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200 GeV/핵자 유황이온과 핵건판핵의 충돌에 의해 생성된 헬륨 파쇄핵의 극한파쇄 연구
김동철,송진섭,윤천실,정성헌,박인곤,김종오,김철수,김태연,이승희,조재희,천병구,김재률,김준원,김태익,박명렬,장한일,임인택 慶尙大學校 기초과학연구소 1992 基礎科學硏究所報 Vol.8 No.-
고에너지 중이온 원자핵과 핵건판의 충돌에서, 200GeV/핵자 유황이온에 의해 생성된 파쇄 헬륨핵(Z=2)의 실험실계의 방출각 분포는 표적핵에 무관한 회귀공식. dN=exp[a+k exp(η-y_b)]d[exp(η-y_b)]로 잘 표현된다. 여기에서 의사신속도 η=-ln[tan(θ/2)]이고, y_b는 실험실계의 입사입자(^32S)의 신속도이다. 이 공식에 의한 적합에서 k=-0.057±0.008로 얻어진다. 즉, 핵건판과 고에너지 중이온의 충돌에서 파쇄 헬륨핵의 exp(η-y_b)의 분포는 "극한파쇄" 현상을 잘 설명하고 있다. The angular distribution of emission angle θ of helium (Z=2) produced in the collisions of incident particles of 200 GeV/nucleon ^32S in nuclear emulsion is well expressed by dN=exp[a+k exp(η-y_b)]d[exp(η-y_b)] where the pseudorapidity is η=-ln[tan(θ/2)], the laboratory system primary rapidity is y_b, and k=-0.057+0.008. The shape of this frequency of occurrence distributions in terms of exp(η-y_b) attests to the validity of the concept of "limiting fragmentation" for helium projectile fragments produced in the projectile fragmentation regions of heavy ion collisions in nuclear emulsion.
Caspase-3 activation as a key factor for HBx-transformed cell death
Kim, A.,Kwon, O. S.,Kim, S. O.,He, L.,Bae, E. Y.,Lee, M. S.,Jeong, S. J.,Shim, J. H.,Yoon, D. Y.,Kim, C. H.,Moon, A.,Kim, K. E.,Ahn, J. S.,Kim, B. Y. Blackwell Publishing Ltd 2008 Cell proliferation Vol.41 No.5
<P>Abstract. </P><P><I>Objectives</I>: Nuclear factor-kappa B (NF-&kgr;B) activation has been associated with the tumorigenic growth of hepatitis B virus X protein (HBx)-transformed cells. This study was aimed to find a key target for treatment of HBx-mediated cancers. <I>Materials and methods</I>: NF-&kgr;B activation, endoplasmic reticulum-stress (ER-stress), caspase-3 activation, and cell proliferation were evaluated after Chang/HBx cells permanently expressing HBx viral protein were treated with inhibitors of NF-&kgr;B, proteasome and DNA topoisomerase. <I>Results</I>: Inhibition of NF-&kgr;B transcriptional activity by transient transfection with mutant plasmids encoding Akt1 and glycogen synthase kinase-3&bgr; (GSK-3&bgr;), or by treatment with chemical inhibitors, wortmannin and LY294002, showed little effect on the survival of Chang/HBx cells. Furthermore, I&kgr;Bα (S32/36A) mutant plasmid or other NF-&kgr;B inhibitors, 1-pyrrolidinecarbonidithioic acid and sulphasalazine, were also shown to have little effect on the cell proliferation. By contrast, proteasome inhibitor-1 (Pro1) and MG132 enhanced the HBx-induced ER-stress response and the subsequent activation of caspase-12, -9 and -3 and reduced cell proliferation. Camptothecin (CPT), however, triggered activation of caspase-3 without induction of caspase-12, and reduced cell proliferation. In addition, CPT-induced cell death was reversed by pre-treatment with z-DEVD, a caspase-3-specific inhibitor. <I>Conclusions</I>: Detailed exploitation of the regulators of caspase-3 activation could open the gate for finding an efficient target for development of anticancer therapeutics against HBx-transformed hepatocellular carcinoma.</P>
Nd - Fe - B계 소결자석의 자기적특성 향상 연구
김윤배(Yoon B. Kim),정우상(W.S. Jung),정원용(W.Y. Jeung) 한국자기학회 2002 韓國磁氣學會誌 Vol.12 No.2
In order to increase the magnetic properties of a Nd-Fe-B sintered magnet, the general factors including particle size and its distribution, volume fraction of Nd₂Fe₁₄B phase, degree of alignment of Nd₂Fe₁₄B grain, oxygen content and grain size etc. should be optimized by controlling the composition of Nd-Fe-B alloy as well as the manufacturing process. In this study, fabrication of the Nd-Fe-B sintered magnet was carried out in a laboratory scale by controlling the composition of Nd-Fe-B alloy and the manufacturing process. The optimum milling condition was found by investigating the milling media, milling time and ball size. The addition of FeGa was effective to increase the coercivity of the Nd-Fe-B sintered magnet. A remanence of 14.4 kG, a coercivity of 9.4 kOe and a maximum energy product of 47 MGOe were obtained from the sintered magnet.
