흰쥐 시상하부에서 NMDA에 의한 c-fos의 발현

이영기,최기열,이원돈,유영복,이왕재,황덕호,조사선,장가용 대한해부학회 1994 Anatomy & Cell Biology Vol.27 No.3

한국인 심부전증 환자 심근에서의 인형 거대 세포 바이러스 감염

이명용,이무용,김영권,한성식,최성준,김효수,이영우,서정돈 단국대학교 1998 論文集 Vol.33 No.-

Objectives: In order to evaluated the prevalence and the site of infection of cytomegalovirus in terminally failing heart, cytomegaloviral DNA was detected in the explanted hearts of transplantation recipients. Methods: DNA extractions were performed from explanted failing hearts(N=22) and normal hearts(N=5) and polymerase cain reactions(PCRs) were done for detection of late gene sequence coding pp150 glycoprotein. The products were confirmed by electrophoresis on the 1% agarose gel. n order to improve the detectability of cytomegaloviral genome, nested PCRs were executed with the primers designed for the original 607 bp products. In situ PCRs also were done with the samples which were confirmed as positive for CMV viral genome by nested PCRs. Results: All patients had IgG anti-cytomegalovirus antibody and did not have IgM anti-cytomegalovirus antibody. Cytomegaloviral genomes in myocardium were detected by polymerase chain reaction. The 607bp products by PCRs were found in both explanted failing heart(3 cases/22. 13.5%) and normal hearts( 1 case/5, 20.0%). In nested PCRs, 186bp products were found in both failing hearts(LV 4/22, LA 3/2, RV 4/22, RA 0/17) and normal hearts(LV 2/5, LA 1/4, RV 2/5, RA 2/5). These was no significant change in positivity of cytomegaloviral DNA genome between failing and normal hearts. Total positivity of cytomegaloviral genome in explanted hearts was 44.4% according to the nested PCR results. The positivity of cytomegaloviral DNA by n situ PCR was 33.3%(4/12), and the site of positive reaction was the nuclei of the myocardial cells. Conclusion: Cytomegalovirus was rarely observed in explanted hearts of terminal heart failure and nested PCR could enhance the sensitivity of cytomegaloviral genome detection. The result of the in situ PCR showed the site of the cytomegaloviral infection was nuclei of the myocardial cells. Cytomegalovirus, however, might have no direct causal relationship in the development of terminal heart failure.

융모성림프구를 보이는 비장변연부 림프종 1예

진한영,손창학,주영돈,박정하,이재익,조영완,이원식 인제대학교 2006 仁濟醫學 Vol.27 No.-

Splenic marginal zone lymphoma is very rare B-cell lymphoma, characterized by an indolent clinical course. Clinical features are moderate-to severe splenomegaly, absolute lymphocytosis, and bone marrow intrasinusoidal infiltration of lymphocyte. We report the case of a 37-year-old male with SMZL. He complained of LUQ pain, who had a massive splenomegaly and moderate lymphocytosis in peripheral blood. Immunophenotyping findings and morphologic findings were consistent with SMZL. He underwent splenectomy and received chemotherapy with cyclophosphamide for eight months. Now, one year later after surgery he has a nearly normal blood count with no treatment.

Multiple myeloma 환자에서 Bortezomib치료 후 발생한 마비성 장폐색증 1례

김준영,이원식,손창학,박성길,진한영,박석주,조영완,정은욱,강명주,박정하,주영돈 인제대학교 2006 仁濟醫學 Vol.27 No.-

Bortezomib is the first clinically available proteasome inhibitor that is clinically effective in the treatment of multiple myeloma. A proteasome inhibitor acts through multiple mechanisms to arrest tumor growth, tumor spread, and angiogenesis. The main adverse effects of bortezomib are gastrointestinal symptoms, cytopenia, fatigue, and peripheral neuropathy. To date, severe paralytic ileus has not been reported as a toxic effect of bortezomib treatment in multiple myeloma. Bortezomib is a novel agent that has only been used clinically for 30 months, so a need exists to further evaluate its toxicity. We report a case of grade Ⅲ (NCI CTCAE v3.0) or grade Ⅳ(SWOG toxicity criteria) paralytic ileus in a 65-year-old man with relapsed multiple myeloma who underwent one cycle of single-agent bortezomib treatment scheduled in a 21-day cycle (1.3 mg/㎥ as a single i.v. bolus on days 1, 4, 8, and 11).

