Adverse Drug Events Associated With Remdesivir in Real-World Hospitalized Patients With COVID-19, Including Vulnerable Populations: A Retrospective Multicenter Study

Kang Hyein,Kang Chang Kyung,Im Jae Hyoung,Cho Yoonsook,Kang Dong Yoon,Lee Ju-Yeun 대한의학회 2023 Journal of Korean medical science Vol.38 No.44

Background: Remdesivir is a US Food and Drug Administration-approved drug for coronavirus disease 2019 (COVID-19). Clinical trials were conducted under strictly controlled situations for a selected population, and their reported adverse events may not fully represent conditions in real-world patients. We aimed to estimate the incidence of adverse drug events (ADEs) associated with remdesivir in hospitalized patients with COVID-19, including vulnerable subpopulations, such as those with impaired renal or hepatic function and pregnant women. Methods: This retrospective observational study included hospitalized patients with confirmed COVID-19 treated with remdesivir between January and December 2021 at ten hospitals. ADEs and severe ADEs (Common Toxicity Criteria for Adverse Events grade ≥ 3) were operationally defined and analyzed through laboratory investigations. The incidence of ADEs was compared with that of each matched control in subpopulations with renal or hepatic impairment and pregnant women. Results: Among 2,140 patients, 1,416 (66.2%) and 295 (13.8%) experienced at least one ADE and severe ADE, respectively. The most frequent ADE was 'hepatic injury' (42.9%), followed by anemia (27.6%). The most common severe ADEs were 'hypokalemia' (5.3%), 'hepatic injury' (2.9%), and 'anemia' (3.6%). There was no significant difference in the incidence of ADEs in patients relative to their respective matched-control groups, including those with renal impairment (80.0% vs. control 71.8%, P = 0.063), hepatic impairment (70.4% vs. control 75.0%, P = 0.623) and pregnant women (78.6% vs. control 63.7%, P = 0.067). However, severe ADE incidence was significantly higher in patients with renal impairment (40.8% vs. 16.0%, P < 0.001). The most common severe ADEs in those were 'anemia' (15.3%), 'hypokalemia' (10.5%), and 'thrombocytopenia' (8.9%). There was no statistically significant difference in the incidence of severe ADEs in patients with hepatic impairment or in pregnancy (P = 0.230; P = 0.085). Conclusion: A significant proportion of patients with COVID-19 treated with remdesivir experienced ADEs and severe ADEs. Given the high incidence of severe ADEs, caution is required in patients with renal impairment. Further studies are needed to investigate ADEs in pregnant women and patients with hepatic impairment.

『추락』에서 신뢰할 수 없는 화자가 전하는 서사 뒤집기

강윤숙 ( Yoonsook Kang ) 21세기영어영문학회 2021 영어영문학21 Vol.34 No.2

This paper explores the voice of J. M. Coetzee, the real narrator of his novel Disgrace, as he modifies and turns over the narrative described by the unreliable third-person narrator David Lurie. Coetzee deftly overlaps with the racist protagonist, focusing on Melanie and Isaacs. The first section of this paper examines the meanings of Coetzee’s deliberately adopted ambiguous point-of-view narrative strategy, noting that the story unfolds in a third-person narrator’s point of view but is tilted toward David. The second section analyzes how David’s rape of Melanie is distorted in its depiction by the unreliable narrator. The last section traces the twisted portrayal of Isaacs and at the same time explores the other narrative voice created of narrative by Coetzee. The multi-layered narrative of Disgrace shows the reality of white South Africans’ refusal to accept the changes after Apartheid and the distorted view of Black people created by the country’s troubled history. Coetzee sharply criticizes the reality of South Africa through narrative strategies that realistically express David’s racist views and correct them.