JEON, B.Y.,LEE, H‐,Y.,PARK, E‐,C.,CHOI, K.S.,JUN, J.K.,KIM, Y.,HAN, M.A.,YOON, N‐,H.,KIM, E.J.,JEON, S.M. Blackwell Publishing Ltd 2011 European journal of cancer care Vol.20 No.6
<P>JEON B.Y., LEE H‐Y., PARK E‐C., CHOI K.S., JUN J.K., KIM Y., HAN M.A., YOON N‐H., KIM E.J. & JEON S.M. (2011) <I>European Journal of Cancer Care</I><B>20</B>, 803–809</P><P><B>Satisfaction with mammography in the National Cancer Screening Programme participants of age 40s in Korea</B></P><P>The aim of this study was to evaluate satisfaction with the National Cancer Screening Programme of mammography in Korea and to examine the association between subscales of satisfaction and general satisfaction. We conducted a cross‐sectional telephone survey for women who had obtained a National Cancer Screening Programme mammographic screening at general hospitals between May and October 2008. The present study included 2005 women in their forties. We performed multivariate linear regression using dependent variable as general satisfaction and independent variables as subscales of satisfaction, such as pre‐screening information transfer, staff interpersonal skills, physical surroundings and results reporting. Participants were stratified according to the result of their mammogram as negative or positive. Mean score of satisfaction was above 2.5 of 4 for all subscales. Women who received positive results were less satisfied with all of subscale factors. Staff interpersonal skills were the most important factor that contributed to general satisfaction. Future efforts such as staff training programme of communication/attitude skills, ensuring privacy and explanation of possible discomfort of the screening would be needed.</P>
HBeAg양성인 만성 B형 간염 환자에서 alpha-interferon치료후 반응형태와 장기적 결과, 그리고 lamivudine의 가치
김현영 ( H. Y. Kim ),김성훈 ( S. H. Kim ),윤병철 ( B. C. Yoon ),이상욱 ( S. O. Lee ),한병훈 ( B. H. Han ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
<목적> HBeAg 양성 만성 B형 간염환자에서 alpha-interferon과 lamivudine의 효과 판정기준과 장기적 효과에 대한 연구는 아직까지도 제한적이다. 이에 연자들은 HBeAg 양성인 만성 B형 간염 환자들에서 alpha-interferon의 장기적 효과와 효과판정 기준, 그리고 치료 실패 군에서 lamivudine의 가치를 확인하기 위해서 다음과 같은 연구를 시행하였다. <방법> HBeAg양성 만성B형간염으로 진단받고 alpha-int
Study on the HDDR Characteristics of the Nd-Fe(-Co)-B(-Ga-Zr)-type Alloys
S. W. Shon,H. W. Kwon,D. I. Kang,Yoon. B. Kim,W. Y. Jeung 한국자기학회 1999 Journal of Magnetics Vol.4 No.4
The HDDR characteristics of the Nd-Fe-B-type isotropic and anisotropic HDDR alloys were investigated using three types of alloys: alloy A (Nd_(12.6)Fe_(81.4)B_6), alloy B (Nd_(l2.6)Fe_(81.3)B_6Zr_(0.l)), and alloy C (Nd_(12.6)Fe_(68.8)CO_(11.5)B_6Ga_(1.0)Zr_(0.1)). The alloy A is featured with the isotropic HDDR character, while alloy Band C are featured with the anisotropic HDDR character. Hydrogenation and disproportionation characteristics of the alloys were examined using DTA under hydrogen gas. Recombination characteristics of the alloys were examined by observing the coercivity variation as a function of recombination time. The present study revealed that the alloy C exhibits slightly higher hydrogenation and disproportionation temperatures compared to the alloy A and B. Recombination of the anisotropic alloy Band C takes place more rapidly with respect to the isotropic alloy A. The intrinsic coercivities of the recombined materials rapidly increased with increasing the recombination time and then showed a peak, after which the coercivities decreased gradually. The degraded coercivity was, however, recovered significantly on prolonged recombination treatment. Compared with the isotropic HDDR alloy A the anisotropic HDDR alloy B and C are notable for their greater recovery of coercivity. The significant recovery of coercivity was accounted for in terms of the development of well-defined smooth grain boundary between the recombined grains on prolonged recombination.
