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Improved L2-L∞ Filtering for Stochastic Time-delay Systems
Ying Zhang,Ai-Guo Wu,Guang-Ren Duan 제어·로봇·시스템학회 2010 International Journal of Control, Automation, and Vol.8 No.4
The L2-L∞ filtering problem for continuous-time polytopic uncertain stochastic time-delay systems is investigated. The main purpose is to design a full-order filter guaranteeing a prescribed L2-L∞ attenuation level for the filtering error system. A simple alternative proof is given for an enhanced LMI (linear matrix inequality) representation of L2-L∞ performance. Based on the criterion which keeps Lyapunov matrices out of the products of system dynamic matrices, a sufficient condition for the existence of a robust estimator is formulated in terms of LMIs. The corresponding filter design is cast into a convex optimization problem. A numerical example is employed to demonstrate the feasibility and advantage of the proposed design.
Ni Germanide Utilizing Ytterbium Interlayer for High-Performance Ge MOSFETs
Zhang, Ying-Ying,Oh, Jungwoo,Li, Shi-Guang,Jung, Soon-Yen,Park, Kee-Young,Shin, Hong-Sik,Lee, Ga-Won,Wang, Jin-Suk,Majhi, Prashant,Tseng, Hsing-Huang,Jammy, Raj,Bae, Tae-Sung,Lee, Hi-Deok The Electrochemical Society 2009 Electrochemical and solid-state letters Vol.12 No.1
Zhang Ying,Niu Dongxiao 인하대학교 정석물류통상연구원 2009 인하대학교 정석물류통상연구원 학술대회 Vol.2009 No.10
This paper attempts to provide direct evidence on the effectiveness of internal control and its determinants. Since there are four objectives for internal control according to COSO, we examine the effectiveness of internal control and its determinants from four aspects. Using a sample of 126 Chinese firms collected by questionnaire. we find that; (1) Effective internal control over compliance is more likely for firms that are larger, at maturity state, financially stronger, with more decentralized ownership, with more centralized management mode, with stronger enterprise culture and better management philosophy, with internal auditing of higher quality. The nature of largest shareholder is not significantly correlated to the effectiveness of internal control over compliance. (2) Effective internal control over reporting is more likely for firms that are larger, older, financially stronger, with core centralized management mode, with weaker control power of largest shareholder, with better management philosophy. (3) Effective internal control over operation is more likely for firms that are larger, older, financially stronger, with more centralized management mode, with weaker control power of largest shareholder, with stronger enterprise culture and better management philosophy. (4) Effective internal control over strategy is more likely for firms that are larger and at maturity stage.
The Spring Image in Hawthorne’s “The Canterbury Pilgrims”
( Zhang Ying ) 현대영미어문학회 2019 현대영미어문학회 추계학술대회 발표논문집 Vol.2019 No.-
The spring in Nathaniel Hawthorne’s “The Canterbury Pilgrims” is a very profound symbol. The spring contains the multiple meanings of religion, sex and life experience. Through close reading the spring will be analyzed from the perspective of culture, mythology and history to show the plurality, ambiguity and profundity of the image.
Chemical Synthesis and Cloning of Panax ginseng Peptide Gene
Zhang, Hong-Ying,Chen, Dong-Song,Zhang, Jin The Korean Society of Ginseng 1990 Journal of Ginseng Research Vol.14 No.2
The sequence of ginseng peptide gene was designed and synthesized by the solid phase phosphoramidiate method. Synthetic segments were isolated, pllrified and joined to the plasmid pUC19. E.icherichiu coli JM101 cells were transformed with above hybrid plasmids. AmpiciIBin resistant transformants were screened and identified by in situ colony hybridization and Southern blot techniques. Finally the gene sequencing was done by the Sanger dideoxy method using primer extension.
