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Microstructure and Mechanical Properties of Friction Stir Spot Welded Galvanized Steel
Baek, Seung-Wook,Choi, Don-Hyun,Lee, Chang-Yong,Ahn, Byung-Wook,Yeon, Yun-Mo,Song, Keun,Jung, Seung-Boo The Japan Institute of Metals 2010 MATERIALS TRANSACTIONS Vol.51 No.5
<P>Joints of galvanized steel were obtained by friction stir spot welding (FSSW) with lap configuration using CPS design tool. No mechanically mixed layer was formed between the top and bottom plates at the weld nugget due to the limited tool penetration and the lower pin height of the welding tool than the steel plate thickness. A deformed region, in which ZnO particles were detected, was observed in the joint. The formation of this deformed region was attributed to the explosion of the Zn coating layer due to friction heating and tool compression. With increasing tool penetration depth, the tensile shear strength of the joint increased to a maximum value of 3.07 kN at a tool penetration depth of 0.52 mm.</P>
4-Week repeated oral dose toxicity study of 1,4-dichlorobutane in rats
Wook-Joon Yu,In-Chul Lee,Jinsoo Lee,Sang-Min Lee,Sung-Hwan Kim,Hyung-Seon Baek,Changjong Moon,Sung-Ho Kim,Yong-Hyun Chung,Jong-Choon Kim 한국실험동물학회 2013 Laboratory Animal Research Vol.29 No.1
The present study investigated the potential subacute toxicity of 1,4-dichlorobutane by a 4-week repeated oral dose in Sprague-Dawley rats. The test article was administered once daily by gavage to male rats at dose levels of 0, 100, 300, and 1,000 mg/kg/day for 4 weeks. All rats were sacrificed at the end of the treatment period. During the test period, clinical signs, mortality, body weight, hematology, serum biochemistry, gross findings, and organ weight were examined. At 1,000 mg/kg/day, an increase in the clinical signs and weights of the liver and kidneys was observed in the male rats. Serum biochemical investigations revealed an increase in alanine aminotransferase, alkaline phosphatase, total cholesterol, total bilirubin, phospholipids, blood urea nitrogen, and gamma glutamyl transferase levels. There were no treatment-related adverse effects in the low and middle-dose groups. In the present experimental conditions, the target organs were determined to be liver and kidney. The no-observed-adverse-effect level was considered to be 300 mg/kg/day in rats.
Baek, Seung-Wook,Choi, Don-Hyun,Lee, Chang-Yong,Ahn, Byung-Wook,Yeon, Yun-Mo,Song, Keun,Jung, Seung-Boo The Japan Institute of Metals 2010 MATERIALS TRANSACTIONS Vol.51 No.2
<P>Low carbon steel plates were joined by friction stir spot welding (FSSW) with lap configuration. The tool penetration depth exerted a strong effect on the failure mode of the joined samples and a weak effect on the joint shear strength. With increasing tool penetration depth, and consequently with increasing depth of the tool shoulder pressing into the top sample, the failure mode in a lap-shear test changed from brittle to ductile and concentrated near the pinhole located away from the weld towards the base metal. No mechanically mixed layer was formed between the top and bottom plates at the weld nugget due to the limited tool penetration and the fact that the pin height of the welding tool was less than the steel plate thickness. The region under the pin exhibited a fully recrystallized microstructure, with grain growth and a different texture.</P>
Antiallergic Effect of Two Variants of Artemisia princeps Pampanini
Yong-Wook Shin,Eun-Ah Bae,Bomi Lee,민성원,Jin Hee Lee,Nam-In Baek,Su-No Ryu,Hae-Gon Chung,Nam-Jae Kim,Dong-Hyun Kim 한국생약학회 2006 Natural Product Sciences Vol.12 No.2
activities of two variants of Artemisia princeps Pampaniniand SS-1 (named as Sajuarissuk) cultivated in Ganghwado, which contain high content of eupatilin compared tothose cultured by other places, were investigated to evaluate the possibility as inhibitors against allergic diseases.Ethanol and supercritical fluid extracts of SJ-1 and S-1 inhibited the release of β-hexosaminidase from RBL-2H3cels, although their water extracts were inactive. These extracts potently inhibited lipopolysaccharide-induced NOproduction of RAW264.7. However, these extracts almost did not scavenge free radicals. Oral administration ofhylaxis reaction induced by IgE, and acute dermatitisinduced by 12-O-tetradecanoylphorbol-13-acetate. However, these extracts did not inhibit chronic dermatitis.Scratching behaviors, vascular permeability, and writhing syndromes were weakly inhibited by these extract at adose of 50mg/kg. Based on these findings, we believe that SJ-1 and SS-1 can improve IgE-induced allergicdiseases such as rhinitis and asthma.KeywordsArtemisia princeps Pampanini, Sajabalssuk, Sajuarissuk, antiallergic effect, passive cutaneousanaphylaxis reaction, acute dermatitis