정상인에서 베타3-아드레날린 수용체 유전자의 변이가 복부 비만도 및 지질대사에 미치는 영향

김영선,윤석기,김철희,서교일,김학선,김극배,변동원,유명희 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.1

The β₃-adrenergic receptor is expressed in visceral adipose tissue in humans and is thought to contribute to the regulation of the resting metabolic rate and lipolysis. We studied the influence of a mutation in the β₃ -adrenergic receptor gene(Trp64Arg) on body fat distribution, central obesity, lipid metabolism in 65 healthy young male adults. One out of 65 subjects were homozygous (Arg/Arg) for the trp64Arg mutation, 17 subjects were heterozygous (Trp/Arg), and 47 lacked the mutation(Trp/Trp). The body weight, height, body mass index, waist-to-hip ratio were similar between the subjects with- and without the mutation. Total body fat, abdominal fat amount, body fat distribution, serum total- and HDL-cholesterol, triglyceride, glucose, and insulin concentrations were also not different according to the presence or absence of the mutation. These results suggested that Trp64Arg mutation in β₃-adrenergic receptor gene is not a major contributing factor for central obesity or change in lipid metabolism in Korean young adults.

배달 미니 게임 개발:"최고의 웨이터를 꿈꾸며"

김정훈,정한교,김영옥,김중곤,박정윤,윤진성,김경식 호서대학교 반도체제조장비국산화연구센터 2001 반도체장비학술심포지움 Vol.2001 No.-

본 미니 게임은 웨이터라는 직업을 모티브로 하여서 남녀노소 누구나 재미를 느낌과 동시에 기억력 향상시켜 주는 게임제작이라는 목적아래 제작되었다.본 논문에서는 이 게임의 제작과정을 기술하고자 한다.이 게임은 제3회 AGC(한국 아마추어 게임제작 공모전)에서 우수 작으로 선정되었다.

항갑상선제로 치료한 그레이브스병 환자의 관해예측인자

남일송,윤여일,김선규,김용현,이주영,목지오,윤석기,김철희,김영선,변동원,서교일,유명희 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background: Most cases of Graves' disease have been treated by antithyroid drugs in Korea. The major drawbacks of antithyroid drugs are the relative high rate of relapse and the inconvinience of long term therapy. Measurement of TBII and TRH stimulation test have been considered as the most reliable tests predicting relapse, but the predictive power is not high enough to use in clinical situation. This study was performed to find good prognostic indicators in Graves' disease patients after the discontinuation of antithyroid drug therapy. Subjects and methods : We restrospectively evaluated 96 patients with Graves' disease who showed normal TRH test at the end of antithyroid drug therapy and were followed for more than one year. Serum T3, T4, T3/T4 ratio, TBII, Anti-TPO Ab and TGAb levels were measured at the time of diagnosis and at the end of therapy. Two to three months after withdrawal of antithyroid medication, serum TSH and free T3 responses to TRH were examined. These parameters were compared between the relapse group and the remission group. Results : Among the 96 patients, 22 patients(22.9%) relapsed(Group Ⅱ) and 74 patients(77.1%) remained in remmision(Group Ⅰ). No significant difference was observed between the relapse and the remission group in clinical parameters, serum T3, T4, TSH, T3/T4 ratio, TBⅡ and Anti-TPO Ab determined before and after treatment. Serum TSH and free T3 levels measured after TRH stimulation were also similar in both groups. Serum TGAb levels determined at the end of treatment were significantly higher in the remission group(p<0.05). Relapse following the discontinuation of therapy occured within 24 months in 72.7% of the relapsed cases. After 24 months, relapse rate was reduced significantly. Conclusion : These results suggest that high serum TGAb levels could be a favorable prognostic indicator for the long term remission of Graves' disease treated with antithyroid drugs, and may suggest that Hashimoto's thyroiditis is combined with Graves' disease in those patients.

