혈관 생성 억제 제를 투여한 신생마우스 폐 조직에서 Retinoic acid의 세포자멸사의 억제

주선영 ( Sun Young Ju ),조경아 ( Kyoung Ah Cho ),유경하 ( Kyung Ha Ryu ),우소연 ( So Youn Woo ),박은애 ( Eun Ae Park ),조수진 ( Su Jin Cho ) 대한주산의학회 2008 Perinatology Vol.19 No.1

목적: Retinoic acid는 폐포 재생에 중요한 역할을 하는 것으로 알려져 있어서 미숙아의 기관지폐이형성중의 예방에 사용되고 있다. 기관지폐이형성중의 병태생리는 미숙한 폐의 내피세포와 외피세포의 세포자멸사를 일으킴과 관련이 있다. 이에 본 연구에서 VEGFR2 억제가 신생 폐에서 세포자멸사를 증가시키는지, 또 retinoic acid의 투여가 본 폐 발달 억제 동물모형에서 세포자멸사를 억제하는지 알아보고자 하였다. 방법: VEGFR2 억제제인 SU1498을 생후3일된 마우스에 주사하고, 폐포발달이 이루어지는 그 후 10일간 retinoic acid나 위약을 주사하였다. 형태학적인 분석을 하였고, 세표자멸사를 비교분석하기 위해서 TUNEL 염색과 Annexin V을 표지자로 FACS출 시행하였다. 자멸사한 세포를 확인하기 위해서 동일초점 현미경으로 분석하였다. 결과: SU1498를 주사한 마우스에서 폐포면적과 평균폐포용적이 의미 있게 감소하였다. 세포자멸사도 약 3배 의미 있게 증가하였다. 자멸사한 세포는 내피세포와 상피세포에 분포하였다. Retinoic acid를 주사한 약 50%의 세포자멸사가 감소하였고, 형태학적으로 정상에 가까운 폐포 발달이 유지되었다. 결론: VEGFR2 억제를 하면 내피세포와 상피세포의 세포자멸사가 증가되면서 폐 발달이 저해되었다. 이어서 retinoic acid를 주사하면 세포자멸사가 억제되어 폐 발달유지에 도움이 되었다. 이러한 retinoic acid에 의한 세포자멸사의 억제가 기관지폐이형성증 예방에 기여할 것으로 추정된다. Background: Retinoic acid is known to play a role in alveolar regeneration and is used in the prevention of bronchopulmonary dysplasia (BPD) in premature infants. Many factors involved in the pathogenesis of BPD induce apoptosis of the endothelium and epithelium of the premature lung. We hypothesized that VEGFR2 inhibition would increase apoptosis in the newborn lung and retinoic acid would decrease apoptosis in our model of inhibited lung growth. Material and Methods: SU1498, a VEGFR2 inhibitor or vehicle was given to three-day-old mice. Subsequent retinoic acid or vehicle injection was given for ten days for the duration of alveolarization. Morphometric analyses were performed. Apoptosis was assessed with TUNEL staining and Annexin V staining. Co-localization of apoptotic cells with endothelial and epithelial cells was performed. Results: SUI498 injection reduced alveolar surface area and mean alveolar volume in newborn mice. Apoptosis was increased by three-fold in SU1498 injected mice. Apoptotic cells co-localized to endothelial and epithelial cells. Retinoic acid significantly reduced the degree of apoptosis by 50% in SU1498 injected mice and maintained lung development. Conclusion: VEGFR2 inhibition caused an arrest in lung development accompanied by an increase in apoptosis of endothelial and epithelial cells of the neonatal lung in mice. Subsequent retinoic acid treatment reduced apoptosis and we speculate that retinoic acid may preserve lung growth in bronchopulmonary dysplasia by inhibiting apoptosis in the neonatal lung.

