Thalidomide Combined with Chemotherapy in Treating Patients with Advanced Colorectal Cancer

Huang, Xin-En,Yan, Xiao-Chun,Wang, Lin,Ji, Zhu-Qing,Li, Li,Liu, Meng-Yan,Qian, Ting,Shen, Hui-Ling,Gu, Han-Gang,Liu, Yong,Gu, Ming,Deng, Li-Chun Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.17

Objective: To assess the safety and effectiveness of thalidomide (produced by CHANGZHOU PHARMACEUTICAL FACTORY CO.LTD) combined with chemotherapy in treating patients with advanced colorectal cancer. Method: A consecutive cohort of pretreated patients with advanced colorectal cancer were treated with thalidomide combined with chemotherapy. And chemotherapy for patients with advanced colorectal cancer were administered according to the condition of patients. Thalidomide was orally administered at a dosage of 50mg/day to 150mg/day before sleeping for at least 14 days. After at least 14 days of treatment, safety and side effects were evaluated. Results: There were 12 female and 3 male patients with advanced cancer recruited into this study, including 9 patients with colon, 6 patients with rectal cancer. The median age of patients was 57(41-82) years. Partial response was observed in 2 patients (2/15), and stable disease in 3 patients(3/15). Incidences of Grade 1 to 2 myelosuppression was observed in 1/15 patients, and Grade 1 to 2 elevation of hepatic enzyme was recorded in 1/15 patients. Adverse effects on the gastrointestinal tract were documented in 1/15 patients, and were Grade 1. No Grade 3-4 toxicities were diagnosed. No treatment related death was found. Conclusions: Thalidomide combined with chemotherapy was safe and mildly effective in treating patients with advanced colorectal cancer. However, further study should be conducted to clarify the effectiveness of this combination.

Privet golden leaves adapt unexpectedly well to light changes

Ming Yuan,Bo Huang,Li-Hua Dong,Qiao-Hong Han,Yong Yang,Chun-Bang Ding,Chao Hu,Yang-Er Chen,Zhong-Wei Zhang,Shu Yuan 한국원예학회 2020 Horticulture, Environment, and Biotechnology Vol.61 No.4

Golden-leaf privet ( Ligustrum × vicaryi ) is widely used as a horticultural shrub because of its upper golden leaves, butits lower leaves are green. However, the putative mechanisms of its upper golden leaves and the leaf color changes inresponse to light shifts have not been well studied so far. Here, chlorophylls (Chl), carotenoids, and Chl precursors from bothgolden and green leaves grown in full sunlight (approximately 1200 μmol photons m −2 s −1 at noon) or low-light conditions(180 μmol m −2 s −1 ) were determined spectrophotometrically. In addition, their gas exchange parameters and Chl fl uorescencewere measured in situ. Metabolic fl ux analysis of chlorophyll intermediates indicated that the conversion of prochlorophyllideto chlorophyllide was signifi cantly blocked in golden leaves when compared with green leaves. Green leaves showed higherphotosynthetic capacity in low light than golden leaves, but golden leaves presented unexpectedly stronger photosyntheticcapacity and lower reactive oxygen species accumulation under the high-light condition. Furthermore, golden leaves showeda higher level of nonphotochemical quenching (NPQ) after the light-to-dark shift and presented a stronger adaptive abilityto a broad range of light environments. Higher NPQ values and less oxidative damage in golden leaves may be correlatedwith their higher carotenoid levels. The results imply that lower chlorophyll levels and higher carotenoid levels in canopyleaves may help privet plants acclimate better to illumination changes. This study demonstrates the key role of irradiance ingenerating the two types of Ligustrum × vicaryi leaves and sheds a light on cultivation of other ornamental foliage plants.

Cytotoxic Isoflavanones from Uraria clarkei

Huang, Xiang-Zhong,Bai, Xi-Shan,Liang, Hui,Wang, Chao,Li, Wen-Juan,Guo, Jun-Ming,Jiang, Zhi-Yong Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.5

Two new isoflavanones, (3R) 5,7,3',4'-tetrahydroxy-2'-methoxyisoflavanone (1) and (3R) 5',8-di-(${\gamma}$,${\gamma}$-dimethylallyl)-2',5-dihydroxyl-4',7-dimethoxyl-isoflavanone (2), were isolated from Uraria clarkei, together with two known compounds dalbergioidin (3), 5,7-dihydroxy-2',4'-dimethoxyisoflavanone (4). The structures involving the absolute configuration of the new compounds were well elucidated by MS, IR, UV, CD, 1D and 2D NMR analyses. Cytotoxicity of the four compounds were assessed, results suggested that compound 2 possessed well cytotoxic activity, against the Hela, K562, and HL60 cell lines with $IC_{50}$ values of 28.0, 40.6 and $35.1{\mu}M$, respectively.

