복합형서점 상품판매대 디자인의 조사와 연구 - 부산 서면 교보문고서점을 사례로 들어보자

판잉잉(Pan Ying Ying),김명수(Kim Myung Soo) 한국기초조형학회 2020 한국기초조형학회 학술발표논문집 Vol.2020 No.5

한·중 지하철역 공공공간 기능 디자인 비교연구

판잉잉(YING-YING PAN),김명수(MYUNG-SOO KIM) 한국디자인학회 2019 한국디자인학회 학술발표대회 논문집 Vol.2019 No.5

Query Algebra for the Very Loosely Structured Data Model

Ying Pan,Changan Yuan,Zhengqi Li,Wenjing Li 보안공학연구지원센터 2015 International Journal of Database Theory and Appli Vol.8 No.1

In order to realize the idea of pay-as-you-go (PAYG) data management which dataspace emphasizes, the very loosely structured data model is usually used to describe the massive, heterogeneous and dynamic data in dataspace. However, the present study mainly concentrates on the applications of the data model, and the query theory research is less. The query algebra is a theoretical foundation for query and its optimization in a PAYG fashion, so that how to establish a complete algebra based on the characteristics of loosely structured data model is an important problem need to be solved. In this paper, a formal definition of very loosely structured data model is given, then the query model and query algebra based on the model are proposed, which support to not only the operations such as set operators, selection, projection and join, but also association query in dataspace.

The Anti-detective Element in the New York Trilogy by Paul Auster

Pan, Ying-Hui 신영어영문학회 2023 신영어영문학 Vol.85 No.-

This paper mainly studies the anti-detective element in the New York Trilogy (1987) by Paul Auster, who is a famous American postmodern novelist. As Auster’s masterpiece, this work is a collection of three typically detective novels City of Glass (1985), Ghosts (1986) and The Locked Room (1986). It typically belongs to the anti-detective genre because Auster subverts the traditional detective conventions. The anti-detective element is one of the essential postmodern elements. The two anti-detective elements of language and identity are investigated in this paper. Paul Auster suggests that language is arbitrary and the signifer and the signified are separated from each other. The identity is uncertain and shifting. Auster intends to search truth and meaning by using these two tools. However, there is no absolute truth in the postmodern world. Auster himself claims that it is fiction, not reality. This work is studied a lot from the perspective of intertextuality, narration and so on. It is innovative to study the anti-detective element in Auster’s detective novels by analysing the element of language and identity, which presents the readers a new perspective to interpret Auster’s detective fiction.

Curcumin Alleviates Dystrophic Muscle Pathology in mdx Mice

Ying Pan,Chen Chen,Yue Shen,Chun-Hua Zhu,Gang Wang,Xiao-Chun Wang,Hua-Qun Chen,Min-Sheng Zhu 한국분자세포생물학회 2008 Molecules and cells Vol.25 No.4

Abnormal activation of nuclear factor kappa B (NF-κB) probably plays an important role in the pathogenesis of Duchenne’s muscular dystrophy (DMD). In this report, we evaluated the efficacy of curcumin, a potent NF-κB inhibitor, in mdx mice, a mouse model of DMD. We found that it improved sarcolemmic integrity and enhanced muscle strength after intraperitoneal (i.p.) injection. Histological analysis revealed that the structural defects of myofibrils were reduced, and biochemical analysis showed that creatine kinase (CK) activity was decreased. We also found that levels of tumor necrosis factor alpha (TNF-α), interleukin-1 beta (IL-1β) and inducible nitric oxide synthase (iNOS) in the mdx mice were decreased by curcumin administration. EMSA analysis showed that NF-κB activity was also inhibited. We thus conclude that curcumin is effective in the therapy of muscular dystrophy in mdx mice, and that the mechanism may involve inhibition of NF-κB activity. Since curcumin is a nontoxic compound derived from plants, we propose that it may be useful for DMD therapy.

