Elderly kidney transplant recipients have favorable outcomes but increased infection-related mortality

임정훈,Lee Ga Young,Jeon Yena,Jung Hee-Yeon,Choi Ji Young,CHO, JANG-HEE,Park Sun Hee,김용림,Kim Hyung-Kee,Huh Seung,유은상,Won Dong Il,Kim Chan-Duck 대한신장학회 2022 Kidney Research and Clinical Practice Vol.41 No.3

Background: The number of elderly patients with end-stage kidney disease has been increasing, but the outcomes of kidney transplants (KT) remain poorly understood in elderly patients. Therefore, we evaluated the clinical outcomes of elderly KT recipients and analyzed the impact of elderly donors. Methods: This retrospective cohort study included patients who underwent KT between 2000 and 2019. KT recipients were divided into four groups according to a combination of recipient and donor age (≥60 or <60 years); elderly recipients: old-to-old (n = 46) and young-to-old (n = 83); young recipients: old-to-young (n = 98) and young-to-young (n = 796). We compared the risks of mortality, graft failure, and acute rejection between groups using Cox regression analysis. Results: The incidence of delayed graft function, graft failure, and acute rejection was not different among groups. Annual mean tacrolimus trough level was not lower in elderly recipients than young recipients during 10-year follow-up. Mortality was significantly higher in elderly recipients (p = 0.001), particularly infection-related mortality (p < 0.001). In multivariable Cox regression analysis, old-toold and young-to-old groups had increased risk of mortality (adjusted hazard ratio [aHR], 2.89; 95% confidence interval [CI], 1.14– 7.32; p = 0.03; aHR, 3.06; 95% CI, 1.51–6.20; p = 0.002). However, graft failure and acute rejection risks were not increased in elderly recipients. Conclusion: In elderly recipients, graft survival and acute rejection-free survival were not inferior to those of young recipients. However, mortality, especially risk of infection-related death, was increased in elderly recipients. Thus, low immunosuppression intensity might help decrease mortality in elderly recipients.

금 박막의 기계적 물성에 끼치는 두께와 미세조직의 영향

전영선(Young-Sun Jeon),이상주(Sang-Joo Lee),현승민(Seung-Min Hyun),이학주(Hak-Joo Lee) 대한기계학회 2007 대한기계학회 춘추학술대회 Vol.2007 No.10

We have used Visual Image Tracing(VIT) strain measurement system coupled with a micro tensile testing unit to test thickness and microstructure dependent mechanical behavior of Au film. The advantage using this method is to monitor the real time images of specimen during the test in order to determine its Young’s modulus, yield strength and tensile strength. 0.5, 1 and 2 ㎛ thick films were deposited by sputtering system. Free standing films were prepared through lithography and etching processes. Au films were annealed at 300℃ and 350℃ to achieve microstructure evolution and Focus ion beam (FIB SEM) and transmission electron microscopy (TEM) were employed to characterize grain sizes of films. Thickness and grain sizes dependent mechanical behavior such as stress-strain curve, Young’s modulus and yield strength of Au thin film will be presented.

Helicobacter pylori와 대장균의 Shuttle Vector 개발

조명제,이우곤,이상룡,김경희,안영숙,김성희,김현주,류복덕,최여정,윤영혜,백승철,전영석,이광호 경상대학교 유전공학연구소 1997 遺傳工學硏究所報 Vol.16 No.-

In this study, a vehicle vector using cryptic plasmids was constructed for gene transfer in Helicobacter pylori. pHP51(3.9 kb) and pHP489(1.2 kb) were selected for constructing vectors from cryptic plasmid of H. pylori isolates in Korea. The HindⅢ-digestedDNA fragment(1.2kb) of pHP489 and 1.6kb DNA fragment of pHP51 were ligated with a kanamycin resistance gene(aph3'-Ⅲ) from C. jejuni to produce the recombinant plasmids pHP489K and pHP51K, respectively. Transformation frequency of pHP51K by electroporation was low. But pHP489K could be effectively transformed into various H. pylori strains. In order to design an intermdiate vehicle vector for gene transfer into H. pylori, pBlueHP489K was prepared by recloning pHP489K DNA into pBluescript and pTZ19R vector. This vector permitted the DNA fragment containing pHP489 sequence, aph3'-Ⅲ, and cloned DNA to be cut and self-ligated in the SacⅠ site after cloning. ureA and ureB gene were inserted into pBlueHP489K, resulting in pBlueHP489K/AB. The DNA fragment containing pHP489, kanamycin resistance gene(aph3'-Ⅲ), and urease structural gene was cut away from pBlueHP489K/AB and self-ligated to generate pBlueHP489K/AB. pBlueHP489K/AB made urease-negative H. pylori strains restore their urease activity. By this experiment, pBlueHP489K was confirmed to be the vehicle system for transferring H. pylori genes.