젊은 성인에서 흡연에 의한 상완동맥 내피기능의 부전에 관한 연구

이상철,권영주,방덕원,이선해,이보영,김지욱,김영훈,온영근,현민수,김성구 순천향의학연구소 2002 Journal of Soonchunhyang Medical Science Vol.8 No.1

Background and Objectives : Cigarette smoking is a major factor and the most modifiable risk factor for atherosclerosis. Endothelial dysfunction is an early event in atherosclerosis, before the structural change of the systemic arteries. We hypothesized that endothelial dysfunction might be present in the systemic arteries of young adult smokers and that this might be dose-dependent phenomenon. Therefore, we try to certify that smoking is associated with endothelial dysfunction in healthy young adults without other risk factor of atherosclerosis. Subjects and Methods : we studied noninvasively 29 subjects aged 3 to 4 decades without other risk factor of atherosclerosis, they were composed of the two groups, current smokers(n=15) and nonsmokers(n=14). Smoking history varied from 3 to 20 pack years. Using high-resolution ultrasound, vessel diameter and mean flow rate were measured at rest, during reactive hyperemia(with flow-mediated endothelium-dependent dilation), and after sublingual nitroglycerin(NG-induced endothelium-independent vasodilation). Result : Flow mediated endothelium dependent dilation was observed in the control subjects (9.4±3.44%) but was impaired in the smokers(5.8±2.51%)(p=0.004). NG-induced endothelium independent dilation is no difference in all subjects. Conclusion : Cigarette smoking is associated with endothelial dysfunction in healthy young adults.

Solar urticaria in Korean patients

( Sung Min Kim ),( Young Ah Cho ),( Ji Su Lee ),( Ji Youn Hong ),( Jin Hee Kim ),( Joo Ran Hong ),( Hye In Cheon ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1

Background: Solar urticaria (SU) is an uncommon type of photodermatoses characterized by erythematous wheal with pruritus after sunlight exposure, which shows a female predominance. Only a few studies to analyze the clinical features of SU were reported in Asia. Objectives: We aimed to analyze the clinical and photobiological characteristics of SU in Korea. Methods: We retrospectively investigated the medical records of patients with SU who visited the department of dermatology, Konkuk university medical center from January 2005 to January 2020. Results: Of a total of 44 patients, 36 (81.8%) were male and 8 (18.2%) were female. The mean age at onset was 17.6 years (range, 5-47) and the mean threshold time was 19.7 minutes. Among 32 patients who underwent phototesting, the action spectrum most commonly implicated was ultraviolet (UV) A only in 12 (37.5%), and then visible light (415nm) only was responsible for SU in 8 (25.0%). Three patients (9.4%) were induced by both UVA and visible light (415nm). Even 4 patients (12.5%) were triggered by only natural sunlight. Serum immunoglobulin E levels were measured in 33 patients, and 17 (51.5%) showed values higher than normal. The treatment most widely used were oral antihistamine (43.2%), followed by phototherapy (13.6%). Conclusion: SU is a rare photodermatosis in Korea, which shows a male preponderance. In this study, UVA and visible light (415nm) were predominant action spectrum of SU.

노년기 주관적 연령과 건강노화와의 관계: 연령집단별 분석

최은영 ( Choi Eun Young ),조성은 ( Cho Sung Eun ),오영삼 ( Oh Young Sam ),장희수 ( Chang Hee Su ),김영선 ( Kim Young Sun ) 한국보건사회연구원 2017 保健社會硏究 Vol.37 No.1

The purpose of this study is to examine the relationship between subjective age (whether one subjectively perceives himself as `the elderly` or `not the elderly`) and healthy aging. Using data from the 2014 National Elderly Survey (KIHASA), this study selected a total of 9,653 participants consisting of young-olds (aged 65-74) and old-olds (aged 75-84) For both the young-old and the old-old, multiple regression analyses were conducted to examine the research model. In the young-old population, one`s considering oneself as “non-elderly” was significantly associated with higher cognitive functioning, fewer chronic diseases, lower depressive symptoms, and higher level of social engagement. On the other hand, in the old-old population, one`s considering oneself as “non-elderly” was associated only with higher cognitive functioning, and not with the other domains of healthy aging. The findings suggest that subjective age can be considered as an important predictors of older adults` healthy aging. These findings indicate that the association between subjective age and healthy aging has a different pattern depending on the age group.