Boro-Nitriding 처리한 FC-25계 편상흑연주철의 표면특성에 관한 연구
허인창,손근수,윤재홍,조동율,박봉규,김현수,김인수 국립7개대학공동논문집간행위원회 2004 공업기술연구 Vol.4 No.-
Surface properties and oxidation behaviors were studied for FC-25 gray cast iron (GCI), plasma nitrided FC-25 GCI (P-N GCI), powder boronized FC-25 GCI (B GCI) and powder boronized N GCI (B-N GCI). A boride (Fe2B, FeB) layer with a tooth shape was formed by boronizing GCI at temperatures of about 650℃. The thickness and hardness of the layers were proportional to the boronizing temperature and time. The hardness was decreased by increasing boronizing depth. The activation energy for boride formation was 73.8kJ/mol. The thickness of the graphite layer formed by boronizing was increased by the temperature and time. A silicon layer insoluble in borides was accumulated under the boride layer. The major phases were Fe4N, Fe3N and FeN in a nitride layer formed by plasma. The thickness and hardness of the layer were increased with nitriding temperatures and time under the Fe4N decomposition temperature of 680℃. The hardness was maximum at the surface and decreased with nitrided depth on B-N GCI at 700℃, above the decomposition temperature of the Fe4N. Hardness of B-N GCI at the layer depth of 10 ㎛ was ≒1000Hv, which was lower than ≒1500Hv of the B GCI at the same condition. Also the layer thickness was 50 ㎛; deeper than that of B GCI by 10 ㎛ The reasons were that the nitrogen given off by the decomposition made the layer porous and facilitated the diffusion of oxygen and other reactants. The samples were oxidated at 800℃ for 48hrs under atmospheric air. Oxidation rate was in decreasing order of N GCI, GCI, B GCI and G-N GCI. Oxidation rates were greatly influenced by the diffusion of nitrogen formed by Fe4N decomposition over the decomposition temperature of 680℃ and by the oxidation barrier of the less corrosive boride layer.
Loss-of-function screens of druggable targetome against cancer stem–like cells
Song, Mee,Lee, Hani,Nam, Myung-Hee,Jeong, Euna,Kim, Somin,Hong, Yourae,Kim, Nayoung,Yim, Hwa Young,Yoo, Young-Ji,Kim, Jung Seok,Kim, Jin-Seok,Cho, Yong-Yeon,Mills, Gordon B.,Kim, Woo-Young,Yoon, Sukjo Federation of American Societies for Experimental 2017 The FASEB Journal Vol.31 No.2
<P>Cancer stem–like cells (CSLCs) contribute to the initiation and recurrence of tumors and to their resistance to conventional therapies. In this study, small interfering RNA (siRNA)-based screening of ∼4800 druggable genes in 3-dimensional CSLC cultures in comparison to 2-dimensional bulk cultures of U87 glioma cells revealed 3 groups of genes essential for the following: survival of the CSLC population only, bulk-cultured population only, or both populations. While diverse biologic processes were associated with siRNAs reducing the bulk-cultured population, CSLC-eliminating siRNAs were enriched in a few functional categories, such as lipid metabolism, protein metabolism, and gene expression. Interestingly, siRNAs that selectively reduced CSLC only were found to target genes for cholesterol and unsaturated fatty acid synthesis. The lipidomic profile of CSLCs revealed increased levels of monounsaturated lipids. Pharmacologic blockage of these target pathways reduced CSLCs, and this effect was eliminated by addition of downstream metabolite products. The present CSLC-sensitive target categories provide a useful resource that can be exploited for the selective elimination of CSLCs.—Song, M., Lee, H., Nam, M.-H., Jeong, E., Kim, S., Hong, Y., Kim, N., Yim, H. Y., Yoo, Y.-J., Kim, J. S., Kim, J.-S., Cho, Y.-Y., Mills, G. B., Kim, W.-Y., Yoon, S. Loss-of-function screens of druggable targetome against cancer stem–like cells.</P>