YING LIU,Jing Zheng,Hong-Ping Zhang,Xin Zhang,Lei Wang,Lisa Wood,Gang Wang 대한천식알레르기학회 2018 Allergy, Asthma & Immunology Research Vol.10 No.6
Purpose: Obesity is associated with metabolic dysregulation, but the underlying metabolic signatures involving clinical and inflammatory profiles of obese asthma are largely unexplored. We aimed at identifying the metabolic signatures of obese asthma. Methods: Eligible subjects with obese (n = 11) and lean (n = 22) asthma underwent body composition and clinical assessment, sputum induction, and blood sampling. Sputum supernatant was assessed for interleukin (IL)-1β, -4, -5, -6, -13, and tumor necrosis factor (TNF)-α, and serum was detected for leptin, adiponectin and C-reactive protein. Untargeted gas chromatography time-of-flight mass spectrometry (GC-TOF-MS)-based metabolic profiles in sputum, serum and peripheral blood monocular cells (PBMCs) were analyzed by orthogonal projections to latent structures-discriminate analysis (OPLS-DA) and pathway topology enrichment analysis. The differential metabolites were further validated by correlation analysis with body composition, and clinical and inflammatory profiles. Results: Body composition, asthma control, and the levels of IL-1β, -4, -13, leptin and adiponectin in obese asthmatics were significantly different from those in lean asthmatics. OPLS-DA analysis revealed 28 differential metabolites that distinguished obese from lean asthmatic subjects. The validation analysis identified 18 potential metabolic signatures (11 in sputum, 4 in serum and 2 in PBMCs) of obese asthmatics. Pathway topology enrichment analysis revealed that cyanoamino acid metabolism, caffeine metabolism, alanine, aspartate and glutamate metabolism, phenylalanine, tyrosine and tryptophan biosynthesis, pentose phosphate pathway in sputum, and glyoxylate and dicarboxylate metabolism, glycerolipid metabolism and pentose phosphate pathway in serum are suggested to be significant pathways related to obese asthma. Conclusions: GC-TOF-MS-based metabolomics indicates obese asthma is characterized by a metabolic profile different from lean asthma. The potential metabolic signatures indicated novel immune-metabolic mechanisms in obese asthma with providing more phenotypic and therapeutic implications, which needs further replication and validation.
Zhang, Ying,Nakano, Shunji,Choi, Soon-Yong,Zuber, Peter American Society for Microbiology 2006 Journal of Bacteriology Vol.188 No.12
<B>ABSTRACT</B><P>The Spx protein of <I>Bacillus subtilis</I> exerts both positive and negative transcriptional control in response to oxidative stress by interacting with the C-terminal domain of the RNA polymerase (RNAP) alpha subunit (αCTD). Thus, transcription of the <I>srf</I> operon at the onset of competence development, which requires the ComA response regulator of the ComPA signal transduction system, is repressed by Spx-αCTD interaction. Previous genetic and structural analyses have determined that an Spx-binding surface resides in and around the α1 region of αCTD. Alanine-scanning mutagenesis of <I>B. subtilis</I> αCTD uncovered residue positions required for Spx function and ComA-dependent <I>srf</I> transcriptional activation. Analysis of <I>srf-lacZ</I> fusion expression, DNase I footprinting, and solid-phase promoter retention experiments indicate that Spx interferes with ComA-αCTD interaction and that residues Y263, C265, and K267 of the α1 region lie within overlapping ComA- and Spx-binding sites for αCTD interaction. Evidence is also presented that oxidized Spx, while enhancing interference of activator-RNAP interaction, is not essential for negative control.</P>
Zhang Ying,Wang Peng,Jin Mei-xian,Zhou Ying-qi,Ye Liang,Zhu Xiao-juan,Li Hui-fang,Zhou Ming,Li Yang,Li Shao,Liang Kang-yan,Wang Yi,Gao Yi,Pan Ming-xin,Zhou Shu-qin,Peng Qing 한국조직공학과 재생의학회 2023 조직공학과 재생의학 Vol.20 No.3
