실시하고 그 결과를 상업용 진단 kit와 비교 분석하였다. 결과 : 99건의 뎅기열 유사증상 환자의 검체는 상업용 진단 kit에 의해 333%의 뎅기 항체 양성으로 확인되었으며 이들 환자의 해외 방문국의 조사 결과 타일랜드 등 4개국 여행자에서 절반 이상의 양성자가 확인되었다. 또한 진단법 비교시험을 위해 25개 검체를 상업용 진단 kit와 자체 제작한 IFA법으로 시험한 결과 진단 kit에서 양성 9명, IFA에서 양성 13명으로 나타나 결과의 차이가 있었다. 결론 : 한국인의 뎅기 바이러스 감염자가 국내에서 처음으로 확인되었으며 환자 발생의 원인과 지역, 환자의 발생을 확인할 수 있었다. 이에 따라 뎅기열에 대한 실험실적 감시체계 구축과 진단시험체계의 확립이 필요함을 확인하였다. 또한 상업용 진단 kit를 사용함에 따라 발생하는 고가의 비용을 최소화 할 수 있는 민감도와 특이도 등 효능이 높은 진단법 개발이 요구되었다. Background : Recently, dengue fever has increased throughout tropical regions and emerged as the most important vector borne viral disease in human. 4 serotypes of viruses are circulating concurrently in these regions and thus it may be anticipated to increase risk of dengue hemorrhagic fever. Even though dengue fever is still not endemic in Korea, it is necessary to test antibodies against dengue viruses because the number of Koreans who have visited these regions is continuously increasing. Materials and methods : Serum specimens from persons with suspected dengue fever had been collected. Commercial kit, immunochromatographic test (ICA), and the IgM capture enzyme-linked immunosorbent assay (MAC-ELISA) were employed for dengue fever detection in these studies. For confirmation randomized 25 specimens among total of 99 specimens were selected and compared with those results from commercial kit and IFA. Results : 33 (33.3%) among 99 specimens showed positive antibody against dengue virus by commercial kit. Positive rate of traveller who have visited Indonesia, Philippines, Malaysia, Thiland was 54.5%. To compare the efficiency of test methods, 25 randomly selected specimens were tested by the MAC-ELISA and IFA simultaneously. 9 specimens showed postive results with the MAC-ELISA method whereas 13 speciments were positive with the IFA methods. Conclusion : Confirming the diagnosis of dengue fever with antibody against dengue virus was attempted for the first time in Korea. The results from our study indicate that establishing a national surveillance and/or laboratory diagnostic system in Korea are necessary. In addtion, antibody test strategies for national surveillance system should be carefully considered.

Efficacy of S-pantoprazole 10 mg in the Symptom Control of Non-erosive Reflux Disease: A Phase III Placebo-controlled Trial

( Yu Kyung Cho ),( Myung-gyu Choi ),( Hyojin Park ),( Ji Won Kim ),( Dong Ho Lee ),( Kwang Hyun Ko ),( Sang Gyun Kim ),( Hwoon-yong Jung ),( Su Jin Hong ),( Yong Chan Lee ),( Si Hyung Lee ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2021 Journal of Neurogastroenterology and Motility (JNM Vol.27 No.2

Background/Aims S-isomer (S) pantoprazole is more bioavailable and less dependent on cytochrome 2C19 than is racemic pantoprazole. We aim to evaluate the efficacy and safety of 10 mg S-pantoprazole for treatment of non-erosive reflux disease (NERD). Methods In this phase 3, double-blind, randomized placebo controlled, multicenter study, 174 NERD patients were randomized to one of both treatment groups: 10 mg S-pantoprazole, or placebo once daily for 4 weeks. Symptoms and safety were assessed. The efficacy endpoints were complete relief of symptoms, > 50% improvement of all reflux symptoms and recurrence. Results Eighty-eight patients were assigned to the S-pantoprazole group (25 males, mean 43.7 years old) and 86 to the placebo group (32 males, mean 43.0 years old), and 163 patients were subjected to full Analysis Set. A higher proportion of patients in the S-pantoprazole group had complete symptom relief (42.0 % [34/81] vs 17.1% [14/82], P < 0.001) and > 50% symptom responses (66.0% vs 50.0%, P = 0.010 for heartburn; 64.2% vs 28.0%, P = 0.010 for acid regurgitation; and 51.9% vs 30.5%, P = 0.03 for epigastric discomfort) compared to the placebo group. The factors associated with poor responsiveness to PPI were older age, female, greater body mass index, and severe baseline symptoms. Conclusions Low dose of S-pantoprazole (10 mg) for 4 weeks was more efficacious than placebo in providing reflux symptom relief in patients with NERD, especially acid regurgitation. More doses or longer periods of treatment with S-pantoprazole would be needed to completely eliminate symptoms. (J Neurogastroenterol Motil 2021;27:223-230)