항결핵 치료과정에서 호전되었다가 악화된 뇌 결핵종 1예 보고

이대훈,유진홍,강미자,김홍기,김선화,고동훈,천지성,유원종 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.3

In spite of nationmide tuberculosis control program, tuberculosis is still prevalent in Korea. Accordingly, tuberculous meningitis also poses one of the main trouble some problems. Recently, We experienced a perplexing case of tuberculous menin-gitis and tubercdoma in a 24-year old female patient. She was admitted to our hospital owing to meningeal irritation sign, aphasia, VI nerve palsy, and ,fever. CSF analysis showed a finding consistent with that of presumptive tuberculous meningitis.. Initial MRI of the brain revealed a large mass(tuhercu1oma) on left parieto-temporal area. Antitubeculous regimen(1soniazid (INH), rifampin(RMP), ethambutol(EMB), pyrazinamide(PZA)} of meningeal dose was given immediately, and her symptoms and signs were dramatically disappeared with a few days after treatment. She was discharged with improved condition and under maintenance treatment of tuberculosis. Follow-up one year after treatment. revealed that the previous lesion was nearly diminished. She showed no symptom at all until she recognized a total blindness of sudden onset on her left eye a t the 18th month of treatment. Brain MRI checked at that time showed multiple masses of tuberculoma scattered over the brain base and one of them invaded left optic nerve. In our opinion, the cause of relapse in this patient might he explained by the selection and ultimate replication of a minor population of resistant strain. Although such relapse is an extremely rare event, we think that we should always pay attention to this possible resistance problem every time we meet patients with tuberculous meningitis.

Study of Required Functions of Care Robots for Supporting Activities of Daily Living of Elderly

Yu Hwa Hong(홍유화 ),Jong Hyun Kim(김종현),Chang Ki Lee(이창기),Byeong Hee Won(원병희) 대한인간공학회 2019 대한인간공학회 학술대회논문집 Vol.2019 No.10

취학기 아동을 위한 야외놀이학습 IoT 서비스

Yu Hwa Hong,Youn Seon Jang,Tae Kyun Kim 한국서비스디자인학회 2018 한국서비스디자인학회 학술대회자료집 Vol.2018 No.1

Extraction of Items for the Usability Evaluation of Lifecare Service for elderly

Yu Hwa Hong(홍유화),Jong Hyun Kim(김종현),Chang Ki Lee(이창기),Byeong Hee Won(원병희) 대한인간공학회 2019 대한인간공학회 학술대회논문집 Vol.2019 No.10

서포트 부위에 따른 허리보호대의 보조효과 연구

홍유화(Yu Hwa Hong),김재인(Jae In Kim),정영현(Yeong Hyeon Jeong),박용래(Yong-Lae Park),안주은(Jooeun Ahn) 대한인간공학회 2019 대한인간공학회 학술대회논문집 Vol.2019 No.5

Inhibitory Effects of Rice Bran Water Extract Fermented Lactobacillus plantarum due to cAMP-dependent Phosphorylation of VASP (Ser<SUP>157</SUP>) on human Platelet Aggregation

Hyun-Hong Kim,Dong-Ha Lee,Jeong Hwa Hong,Pajaree Ingkasupart,Gi Suk Nam,Woo Jeong Ok,Min Ji Kim,Young-Bin Yu,Hyo-Chan Kang,Hwa-Jin Park 대한의생명과학회 2015 Biomedical Science Letters Vol.21 No.2

In this study, we investigated the effect of rice bran water extract fermented with Lactobacillus plantarum KCCM-12116 (RBLp) on ADP (20 μM)-, collagen (10 μg/mL)-, and thrombin (0.2 U/mL)-stimulated platelet aggregation. RBLp dose-dependently inhibited ADP-, collagen-, and thrombin-induced platelet aggregation, with IC50 values of 501.1, 637.2, and > 2,000 μg/mL, respectively. The platelet aggregation induced by ADP plus RBLp (750 μg/mL) was increased by the adenylate cyclase inhibitor, SQ22536, and the cAMP-dependent protein kinase (A-kinase) inhibitor, Rp-8-Br-cAMPS. Treatment with RBLp increased the phosphorylation of VASP (Ser<SUP>157</SUP>), an A-kinase substrate, which was also inhibited by SQ22536 and Rp-8-Br-cAMPS. It is thought that the RBLp-induced increases in cAMP contributed to the phosphorylation of VASP (Ser<SUP>157</SUP>), which in turn resulted in an inhibition of ADP-induced platelet aggregation, thereby indicating that RBLp has an antiplatelet effect via cAMP-dependent phosphorylation of VASP (Ser<SUP>157</SUP>). Thus, RBLp may have therapeutic potential for the treatment (or prevention) of platelet aggregation-mediated diseases, such as thrombosis, myocardial infarction, atherosclerosis, and ischemic cerebrovascular disease.

