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Comparison of Asthma Phenotypes Using Different Sensitizing Protocols in Mice
( Yoon Seok Chang ),( Yoon Keun Kim ),( Joon Woo Bahn ),( Sang Heon Kim ),( Heung Woo Park ),( Tae Bum Kim ),( Sang Heon Cho ),( Kyung Up Min ),( You Young Kim ) 대한내과학회 2005 The Korean Journal of Internal Medicine Vol.20 No.2
Comparison of Two pMDIs in Adult Asthmatics: A Randomized Double-Blind Double-Dummy Clinical Trial
Sang Min Lee,Tae-Hyun Nam,Sung-Yoon Kang,Tae- Bum Kim,Sang Pyo Lee 대한결핵및호흡기학회 2022 Tuberculosis and Respiratory Diseases Vol.85 No.1
Background: Only a few studies directly compared the therapeutic efficacy and safety of two pressurized metereddoseinhalers (pMDIs) in asthma. We analyzed the asthma treatment outcomes, safety, and patient preferences usingformoterol/beclomethasone (FORM/BDP), a pMDI with extra-fine particles, compared with formoterol/budesonide(FORM/BUD), another pMDI with non-extra-fine particles. Methods: In this randomized, double-blind, double-dummy parallel group study, 40 adult asthmatics were randomized toFORM/BDP group (n=18; active FORM/BDP and placebo FORM/BUD) or FORM/BUD group (n=22; active FORM/BUDand placebo FORM/BDP). During the two visits (baseline and end of 8-week treatment), subjects were asked to answerquestionnaires including asthma control test (ACT), asthma control questionnaires (ACQ), and Quality of Life Questionnaire forAdult Korean Asthmatics (QLQAKA). Lung function, compliance with inhaler, and inhaler-handling skills were also assessed. Results: Ten subjects in the FORM/BDP group and 14 in the FORM/BUD group completed follow-up visits. ACT, ACQ,QLQAKA (a primary outcome), and adverse events did not differ between two groups. We found that the increase inforced expiratory volume in 1 second/forced vital capacity and forced expiratory flow at 25% to 75% of the pulmonaryvolume in the FORM/BDP group was higher than in the FORM/BUD group. Regarding preference, subjects respondedthat the flume velocity of FORM/BDP was higher, but more adequate than that of FORM/BUD. They also answered thatFORM/BDP reached the trachea and bronchus and irritated them significantly more than FORM/BUD. Conclusion: The use of pMDI with extra-fine particles may relieve small airway obstruction more than the one withnon-extra-fine particles despite no significant differences in overall treatment outcomes. Some asthmatics have amisconception about the adequacy of high flume velocity of pMDIs.
( Sung Bum Cho ),( Jong Sun Rew ),( Sung Young Park ),( Hyeng Chen Park ),( Kyeong Won Yoon ),( Seok Cho ),( Wan Sik Lee ),( Chang Hwan Park ),( Hyen Soo Kim ),( Sung Kyu Choi ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background Aims: Rectal carcinoid has been increasingly detected due to the recent wide use of colonoscopy for routine health examination. Although endoscopic resection should be considered as the treatment for rectal carcinoid, the scar formation after colonoscopic biopsy can lead to unpredicted difficulty in this procedure. This study evaluates the per-procedure findings and treatment results in an attempt to elucidate the effect of scar formation after colonoscopic biopsy in endoscopic resection for rectal carcinoid. Methods: Twelve cases of rectal careinoid with scar formation were compared with 18 non-scar cases, which were treated using the endoscopic resection from January 2002 to August 2007, in terms of the endoscopic findings, resection methods and treatment results. Results: The differences in the clinical findings and tumor size between the scar group and the non-scar group were nonspecific. The average waiting-time between biopsy and resection was shorter (13±16 vs 42±26 ds; p=0.11) in the scar group. During endoscopic resection, small active ulcer was found in 4 scar cases with lesser than 7 days of waiting-time. The risk of limited elevation after submucosal injection was higher (83% vs 44%, p=0.03) in the scar group. In resection methods, ESD was frequently adopted in the scar group (4 cases vs 1 case). The difference in the result of pathologic complete resection between two group were nonspecific. Four patients in the scar group should be admitted (vs 1 case in the non-scar group). Conclusions: ESD technique should be considered in selected cases, because of the postbiopsic scar can block the submucosal elevation in endoscopic resection for rectal carcinoid.
Multicentric Biatrial Myxoma in a Young Female Patient : Case Report
Sang Jeong Yoon,Soon Chang Park,Yun Pyo You,Bum Yong Kim,Myong Kon Kim,Kyung Tae Jeong,Jae Won Lee 대한내과학회 2000 The Korean Journal of Internal Medicine Vol.15 No.3
We report a case of multicentric, biatrial cardiac myxoma in a 29-year-old female who complained of exertional dyspnea, abdominal distension and peripheral edema. Any other associated skin lesions, breast mass or endocrine disorder presenting complex form
( Sung Hyub Han ),( Ji Won Byun ),( Won Soo Lee ),( Hoon Kang ),( Yong Chul Kye ),( Ki Ho Kim ),( Do Won Kim ),( Moon Bum Kim ),( Seong Jin Kim ),( Hyung Ok Kim ),( Woo Young Sim ),( Tae Young Yoon ) 대한피부과학회 2012 Annals of Dermatology Vol.24 No.3
Background: Androgenetic alopecia (AGA) is a common hair loss disease with genetic predisposition among men and women, and it may commence at any age after puberty. It may significantly affect a variety of psychological and social aspects of one`s life and the individual`s overall quality of life (QoL). Objective: This study aimed to investigate the QoL of AGA patients and discover the factors that can influence the QoL of AGA patients, including previous experience in non-medical hair care, reasons for hospital visits, age, duration, and the severity of AGA. Methods: A total of 998 male patients with AGA were interviewed, using the Hair Specific Skindex-29 to evaluate the QoL of AGA patients. Results: The results of the Hair Specific Skindex-29 on patients with AGA were as follows: symptom scale: 26.3±19.5, function scale: 24.0±20.1, emotion scale: 32.1±21.8, and global score: 27.3±19.1. According to this assessment, QoL was more damaged if the patient had severe alopecia, a longer duration of AGA, younger age, had received previous non-medical hair care, and visited the hospital for AGA treatment. Conclusion: This study showed that AGA could harmfully affect the patients` QoL. These findings indicate that dermatologists should address these QoL issues when treating patients with alopecia.