SALT-INDUCED CHLOROPLAST PROTEIN (SCP) is Involved in Plant Tolerance to Salt Stress in Arabidopsis

Yong Zhuang,Yangxuan Liu,Yuxiang Li,Ming Wei,Yuying Tang,Penghui Li,Zhijian Liu,Hui Li,Weizao Huang,Songhu Wang 한국식물학회 2019 Journal of Plant Biology Vol.62 No.6

Soil salinization threats the agricultural productionand food security worldwide. Salt stress induced plantsenescence and chloroplast degradation. However, it remainslargely unknown how the chloroplast-localized proteins affectplant response to salt stress. Here, we characterized a novelgene (At5g39520) in Arabidopsis, which is induced by saltstress and encodes a chloroplast-localized protein. Thus, thisgene was named SALT-INDUCED CHLOROPLAST PROTEIN(SCP). A T-DNA insertion mutant of SCP gene (scp-1)showed the enhanced tolerance to salt stress, as indicated bythe increased survival rates, fresh weights and chlorophyllcontents compared with wild type plants under salt treatment. Salt-induced leaf senescence was also delayed in scp-1 mutant. The scp-1 complementation line and SCP overexpressionlines displayed the hypersensitivity to salt stress. The qRTPCRanalysis indicated that the transcripts of CHLOROPLASTVESICULATION (CV), which mediates stress-inducedchloroplast degradation, were altered in scp-1 mutant andSCP overexpression lines. Taken together, our results suggestthat SCP gene plays a negative role in response to salt stress andhas potential application for genetic modification of improvingplant tolerance to salt stress.

Assessment of mulberry leaf as a potential feed supplement for animal feeding in P.R. China

Ming Cai,Lan Mu,Zong-li Wang,Jian-yong Liu,Tian-liang Liu,Metha Wanapat,Bi-zhi Huang 아세아·태평양축산학회 2019 Animal Bioscience Vol.32 No.8

Objective: Mulberry (Morus alba L.) is a cultivated shrub grown widely in the sub-tropical and tropical areas. It has been shown that mulberry leaf contains high levels of protein while having polyphenols as phytonutrients. Therefore, it is important to conduct an experiment to assess potential toxic level from mulberry on behavior, blood hematological and coagulation parameter using Sprague-Dawley (SD) rats. Methods: Both male and female SD rats were given an intragastric administration of respective treatments of mulberry leaf intakes (control, low and high levels). Parameters of feed intake, hematological and coagulation of blood parameters, as well as liveweight changes were taken during the 7 d of adaptation, 28 d of treatment exposure, and 14 d of recovery periods, respectively. All treatment data were statistically analyzed using analysis of variance of SPSS17.0 for Windows Statistical Software following the Randomized complete block design with sex as a block. Results: Most of the parameters of the physical symptoms of the SD rats, were not significantly different (p>0.05) when compared with that of the control group. Those which remain unchanged in each dose group were, body weight (BW) gain, feed intake, the hematology and coagulation indexes. Although, there were a few individual indicators that were abnormal, but the overall physiological appearance of the rats were normal. Conclusion: Results under this experiment revealed that most hematological and coagulation parameters of the SD rats in both male and female were normal, although the weight gain of female rats in high-dose group was significantly reduced than those of the male rats. Under this study, the use of mulberry leaf up to 2 g/kg BW did not result in abnormal phenomenon in the SD rats. These findings would offer useful information for further in vivo feeding trials in animals to extensively use of mulberry leaf to improve animal production, particularly in P.R. China.

Comparative analysis of the wind characteristics of three landfall typhoons based on stationary and nonstationary wind models

Yong Quan,Guo Qiang Fub,Zi Feng Huang,Ming Gu 한국풍공학회 2020 한국풍공학회지 Vol.24 No.4

The statistical characteristics of typhoon wind speed records tend to have a considerable time-varying trend; thus, the stationary wind model may not be appropriate to estimate the wind characteristics of typhoon events. Several nonstationary wind speed models have been proposed by pioneers to characterize wind characteristics more accurately, but comparative studies on the applicability of the different wind models are still lacking. In this study, three landfall typhoons, Ampil, Jongdari, and Rumbia, recorded by ultrasonic anemometers atop the Shanghai World Financial Center (SWFC), are used for the comparative analysis of stationary and nonstationary wind characteristics. The time-varying mean is extracted with the discrete wavelet transform (DWT) method, and the time-varying standard deviation is calculated by the autoregressive moving average generalized autoregressive conditional heteroscedasticity (ARMA-GARCH) model. After extracting the time-varying trend, the longitudinal wind characteristics, e.g., the probability distribution, power spectral density (PSD), turbulence integral scale, turbulence intensity, gust factor, and peak factor, are comparatively analyzed based on the stationary wind speed model, time-varying mean wind speed model and time-varying standard deviation wind speed model. The comparative analysis of the different wind models emphasizes the significance of the nonstationary considerations in typhoon events. The time-varying standard deviation model can better identify the similarities among the different typhoons and appropriately describe the nonstationary wind characteristics of the typhoons.