군용 PPE 평가를 위한 동작 프로토콜 개발

홍유화(Yu Hwa Hong),이주연(Jooyeon Lee),조예성(Yesung Cho),박주연(Juyeon Park) 대한인간공학회 2022 대한인간공학회 학술대회논문집 Vol.2022 No.4

RESEARCH ON WEARING CONDITIONS AND SATISFACTION FOR USER-CENTERED KOREAN FLIGHT SUIT DESIGN

Ah Lam Lee,Yu Hwa Hong,Yun Ja Nam 글로벌지식마케팅경영학회 2015 Global Fashion Management Conference Vol.2015 No.06

A flight suit worn by fighter pilots in the Korea Air Force is in the form of coveralls and can be donned/doffed with a slide fastener located on the center front of the body. This all-in-one styled garment encompasses the easy movement of an Air Force pilot in the cockpit (Choi, 2012) as well as protects from flames in an emergency. The standard Korean flight suit was designed based on a modulated American flight suit (Jeon, Park, You, & Kim, 2010); however, it is necessary to develop a new Korean flight suit with a Korean pilot-centered design. This study investigates wearing conditions and satisfaction of Korean flight suit wearers and provides basic data for a user-centered Korean flight suit design. Researchers visited two Korea Air Force wings and interviewed the fighter pilots. The results of the interview were derived through a questionnaire. The main topics of the questionnaire were: demographics, actual wearing conditions, size/fit, subjective perceptions of comfort on mobility, satisfaction of appearance, frequency of pocket usage, improvement requirements and fabric satisfaction. A total 439 questionnaires were collected in January 2015 and 428 used for analysis analyzed (except for 11 female responders).The average age of respondents was 29.12±4.67 years old and their mean work experience was 5.96±4.46 years. Over half of those questioned were captains(52.6%).The results of the questionnaires are summarized as follows. First, only 45.8% of respondents filled their chest size; however, most of them completed their height and weight. There were 52.8% who referred to their height (or used eye measurement)when selecting the flight suit size, even though the actual sizing system for Korean flight suits suggests a height and chest size by choice. It is necessary to offer new guidelines in which the wearer could select their size easier. Second, the summer flight suit appearance satisfaction was significantly lower(p<0.01) than winter flight suits and could infer (based on the pre-interview responses) that the air- summer suit vents might be a factor that lowered the appearance satisfaction. Third, the responders felt crotch and shoulder inconvenience during body motions; therefore, it is important to set quantitative standard of ease based upon the extension of skin surface and anthropometric properties of pilots. Forth, questions on suit fabric indicated that they were generally satisfied with protection characteristics such as anti-electrostatic qualities (3.27±0.78, 5-point Likert scale) while comfort characteristics such as thermal insulation, absorbency and elasticity indicated a relatively low satisfaction (2.39±0.794, 2.99±0.87 and 2.65±0.83 respectively, 5-point Likert scale). Therefore, fabric development is also needed to improve user satisfaction. Fifth, survey respondents had a negative opinion on changing flight sites. They preferred improvements in quality or better ease of length and width. Therefore, we have to find a way to improve flight suit function with respect to current designs rather than pursuing a dramatic change of appearance.

Therapeutic effects of combination of Galla rhois extract and Sodium chlorate on Mice infected with Brucella abortus

Chun-Nam Cha, Il-Hwa Hong, Eun-Ah Yu, Eun-Kee Park, Chang-Yeol Yoo, Suk Kim, Hu Jang Lee 충북대학교 동물의학연구소 2014 Journal of Biomedical and Translational Research Vol.15 No.1

This study investigated the therapeutic effects of Galla rhois (GR) ethanol extract (GRE), sodium chlorate (SC), and a combination of GRE and SC on mice infected with Brucella abortus (B. abortus). Mice were infected intraperitoneally with B. abortus and then treated with GRE, SC, and a combination GRE and SC in drinking water for 14 days. Then, serum antibodies were used in a tube agglutination test (TAT), after which the weight and CFUs from each spleen were measured. In addition, histopathological changes in each liver were examined at 14 days post-infection. At 14 days post-infection, negative reactions of serum antibodies in PC (positive control), SCT (SC 1.6 g/L drinking water), GRT (GRE 200 mg/L drinking water), and GST (GRE 200 mg + SC 1.6 g/L drinking water) were 0, 40, 60, and 80%, respectively. The average spleen weight was not significantly different between the groups. At 14 days post-infection, bacterial numbers in all treated groups were significantly lower compared to to that of the PC (GRT and SCT, P<0.05; GST, P<0.001). In terms of histopathological changes in the livers, there were numerous multifocal microgranulomas in the PC, whereas this number successively decreased in the SCT, GRT, and GST groups. Conclusively, a combination of GRE and SC exhibits therapeutic effects on mice infected with B. abortus. These results suggest the potential efficacy of a mixture of GRE and SC in the treatment of brucellosis.