탄소나노튜브를 이용한 고강도 나노복합재료

박영수(Young Su Park),허몽영(Mong Young Huh),안계혁(Kay-hyeok An),김은성,강신재(Shinjae Kang) 한국자동차공학회 2008 한국자동차공학회 지부 학술대회 논문집 Vol.2008 No.11

With major causes of exhaustion and global warming of limited fossil fuel, according to policy of saveenergy and nature-friendly products, it is needed for gas milage to beb increased by compulsion regulation (Corporate Average Fuel Economy, CAFE). For this regulation solution, the diverse and hard tries such as light-weight vehicle, electric car, and fuel cell have carried out to elevate engine efficiency and to reach to a next generation zero-emission vehicle. In light-weight field, it has been tried to find or make much stronger and lighter materials or composites, magnesium alloy and carbon fiber would be a powerful candidate in metals and reinforced plastic composites for light weight vehicles. But, we here introduced carbon nanotube (CNT), which is one of the highest Young’s modulus and strength, and its nanocomposite which would be a new and powerful material to make light weight vehicle. CNT reinforced nanocomposite would solve waste disposal to make up environmental problem and have the advantage in recycling problem that would be or has been occurred in other reinforced composites.

성인여성이 인식하는 미인의 안면비율과 평균계측비

오수나 ( Su-na O ),오인영 ( In-young O ) 한국미용예술경영학회 2011 미용예술경영연구 Vol.5 No.1

In this research, we selected and observed the features of facial ratio of female entertainers that worked in early 1990s and late 2000s who recognized by adult women as ‘beauty-face’. Participants were 189 women living in Seoul and Kyung-gi area, and they are interested in beauty-related blog and other website. And we measured and calculated average facial ratios of 10 female entertainers with their pictures (1 picture for each). As result, women with ages of 40s recognized that actress who has 'beauty- face’ in late 2000s have short ‘middle face’ and ‘lower face’ compared to actress of late 1990s, and they have wider ‘Endocanthion-endocanthion’ but shorter ‘Cheilion-cheilion’. These factors make them to look younger. Moreover, they have short and narrow lower jaw and this is one of typical features of young-looking face. Therefore, the ‘beauty- face’, that thought about women has the factors of young-looking face. This is because ‘young-looking face’ became the ideal of beauty face in our society and it reflected to women's awareness of beauty-face.