M.A.Newman 이론의 분석과 평가 : 의식확장으로 본 건강이론 Newman's Theory of Health as Expanding Consciousness

강윤숙 적십자간호전문대학 1996 적십자간호전문대학논문집 Vol.18 No.-

「재해건강서비스」 교과 개발

강윤숙,이옥철 적십자간호전문대학 1996 적십자간호전문대학논문집 Vol.18 No.-

사회적기업가 정신과 조직성과간의 네트워크 조절효과: 제주지역 사회적기업 근로자를 대상으로

강문실,김윤숙,Kang, MoonSil,Kim, YoonSook 서비스사이언스학회 2016 서비스연구 Vol.6 No.4

본 연구는 사회적기업가 정신이 조직성과에 미치는 영향을 알아보고, 사회적기업가 정신이 조직성과에 미치는 영향에 대한 네트워크의 조절효과를 알아보기 위하여 수행되었다. 이를 위해 사회적기업 근로자들을 대상으로 189명으로부터 수집된 자료를 SPSS 18.0 프로그램을 사용하여 분석하였다. 분석결과 첫째, 사회적기업가 정신 하위요인 혁신성, 진취성, 사회적가치지향성은 사회적성과에 유의한 정(+)의 영향을 미치는 것으로 나타났다. 둘째, 사회적기업가 정신 하위요인인 진취성, 위험감수성, 사회적가치지향성과 경제적성과에 유의한 정(+)의 영향을 미치는 것으로 나타났다. 셋째, 네트워크는 사회적기업가 정신 하위요인 중 혁신성, 진취성, 사회적가치지향성과 사회적성과에 미치는 영향력을 유의하게 조절하는 것으로 나타났다. 넷째, 네트워크는 사회적기업가 정신의 하위요인 중 진취성과 경제적성과에 미치는 영향력을 유의하게 조절하는 것으로 나타났다. 이러한 결과는 사회적기업에서 사회적기업가 정신이 네트워크를 활성화시킴으로써 조직성과가 높이는데 효과적일 수 있음을 알 수 있었으며, 조사방법과 관련하여 후속연구에 유용한 접근방법을 제안하고 있다. The purpose of this study is to examine the effects of social entrepreneurship on organizational performance and to identify network moderating effects on social entrepreneurship and organizational performance. Data collected from 189 employees working in social enterprises were analyzed by using SPSS 18.0 program. Results are as follows: First, innovativeness, proactiveness, and social value orientation which were sub-factors of social entrepreneurship had positive effects on social performance. Second, proactiveness, risk-taking, and social value orientation which were sub-factors of social entrepreneurship had positive effects on economic performance. Third, the network significantly moderated the effects on innovativeness, proactiveness, social value orientation which were sub-factors of social entrepreneurship, and social performance. Fourth, the network significantly moderated the effects on proactiveness which was a sub-factor of social entrepreneurship, and economic performance. These results exhibited that the social entrepreneurship was effective to increase the organizational performance by activating the network and proposed a useful approach for further studies as an investigation method.

Study on the Safety Evaluation of Cosmetic Ingredients Using 3D-Alternative Animal Testing Method

Min Kyung HYUN,Nam-Hee KANG,Joohwan KIM,MinHee CHA,Yoonsook LEE,Seo Young BANG 한국생물공학회 2023 한국생물공학회 학술대회 Vol.2023 No.4

저장 고춧가루의 색 관련 이화학적 특성과 관능적 특성과의 관계

성미선(Misun Sung),강혜정(Hye Jeong Kang),김윤숙(Yoonsook Kim) 한국식품영양과학회 2012 한국식품영양과학회지 Vol.41 No.10