UNIQUE POINT OF COINCIDENCE FOR TWO MAPPINGS WITH ϕ- OR ψ-φ-CONTRACTIVE CONDITIONS ON 2-METRIC SPACES

Ming-Xing Xu,Xin Huang,Yong-Jie Piao 충청수학회 2016 충청수학회지 Vol.29 No.3

We discuss and obtain some existence theorems of unique point of coincidence for two mappings satisfying ϕ-contractive conditions or ψ-φ-contractive conditions determined by semi-continuous functions on non-complete 2-metric spaces, in which the mappings do not satisfy commutativity and uniform boundedness. The ob-tained results generalize and improve many well-known and corre-sponding conclusions.

Interplay of nonsymmorphic symmetry and spin-orbit coupling in hyperkagome spin liquids: Applications to Na4Ir3O8

Huang, Biao,Kim, Yong Baek,Lu, Yuan-Ming American Physical Society 2017 Physical Review B Vol.95 No.5

<P>Na4Ir3O8 provides a material platform to study three-dimensional quantum spin liquids in the geometrically frustrated hyperkagome lattice of Ir4+ ions. In this work, we consider quantum spin liquids on a hyperkagome lattice for generic spin models, focusing on the effects of anisotropic spin interactions. In particular, we classify possible Z(2) and U(1) spin liquid states, following the projective symmetry group analysis in the slave-fermion representation. There are only three distinct Z2 spin liquids, together with 2 different U(1) spin liquids. The nonsymmorphic space group symmetry of the hyperkagome lattice plays a vital role in simplifying the classification, forbidding 'pi-flux' or ' staggered-flux' phases in contrast to symmorphic space groups. We further prove that both U(1) states and one Z2 state among all 3 are symmetry-protected gapless spin liquids, robust against any symmetry-preserving perturbations. Motivated by the 'spin-freezing' behavior recently observed in Na4Ir3O8 at low temperatures, we further investigate the nearest-neighbor spin model with the dominant Heisenberg interaction subject to all possible anisotropic perturbations from spin-orbit couplings. We find that a U(1) spin liquid ground state with spinon Fermi surfaces is energetically favored over Z(2) states. Among all spin-orbit coupling terms, we show that only the Dzyaloshinskii-Moriya interaction can induce spin anisotropy in the ground state when perturbing from the isotropic Heisenberg limit. Our work paves the way for a systematic study of quantum spin liquids in various materials with a hyperkagome crystal structure.</P>

UNIQUE POINT OF COINCIDENCE FOR TWO MAPPINGS WITH '- OR --CONTRACTIVE CONDITIONS ON 2-METRIC SPACES

Ming-Xing Xu,Xin Huang,Yong-jie Piao 충청수학회 2016 충청수학회지 Vol.29 No.3

We discuss and obtain some existence theorems of unique point of coincidence for two mappings satisfying '-contractive con- ditions or --contractive conditions determined by semi-continuous functions on non-complete 2-metric spaces, in which the mappings do not satisfy commutativity and uniform boundedness. The ob- tained results generalize and improve many well-known and corre- sponding conclusions.

Classification and properties of quantum spin liquids on the hyperhoneycomb lattice

Huang, Biao,Choi, Wonjune,Kim, Yong Baek,Lu, Yuan-Ming American Physical Society 2018 Physical Review B Vol.97 No.19

<P>The family of 'Kitaev materials' provides an ideal platform to study quantum spin liquids and their neighboring magnetic orders. Motivated by the possibility of a quantum spin liquid ground state in pressurized hyperhoneycomb iridate beta-Li2IrO3, we systematically classify and study symmetric quantum spin liquids on the hyperhoneycomb lattice, using the Abrikosov-fermion representation. Among the 176 symmetric U(1) spin liquids (and 160 Z(2) spin liquids), we identify eight 'root' U(1) spin liquids in proximity to the ground state of the solvable Kitave model on the hyperhonecyomb lattice. These eight states are promising candidates for possible U (1) spin liquid ground states in pressurized beta-Li2IrO3. We further discuss physical properties of these eight U(1) spin liquid candidates, and show that they all support nodal-line-shaped spinon Fermi surfaces.</P>