한국놀이〈우리 집에 왜 왔니〉와 일본놀이〈하나이치 몬메はないちもんめ〉와의 관계 연구

임영수(Im, Young-su),전영숙(Jeon, Young-suk) 아시아강원민속학회 2020 아시아강원민속 Vol.34 No.-

어린이 놀이〈우리집에 왜 왔니〉는 교과서에 수록되어 있어 초등학교에서 저학년들이 즐겨 노는 놀이 중 하나이다. 도구가 필요 없고 실내나 실외에서 적당한 공간만 확보되면 언제 어디서나 쉽게 놀 수 있기에 교사들도 어린이 놀이로 권장하고 있고 50~60대 어른들은 어렸을 때 놀았던 추억의 놀이로 기억하고 있다. 그런데 이 놀이가 일본의〈하나이치 몬메はないちもんめ〉라는 놀이가 일제강점기 때 들어온 것으로 놀이의 유래는 일본문화가 숨어있는 인신매매의 내용을 담고 있다는 내용을 듣고 이에 관련된 자료를 찾아 정리하였고 초등학교 교과서에는 이와 비슷한 일본놀이가 27개 수록되어 있다는 것을 알고 교육부에 그 사실을 알리는 과정에서〈우리집에 왜 왔니〉는 우리나라 전통놀이라는 의견이 나와 그것이 아님을 증명하고 일본이 문화말살 정책으로 우리 놀이를 못 놀게하고 일본놀이만 놀게 하였는데 해방 후 이것을 제자리로 돌려놓지 않아 초등학교 교과서에 일본 전승놀이가 그대로 수록되어 있음을 알리는 연구 논문이다. Children’s Play 〈Why Did You Come to My House〉 is included in the textbook and is one of the games that low-grade students enjoy playing in elementary school. It doesn’t need any tool and if a proper space indoors or outdoors were secured, it can easily be played anytime, anywhere. Therefore, teachers also recommend as children’s play, and adults in their 50s and 60s remember it as a memory play when they were young. However, 〈Why Did You Come to My House〉 was influenced by〈Hanaichi Monmeはないちもんめ〉in Japan. It was introduced at Japanese colonial era and includes the content of human trafficking. The elementary school textbook contains 27 similar Japanese games. 〈Why did you come to my house〉proved that it was not a traditional Korean game, although there was an opinion that it was a traditional Korean game. Japan prevented us from playing Korean games due to its cultural extermination policy and only allowed us to play Japanese games, but they were not returned to their original place after the liberation, so Japanese games were left included in elementary school textbooks.

新羅 法光寺 石塔記

黃壽永(Hwang Su-young) 백산학회 1970 白山學報 Vol.- No.8

Buddhism in Silla spread widely to local provinces with the be-ginning of the 9th century, and consequently many new temples of all sizes were founded here and there. Most of the stone pagodas of later Silla period now remaining in other areas than Kyongju, are those that were erected with this trend in the background. The site of Bopkwang-sa Temple(法光寺), now preserved at the eastern foot of Mt. Bi-hak(飛鶴山) in Sin-kwang-myon(神光面), Young-il-gun(迎日郡), North Kyongsang Province is one of the historical remains of Silla, especially one of those dating back to this period. There is a three-storeyed stone pagoda standing on this site today. Unfortunately, the sarira and other valuable articles of this stone pagoda were stolen by thieves only a few years ago, but there remain two small tablets (jiseok-誌石). Through the inscriptions on these stones the dates of the erection and repairs of the stone pagoda were learned, and, further, through the names of persons in the inscriptions was found the fact that this temple had been in close relationship with the royal family of the kingdom. The tablets each bear six letters ‘Bopkwang-sa-seok-tab-gi’(法光寺石塔記)-epitaph for the stone pagoda-inscribed on a side, and the main inscriptions on the other surfaces are, in summary, as follows: [On the first tablet, 10. 8 ㎝ long and 4 ㎝ wide] “This pagoda is erected by Hyang-jo(香照) and Weon-jeok(圓寂) in the seventh moon of the second year of Dae-hwa(大和2年)-(A.D. 828) and the supporter is King Seong-deok(成德大王). “The pagoda is moved and repaired in the ninth moon of the sixth year of Hoe-chang(會昌6年). Prayed is that the supporters generation after generation may be reborn in Paradise, and that the king may live long in happiness. “Twenty-two sarira in the pagoda” [On the second tablet, 6.2 ㎝ long and 2.7 ㎝ wide] “Is repaired in the seventh moon of the 37th year of K’anghsi (康熙37年-A.D. 1638). “Is repaired in the second moon of the 12th year of Chienlung (乾隆12年-A.D. 1747). “Chief executives are Myeong-ok(明玉) and Dam-hak(談學)...” By the first stone it is certain that the pagoda was first erected in 828 and moved to the present site in 846. But the epitaph itself must have been inscribed in 846, the latter date. For King Seong-deok being the father of King Sin-mu(神武王), began to be called by this posthumous title only in the first year of King Sin-mu (A.D. 839). King Seong-deok had been, in life, that Kim Kyun-jeong the famous character in Silla history, and he could hardly have been called by that title in A.D. 828, when the pagoda was first erected. From the inscriptions stating that King Seong-deok was the main supporter of this Bopkwang-sa Temple, it is clearly to be seen that the temple was supported by him and his descendants of the direct line, King Sin-mu, King Mun-seong,(文聖王), etc. Temples of Later Silla period were each founded and supported by opposing sects or lines of royalty. The second stone makes it clear that the pagoda was twice repaired in modern times. Especially, the repair made in the reign of King Young-jo of Yi Dynasty is recorded in detail in the inscriptions on the monument standing in the back of the pagoda. This monument, erected in the 15th year of Chienlung(1750), tells us not merely of the existence of the two tablets, but of the way of preserving the sarira and also lists the stored items. This three-storeyed stone pagoda, although it is of a small size, will serve as a standard in study of other stone pagodas of Silla period, now that its date of erection has been determined. And the two small tablets, too, are rightfully important data for study of ancient epigraphy.