갑상선 종양에서 thrombin receptor (PAR-1)의 발현 양상

박지영,목지오,김여주,박형규,김철희,변동원,서교일,유명희,조현득,오미혜,김상진 순천향의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.2

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Calcitonin Gene Related Peptide에 의한 치수미세순환 조절

김성교,,김영경,진명욱 大韓齒科保存學會 2005 Restorative Dentistry & Endodontics Vol.30 No.6

본 연구에서는 감각성 neuropeptide인 CGRP의 치수혈류 조절에 관해 교감신경과의 유기적 관계를 연구함으로써 CGRP의 치수혈류 조절기전을 밝히고자 하였다. 열두 마리의 전신마취된 고양이에서 실험하였으며 CGRP를 혈관을 통해 전신적 또는 국소적으로 투여하였다. 견치에서 치수혈류의 변화를 측정하고 paired t-test로 통계분석 하였으며 95% 수준에서 유의성을 검증하였다. CGRP (0.3㎍/㎏)를 전신정맥으로 주사시, 전신혈압에 현저한 영향을 나타내면서 치수혈류는 평균 68.85%의 일차적인 증가와 감소를 보였고 이차적으로 다시 평균 161.8% 증가하였다가 감소하였다. CGRP를 저용량 (0.3㎍/㎏)으로 국소적으로 투여시, 치수혈류는 평균 2.92%의 미약한 증가를 나타내었다. 교감신경을 전기자극시 (10 Hz, 4 V, 1.5 ms), 전신혈압은 영향을 받지 않으면서 치수혈류가 유의하게 평균57.88% 감소하였다. 교감신경 자극으로 치수혈류가 저하되어 있는 동안 주입한 CGRP는 저하된 치수혈류를 유의하게 회복시켰다. CGRP의 이 치수혈류 증가 효과는 CGRP_(8-37)에 의해 효과적으로 차단되었다. The purpose of this study was to investigate the function of calcitonin gene-related peptide (CGRP) in regulatory mechanism of pulpal microcirculation with the aim of elucidating neurogenic inflammation. Experiments were performed on twelve cats under general anesthesia. CGRP was administered through the femoral vein to see the systemic influence and through the external carotid artery to see the local effect. Sympathetic nerve to the dental pulp was stimulated electrically and pulpal blood flow (PBF) was measured with a laser Doppler flowmeter on the canine teeth to the drug administration. The paired variables of control and experimental data were compared by paired t-test and differences with p < 0.05 were considered statistically significant. Systemic administration of CGRP (0.3 ㎍/㎏) exerted decreases in systemic blood pressure and caused changes in PBF with an initial increase followed by decrease and a more marked second increase and decrease. Close intra-arterial (i.a.) injection of CGRP (0.03 ㎍/㎏) resulted in slight PBF increase. The effect of CGRP resulted in no significant increase in PBF in the presence of CGRP. The electrical stimulation of the sympathetic nerve alone resulted in PBF decreases. The i.a. administration of CGRP following the electrical stimulation of the sympathetic nerve compensated the decreased PBF. Therefore, CGRP effectively blocked the sympathetic nerve stimulation-induced PBF decrease. Results of the present study have provided evidences that even though the local vasodilatory function of CGRP are weak. CGRP is effectively involved in blocking the vasoconstriction caused by sympathetic nerve stimulation in the feline dental pulp.

淨水場 單位工程의 最適化 自動制御 시스템에 관한 硏究

김성순,문교영,김갑진 중앙대학교 기술과학연구소 1998 기술과학연구소 논문집 Vol.28 No.-

본 연구는 상수도 공급의 합리적 방안 연구의 일환으로서 수질개선과 효율적인 공급관리 체계확립을 연구하였다. 먼저 상수도 체계도를 각각 단계별로 분류하였으며, 정수장의 수처리 공정에서 발생하는 근원적인 문제점과 실태를 조사ㆍ분석하여 개선책과 대안들을 제시하고자 하였다. 또한 상수도 관리공정의 자동화 및 계측제어 system 방식의 도입을 통하여 비효율적인 기존의 인위적 생산방식을 탈피하고, 제한된 용수자원을 최대한 호라용하여 능률적인 상수원 공급체계를 확립하고자 하였다. Water Supply in Water Treatment Plants has been accomplished at a great extent for last decade in Anyang City. Some problems to be solved were disclosed in the survey which dealt with operation and the installation procedure. Optimum Auto-Control System is a kind of preventive maintenance equipment which monitors continuously the operating condition of equipment and alarms to the operator in case of abnormal condition to prevent equipment from transition to big trouble. This system monitoring the efficiency of water treatment plants. By suggesting standard model of Optimizing Control System after completion, it will be possible to adapt this model to the renewaland/or new construction of other Water Supply System. Also it will contribute to the effective equipment operation by maintenancing cost cut-down and remote monitoring and control.