본 연구는 장기간 저장하는 동안 고춧가루의 품질변화에 대한 물리적 측정치와 시각적으로 인지하는 관능치와의 상관관계를 규명하고자 하였다. 이를 위하여 빛의 투과 여부가 다른 2종류의 포장재 linear low density polyethylene(LLDPE)과 aluminum/linear low density polyethylene(Al/LLDPE)를 선정하여 저장온도와 기간에 따른 수분함량, 색도, ASTA color value, capsanthin 함량 변화를 측정하고고춧가루의 시각으로 인지하는 색과 기호도에 대한 관능검사를 실시하여 비교분석하였다. 고춧가루의 초기 수분 함량은 저장고의 상대 습도에 의해 영향을 받으며 저장고의 온도나 포장재의 재질에 따른 차이는 나타나지 않았다. 색차계로 측정한 L, a, b값 중 적색도를 나타내는 a값은 저장기간이 늘어날수록 감소하였고 황색도를 나타내는 b값은 증가하였다. 두 측정값 모두 저온보다는 고온에서 저장 시 더 많은 영향을 받았으며 포장재의 재질별로 유의적인 차이는 나타나지 않았다. 또한 ASTA color value와 capsanthin 함량은 저장기간이 길어질수록 감소하였고 고온에서 저장 시 더 유의적인 차이가 있었으며 ASTA color value는 빛이 투과하는 LLDPE 재질의 포장재에 저장하였을 경우 더 많이 감소였다. 관능검사 결과 저장 기간이 길어질수록 황색의 강도는 증가하고 매운맛 색과 적색은 감소하여 점차 어두운 적색을 띄며 고온에서 저장 시 더 어두운 적색을 띄는 것으로 평가되었다. 포장재의 재질에 따른 차이는 매운맛 색에 대한 평가에서만 나타났으며 다른 항목에서는 나타나지 않았다. 전체적인 기호도는 적색과 매운맛 색이 감소하고 황색의 강도가 증가할수록 감소하는 것으로 평가되었다. 색소 성분의 물리적 측정치와 관능적 기호도의 상관관계에 대하여 조사한 결과 a값, ASTA color value, capsanthin 함량은 전체적인 외관기호도와 정의 상관관계가 있으며 그중 ASTA color value가 관능적 기호도와 가장 높은 상관관계가 있었다. 따라서 본 연구 결과 고춧가루 저장 시 빛이 통과하지 않는 Al/LLDPE 재질의 포장재에 저장하였을 경우에 품질 변화가 적었고 색소 성분의 물리적 측정치와 관능적 기호도 간에 높은 상관관계가 있는 것으로 나타났으며 고춧가루의 소비자 선호도는 색도계를 이용한 적색도나 ASTA color value, capsanthin 함량에 의해 결정될 수 있다. The present study investigated the relationship between physical conditions and sensory properties of red pepper powder stored at different temperatures (-20℃, 0℃, 20℃) and in different wrap materials (linear low density polyethylene, LLDPE; aluminum/linear low density polyethylene, Al/LLDPE). Red pepper powders with initial moisture contents of 17.35±0.32% were not affected by the packaging material or storage temperature. Hunter a values of red pepper powder decreased while Hunter b values increased as storage temperature increased. There were no significant differences according to packaging materials. The American Spice Trade Association (ASTA) color value (60.85±0.13) significantly decreased with increasing temperature from -20℃ to 20℃ (21.70±0.06 to 56.03±0.24). The ASTA color value of samples packed with LLDPE (21.70±0.06) decreased more compared to samples packed with other materials. Further, capsanthin contents (13.74±0.02 mg/100 g) significantly decreased with increasing temperature from -20°C (0.25±0.01 to 0.28±0.01 mg/100 g) to 20℃ (0.13±0.01 to 0.25±0.01 mg/100 g). In the sensory evaluation of red pepper powder, overall acceptability was influenced by redness, yellowness, and pungency color. All physicochemical and sensory properties of red pepper powder were compared. Hunter a values, ASTA color values, and capsanthin contents were significantly associated with sensory preferences. In particular, ASTA color value showed a close relationship with color preference for red pepper (R2=0.922). Thus, we suggest that the preference for red pepper powder can be determined based on instrumental measurements of Hunter a values, ASTA color values, and capsanthin contents.

Effectiveness of Integrated Nursing Curriculum

Ogcheol Lee,Kapchul Cho,Sunhee Yang,Yoonsook Kang 한국간호과학회 2011 한국간호과학회 학술대회 Vol.2011 No.10

The Development of Phototoxicity Test Method Using KeraSkin™ and Eye Irritation Reference Chemical Database System for Support of Validation Study for Alternative Test Methods

So-Hee KIM,Nam-Hee KANG,Joohwan KIM,Yoonsook LEE 한국생물공학회 2023 한국생물공학회 학술대회 Vol.2023 No.4