급성심근경색증에서 운동부하 심전도상 유발된 ST절 변화와 심근관류와의 관계

임도선,김영훈,김병회,김미양,김수미,황교승,안정천,송우혁,박창규,서홍석,심완주,오동주,노영무 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.5

인지행동적 분노치료 모델 설정을 위한 탐색적 연구

천성문,이영순,이현림 한국동서정신과학회 1998 동서정신과학 Vol.1 No.1

최근 분노가 모든 정서장애의 기저감정이라는 인식과 더불어 분노의 치료방법에 대한 관심이 증가하고 있다. 분노치료에 관한 선행연구를 살펴보면 분노치료 성과연구들이 대부분 인지행동적 치료접근법을 사용하였고, 이에 대한 치료의 효율성을 평가하였다. 이에 본 연구에서는 치료의 효율성이 입증되고 있는 인지행동적 치료접근법의 모델들을 살펴보고, 이 모델들의 연구동향과 과제에 대해 검토해 보았다. 또한 서로 다른 개념으로 사용되고 있는 분노개념과 분노와 밀접한 관련이 있는 변인들을 서술하였고, 인지행동적 접근의 형태를 취하는 대표적인 치료모델과 선행연구 그리고, 미래의 연구과제에 대해 논하였다. Even though anger often appears as a significant client concern, Outcome research has hagged behind other areas such as treatment of anxiety and mood disorders. To date, the most researched interventions has been cognitive-behavioral approaches that are effective in reducing anger in various populations. From this viewpoint, this study intend to review the cognitive-behavioral interventions model in the treatment of anger problems. Several dominant treatment models are discussed, the Emotional control model of anger reduction, Social Skill Model, Combined Cognitive-relaxation intervention Model etc. Empirical Studies explained the effectiveness of the treatment for helping clients deal with anger related problems. The article concludes with a discussion of implication for future research and practice.

심정지환자에서 epinephrine투여시 혈중 catecholamine의 변화

임경수,황성오,이부수,이강현,이진웅,임종천,김영식,김선만,김 현 대한응급의학회 1995 대한응급의학회지 Vol.6 No.1

Background : Cardiac arrest is a potent stimulus for the release of endogenous catecholamine and high plasma catecholamine concentration has been reported during cardiopulmonary resuscitation(CPR). Few data were present about the clinical effect of high plasma catecholamine and endogenous catecholamine response to exogenous epinephrine administration during CPR. Purpose : This study was designed to evaluate endogenous catecholamine response to cardiac arrest and exogenously administered epinephrine during CPR. Method : In 21 cardiac arrest victims, blood sample for epinephrine and norepinephrine was drawn before and 1 minute after each epinephrine administration during CPR. 1mg of epinephrine was administered immediately after intravenous access and 3 minute interval during CPR. Plasma catecholamines were quantitated by high-performance liquid chromatography. Result : Baseline plasma epinephrine concentraqtion was higher in patients with cardiac arrest than normal controls (985±1627 vs 194±173 pg/ml, p<0.05). Baseline plasma norepinephrine concentration was also elevated in patients with cardiac arrest than normal controls, although statistically insignificnat(1965±4915 vs 360±250 pg/ml). Plasma epinephrine concentration in cardiac arrest patients was significantly elevated after exogenous administration of epinephrine, but its response was blunted after the third does of epinephrine. Plasma norepinephrine concentration in cardiac arrest patients was also elevated, but its response was observed only after the first epinephrine administration. Plasma epinephrine concentration was persistently higher in patients with return of spontaneous circulation (ROSC) than patients without ROSC. there was no significant difference of plasma norepinephrine concentration whether spontaneous circulation was restored or not. Endogenous epinephrine response to exogenous epinephrine was not observed in patients having prolonged arrest time over 20 minutes. Conclusion : Results of this study suggests that significant amount of catecholamine is released by exogenous epinephrine administration in spite of high plasma catecholamine concentration, and degree of endogenous catecholamine response influences resuscitation outcome.