해녀에서 발생한 성게육아종 1례

전영승,김상태,서기석 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.4

Some aquatic animals can cause important skin diseases in humans. Sea urchin granuloma is a rare skin disorder showing chronic granulomatous lesion caused by injury with sea-urchin spines. Sometimes patients were injured in fishing activities and among them, correspond to divers involved in sea-urchin harvesting. We report a case of sea-urchin granuloma in 67-year-old female, who presented with multiple erythematous pin-head to rice-grain sized papules on the both elbow and knee.

CT flouroscopy를 이용한 중재적 시술의 유용성

전혜정,박정희,서보경,박상우,신현준,최영철,한혜승,이창희 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-

Conventional CT-guided needle localization has been reported many times, but a few reports of interventional procedures by using multidetector CT scan with CT-fluoroscopy have been described. We presented 36 cases of CT-fluoroscopy guided interventional procedures focusing on the puncture technique. Two cases of small pneumothorax and one case of pulmonary hemorrhage out of 2lcases after lung biopsy, were not needed any treatments We can easily and accurately access to the lesion by using CT-fluoroscopy and unique our marker system.

米穀生産에서 利潤函數에 의한 規模의 經濟性 分析

전영길,한승희 안성산업대학교 1994 論文集 Vol.26 No.-

This aims at testing statistically and estimating the economies of size for each farm size. Total of 137 rice farmers at three Counties besides the Oak Gue in the Chun Buk province had been interviewed on the spot and mail-interviewed. The results are in summary as follows By using the data, the normalized, restricted, translog profit function has been applied to investigate the above mentioned purposes, based on the rejection of C-D hypothesis test at the 1% significance level. Also the co-efficients of the model has been estimated by OLS and SUR(A.Zellner,1962) under restricted and unrestricted conditions respectively. The results of parameter estimates have shown that estimation by SUR was more suitable than by OLS, and estimates under the restricted condition was statistically better than under the unrestricted. This implies, among other things, that the sample farms, on the average, maximize profits, thus supporting empirically the assumption of profit maximization. And the statistical test has been carried out to test for constant return to size to fixed factors of production. Again the hypothesis could be rejected at 3% significance, implying that the sample farmers have experienced economies of size. The estimated parameters for fixed inputs, land and machinery, have +1.3656 and +0.0231 respectively, suggesting that the economies of size be, for the most part, ascrived to land input. Referring to each farm size, only the middle farms were experiencing economies of size, but small and large farms diseconomies of size. It has been due to the enlargement of farm-size for middle farms, to added machinery and equipment for large farms.

ZnSe 단결정에 대한 열자극 발광과 열자극 전류의 동시측정

전경남,유승철,고석룡,신용규,김택성,이춘호 全北大學校 基礎科學硏究所 1994 基礎科學 Vol.17 No.-

두 종류의 ZnSe 분말을 사용하여 sublimation 방법으로 성장한 ZnSe 단결정(as grown)에 대하여 TSC와 TSL을 동시 측정하였으며, PL과 DLTS를 측정하였다. PL 측정으로 I_1, I_2와 DAP 발광을 관측하였으며 DLTS에 의한 깊은준위를 관측하였다. TSL과 TSC의 동시 측정으로부터 얻은 그로우 곡선을 점근 해법으로 분해하여 세개의 준위를 얻었으며 그들의 활성화에너지값은 0.22 eV, 0.30 eV, 0.39 eV이었다. PL spectrum과 열자극 완화과정의 동시 측정 결과로부터 0.22 eV 근방에 impurity에 의한 주게준위와 native defect에 의한 받게준위가 각각 전도대의 아래와 가전자대의 위에 존재하는 것으로 판명되었다. DLTS 측정과 동시측정 결과로부터 0.30 eV와 0.39 eV의 준위는 V_se vacancy와 관련되는 주게 준위임을 알았다. Simultaneous measurements of TSL were carried out on ZnSe single crystals grown by high pressure Bridgman technique and the PL and DLTS signals were observed. Photoluminescence spectrum at 10 K on the ZnSe crystal reveals I_1 and I_2 lines, as well as DAP emission line. DLTS spectrum on the ZnSe crystal show electron trap at 0.33 eV. Two TSC and TSL peaks were observed near 215 K and 230 K, which are identified as having originated from two donor trap levels at 0.30 eV and 0.39 eV, respectively, below the bottom of the conduction band. We also observed single TSL and TSC peaks at 150 K which were identified as having originated from a donor and acceptor trap levels at about 0.22 eV below the conduction band and over the top of the valence band, respectively.

