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Efavirenz, indinavir, lopinavir, ritonavir의 LC-MS/MS를 이용한 동시 정량법
채정우,배경진,백인환,서정원,이병요,이은주,남진경,강원구,권광일 충남대학교 약학대학 의약품개발연구소 2009 藥學論文集 Vol.24 No.-
Efavirenz indinavir and kaleta (co-formulation of lopinavir and ritonavir) are important antiretroviral drugs which have been proved to be human immunodeficiency virus (HIV) protease inhibitors and reduced the morbidity and mortality associated with HIV-1 infection. A brief and fast high performance liquid chromatography coupled with electrospray mass spectrometry (LC-MS/MS, API 4000) method for the determination of 4 anti-retroviral agents (efavirenz, lopinavir, indinavir, ritonavir) in human plasma was developed and validated. A simple protein precipitation method was used on 100μl of human plasma. And internal standard solution (10 ng/ml methaqualone) 1ml and reconstitution solution (MeOH) 1ml were added. After vortexing for 30 s and centrifuging at 13,200rpm for 10min, 2μl of supernatant was injected into the column (XTerra MS C_(18) column, 2.1mm × 50mm 3.5㎛ particle size). The mobile phase consisted of MeOH and 0.1% formic acid in water (80:20 , v/v). The chromatogram was run for 1.5 min at a flow rate of 300μl/min. A triple quadrupole mass spectrometer was operated in a positive ion mode (lopinavir, indinavir, ritonavir) and negative mode (efavirenz), simultaneously and multiple reaction monitoring (MRM) was used for drug quantification. The precursor-to-product ion transitions of m/z 316→69 (efavirenz) and 629→447 (lopinavir) and 614→421 (indinavir) and 721→296 (ritonavir)were used to measure and quantify the analyte. The limit of quantitation (LOQ) was 50 ng/ml (efavirenz, indinavir, ritonavir) and 100 ng/ml (lopinavir). The weighted (l/y²) calibration curve was linear over human plasma range 50∼5000ng/ml (efavirenz), 100∼20000ng/ml (lopinavir), 50∼10000ng/ml (indinavir), 50∼2000ng/ml (ritonavir), correlation coefficient(r²) of 4 antiretroviral agents were higher than 0.998. Accuracies and intra-run precisions ranged within 86.60 and 113.29%, 1.06 and 11.16% for all 4 drugs analysed. This analytical method used to determine these drugs was fast and easy to perform, with minimal sample preparation, and without compromising precision and accuracy. The developed method was successful to determine antiretroviral agents in human plasma, and proved suitable for clinical pharmacokinetic study.
Living donor liver transplantation for patients with alcoholic liver disease
Yo-Han Park,Shin Hwang,Chul-Soo Ahn,Ki-Hun Kim,Deok-Bog Moon,Tae-Yong Ha,Gi-Won Song,Dong-Hwan Jung,Gil-Chun Park,Jung-Man Namgoong,Hyung-Woo Park,Chun-Soo Park,Sung-Hwa Kang,Bo-Hyeon Jung,Sung-Gyu Le 한국간담췌외과학회 2013 한국간담췌외과학회지 Vol.17 No.1
Backgrounds/Aims: Since most transplantation studies for alcoholic liver disease (ALD) were performed on deceased donor liver transplantation, little was known following living donor liver transplantation (LDLT). Methods: The clinical outcome of 18 ALD patients who underwent LDLT from Febraury 1997 to December 2004 in a large-volume liver transplantation center was assessed retrospectively. Results: The model for end-stage liver disease score was 23±11, and mean pretransplant abstinence period was 16±13 months, with 14 (77.8%) patients being abstinent for at least 6 months. Graft types were right lobe grafts in 11, left lobe grafts in 2 and dual grafts in 5. Graft to recipient body weight ratio was 0.94±0.16. The relapse rates in patients who did and did not maintain 6 months of abstinence were 7.1% and 50%, respectively (p=0.097). Younger recipient age was a significant risk factor for alcohol relapse (p=0.027). Five recipients with antibody to hepatitis B surface antigen (HBsAg) received core antibody-positive liver graft, but two of them showed positive HBsAg seroconversion. Overall 5-year patient survival rate following LDLT was 87.8%, with a 5-year relapse rate of 16.7%. Conclusions: Pretransplant abstinence for 6 months appears to be benefical for preventing posttransplant relapse. Life-long prophylactic measure should be followed after use of anti-HBc-positive liver grafts regardless of hepatitis B viral marker status of the recipient.