증발잔류 광물의 광물학적 연구

박천영,박신숙,김성구,조갑진,임성수 조선대학교 에너지.자원신기술연구소 2003 에너지·자원신기술연구소 논문지 Vol.25 No.1

This study has focused on mineralogical and geochemical characteritics of evaporated minerals from the mine waters and on variation of constituents in mine water during the evaporation The evaporated minerals are shown in mine waters at the field. In order to form of evaporates in the laboratory, mine waters were sampled from the abandoned mine area(HS, LG and BJ) and were air dried in laboratory for room temperature. During the evaporation of mine waters, TDS, EC values and the concentration of major and minor ions increased, whereas dissolved oxygen(DO) values decreased with the sampling time. Gypsum, epsomite, kaolinite, dolomite and illite were identified in BJ sample, gypsum and epsomite were observed in LG sample, and gypsum, epsomite and vermiculite were founded in HS sample by x-ray powder diffraction studies. The infrared spectra for evaporated minerals show major absorption banded due to OH stretching, adsorbed molecular water and sulfate stretching, respectively. Evaporated minerals were heated at 65, 150, 250 and 350℃ for 1 hour in electrical Furnaces. Gypsum transformed the bassanite at 150℃ heating temperature and epsomite transformed the hexa-hydrite at 65℃, and then converted the kieserite at 250℃. With increasing heating temperature, the intensity of absorption OH band(3407 11㎝^(-1)), adsorbed molecular water band (1654.39㎝^(-1)) and sulfate stretching band (1113.46㎝^(-1)) were decreased, whereas sulfate stretching bands(668.35㎝^(-1) and 603.85㎝^(-1)) were relatively increased in IR due to dehydration.

급성호흡부전증 환자에서 초기 인공환기방식의 중요성 : 인공환기시 혈역학적으로 유의한 부정맥의 유발요인 분석

이영주,김원,김영득,천석천,임경수 대한응급의학회 2000 대한응급의학회지 Vol.11 No.4

Background: The purpose of this article was to identify the risk factors related to development of hemodynamically significant cardiac arrythmias in patients with mechanical ventilation. Methods and Results: Holter recording and echocardiogram were performed after 30 minutes of ventilator initiation in patients on mechanical ventilation(MV) owing to respiratory failure(RF) from various reasons. From 68 patients, hemodynamically significant cardiac arrythmias were detected in 18 patients(26.5%). Initial mean arterial pressure, maximal heart rate, and initial pH were identified as risk factors for hemodynamically significant cardiac arrythmlas. Additionally, the patients with pressure-controlled ventilation as an initial ventilatory mode developed hemodynamically significant cardiac arrythmias less frequently than the patients with other modes(15.8% vs. 40%, p=0.03). In multivariate analysis, initial mean arterial pressure(<70mmHg, odds ratio[OR]: 5.5; 95% confidence interval[CI]: 1.2 to 24.2, p=0.026), maximal heart rate(>120/min, OR: 19.7; 95% CI: 2.0 to 190.9, p=0.01), and pressure-controlled ventilation(OR: 0.13, 95% CI: 0.03 to 0.55, p=0.006) were associated with the development of hemodynamically significant cardiac arrhythmias. Conclusion: Theses findings suggest that during the early stages of mechanical ventilation with acute respiratory failure, hemodynamically significant cardiac arrhythmias are directly associated with tachycardia(>120/min), initial MAP(<70 mmHg), and, inversely, the initial use of pressure-controlled ventilation.

단기교육으로 시행가능한 심실기능평가법

김원,임경수,오병연,홍은석,김영식,김선만,이부수,현석천,김영득 대한응급의학회 2000 대한응급의학회지 Vol.11 No.4

Background: The initial history, physical examination, and ECG assessment should focus on identification of potentially serious noncardiac or cardiac disorders, including coronary artery disease, congestive heart failure, and electrical instability at the emergency room. additionally, it is essential to define disease severity, stability and need for emergency therapy. echocardiography is a useful tool for this purpose. especially Doppler echocardiography may be more sensitive and time-saving diagnostic tool for the evaluation of patients presenting with cardiogenic symptoms. So we evaluate the feasibility of the echocardiographic measurement by emergency physicain after short-term course. Method and Results: Twenty volunteers(10 male, 38.8±9.3 years) were included in the study for measurement of myocardial performance index and established parameters of ventricular function using conventional echo-Doppler methods. Myocardial performance index: (ICT+IRT)/ET, was obtained by subtracting ejection time(ET) from the interval between cessation and onset of the mitral inflow velocity to give the sum of isovolumic contraction time(ICT) and isovolumic relaxation time(IRT). The most of mean values of echocardiogrphic parameters were not significantly different between those of cardiologist and those of emergency physicians(p<0.01). The duration for measuring myocardial performance index was shortest among echocardiographic parameters. the validity of echocardiographic parameters measured by emergency physicians was proved relatively good. Conclusion: It is proved to be feasible for emergency physician to perform echocardiographic evaluation of ventricular function after short-term course

