The Effects of Market Orientation, Marketing and R&D Interface and Technology Orientation on Product Creativity and Performance

Yang, Youngik 한국전략마케팅학회 2010 마케팅논집 Vol.18 No.3

본 연구는 시장지향성, 마케팅과 개발부서 협업, 기술지향성이 제품창조성과 성과에 미치는 영향을 규명하고 또한 이들 시장지향성과 기술지향성이 제품창조성과 성과에 미치는 영향을 비교 분석하는데 있다. 본 연구의 결과는 다음과 같은 실무적 시사점을 가진다. 첫째, 시장지향성이 마케팅과 개발부서의 협업을 통해서 제품창조성에 긍정적인 영향을 미침에 따라 기업들은 시장지향성 강화가 마케팅과 개발부서의 협업 증대로 이어질 수 있도록 노력해야 한다는 것을 의미하고 있다. 둘째, 시장지향성과 기술지향성 두 가지 모두를 추구하는 기업이 제품창조성과 성과가 월등히 우수하므로 기업은 시장지향성과 기술지향성을 동시에 추구하는 것이 효과적이라는 것을 제시하고 있다. 셋째, 고객지향성, 경쟁사지향성, 기술지향성 중 두 가지 선택의 복합전략 비교에서 고객지향성과 기술지향성이 높은 기업의 제품창조성이 가장 높게 나타났고, 성과 또한 가장 높게 나타나 기술지향성에 투자를 집중해온 국내제조업체들이 제품창조성과 성과를 극대화하기 위한 노력으로 시장지향성을 강화하는 과정에서 경쟁사지향성보다는 고객지향성의 복합전략을 먼저 추구하는 것이 제품창조성과 성과 향상에 더욱 효과적이라는 것을 제시하고 있다. The present study examines how market orientation, marketing and R&D interface and technology orientation influence product creativity and performance. The present study also identifies the relative importance between market and technology orientations to product creativity and performance. The results of the present study have managerially important implications. Since market orientation enhanced product creativity through marketing and R&D interface, a firm has to make sure that an effort of enhancing market orientation should translate into increased marketing and R&D interface. Furthermore, since a firm that pursued both market and technology orientations showed the highest level of product creativity and performance, the adoption of either market or technology orientation to the exclusion of the other may be a less effective strategy in enhancing product creativity and performance. Moreover, since customer and technology orientations showed similar or higher mean values than other combinations, it may be wiser for a technology-oriented firm to strengthen customer prior to competitor orientation when it adopts market orientation.

A novel k-mer mixture logistic regression for methylation susceptibility modeling of CpG dinucleotides in human gene promoters

Yang, Youngik,Nephew, Kenneth,Kim, Sun BioMed Central 2012 BMC bioinformatics Vol.13 No.suppl3

<P><B>Background</B></P><P>DNA methylation is essential for normal development and differentiation and plays a crucial role in the development of nearly all types of cancer. Aberrant DNA methylation patterns, including genome-wide hypomethylation and region-specific hypermethylation, are frequently observed and contribute to the malignant phenotype. A number of studies have recently identified distinct features of genomic sequences that can be used for modeling specific DNA sequences that may be susceptible to aberrant CpG methylation in both cancer and normal cells. Although it is now possible, using next generation sequencing technologies, to assess human methylomes at base resolution, no reports currently exist on modeling cell type-specific DNA methylation susceptibility. Thus, we conducted a comprehensive modeling study of cell type-specific DNA methylation susceptibility at three different resolutions: CpG dinucleotides, CpG segments, and individual gene promoter regions.</P><P><B>Results</B></P><P>Using a k-mer mixture logistic regression model, we effectively modeled DNA methylation susceptibility across five different cell types. Further, at the segment level, we achieved up to 0.75 in AUC prediction accuracy in a 10-fold cross validation study using a mixture of k-mers.</P><P><B>Conclusions</B></P><P>The significance of these results is three fold: 1) this is the first report to indicate that CpG methylation susceptible 'segments' exist; 2) our model demonstrates the significance of certain k-mers for the mixture model, potentially highlighting DNA sequence features (k-mers) of differentially methylated, promoter CpG island sequences across different tissue types; 3) as only 3 or 4 bp patterns had previously been used for modeling DNA methylation susceptibility, ours is the first demonstration that 6-mer modeling can be performed without loss of accuracy.</P>

A Mediating Effect of Cross-Functional Interface in the Relationship between Market Orientation and the Level of IMC Implementation