Trigger point를 利用한 口眼괘斜 患者 10例에 대한 臨床的 考察

鄭榮敦,李浚龜,金永一,朴泰均,辛泳一,黃載然,李賢,李秉烈 대전대학교 한의학연구소 2002 한의학연구소 논문집 Vol.10 No.2

From July 1th 2001 to October 31th 2001, the Clinical investigation studies were carried out 10 cases of patient with Bell's palsy using Trigger point treatment group, who had been treated in Han-seung Oriental Medical Clinic. The results were like below : 1. The distribution of sex : Male were 4cases, female were 6case and the female to male ratio was 1.5 : 1. 2. The distribution of contributing factor : Unknown reason was most predominant 4 cases, and then were revealed to labor too hard, menttal stress(3 cases), trauma·common cold(1 case) in turn. 3. The distribution of perid to fall ill : Under a week was the most number 6cases, and then were revealed a week under two weeks(3 cases), over two weeks(1 case) in turn. 4. About period of treatment : The Trigger point treatment group is shorter than the Acupuncture treatment group. 5. The distribution of grade on admission in descending order : GrⅠ was the most number and then GrⅡ, GrⅢ in turn. 6. The distribution of clinical symptoms on adimission : Mastoid pain was the most number 9 cases and then lacrimal gland disorder 8 cases, dysgeusia 4 cases, hyperacusis 2 cases, the others 2 cases in turn. 7. About effect of treatment : The Trigger point treatment group is more excellent than the Acupuncture treatment group. 8. The more patient age is young, the more effect of treatment was excellent, had nothing to do with both groups. 9. The more perid to fall ill is short, the more effect of treatment was excellent, had nothing to do with both groups. 10. About period of improved frontal belly : The Trigger point treatment group is more excellent than the Acupuncture treatment group.

야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

Phenylephrine이 토끼 유두근의 수축력과 활동전압에 미치는 영향

이영배,고인송,박종완,엄대용,이상돈 중앙대학교 의과대학 의과학연구소 1989 中央醫大誌 Vol.14 No.1

In order to clarify the receptor types and mechanisms underlying the positive inotropic effect of phenylephrie on the mammalian ventricular myocardium, the action potential, its first derivatives and isometric contraction of the rabbit papillary muscle were recorded using a free transducer and glass capillary microelectronics filled with 3M KCI, and results were analyzed. The results were as follows; l. In normal Tyrode solution, the contractile force was increased with increments of phenylephrine concentration and maximum effect was reached at the stimulation frequency of 1 Hz in 10^-5 M phenylephrine. 2. In 22 mM K^+-Tyrode solution, the maximum rate of rise (Vmax) of action potential, overshoot and the duration oction potential were significantly increased with increments of phenylephrine concentration (10^-6 ~ 10^-4 M). 3. The negative inotropic effect induced by verapamil was reversed by phenylephrine. 4. Phentolamine (3x10^-6 M) shifted the dose response curve for phenylephrine to the right more than propranolol (10^-6 M) did. The above results may be interpreted as follow; The positive inotropic effect of phenylephrine is caused by increase in slow inward current (Ca^2+influx into the myocardial cell), and is mediated through α- and β-adrengergic receptors in the rabbit pailary muscle

