수종의 고정성 보정장치에 따른 유성견의 치주조직 반응

조명훈,윤영주,김광원 대한치과교정학회 2001 대한치과교정학회지 Vol.31 No.1

교정력을 가한 후 각기 다른 재료로 제작된 고정성 보정장치를 적용한 경우에 발생하는 치주조직의 재형성과 치유과정을 조직학적으로 관찰하기 위해 건강한 치주상태를 가진 네 마리의 유성견을 대상으로 최초 교정력이 200gm이 되도록 견인 스프링 (sentalloy closed coil springR, Tomy Co., Japan)을 대상 치아에 결찰하여 1주일 간 교정력을 가한 후, 각각의 실험동물에 3가닥 호선인 0.018인치 DentaflexR(Dentarum Co., Germany), 3가닥 호선인 0.020인치 DentaflexR(Dentarum Co., Germany), 6가닥 호선인 0.0195인치 RespondR(G&H Co., U.S.A.)를, 그리고 자가중합형 레진 접착제인 Superbond C&BR를 고정성 보정장치의 재료를 이용하여 보정장치를 접착한 군과 보정장치를 접착하지 않은 군으로 나누어 3주간 적용 후 희생하여 H-E염색군, M-T염색군으로 나누어 광학현미경으로 관찰하여 다음과 같은 결과를 얻었다. 1.0.0195인치 RespondR를 접착시킨 군은 0.018인치 DentaflexR, 0.020인치 DentaflexR, Superbond C&BR를 접착시킨 군에 비교할 때 압박측에서의 거대세포 침윤 감소와 긴장측에서의 신생골 형성 증가가 매우 두드러지게 나타났으며 치주인대는 형태와 배열에서 대부분 정상적인 소견을 보였다. 2.실험 1군의 모든 실험대상에서 압박측 치조골 내부의 괴사골이 관찰되었고, 압박측과 긴장측 모두에서 치조골 표면의 골양조직 및 sharped 섬유의 형성과 치주인대의 재형성 현상이 나타나는 것이 관찰되었다. 3.실험 2군은 실험 1군에 비교하여 압박측에서 거대세포 침윤이 현저히 감소되었고 치주인대는 거의 정상적인 소견을 보였다. 긴장측에서는 수층의 골침착을 보이며 치주인대 측으로 골양조직과 골아세포가 구상으로 나타나는 활성화 소견을 보였다. 이상의 결과에서 더 여러 가닥이 꼬인 6가닥 호선인 0.0195인치 RespondR(G&H Co., U.S.A.)를 보정장치로 적용한 경우가 다른 재료의 고정성 보정장치보다 더 활발한 신생골주 형성의 활성화 소견이 관찰되었으며 대조군과 유사한 배열과 형태를 보이는 정상적인 치주인대 섬유의 배열양상이 관찰되어 다른 재료들에 비교하여 치주조직의 초기 재형성과정을 더 신속하게 유도하는 것으로 사료된다. The purpose of this study was to evaluate the material for fixed type retainer, allowing physiologic tooth movement. and proper remodeling of periodontal tissue during retention period. The present study was performed to observe the histologic changes of periodontal tissue after application of different types of fixed type retainer after orthodontic tooth movement in young adult dogs. For this study, 4 young adult dogs were used as a experimental animal and experimental group was divided into three groups ; experimental group 1 contained right side maxillary third incisors and canines, experimental group 2 contained contralateral teeth of same animals, and control group contained mandibular premolars. And each dogs were applied the 4 different types of fixed type retainer to experimental group 1. The experimental teeth were ligated on the Sentalloy closed coil springR(Tomy Co., Japan) from maxillary third incisors and canines and applied orthodontic force at initial 200gm-forced during 1 week. All the experimental animals were sacrificed on the 3rd week after the orthodontic teeth movement and then the specimens were taken, fixed in formalin, embeded in parafin, sectioned 6-8μm in thickness and stained with Hematoxylin-Eosin staining, and Masson's trichrome staining method. Examined under the light microscopy. The following results were observed. There were observed that decreased infiltration of giant cells in pressure side and increased the new bone forming in tension side on the specimen of 6-stranded 0.0195' RespondR(G&H Co., U.S.A.) group. Periodontal ligament fibers were much compressed or elongated in 3-stranded 0.018', 0.020' DentaflexR(Dentarum Co., Germany), and Superbond C&BR(Sun Medical Co., Japan) groups. 2. In experimental group 1, necrotic bone inside the alveolar bone of pressure side, forming of the sharpey's fiber in osteoid tissue, and remodeling of the periodontal ligament were observed in all animals. 3. In experimental group 2, it was observed that the amount of bone resorption was equal or decreased in pressure side, and increased new bone forming and significantly decreased Infiltration of giant cell than the experimental group 1. By this results, it considered that 6-stranded RespondR(G&H Co., U.S.A.) wire was the most useful material allowing early periodontal tissue remodeling.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Effect of gel spinning accompanied with cross-linking using boric acid on the structure and properties of high-molecular-weight poly(vinyl alcohol) fiber

