Genome-wide investigation of a Korean synthetic breed, Woori-Heukdon using the Illumina PorcineSNP60K BeadChip

Yong‑Min Kim,Ha‑Seung Seong,Jung‑Jae Lee,Da‑Hye Son,Jin‑Su Kim,Soo‑Jin Sa,Young‑Sin Kim,Tae‑Jeong Choi,Kyu‑Ho Cho,Joon‑Ki Hong,Jung‑Woo Choi,Eun‑Seok Cho 한국유전학회 2020 Genes & Genomics Vol.42 No.12

Background: Woori-Heukdon (KWH) is a Korean synthetic pig breed generated using Chookjin-Duroc (KCD), Chookjin-Chamdon (KCC), and their crossbreds. Currently, there is a severe lack of studies investigating the Korean breed populations including wild boars (KWB) throughout the genome. Objective: This study was performed to investigate the genetic characteristics of Korean pig populations at the genome-wide level. Methods: Using the SNP dataset derived from genotyped and downloaded datasets using the Illumina PorcineSNP60K BeadChip, we compared the genomes of 532 individuals derived from 23 pig breeds to assess the genetic diversity, inbreeding coefficient, genetic differentiation, and population structure. Results: KWB showed the lowest average expected heterozygosity (HE = 0.1904), while KWH showed the highest genetic diversity (HE = 0.02859) among Korean populations. We verified that the genetic composition of KWH, showing USD of 74.8% and KCC of 25.2% in ADMIXTURE analysis. In population structure analyses, KCC was consistently shown to be separated from other pig populations. In addition, we observed gene flow from Western pigs to a part of Chinese populations. Conclusion: This study showed that Korean native pigs, KCC have genetic differences in comparison with Chinese and Western pigs; despite some historical records and recent genetic studies, we could not find any clear evidence that KCC was significantly influenced by Chinese or Western breeds in this study. We also verified the theoretical genomic composition of KWH at the molecular level in structure analyses. To our knowledge, this is the first genomic study to investigate the genomic characteristics of KWH and KCC.

우심방을 침범한 거대 비호지킨씨 림프종 1예

강상범,진승원,이은경,박용현,최용호,김용주,박준철,김재형,홍순조,최규보,권종범,원용순,박건,이은희 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

고교 물리교육과정 변천에 관한 비교 연구 : 에너지 단원을 중심으로

최원식,김규용 濟州大學校 師範大學 科學敎育硏究所 1987 科學敎育 Vol.4 No.-

Whenever there have been reforms of the high school curricula, the contents and formation of physics education have also been changed much. Especially the Energy parts has influenced not only various fields of studies but also our daily lives. Recently the influence is increasingly striking Therefore, how to instruct physics, especially Energy parts, at high school level should be carefully considered Thus, the changes in Energy parts at high school level dut to the several stages of the curricular reforms since 1945 should be analyzed. Particular emphasis should be given in change of the level and method of physics instruction as well as physics experiments contained in the text books.

새마을運動과 土地政策의 住民參與

崔龍奎 청주대학교 새마을연구소 1989 새마을硏究論文集 Vol.6 No.-

Saemaul Undong started in 1970 to be driven to arrange the small cities for the purpose of improving the rural surrounding. Then Saemaul Undong was spreaded over every work place including the rurals and cities over the country of Korea through an experimental stages. The main purposes of Saemaul Undong are the development of spirit, the improvement of environment and the increase of income, and war driven on the basis of the principle of general development. The spirit is a movement to render service to the national development by accomplishing the development of spirit and the economical development with a trnity of village people, village leader, and government together on the basis of self-support, self-reliance and cooperation. Therefore, Saemaul Undong is a pan-national movement of effort for the modernization of fatherland by promoting self-development in order that the village people as well as nationals may better theirselves' life. Now Semaul Undong needs the voluntary participation of people at the time when the local self-government will be realized in the near future. In this paper, Saemaul Undong and the policy in order to take effect on the importance of land shall be realized under the positive participation of people of Saemaul Undong and policy of land. The content of the statement of this theory has a case that the people residing in Mokdong of citizen participated in the development of Mokdong area.

