http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Cysteinyl Leukotrienes and Their Receptors; Emerging Concepts
Yoshihide Kanaoka,Joshua A. Boyce 대한천식알레르기학회 2014 Allergy, Asthma & Immunology Research Vol.6 No.4
Cysteinyl leukotrienes (cys-LTs) are potent mediators of inflammation derived from arachidonic acid through the 5-lipoxygenase/leukotriene C4 synthasepathway. The derivation of their chemical structures and identification of their pharmacologic properties predated the cloning of their classicalreceptors and the development of drugs that modify their synthesis and actions. Recent studies have revealed unanticipated insights into the regulationof cys-LT synthesis, the function of the cys-LTs in innate and adaptive immunity and human disease, and the identification of a new receptorfor the cys-LTs. This review highlights these studies and summarizes their potential pathobiologic and therapeutic implications.