Yang, Youngik 한국전략마케팅학회 2011 마케팅논집 Vol.19 No.1

본 연구는 부서간의 협업이 시장지향성과 IMC 실행수준과의 관계에 미치는 매개효과를 규명하고자 하였다. 구조방정식 모델 분석결과, 시장지향성이 부서간의 협업을 증대시켜 IMC 실행수준을 향상함으로써 궁극적으로 기업의 성과에 긍정적인 영향을 미친다는 가설들이 지지되었다. 또한 산업분석에 있어서 본 연구가 제시한 구조적관계가 특정산업에 구분 없이 적용된다는 것을 밝혀냈다. 따라서 본 연구의 결과는 다음과 같은 실무적 시사점을 가진다. 첫째, 시장지향성이 부서간의 협업을 통해서 IMC 실행수준을 향상시키기 때문에 기업들의 IMC 실행수준을 증대하기 위한 시장지향성 강화가 부서간의 협업 증대로 이어져야 한다는 것을 의미하고 있다. 이러한 연구결과는 치열한 외부경쟁으로 말미암아 기업 내부에서 부서간의 경쟁을 조장하는 기존의 관리체계를 유지하면서, 부서간의 협업을 강화할 수 있는 수단을 제공한다는 점에서 중요한 시사점을 제공하고 있다. 둘째, 산업별 분석결과 본 연구가 제시하는 구조적모델이 특정산업에 구분이 없이 적용되기 때문에, 소비재뿐만 아니라 산업재를 생산하는 기업들에게도 중요한 의미를 제시하고 있다. 즉 산업재 기업들도 부서간의 협업을 매개로 하여 시장지향성 강화를 통하여 IMC 실행수준을 강화시킴으로써 기업의 성과를 증대시킬 수 있다는 것을 의미하고 있기 때문이다. The present study examines the intermediate effect of cross-functional interface in the relationship between market orientation and IMC implementation. The results of structural equation modeling indicated that market orientation enhances the level of IMC implementation and thus performance through cross-functional interface. The analysis of the mediating effect demonstrated that cross-functional interface fully mediates between market orientation and the level of IMC implementation. In the industry analysis, the results suggested that the hypothesized structural relationship applies across industries. The results of the present study have the following managerial implications. First, because market orientation enhances the level of IMC implementation through cross-functional interface, a firm must ensure that an effort to enhance market orientation translates into increased cross-functional interface. Second, as shown in the industry analysis, the hypothesized structural relationship may apply across industries. This finding also provides important implications especially for Korean industrial goods firms. That is, the industrial goods manufactures may also increase their performance with the high level of IMC implementation.

BioVLAB-MMIA: A Cloud Environment for microRNA and mRNA Integrated Analysis (MMIA) on Amazon EC2

Hyungro Lee,Youngik Yang,Heejoon Chae,Seungyoon Nam,Donghoon Choi,Tangchaisin, P.,Herath, C.,Marru, S.,Nephew, K. P.,Sun Kim IEEE 2012 IEEE transactions on nanobioscience Vol.11 No.3

<P>MicroRNAs, by regulating the expression of hundreds of target genes, play critical roles in developmental biology and the etiology of numerous diseases, including cancer. As a vast amount of microRNA expression profile data are now publicly available, the integration of microRNA expression data sets with gene expression profiles is a key research problem in life science research. However, the ability to conduct genome-wide microRNA-mRNA (gene) integration currently requires sophisticated, high-end informatics tools, significant expertise in bioinformatics and computer science to carry out the complex integration analysis. In addition, increased computing infrastructure capabilities are essential in order to accommodate large data sets. In this study, we have extended the BioVLAB cloud workbench to develop an environment for the integrated analysis of microRNA and mRNA expression data, named BioVLAB-MMIA. The workbench facilitates computations on the Amazon EC2 and S3 resources orchestrated by the XBaya Workflow Suite. The advantages of BioVLAB-MMIA over the web-based MMIA system include: 1) readily expanded as new computational tools become available; 2) easily modifiable by re-configuring graphic icons in the workflow; 3) on-demand cloud computing resources can be used on an “as needed” basis; 4) distributed orchestration supports complex and long running workflows asynchronously. We believe that BioVLAB-MMIA will be an easy-to-use computing environment for researchers who plan to perform genome-wide microRNA-mRNA (gene) integrated analysis tasks.</P>

Complete gammaproteobacterial endosymbiont genome assembly from a seep tubeworm Lamellibrachia satsuma

Patra Ajit Kumar,Kwon Yong Min,Yang Youngik 한국미생물학회 2022 The journal of microbiology Vol.60 No.9

Siboglinid tubeworms thrive in hydrothermal vent and seep habitats via a symbiotic relationship with chemosynthetic bacteria. Difficulties in culturing tubeworms and their symbionts in a laboratory setting have hindered the study of host-microbe interactions. Therefore, released symbiont genomes are fragmented, thereby limiting the data available on the genome that affect subsequent analyses. Here, we present a complete genome of gammaproteobacterial endosymbiont from the tubeworm Lamellibrachia satsuma collected from a seep in Kagoshima Bay, assembled using a hybrid approach that combines sequences generated from the Illumina and Oxford Nanopore platforms. The genome consists of a single circular chromosome with an assembly size of 4,323,754 bp and a GC content of 53.9% with 3,624 protein-coding genes. The genome is of high quality and contains no assembly gaps, while the completeness and contamination are 99.33% and 2.73%, respectively. Comparative genome analysis revealed a total of 1,724 gene clusters shared in the vent and seep tubeworm symbionts, while 294 genes were found exclusively in L. satsuma symbionts such as transposons, genes for defense mechanisms, and inorganic ion transportations. The addition of this complete endosymbiont genome assembly would be valuable for comparative studies particularly with tubeworm symbiont genomes as well as with other chemosynthetic microbial communities.

Complete genome sequence of Parasphingopyxis sp. CP4, an asparaginase-producing marine bacterium

Yong Min Kwon,Dawoon Chung,Eunseo Cho,Youngik Yang 한국미생물학회 2020 미생물학회지 Vol.56 No.4

A novel marine bacterium belonging to the genus Parasphingopyxis designated as strain CP4 was isolated from seawater around Chujado island in Korea. In the present study, we report the complete genome of Parasphingopyxis sp. CP4, which was determined using a hybrid approach combining the PacBio RS II and Illumina HiSeq platforms. The genome consists of one circular chromosome of 2,963,413 bp with a G + C content of 58.55 mol%. Furthermore, the genome contains 2,867 proteincoding sequences, 3 rRNA genes, 44 tRNA genes, 4 non-coding RNA genes, and 9 pseudogenes. The CP4 strain harbors asparaginase genes, which have applications in the field of clinical research pharmacology and in the food industry.