Distributed optimization and statistical learning for large-scale penalized expectile regression

Pan Yingli 한국통계학회 2021 Journal of the Korean Statistical Society Vol.50 No.1

Large-scale data from various research felds are not only heterogeneous and sparse but also difcult to store on a single machine. Expectile regression is a popular alternative for modeling heterogeneous data. In this paper, we devise a distributed optimization approach to SCAD and adaptive LASSO penalized expectile regression, where the observations are randomly partitioned across multiple machines. We construct a penalized communication-efcient surrogate loss (CSL) function. Computationally, our method based on the CSL function requires only the master machine to solve a regular M-estimation problem, while other worker machines compute the gradient of the loss function on local data. Our method matches the estimation error bound of the centralized method during consecutive rounds of communication. Under some mild assumptions, we establish the oracle properties of the SCAD and adaptive LASSO penalized expectile regression. We then develop a modifed alternating direction method of multipliers (ADMM) algorithm for the implementation of the proposed estimator. A series of simulation studies are conducted to assess the fnite-sample performance of the proposed estimator. Applications to an HIV study demonstrate the practicability of the proposed method.

Reading The New York Trilogy from thePerspective of Existentialism

Pan, Ying-Hui 한국현대영어영문학회 2023 현대영어영문학 Vol.67 No.4

Paul Auster (1947-) is a remarkable American postmodern novelist. The New York Trilogy is regarded as his masterpiece, which is a postmodern interpretation of detective fiction, exploring various philosophical themes. This paper targets at using the theory of existentialism to analyze this work. Existentialism focuses on humanity, individuality and freedom. It insists the idea that the existence of people is absurd and meaningless. However, based on existence, people can create their own self to attain a colorful life. Existentialist perspectives can be found in Paul Auster’s novels. The features of absurdity, identity crisis and free choice will be discussed in this paper. The absurdity shows in two angles. One is the image of the wanderer. The other one is the absurdity of the plot. The identity crisis is an important theme and all the characters suffer from the identity crisis. People have freedom to make their choices and become responsible for their free choices in their life. So it is significant to study The New York Trilogy from the perspective of existentialism. This study is valuable and can offer readers a new perspective to interpret Paul Auster’s other novels.

QTL mapping and identification of candidate genes for cold tolerance at the germination stage in wild rice

Pan Ying-Hua,Nong Bao-Xuan,Chen Lei,Yang Xing-Hai,Xia Xiu-Zhong,Zhang Zong-Qiong,Qing Dong-Jin,Gao Ju,Huang Cheng-Cui,Li Dan-Ting,Deng Guo-Fu 한국유전학회 2023 Genes & Genomics Vol.45 No.7

Background Cold damage stress significantly affects rice growth (germination and seedling) and causes serious losses in yield in temperate and high-altitude areas around the globe. Objective This study aimed to explore the cold tolerance (CT) locus of rice and create new cold-tolerant germplasm. We constructed a chromosome segment substitution line (CSSL) with strong CT and fine mapped quantitative trait loci (QTLs) associated with CT by performing the whole-genome resequencing of CSSL with phenotypes under cold treatment. Methods A chromosome CSSL, including 271 lines from a cross between the cold-tolerant wild rice Y11 (Oryza rufipogon Griff.) and the cold-sensitive rice variety GH998, was developed to map QTLs conferring CT at the germination stage. The whole-genome resequencing was performed on CSSL for mapping QTLs of associated with CT at the germination stage. Results A high-density linkage map of the CSSLs was developed using the whole-genome resequencing of 1484 bins. The QTL analysis using 615,466 single-nucleotide polymorphisms (SNPs) led to the identification of 2 QTLs related to germination rate at low-temperature on chromosome 8 (qCTG-8) and chromosome 11 (qCTG-11). The qCTG-8 and qCTG-11 explained 14.55% and 14.31% of the total phenotypic variation, respectively. We narrowed down qCTG-8 and qCTG-11 to 195.5 and 78.83-kb regions, respectively. The expression patterns of important candidate genes in different tissues, and of RNA-sequencing (RNA-seq) in CSSLs, were identified based on gene sequences in qCTG-8 and qCTG-11 cold-induced expression analysis. LOC_Os08g01120 and LOC_Os08g01390 were identified as candidate genes in qCTG-8, and LOC_Os11g32880 was identified as a candidate gene in qCTG-11. Conclusions This study demonstrated a general method that could be used to identify useful loci and genes in wild rice and aid in the future cloning of candidate genes of qCTG-8 and qCTG-11. The CSSLs with strong CT were supported for breeding cold-tolerant rice varieties.