BACKGROUND: Human umbilical cord mesenchymal stem cells (hUCMSCs) have emerged as promising therapy for immune and inflammatory diseases. However, how to maintain the activity and unique properties during cold storage and transportation is one of the key factors affecting the therapeutic efficiency of hUCMSCs. Schisandrin B (SchB) has many functions in cell protection as a natural medicine. In this study, we investigated the protective effects of SchB on the hypothermic preservation of hUCMSCs. METHODS: hUCMSCs were isolated from Wharton’s jelly. Subsequently, hUCMSCs were exposed to cold storage (4 C) and 24-h re-warming. After that, cells viability, surface markers, immunomodulatory effects, reactive oxygen species (ROS), mitochondrial integrity, apoptosis-related and antioxidant proteins expression level were evaluated. RESULTS: SchB significantly alleviated the cells injury and maintained unique properties such as differentiation potential, level of surface markers and immunomodulatory effects of hUCMSCs. The protective effects of SchB on hUCMSCs after hypothermic storage seemed associated with its inhibition of apoptosis and the anti-oxidative stress effect mediated by nuclear factor erythroid 2–related factor 2 signaling. CONCLUSION: These results demonstrate SchB could be used as an agent for hypothermic preservation of hUCMSCs.
Zhang, Yi,Sun, Dongxiao,Yu, Ying,Zhang, Yuan Asian Australasian Association of Animal Productio 2008 Animal Bioscience Vol.21 No.9
Domestic buffalo and cattle are two extremely important livestock species in worldwide agricultural production. In this paper, to investigate genetic diversity and divergence among swamp buffalo, river buffalo and cattle, 30 microsatellite markers were screened on 168 individuals sampled from five populations. Substantial differences were observed among the three groups of animals with respect to allele frequency distribution, allele size and polymorphism. The cattle sample (Mongolian) showed significantly higher genetic variability (0.674 of gene diversity, p<0.01), and the swamp and river buffalo samples displayed similar degree of genetic variation (0.536 in swamp and 0.546 in river, p = 0.92). Results of both phylogenetic tree and multivariate analysis could distinguish three groups of animals, suggesting their deep evolutionary divergence. Additionally, using $({\delta}{\mu})^2$ genetic distance, we estimated a divergence time of 1.7 million years between swamp and river buffalo that strongly supported distinct genetic origins for the two buffalo types.
Ying-Yuan Lu,Xiao-Wei Wang,Xin Wang,Wen-Bing Dai,Qiang Zhang,Pu Li,Ya-Qing Lou,Chuang Lu,Jun-Yi Liu,Guo-Liang Zhang 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.7
The purpose of this study was to characterize the disposition, distribution, excretion and plasma protein binding of 6-benzyl-1-benzyloxymethyl-5-iodouracil (W- 1) in rats. Concentrations of W-1 within biological samples were determined using a validated high performance liquid chromatography method. The plasma protein binding of W-1 was examined by equilibrium dialysis method. After oral administration of W-1 (50, 100 and 200 mg/kg, respectively) in self-microemulsifying drug delivery system formulation, the pharmacokinetic parameters of W-1 were as follows: the peak plasma concentrations (Cmax) were 0.42, 1.50 and 2.55 μg/mL, the area under the curve (AUC0-t) were 0.89, 2.27 and 3.96 lg/h mL and the plasma half-life (t1/2) were 5.15, 3.77 and 3.77 h, respectively. Moreover, the prototype of W-1 was rapidly and extensively distributed into fifteen tissues, especially higher concentrations were detected in intestine, stomach and liver, respectively. The plasma protein binding of W-1 in rat, beagle dog and human were in the range of 97.96–99.13 %. This study suggested that W-1 has an appropriate pharmacokinetics in rats, such as rapid absorption, moderate clearance, and rapid distribution to multiple tissues. Those properties provide important information for further development W-1 as an anti-HIV-1 drug candidate.