Methyl Aminolevulinate(MAL)와 Light Emitting Diodes(LEDs)를 이용하여 국소 광역동 요법으로 치료한 여드름 1례

전영승,서기석,김상태 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.4

Ance is a common multifactorial skin disease of the pilosebaceous unit. Conventional treatments of acne include a variety of topical agents (cleansing, antibiotics agents, benzoyl peroxide, retinoids) and oral medications (antibiotics, retinoids, hormones). But there are some disadvantages in terms of adverse effects and patient inconvenience with such treatments. Therefore new effective well-tolerable treatments needed. Photodynamic therapy (PDT) is a non-invasive therapeutic modality which is developing increasing use in dermatology. Photodynamic therapy (PDT) using with the new highly selective photosensitizer methyl aminolevulinate (MAL)(MetvixⓇ, Galderma, U.K.) is a promising treatment modality for acne. We report herein a case of acne treated by PDT using with MAL, with satisfactory outcome in clinical aspects.

남한 내 북한이탈주민들의 3년간 사회의식 변화 및 생활 만족도에 대한 추적연구

전우택,유시은,조영아,홍창형,엄진섭,서승원 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.3

Objectives : The aim of this study was to examine the change in attitudes and satisfaction level of North Korean defectors in South Korea over a 3 year period (2001-2004). Methods : In our first study in 2001, a total of 200 detectors were interviewed. In the follow up study after 3 years, 151 defectors were re-interviewed by an in-person interview. Results : The level of satisfaction to the governmental support policy to defectors decreased significantly. However, the general level of satisfaction increased slightly (from 3.52 to 3.56 ; 5-score scale). This shows that North Korean defectors are stably adapting to South Korean society. The level of satisfaction significantly correlated with the defectors' confusion of the different value systems, the defectors' understanding of the South Korean people, satisfaction with their physical and mental health, and the Prejudice of South Korean people to defectors. In terms of the attitudes, the type of schooling, the military service and the communist party membership in North Korea were not related to the change in attitude. However, there was a significant correlation with gender and age. Women showed a greater change in attitude compared to men. Older people had difficulty in understanding the South Korean people, but they showed little psychological affiliation to North Korea. Moreover, they showed a high level of satisfaction with the economic situation in South Korea and had an optimistic viewpoint for their future than younger people. Even though many defectors attended churches, religion was not associated with the level of satisfaction or their change in attitude. Conclusion : The factors that influence the level of satisfaction and attitudes of North Korean defectors have changed over 3 years. Therefore, the government, nongovernmental organizations (NGOs) associated with defectors and the churches need to be more sensitive to these changes and make plans to support the adaptation of defectors to South Korean society.

Cr,Cu,Fe가 첨가된 MgO 단결정의 열자극 발광 스펙트럼 분석

田耕南,兪昇喆,杜夏榮,李春鎬 全北大學校 1994 論文集 Vol.38 No.-

On the MgO single crysital doped artificially with Cr, Cu, Fe we observed thermally stimulated luminescence(TSL) glow curves and spectra, and analyzed them in the temperatured range from 500 to 77 k after excitation with UV or X-ray irradiation. TSL glow curves obtained from these samples show five peaks at 136.5K, 223.5 K, 390 K, 440 K, and their estimated activation energies are 1.08 eV, 0.27 eV, 0.63 eV, 1.19 eV, and 1.33 eV, respectively. When we measured TSL spectrum at the range of 200 nm to 650 nm, we also analysed the peak wavelength which obtained at 345 nm, 375 nm, and 410 nm from measurement of TSL spectrum and described their luminescence mechanisms.