Jo, Yong Gu,Shin, Eun Joo,Lee, Young Jae,Yoon, Won Sik,Han, Sung Soo,Lee, Yang Hun,Lee, Yong Rok,Noh, Seok Kyun,Gal, Yeong Soon,Lyoo, Won Seok Wiley Subscription Services, Inc., A Wiley Company 2009 Journal of applied polymer science Vol.113 No.3

<P>To enhance the thermal stability of poly(vinyl alcohol) (PVA) fiber, the fiber was prepared from the gel spinning of high molecular weight (HMW) PVA by using dimethyl sulfoxide/water (8/2, v/v) as a solvent, accompanied with the cross-link by boric acid (B-PVA). In addition, the structure and properties of the B-PVA fiber were compared with those of the HMW PVA fiber obtained by using the same spinning system without cross-linking (NB-PVA). Through a series of experiments, it turned out that cross-linking actualized by an optimum amount of boric acid (0.3 wt % based on PVA) and zone drawing caused significant changes in the properties of HMW PVA gel fiber. That is, cross-linking increased thermal degradation temperatures at each degradation step and amounts of final residues, resulting in improving thermal properties of the PVA fiber. On the contrary, it was found that in the case of the B-PVA fiber, some broadening of the original PVA unit cell occurred, which was identified by the peak shift to lower angle in X-ray diffractogram. The tensile strength and Young's modulus of B-PVA fiber with draw ratio of 15 are 23.1 and 308.3 g/d, respectively. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009</P>

Coacervation-상분리법으로 만든 Ethyl Cellulose 마이크로캅셀의 Glibenclamide 방출특성 및 수용성 첨가제의 영향

김병조,장정수,이문주,김상헌,최영욱 중앙대학교 약학연구소 1996 약학 논총 Vol.10 No.-

Glibenclamide (GBC) is a well-known antidiabetic agent, which stimulates the secretion of endogenous insulin by pancreatic βcells. However, administration of GBC at a high dose can occasionally induced the fatal hypoglycemia, especially in the patients with impaired liver function. Therefore, in order to develop an oral sustained-release preparation which reduces the side effect, microcapsulation of GBC has been carried out in this experiment. Microcapsules of GBC were prepared by coacervation-phase separation method with ethylcellulose as a wall-forming material in cyclohexane, using polyisobutylene as a coacervation-inducing agent. Different amounts of hydrophilic additives. L-arginine(ARG) and polyethylene glycol 4000 (PEG), were added to the microcapsule wall, in order to alter the porosity of the wall and hence to enhance the release of the core material. The microcapsules prepared were examined for physical properties by scanning electron microscopy (SEM) and particle size analysis. The release of the poorly water-soluble GBC was found to be very slow from the microcapsules and strongly dependent on the core to wall ratio of the microcapsules, but it was accelerated considerably with increasing amount of PEG or ARG. In general, on the basis of dissolution kinetics, GBC releases from microcapsules were followed apparent first-order kinetics, while the dissolution data of GBC powder conformed to Hixon-Crowell's cube root law. Therefore, in conclusion, it might be possible to design the sustained-release formulation by the combination of both GBC powder and microcapsules of different core wall ratio with or without hydrophilic additives.

『諸病源候論』에서의 呼吸修練法에 대한 考察

이상훈,신조영 한국전통의학연구소 2002 한국전통의학지 Vol.12 No.1

The word "Qi-Gong" firstly originated from Taoism in the Jin era means to concentrate true energy and to cultivate new energy and thus to make our vitality strong. Qi-Gong, which means breathing method and physical exercise had been developed in various directions from ancient China. "Zhubingyuanhoulun" intensively summarized these various methods for Qi-Gong, and the theory of Qi-Gong as practical treatment. Through this study, this author attempted to newly define the essences of Breathing training method and to review the conception, the history in "Zhubingyuanhoulun".

유방통을 호소하는 한국 여성에서 Gamma Linolenic acid의 임상적인 효과

정재헌,김권천,조현진,민영돈,김성환,김정용,장정환 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1

Background and Objectives : Recently, the incidence of breast cancer is gradually increasing in korea. Many patients visit the hospital with a fear of breast cancer, if she had the pain in her breast. But Breast pain is not a cardinal sign of breast cancer. Only 7% of patient in breast cancer has breast pain. Materials and Method : To know the clinical effects of gamma-linolenic acid(GLA), we analyzed the medical records of 55 cases with breast pain, who visited the outpatient clinic of Chosun university hospital, between July of 1999 to December of 1999. Of the 55cases of breast pain, we analyzed 26 cases of patient with breast pain who was treated with GLA for 2 month and we excluded patients of breast pain who had breast mass or were treated with other drug. Results : 2 Patients we are dropped out because nausea and vomiting were developed, 4 Patient with breast pain were treated with GLA for 1 month, and relieved completely from mastalgia and 8 patients with breast pain were treated with GLA for 2 months and breast pain was relieved completelys. 4 patient had treatment for 2 months, were relieved slightly. But 8 patients with breast pain didn't reveal the relief of symptom after the intake of GLA. Conclusion : We conclude that GLA could be considered a first line drug in patients with mastalgia.