양배추 組織培養에서 體細胞 胚의 誘起

金暎來,朴敎善,朴順五,李永馥 충남대학교부설 생명공학연구소 1991 생물공학연구지 Vol.1 No.-

Leaf tissue segments of cabbage (Brassica oleracea. L.) were cultured on the MS medium supplemented with BA and 2, 4-D or NAA. 2, 4-D promoted callus induction but not shoot or root organogenesis. The highest callus induction frequency obtained at treatment of BA 0.2 and 2, 4-D 0.2 ㎎/l. High concentration of 2, 4-D 5.0㎎/l inhibited callus formation. BA promoted shoot formation at the 1.0㎎/ℓ and complementary treatment of BA and NAA was more effective on the formation of shoot and root. Multiple shoots were formed on the medium supplemented with BA 1.0 and NAA 0.5-1.0㎎/l, and BA 0.5 and NAA 2.0㎎/l. Higher concentration of NAA 5.0㎎/ℓ inhibited shoot formation. The highest root formation was induced at the NAA 1.0-2.0㎎/l. Embryogenesis was not induced on leaf disk culture.

전기화학법에 의해 형성된 Ti 양극산화피막의 특성

김태영,손원우,권태엽,강인규,김교한 大韓齒科器材學會 2002 대한치과재료학회지 Vol.29 No.3

The effects of electrolyte concentration and current density on the behaviour of volt-time curve of the anodizing, morphology, roughness, crystallinity and composition of the oxide layer were studied. Microstructural morphology, crystallinity, composition and surface roughness of oxide layer were analyzed by observed by scanning electron microscopy(SEM) and X-ray diffractometry(XRD), Energy-dispersive spectrometer(EDS), Electron Probe Micro Analyzer(EPMA)and roughness tester, respectively. The results of this study showed that the voltage incresed as the anodizing time increase. The growth of the oxide film developed a barrier layer to a pore-like layer with an increasing of current density, arising a spark discharge. On the morphology of anodic oxide layer the number and size of porosity was increased by increasing anodizing time at a constant concentration of electrolyte. The size of porosity and the roughness of the anodic oxide layer were increased by the increasing of concentration of electrolyte. The anodic oxide layer obtained in the conditions of this experiment was identified as anatase. The crystallinity of oxide layer was decreased by increasing the concentration of electrolyte at constant current density, and increased by the increasing current density at constant electrolyte concentration. In the EPMA analysis of anodic oxide layer, the concentration of phosphorous was increasing the electrolyte concentration and increasing the final voltage at constant electrolyte concentration, The ratio of O/Ti of the oxide layer obtained in this experiment was near 2 confirming this oxide layer was TiO₂

치과용 Au-Ag-Cu-Pd 합금의 시효경화특성

김형일,김영근,장명익,김교한 대한치과기재학회 1997 대한치과재료학회지 Vol.24 No.1

The relationship between the isothermal age-hardening behavior and the phase transformation process in a dental casting Au-Ag-Cu-Pd alloy was investigated by means of hardness test, X-ray diffraction study. 1. The isothermal age-hardening behavior in the 350∼450℃ temperature range showed a similar tendency in the changes. However, the initial hardening was faster and the maximum hardness was higher and the overaging with softening was slower on aging at the lower temperature. 2. By the isothermal aging at 350∼450℃, the metastable Ag-rica α₁’and AuCu Ⅰ’orderd phases were formed from the supersaturated α phase prior to the final formation of the equilibrium Ag-rich α₁’and AuCu Ⅰordered phases. 3. By aging at 450℃, the age-hardening was attributed to the lattice strains of the parent phases resulting from the transformation of the αphase resulting from the transformation to the metastable phases. The X-ray diffraction peaks of the αphase showed a distinct shift toward both the high and low diffraction angles during transformation.

공공 건설공사 중 부도에 따른 공사지연 방지 방안 : Focused on Apartment Houses

김백용,조영준,구교진,현창택 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1

The purpose of this study was to reduce the factor of construction delay in the owner's aspect by analyzing the actual condition of field supervision positively such as construction delay sample and process at the distressed company's construction site. As we analyze the examples of construction delay and reopening into various types, to minimize construction delay after the dishonor of a contractor we propose "Cooperation and reliance fixing between the contract parties through the improvement of order method, Contracting system and Construction management system".