새로운 Acetylcholinesterase inhibitors의 합성

최순규,김형민,조승환,최학기,박유미,이용균,정대일,김인식,한정태 동아대학교 부설 기초과학연구소 2004 基礎科學硏究論文集 Vol.21 No.1

노인성 치매의 일종인 alzheimer's disease의 효과적인 억제제를 합성하기 위해 우리는 분자 모델링에 의한 가장 적합한 물질인 m-[(N,N,N-trimethylammonio)phenyl]boronic acid를 합성하였다. 출발물질인 3-aminophenylboronic acid monohydrate의 경우 boronic acid의 작용기인 hydroxyl group을 protecting시킴으로써 반응의 안정성을 기하였다. Quarternary ammonium salt는 과량의 methyliodide와 염기 촉매인 potassium hydrogen carbonate를 사용하여 용매인 methanol에서 반응시켜 상당히 높은 수율을 얻을 수 있었다. 또한 과량의 methyliodide와 염기촉매인 potassium hydrogen carbonate를 사용하여 용매인 methanol에서 반응시킨 결과 boronic acid의 protection없이도 안정하게 반응이 진행되어짐을 확인할 수 있었다. In order to syntheisize a effective inhibotor for alzheimer's disease, we synthesized m-[(N,N,N-trimethylammonio)phenyl]boronic acid 4 which is designed by molecular modeling form. We protected the hydroxyl group of 3-aminophenylboronic acid monohydrate 1 with ethlyne glycol to remove the reactivity if hydroxyl group. To synthesize m-[(N,N,N-trimethylammonio)phenyl]boronic acid 4, we reacted 3-aminophenylboronic acid monohydrate 1 with ezcess methyl iodide and potassium hydrogen carbonate as a base-catalyst in methanol. but On executed reaction without protection on hydroxyl group, we found out the result that the hydroxyl group of boronic acid group at 3-aminophenylboronic acid monohydrate 1 didn't react with excess methyliodide. Synthesized m-[(N,N,N-trimethylammonio)phenyl]boronic acid 4 is in progress about biological tests as a plausible acetylcholinesterase inhibitor.

소아 악성종양의 진단과 치료(Ⅲ) : 악성 임파종 MALIGNANT LYMPHOMA

최규철,최용묵 한국의학사 1986 診斷과治療 Vol.6 No.6

일련연속교각, 다중연속교각, 말뚝군의 세굴특성에 관한 실험적 연구

최한규,김인호,최용묵 강원대학교 산업기술연구소 2000 産業技術硏究 Vol.20 No.A

As materials on the river bed have been changing through erosion, transportation and accumulation, so does the waterway's section. So many bridges have nowadays been constructed to the same direction as water flows. However further researches are still needed on the scours of succession row piers and multiple row piers. Analyzing them through hydraulic stimulation experiments, this study deals with the scour character with the change of diameters in row piers which have been built in the identical direction of water flow and also the part-scour change in multiple row piers.

유입량에 따른 빈도별 저수용량 결정에 관한 연구

최한규,최용묵,전광제 강원대학교 산업기술연구소 2000 産業技術硏究 Vol.20 No.A

A past monthly data is not faithful so much for a short term. But, the stochastic generation technique was provide of a long-term data. Thus this study is used a data which generated a monthly inflow amounts data by Thomas-Fiering model. This model is needed a certain process which determination of distribution, decision of continuous durability, etc. It was generated a inflow data every one month as Thomas-Fiering method. The generated inflow data was used input data for a monthly cumulative analysis. This analysis obtained a storage capacities which would be required during droughts having various return periods. It was presented a equation of fitting regression that carried out regression analysis of 5,10, 20, 50 years period.

소아 악성종양의 진단과 치료(Ⅰ)

최규철,최용묵 한국의학사 1986 診斷과治療 Vol.6 No.3

水球選手의 無酸素性 파워에 관한 硏究

최선용,이병두,이규성 韓國體育大學校附屬 體育科學硏究所 1990 韓國體育大學校附屬 體育科學硏究所論文集 Vol.9 No.1

The purpose of this study was to analyze the Anaerobic Power and Blood lactate concentration of Water-polo players (University and high school) in incremental load exercise. Subjects were selected from Korean National College of Physical Education and Seoul High School, whose careers had been 3 to 4 years in water-polo. The study utilized isokinetic muscle contraction test and Wingate test by Cybex-Ⅱ and computerized bicycle-ergometer. The results of the study were as follows : 1. Anaeroble powers of water-polo players of the university and high school respectively were 57.62±3.99%, 48.8±8.74% in Extensor and were 45.5±7.30, 39.0±6.96% in Flexor by Cybex-Ⅱ. 2. Anaerobic powers between two groups by wingate test were 57.62±3.99KPM/S in College group, 50.58±3.17PM/S in High School group with a mean power and 68.49±6.19KPM/S in College group, 61.32±3.64KPM/S in High School group with maximal state. But It was a statistically significant differences (p <.001) between two group. Fatigue index of water-polo players of College and high school saparately were 31.14±2.36% and 37.96±4.56%. These data showed a statistically significant difference (p<.001). 3.Maximal blood lactate concentrations between College players and High School Players were 8.6±0.73mmoles/1 and 7.4±1.88 mmoles/1, revealing a statistically significant difference (p< .01) in 3 minute recovery. And recovery ratio respectively are 64.4%, 62.9% in not statistically significant difference at 10 minute of recovery. 4. Correlation coefficients between endurance ratio of extensor, flexor and maximal blood lactate respectively showed 0.872, 0.804 for water-polo player of univ. and high school. Between means, maximal values of wingate test and maximal blood lactate are 0.849, 0.860.