후두 및 하인두 암종에서 p53단백 발현과 Espstein-Barr Virus 검출

최영환,도남용,나한조,이도용,노용훈,김완수,최종선 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and Objectives : When p53 cancer suppressor gene, occurs gene deletion or point mutation, malignancy develops by loss of p53 function with abnormal p53 protein. The Epstein-Barr virus (EBV) is the causative agent of certain type of lymphoma and undifferentiated nasopharyngeal carcinoma. However, the role of EBV as a causative factor in other head &eck tumors is not fully elucidated except nasopharyngeal carcinoma. This study, the author examined that p53 expression and detection rate of EBV correlate to development of laryngeal and hypopharyngeal squamous cell carcinoma(SCC) and play the possible role of prognostic indicators. Materials and Methods : Formalin-fixed, paraffin-embedded tissue specimen from 32 cases of larynx and hypopharyngeal squamous cell carcinomas were studied by immunohistochemical staining for p53 and EBV. The results of analysis were compared with clinicopathological parameters. Results : p53 expression was 56.3% (18 cases) and the detection rate of EBV was 43.6% (14 cases) of 32 cases in laryngeal and hypopharyngeal squamous cell carcinomas. p53 expression was correlate with histologic grade (p<05) only. Detection of EBV was not correlate with clinicopathological parmeters. Conclusion : These results suggest p53 expression and the detection of EBV may be related with development of laryngeal and hypopharyngeal squamous cell carcinoma. And, the expression of p53 protein can be used as a prognosticator in laryngeal and hypopharyngeal squamous cell carcinoma under certain limitation.

국내에서 생장한 Kenaf의 해부학적 특성

권영만,황원중,권성민,조준형,이명구,김남훈 江原大學校 森林科學硏究所 2005 Journal of Forest Science Vol.21 No.-

국내에서 재배한 kenaf의 해부학적 특성을 광학현미경법으로 조사하였다. Kenaf의 수피부에는 인피섬유, 사부방사조직, 피층유세포 등이 존해하였고, 목질부는 도관, 목섬유, 방사조직 등으로 구성되어 있었다. 도관은 고립관공과 2~3개가 방사방향으로 복합한 복합관공이 많이 존재하였고, 방사조직은 평복, 직립, 방형세포가 모두 분포하고 있었다. 접선단면에서 방사조직은 단열 및 다열방사조직으로 구성되었다. 수피비의 인피섬유층은 생장기간과 함께 증가하였다. Anatomical properties of Kenaf cultivated in Korea was investigated using light microscopy. Bast fiber, phloem ray and cortex parencyma cell were observed in bast, and vessel, wood fiber and rat in core. A lot of solitary and multiple radial pores in core existed. The cell type of ray parenchyma in radial section was procumbent, upright and square sell. Uniseriate and multiseriate rays existed in tangential section. The layer of bast fiber in bast increased with in creasing the growth period.

내시경적 절제로 진단된 폴립 형태의 심재성 낭종성 위염 2예

허종현,조영화,성용완,유재훈,구동영,김갑식,노지훈,문원 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2

Gastritis cystica profunda (GCP) is a disease characterized by hyperplastic and significant extension of cystic dilatation of the gastric mucous glands, which results in a cystic lesion in gastric submucosa. It often occurs on the part of gastroenterostomy, but can be found in the stomach without any previous surgery. GCP has variable gross finding including solitary polyps, diffuse ones, submucosal tumors, and rare giant gastric mucosal fold. It is difficult to tell GCP from a cancerous lesion by gross finding that the disease demands a necessary tissue biopsy, though GCP is commonly showed as a benign in the progress. We report a case of GCP in polypoid types diagnosed by endoscopic polypectomy.

신경회로망에 의한 용접 결함 종류의 정량적인 자동인식 시스템 개발에 관한 연구

김재열,김영석,김병현,유신,김훈조,정진홍 한국공작기계학회 1997 한국생산제조학회지 Vol.6 No.1

A neural network approach has been developed to determine the depth of a surface breaking crack in a steel plate from ultrasonic backscattering data. The network is trained by the use of feedforward three-layered network together with a back-scattering algorithm for error correction. The signal used for crack insonification is a mode converted 70˚ transverse wave. A numerical analysis of back scattered field is carried out based on elastic wave theory, by the use of the boundary element method. The numerical data are calibrated by comparison with experimental data. The numerical analysis provides synthetic data for the training of the network. The training data have been calculated for cracks with specified increments of the crack depth. The performance of the network has been tested on other synthetic data and experimental data which are different form the training data.