ANALYSIS OF BODY MEASUREMENT ERROR ABOUT 3D SCAN DATA FOR ELDERLY

Jinhee Park,Juwon Chung,Yu Hwa Hong,Yun Ja Nam 글로벌지식마케팅경영학회 2015 Global Fashion Management Conference Vol.2015 No.06

Measuring body size with a 3D scanner can reduce inter-measurer variability and provide better accuracy compared to using a traditional methods of measurement (Park, Nam, & Park, 2009). Many size measurement projects (or studies) that measure body size established a size measurement method prior to the development of a 3D scanner and automatic size measurement programs that produce 3D virtual body size measurements (Park, &Nam, 2012). Size data measured through an automatic size measurement program are more accurate and have a lower variability that is more appropriate for body measurements (Han, & Nam, 2004; Nam, Choi, Jung, & Yun, 2004). However, this method is limited to healthy subjects who can maintain a correct posture in a 3D scanner. It is difficult for the elderly to maintain the correct posture for body measurements in ‘Basic Human Body Measurements for Technological Design’ of ISO 7250(1997). Body measurement definitions are based on vertical and horizontal directions consequently, it is hard to measure those with a bent body type even if they stand in a correct posture. Most body measurement items are automatically measured in vertical and horizontal directions because current automatic size measurement programs utilize algorithms based on typical body measurement definitions. The size measurement method based on a vertical and horizontal directions tends to have a problem for elderly individuals with a bent body type who have difficulty maintaining a correct posture for 3D scanning as defined in ISO 7250(1997)(Ashdown, & Na, 2008).This study analyzes the problem of present auto-measurement programs that use elderly’s 3D body scan data. We conducted a comparative analysis of elderly’s body sizes using an auto-measurement program from virtual 3D body scan data and direct measurement with traditional measurement methods. We establish 34 typical body size measurements for the use of data from 464 males and 472 females (total 936) between the ages of 70 to 85. For error analysis, data separated to normal values and outliers compared with ISO 20655(2003). ISO 20685 defines the accuracy of extracted measurements by classification and measurement type (segment lengths, body height/breaths/depth, large/small circumferences, and head/hand/foot dimensions). The majority of outliers for the male and female body height type was “height”. Total number of persons with outliers for Height’s data was 603; consequently, 64.4% of subjects (elderly group of 70-85 yrs.) could not maintain a correct posture when scanning. Other data also had many errors from inaccurate measurement postures. A total of 72.3% of males and 70% of females have incorrect values in small circumferences. The segment lengths’ error data was 76.5% of males and 75% of females; in addition, the head dimension’ outliers were 87% for both male and female subjects. Especially 57.46% of males had incorrect data, while 74.67% of females had a type of large circumference. Female chest circumference had significant errors due to sagging breasts. The differences identify with a correlation between type of large circumference (chest, hip, under bust, waist, waist of omphalion) and gender. There were several correlations between the many measurement errors because values over 70% of data have outliers; however, each measurement type has properties in regards to correlation. A substantial positive correlation was found between all measurements (except hip circumference) in the type of large circumference; in addition, one-way ANOVA indicated that the measurements influenced height and were statistically significant. Outliers found in height data for the elderly’s were more likely to have errors in the type of large circumference. The type of body height indicated a strong correlation and statistical significance between the axilla height and other measurements (height, waist, crotch, lateral malleolus). Axilla height with more outliers indicated that other type of body height measurements had a higher potential for errors. The posture for body measurement was standardized as standing erect; however, this study indicated that many measurement errors were possible between using an auto-measurement program and direct measurement. The value of outlier about a particular measurement item can expect increased errors about any group (height: large circumference group/ axilla height: body height group). We have to study the relation in measurements in these types ‘large circumference’ because ‘head dimensions’ types correlate between measurements in each group. We need a more detailed analysis about outliers to find the major factors for measurement errors in regards to the elderly as well as discuss the possibility of ISO measurement-standard’s application for the elderly.