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Kim, Byung-Ho,Han, Yo Seb,Choe, Bong-Keun,Cho, Hyeseong,Nam, Gi Deog,Lee, Jin Woo,Kim, Young Il,Park, Jai Kyung,Dong, Seok Ho,Kim, Hyo Jong,Chang, Young Woon,Lee, Joung Il,Chang, Rin Cognizant Communication Corp. 2005 CELL TRANSPLANTATION Vol.14 No.7
<P>Conditionally immortalized hepatocytes (CIH) established with a gene for the temperature-sensitive mutant of the T antigen (tsT) have characteristics to stop proliferating and to differentiate at nonpermissive temperatures (37-39 degrees C) due to inactivation of the T antigen. Therefore, they may be a good alternative to primary hepatocytes for experimental investigations or clinical applications. Deinduction of the T antigen results in a transient increase of p53 in these cells, leading to reexpression of normal senescence because of the telomere attrition occurring during the early stages of immortalization. To determine this T antigen dependency for the maintenance of immortality, a type of rat CIH was cultured continuously at 39 degrees C. The frequency of occurrence of T-antigen-independent clones ranged from 0.053% to 0.093%. These clones maintained the temperature-sensitive property of the T antigen; nevertheless, they were able to progress to the S phase and proliferate without undergoing apoptosis at 39 degrees C as at 33 degrees C, a permissive temperature. The temperature-sensitive point mutation of tsT was not affected in these clones and the T antigen was functioning properly. The integrity of the p53 pathway was also maintained from the point of Western blot analysis of p21. Although the telomerase continued to be expressed and the telomere length was maintained, marked chromosomal damage could not be avoided in these cells. It is a plausible explanation that this escape phenomenon from conditional immortalization may be related to the change of other genes involved in cell cycles, which have yet to be elucidated. In conclusion, CIH could lose their temperature-sensitive characteristics without the change of tsT, itself, and the T antigen is not always necessary to maintain their immortality. Therefore, the results obtained from experimental investigations using these cells should be interpreted carefully, and unpredictable phenotypic changes should also be taken into consideration when using them in clinical applications.</P>
Yo Seb Han,Byung Ho Kim,Tae Hyung Kim,Seok Ho Dong,Hyo Jong Kim,Young Woon Chang,Joung Il Lee,Rin Chang,Youn Wha Kim,Joo Chul Park 대한내과학회 2000 The Korean Journal of Internal Medicine Vol.15 No.2
Myasthenia gravis is an autoimmune disease that results from an antibody- mediated reaction and occurs with thymoma in 15% of patients. It is very rarely associated with autoimmune hepatitis. Four cases of myasthenia gravis with autoimmune hepatitis have b
김태형,김병호,이정일,김효종,한요셉,장영운,이동근,동석호,김경진,장린 대한소화기내시경학회 2000 Clinical Endoscopy Vol.21 No.6
Lung cancer begins insidiously, metastasizes early, and is frequently nonresectable at the time of diagnosis. Gastrointestinal metastases are considered the most unusual. A 60 year-old man was admitted for the evaluation of dizziness. For two weeks prior to admission, he had mild blood-tinged sputum and melena. He had right cervical lymphadenopathy, measured by 2 X 2 cm. Laboratory studies demonstrated hemoglobin of 3.7 g/dL, Posteroanterior and lateral chest radiographs revealed mass-like lesion of right upper lobe. An umblicated mass was found in the sigmoid colon by colonoscopic examination and biopsy was done. He developed abdominal pain, tenderness and rebound tenderness at admission 10 days, Abdominal CT showed that focal thickened wall and suspicious perforated lesion at the ileum. Operation was done. In recent time, we experienced a case in which perforation of gastrointestinal metastases developed with malignant tumors of the lung.