16주 스텝-밴드 운동이 전기·후기 노인의 체구성과 SFT에 미치는 영향

안동수(An, Dong-Su),변용현(Byun, Young-Hyun) 한국체육과학회 2016 한국체육과학회지 Vol.25 No.4

The purpose of this study was to determine the effects of step-band exercise on body composition and SFT(Senior Fitness Test) in the Young-Old(YOA, n=13) and the Old-Old Adults(OOA, n=19). The step-band exercise needed equipments-a steeper and a thera band was performed for 90 minutes, 2 times a week, for 16-week. Body composition, SFT were measured before and after the step-band exercise. To analyze effects of exercise results, Two-way repeated measures ANOVA was carried out by each variable. The statistical significance level was set for α=.05. The results of this study are as follows: First, Body weight, BMI and WHR significantly were decreased in all group after 16-week exercise(p<.05). BFM(body fat mass), %BF were significantly decreased in OOA after 16-week exercise(p<.05). But MM(muscle mass) was statistically increased in OOA(p<.05). Second, there was no significant an interaction related to SFT between a time and a group and the step-band exercise improved all measurements of SFT in all groups(p<.05). There was no significant differences between two groups(p<.05) in Arm curl, 2-Min step, back stretch area. These results suggest that step-band exercise improves body composition and SFT in young- and old-old adults. In this study, the step-band exercise was especially more effective to the OOA than the YOA.

Rocuronium의 애별투여방법이 모지내전근의 이완에 미치는 영향

최영균,김승수,이원진,조광래,이상은,김영환,임세훈,이정한,이근무,정순호,김영재,신치만 인제대학교 2009 仁濟醫學 Vol.30 No.-

Objective : There are controversies in pnmmg technique of rocuronium whether it can or can't shorten the onset time. We want to compare the effects of two different priming doses and intervals of rocuronium. Materials and Methods : After giving propofol, 50 patients were randomly assigned to 5 groups. Group I received a placebo, followed 3 min later by rocuronium 0.6 mg/kg. Priming doses and intervals of Group II, Ill, N, V were 0.06 rng/kg and 2 min, 0.12 mg/kg and 2 min, 0.06 rug/kg and 3 min, 0.12 mg/kg and 3 min, respectively. Total dose of rocuronium was 0.6mg/kg. Train of four (TOF) count or ratio and 1st twitch height of TOF (T1) were monitored with 15 secondsintervals. TOF ratio of each groups just before bolus injection, duration for TOF count to reach zero and duration for Tl to reach 95% depression after bolus injection were compared. Results : Duration for TOF count to reach zero and duration for Tl to reach 95% depression after bolus injection were decreased in priming groups compared to Group 1 (P < 0.01) In group V, significant depression of TOF ratio just before bolus injection was seen (P < 0.05). Conclusion : Priming technique with rocuronium is effective method to shorten the onset of neuromuscular block. But priming dose of rocuronium itself could cause hypoxia and aspiration in awake patients and should be used carefully. Priming dose of rocuronium 0.06 mg/kg and 2 minutes interval maybe relatively safe method.