Bacillus brevis CD162 Cyclodextrin Glycosyltransferase의 정제 및 특성

김명희,손천배,임영희,오태광 대전대학교 이과대학 기초과학연구소 1997 自然科學 Vol.- No.-

Bacillus brevis CD162가 생산하는 cyclodextrin glycosyltransferase (CGTase)를 ammonium sulfate 침전, DEAE-Sephadex CL-6B 및 Sephadex G-150 컬럼 크로마토그래피를 수행하여 분리정제하였다. 정제된 CGTase는 분자량이 약74.000, 등전점은 약 6.3인 단백질이었고, 정제된 단백질을 SDS-PAGE한 후 변성된 단백질을 재활성시켜 zymogram을 수행한 결과 cyclodextrin glycosyltransferase임을 확인할 수 있었다. 이 효소의 최적활성 pH와 온도는 각각 8.0과 55℃이었으며, pH 5.5~9.0과 50℃까지 안정한 활성을 보였다. 또한, CGTase의 NH₂-말단 부위의 아미노산서열은 Ser-Val-Thr-Asn-Tyr-Ser-Lys-Asp-Val-Ile-Tyr-Gln 이었으며, 전분으로부터 cyclodextrin으로의 전환률을 분석한 결과, α-cyclodextrin은 1.3%, β-cyclodextrin은 33.9%, γ-cyclodextrin은 9.7% 이었다(1997년 7월 10일 접수, 1997년 9월 25일 수리) The cyclodextrin glycosyltrasferase (CGTase, EC 3.2.1.19) from Bacillus brevis CD162 was purified by precipitating with ammonium sulfate, DEAE-Sepharose CL-6B column chromatography and Sephadex G-150 column chromatography. The molecular mass and pI of the purified enzyme were estimated to be 74,000 and 6.3 by SDS-PAGe and isoelectric focusing, respectively. The purified enzyme was clearly identified as the CGTase by zymogram after SDS-PAGE. The optimum pH and temperature for the enzyme activity were 8.0 and 55℃, respectively. The enzyme was stable at the range of pH 5.5~9.0, and up to 50℃. The amino acid sequence from the NH₂-terminal of the purified CGTase was Ser-Val-Thr-Asn-Lys-Val-Asn-Tyr-Ser-Lys-Asp-Val-Ile-Tyr-Gln. The yields of the products from starch as the substrate were 1.3% for α-,33.9% for β-, and 9.7% for γ-cyclodextrin.

Γ-Cyclodextrin Glycosyltransferase 생산균주의 분리, 동정 및 효소 생산조건

김명희,손천배,임영희,배경숙,오태광 대전대학교 이과대학 기초과학연구소 1997 自然科學 Vol.- No.-

Cyclodextrin glycosyltransferase 생산균주를 토양으로부터 분리하여 형태학적, 생화학적 그리고 균주의 세포벽 지방산 조성분석에 의해 Bacillus brevis로 동정하였고, Bacillus brevis CD162로 명명하였다. 또한 배지조성에 따른 cyclodextrin glycosyltransferase의 최적생산조건을 검토한 결과, 2.0% soluble starch, 0.75% yeast extract, 0.5% bacto peptone, 0.2% KHPO₄, 0.05% MgSO₄·7H₂O, 1.5% Na₂CO₃ (pH 10.2)의 배지 조건에서 30℃에서 96시간 배양하였을 때 가장 높은 효소생산인 0.9 unit/ml을 얻을 수 있었다.(1997년 7월 10일 접수, 1997년 11월 21일 수리) A cyclodextrin glycosyltransferase-producing bacterium was newly isolated from soil using alkaline pH medium containg 1% Na₂CO₃, The isolated strain was identified as Bacillus brevis by morphological and biochemical characteristics, and designated Bacillus brevis CD162. The strain showed the best enzyme production of 0.9 unit/ml after 96 hrs of culture at 30℃ in a medium of 2.0% soluble starch, 0.75% yeast extract, 0.5% bacto peptone, 0.2% K₂HPO₄, 0.005% MgSO₄·7H₂O and 1.5% Na₂Co₃at initial pH 10.2

도플러지수를 이용한 급성 심근경색증의 진단에 있어 노인 환자의 특징

김원,조규종,오세현,이영수,이은주,홍진숙,김영득,현석천,임경수 대한노인병학회 2000 Annals of geriatric medicine and research Vol.4 No.4

급성심근경색증을 가진 한국인에 있어 Chlamydia Pneumoniae 감염의 영향에 대한 연구

이은미,오동주,황교승,안정천,송우혁,임도선,박창규,김영훈,서홍석,심완주,노영무,정희진,김우주,김종헌,송기준 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4