용치놀래기, Halicoeres poesilopterus(Temmink et Schlegel) 生殖生態

李榮敦,李澤烈,盧洪吉 濟州大學校海洋硏究所 1991 해양과환경연구소 연구논문집 Vol.15 No.-

1990년 10월부터 1991년 9월까지 제주도 북방함덕연안에서 채집된 용치놀래기, Halicoeres poecilopterus를 대상으로 生殖生態를 파악하기 위하여 生殖巢熟度指數(GSI)와 生殖巢의 組織學的 방법에 의한 生殖週期와 性轉換 과정 등을 조사한 결과는 다음과 같다. 1. 生殖巢熟度指數(GSI)는 암 수 다같이 6월에 급겨히 상승하여 7월에 최대치를 나타내고 있으며, 8월에 접어들면서 하강하기 시작하여 9월부터 낮은 값을 나타내고 있다. GSI최대값은 암컷 6.35 수컷 1.01을 나타냈다. 2. 生殖週期는 성장기(5∼6월), 성숙기(6∼7월), 완숙 및 산란기(7∼8), 회복 및 휴지기(8∼4월)등의 연속적인 주기를 나타냈다. 3. 체장 13.0∼15.0㎝되는 개체들에서 雌性에서 雄性으로 性轉換現像이나타났다. 4. 본종은 一次精巢와 二次精巢가 혼합되어 나타나는 複雄性(diandry)의 雌性先熟魚에 속하는 것으로 나타났다. 5. 암컷에서 수컷으로 性轉換함에 따라 적색에서 청색으로 채색변화가 나타나고 있다. Reproductive ecology of the Wrasse, Halicoeres poecilopterus was investigated histologically on the gonadal development, sex reversal and studied by gonadosomatic index(GSI), color patterns. Samples were collected at the costal area of Ham duck, Cheju-do, Korea from October, 1990 to September, 1991. In male and female, GSI began to increase from june when the water temperature began to increase and the reached maximum value in July, respectively. It began to decrease from August. Thereafter, maintained relatively low value until May of next year. The annual reproductive cycle of this species could be classified into four sucessive developmental stage : growing stage(May), mature stage(June-july), ripe and spent stage(July-August), degenerative and resting stage(August-April). In H.poecilopterus, individuals with hermaphroditic gonad were observed in 13.0-15.0㎝ in standard length. sex reversal of this species could be oceured from 13.0㎝ to 15.0㎝ in standard length. A(red) and B(blue) types of color patterns were observes in this species. The individuals in plain A type coloration are mainly females and hermaphroditic individuals, but few primary and secondary males are included. The individuals in gaudy B type coloration are mostly secondary and primary males.

황놀래기, Pseudolabrus japonicus(HOUTTUYN)의 생식주기와 성전환

이영돈,안철민,이정재,이택열 제주대학교 해양연구소 1992 해양자원연구소연구보고 Vol.16 No.-

Reproductive cycle and sex reversal of Pseudolabrus japonicu s were investigated histologically on the gonadal development, sex change of the gonad and studied by gonadosomatic index(GS1). color patterns. Sample were collected at the costal area of Ham duck in Cheju-do. from December, 1990 to November 1992. In male and female, GSI began to increase from August and reached it's malimum value in October, respectively. It began to decrease from December, the low temperature season, thereafter, maintained relatively low values until July of next year. The annual reproductive cycle of this species could be classified into four sucessive developmental stage : growing stage (August-September), mature stage (September-October), ripe and spent stage (October-December), degenerative and resting stage (December-July). The species is a diandric, protogynous hermaphrodite. and has two color patterns : red-yellow (A) and dark-green (B). A-fish were less than 14.5cm SL and consisted of females (92.7%), secondary males (3.6%), and fish with transitional gonad (3.6%). B-fish consited of secondary male (80.2%). primary male (5.5%). female (5.5%) and fish with transitional gonad (8.8%). In P.japonicus, individuals with hermaphrodic gonad were observed in 11.5-16.0 cm SL. Sex reversal of this species could be occured from 11.5 to 16.0cm SL.

자리돔, Chromis notatus의 성성숙에 따른 간세포 및 GTH세포의 활성변화

이영돈,이택열 제주대학교 해양연구소 1988 해양자원연구소연구보고 Vol.12 No.-