Kim, Byung-Ho,Han, Yo Seb,Choe, Bong-Keun,Cho, Hyeseong,Nam, Gi Deog,Lee, Jin Woo,Kim, Young Il,Park, Jai Kyung,Dong, Seok Ho,Kim, Hyo Jong,Chang, Young-Woon,Lee, Joung-Il,Rin Chang KYUNG HEE UNIVERSITY MEDICAL CENTER 2006 고황의학상 수상논문집 Vol.21-22 No.-
Conditionally immortalized hepatocytes (CIH) established with a gene for the temperature-sensitive mutant of the T antigen (tsT) have characteristics to stop proliferating and to differentiate at nonpermissive temperatures (37-39℃) due to inactivation of the T antigen. Therefore, they may be a good alternative to primary hepatocytes for experimental investigations or clinical applications. Deinduction of the T antigen results in a transient increase of p53 in these cells, leading to reexpression of normal senescence because of the telomere attrition occurring during the early stages of immortalization. To determine this T antigen dependency for the maintenance of immortality, a type of rat CIH was cultured continuously at 39℃. The frequency of occurrence of T-antigen-independent clones ranged from 0.053% to 0.093%. These clones maintained the temperature-sensitive property of the T antigen; nevertheless, they were able to progress to the S phase and proliferate without undergoing apoptosis at 39℃ as at 33℃, a permissive temperature. The temperature-sensitive point mutation of tsT was not affected in these clones and the T antigen was functioning properly. The integrity of the p53 pathway was also maintained from the point of Western blot analysis of p21. Although the telomerase continued to be expressed and the telomere length was maintained, marked chromosomal damage could not be avoided in these cells. It is a plausible explanation that this escape phenomenon from conditional immortalization may be related to the change of other genes involved in cell cycles, which have yet to be elucidated. In conclusion, CIH could lose their temperature-sensitive characteristics without the change of tsT, itself, and the T antigen is not always necessary to maintain their immortality. Therefore, the results obtained from experimental investigations using these cells should be interpreted carefully, and unpredictable phenotypic changes should also be taken into consideration when using them in clinical applications.
3세대 Anti-HCV ELISA 검사의 진단 양성 예측도 및 예측 인자
김영기 ( Kim Yeong Gi ),김병호 ( Kim Byeong Ho ),정용희 ( Jeong Yong Hui ),진은선 ( Jin Eun Seon ),이병욱 ( Lee Byeong Ug ),한요셉 ( Han Yo Seb ),동석호 ( Dong Seog Ho ),김효종 ( Kim Hyo Jong ),장영운 ( Jang Yeong Un ),이정일 ( Le 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<목적> Anti-HCV 양성은 HCV 현재 감염, 과거 감염 또는 위양성을 시사하는데, 자원 공혈자나 건강한 성인 집단에서는 진단 양성 예측도나 특이도가 낮다. 본 연구에서는 3세대 anti-HCV ELISA 검사의 S/CO 비(sample to cut off ratio)에 따른 양성 예측도와 이에 미치는 영향 인자에 대해 알아보았다. <방법> 1998년 11월부터 2002년 1월까지 본원에서 anti-HCV 검사 양성으로 HCV 감염 여부를 확인하기
포스터 전시 : 담도,췌장 ; 장기간 혈액투석을 시행받는 만성 신부전 환자에서 발생한 급성 괴사성 췌장염에 동반된 장 경색 1예
한요셉 ( Yo Seb Han ),동석호 ( Seok Ho Dong ),김한숙 ( Han Suk Kim ),이동근 ( Dong Keun Lee ),김효종 ( Hyo Jong Kim ),김병호 ( Byung Ho Kim ),장영운 ( Young Woon Chang ),이정일 ( Joung Il Lee ),장린 ( Rin Chang ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
만성신부전환자에서 발생하는 급성췌장염은 만성신부전이 없는 환자에서와 달리 원인이 알코올, 담석, 약물에서도 기타의 원인들이 많은 것으로 보고되고 있다. 혈액투석을 시행받는 만성신부전환자에서 급성췌장염의 발생기전은 대부분 전신적인 동맥경화증의 진행으로 인한만성 허혈성 손상에 의한 것이며 그 밖에 이뇨제, 고중성지방혈증, 고칼슘혈증, 저혈압 등이 관여하는 것으로 알려져 있다. 만성신부전환자는 동맥경화성 혈관을 가지고 있고 혈액투석증에 종종 저혈압을 경험하곤