Won, So-Jung,Ki, Yo Sook,Chung, Kyung-Sook,Choi, Jung-Hye,Bae, Ki Hwan,Lee, Kyung-Tae Pharmaceutical Society of Japan 2010 BIOLOGICAL & PHARMACEUTICAL BULLETIN Vol.33 No.9
<P>In the present study, we investigated the effect of 3α,23-isopropylidenedioxyolean-12-en-27-oic acid (IPA), an active compound isolated from <I>Aceriphyllum rossii</I>, on the apoptotic activity and the molecular mechanism of the action in human cervical cancer HeLa cells. Treatment with IPA significantly increased externalization of phosphatidylserine residues and apoptotic DNA fragmentation as shown by Annexin V staining and 4′,6-diamidino-2-phenylindole-dihydrochloride (DAPI) staining, respectively. In addition, IPA induced the activations of caspase-8, -9, -3, and cleavage of poly(ADP ribose) polymerase (PARP-1) in HeLa cells. Pretreatment with a specific caspase-8, -9, or -3 inhibitor neutralized the pro-apoptotic activity of IPA in HeLa cells. Furthermore, IPA was found to induce the loss of mitochondrial membrane potential, the release of cytochrome <I>c</I> to the cytosol, and the increased ratio of mitochondrial Bax/Bcl-2. Moreover, we demonstrated that IPA triggered endoplasmic reticulum (ER) stress, as shown by changes in cytosol-calcium level, activation of μ-calpain and caspase-12, and up-regulation of glucose-regulated protein 78 (GRP78) and growth arrest DNA damage-inducible gene 153 (GADD153). IPA-induced apoptosis was substantially reduced in the presence of an intracellular calcium chelator BAPTA/AM. Taken together, these results suggest that both mitochondrial dysfunction and ER stress contribute to IPA-induced apoptosis of human cervical cancer HeLa cells.</P>
성장기 폭력피해경험, 가부장적 태도, 법 태도가 자녀폭력허용도에 미치는 영향 : 혼인여부의 조절효과를 중심으로
정요한(Jung Yo Han),정혜원(Jung Hye Won) 연세대학교 사회복지연구소 2016 한국사회복지조사연구 Vol.51 No.-
이 연구는 최근 지속적으로 증가하고 있고, 이슈가 되고 있는 자녀폭력사건들에 주목하여 성장기 폭력 피해경험, 전통적인 가부장적 태도, 법 태도가 자녀폭력허용도에 미치는 영향을 살펴보았다. 또한 그 경로에서 혼인여부의 조절효과를 검증하고자 하였다. 이를 위해 2015년 6월~7월까지 (재)경기도가족여성연구원에서 경기도민을 대상으로 실시한 경기도민의 폭력 허용태도 조사 데이터를 사용하였으며, 그 중에서 만19세 이상부터 만 70세 미만의 1,500명을 대상으로 구조방정식 모형 검증 등 통계분석을 실시하였다. 분석 결과에 따르면 첫째, 전통적인 가부장적 태도를 가지고 있을수록 자녀폭력허용도가 높은 것으로 나타났다. 둘째, 법 준수에 대한 태도가 좋지 않을수록 자녀폭력허용도가 높은 것으로 나타났다. 셋째, 자녀폭력허용도에 대한 성장기 폭력피해경험은 통계적으로 유의미하지 않았다. 넷째, 기혼집단의 경우 연령이 많을수록 자녀폭력허용도가 유의미하게 높아졌으나 미혼집단은 통계적으로 유의미하지 않았다. 다섯째, 가부장적 태도가 자녀폭력허용도에 미치는 영향력은 혼인여부에 따라 집단 간에 유의미한 차이가 있었다. 다시 말해서, 기혼집단이 미혼집단보다 자녀폭력허용도의 평균값은 유의미하게 높았으나, 가부장적 태도에 따른 자녀폭력허용도에 미치는 영향력은 미혼집단이 더 큰 것으로 나타났다. 이와 같은 연구결과를 바탕으로 결혼 전 예비부부를 포함한 부모의 자녀폭력에 대한 예방과 개입에 기여할 수 있는 정책적·실천적 함의를 논의하였다. This thesis is designed to study the effect of violence experience during the growth period, traditional patriarchal attitudes and legal attitudes on acceptance of child violence in consideration of child violence that continues to increase in recent days and to verify the control effect according marital status. For this study were used data obtained after the survey on violence acceptance attitudes of Gyeonggi-do residents conducted by Gyeonggido Family & Women Research Institute from June to July 2015 and the structural equation model for 1,500 residents aged from 19 to 70 among them was verified and statistically analyzed. The analytical findings have revealed: First, the more traditional patriarchal attitudes they had, the higher acceptance of child violence. Second, the worse law-abiding attitudes they had, the higher acceptance of child violence. Third, premarital violence experience had no statistically significant effect on acceptance of child violence. Fourth, in case of the married group, the older they were, the acceptance of child violence was significantly high but that of unmarried group was statistically insignificant. Fifth, the effect of patriarchal attitudes on acceptance of child violence varied significantly according to marital status. In other words, the average acceptance of child violence in the married group was significantly higher than that in the unmarried group but the effect of gender roles on acceptance of child violence was greater in the unmarried group. Policy and practical implications, which might contribute to preventing and intervening in the child violence of parents including soon-to-be married couples, were discussed based upon these analytical findings.
주용원 ( Yong Won Joo ),손창남 ( Chang Nam Son ),정경희 ( Kyong Hee Jung ),박혜정 ( Hae Jeong Park ),김상헌 ( Sang Heon Kim ),김태형 ( Tae Hyung Kim ),손장원 ( Jang Won Sohn ),윤호주 ( Ho Joo Yoon ),최요원 ( Yo Won Choi ),정원상 ( 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.65 No.3
A chronic expanding hematoma (CEH) in the thorax is a rare and specific condition of chronic empyema. CEHs in the thorax are often associated with tuberculosis and/or previous surgical procedures. While the incidental detection of a pleural mass and dyspnea are common clinical manifestations, a few cases present with hemoptysis. We encountered a case of CEH in the thorax. This case is unique in that it developed without a prior history of tuberculosis or surgery and presented with massive hemoptysis accompanied by bronchopleural fistula. We report the third case of CEH in the thorax in Korea with a summary of the clinical characteristics of previous cases. (Tuberc Respir Dis 2008;65:216-221)
( Jung Min Park ),( Mun Ju Hwang ),( Yo Han Jeong ),( Seok Hui Kang ),( Kyu Hyang Cho ),( Jong Won Park ),( Jun Young Do ),( Kyung Woo Yoon ),( Nam Hyuk Lee ) 대한신장학회 2013 Kidney Research and Clinical Practice Vol.32 No.2
A 67-year-old male renal transplant patient presented with a right inguinal bulging mass, and was diagnosed with a right indirect inguinal hernia. The day following inguinal herniorrhaphy, serum creatinine became elevated. The patient was oliguric and had abdominal pain on the ?rst day after inguinal herniorrhaphy with a mesh. We diagnosed him with acute renal failure and subsequently performed acute hemodialysis. The kidney computed tomography showed hydronephroureter, with distal ureter obstruction. With urgent percutaneous nephrostomy, we were able to relieve the obstructive uropathy with distal ureteral stenosis. Subsequently, hernia repair was performed with removal of the mesh, followed by the antegrade ureteral stent insertion. Renal function was recovered after ureteral stent insertion. This case shows that acute renal failure can occur due to ureteral obstruction, complicated by an inguinal hernia repair, and this can be successfully treated with percutaneous nephrostomy and inguinal hernia repair with mesh removal.