OrMKK3 Influences Morphology and Grain Size in Rice

Ying Hua Pan,Li Jun Gao,Yun Tao Liang,Yan Zhao,Hai Fu Liang,Wei Wei Chen,Xing Hai Yang,Dong Jin Qing,Ju Gao,Hao Wu,Juan Huang,Wei Yong Zhou,Cheng Cui Huang,Gao Xing Dai,Guo Fu Deng 한국식물학회 2023 Journal of Plant Biology Vol.66 No.3

Although morphology and grain size are important to rice growth and yield, the identity of abundant natural allelic variations that determine agronomically important differences in crops is unknown. Here, we characterized the function of mitogen-activated protein kinase 3 from Oryza officinalis Wall. ex Watt encoded by OrMKK3. Different alternative splicing variants occurred in OrMKK3. Green fluorescent protein (GFP)–OrMKK3 fusion proteins localized to the cell membrane and nuclei of rice protoplasts. Overexpression of OrMKK3 influenced the expression levels of the grain size-related genes SMG1, GW8, GL3, GW2, and DEP3. Phylogenetic analysis showed that OrMKK3 is well conserved in plants while showing large amounts of variation between indica, japonica, and wild rice. In addition, OrMKK3 slightly influenced brassinosteroid (BR) responses and the expression levels of BR-related genes. Our findings thus identify a new gene, OrMKK3, influencing morphology and grain size and that represents a possible link between mitogen-activated protein kinase and BR response pathways in grain growth.

Association of TNF-α-308 and -238 Polymorphisms with Risk of Cervical Cancer: A Meta-analysis

Pan, Feng,Tian, Jing,Ji, Chu-Shu,He, Yi-Fu,Han, Xing-Hua,Wang, Yong,Du, Jian-Ping,Jiang, Feng-Shou,Zhang, Ying,Pan, Yue-Yin,Hu, Bing Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.11

Published data on the associations between tumor necrosis factor-alpha (TNF-${\alpha}$) promoter -308G>A and -238G>A polymorphisms and cervical cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. Data were collected from MEDLINE and PubMed databases. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated in a fixed/random effect model. 13 separate studies including 3294 cases and 3468 controls were involved in the meta-analysis. We found no association between TNF-${\alpha}$-308G>A polymorphism and cervical cancer in overall population. In subgroup analysis, significantly elevated risks were found in Caucasian population (A vs. G: OR = 1.43, 95% CI = 1.00-2.03; AA vs. GG: OR = 2.09, 95% CI = 1.34-3.25; Recessive model: OR = 2.09, 95% CI = 1.35-3.25) and African population (GA vs. GG: OR = 1.53, 95% CI = 1.02-2.30). An association of TNF-${\alpha}$-238G>A polymorphism with cervical cancer was found (A vs. G: OR = 0.61, 95% CI = 0.47-0.78; GA vs. GG: OR = 0.59, 95% CI = 0.45-0.77; Dominant model: OR = 0.59, 95% CI = 0.46-0.77). When stratified by ethnicity, similar association was observed in Caucasian population (A vs. G: OR = 0.62, 95% CI = 0.46-0.84; GA vs. GG: OR = 0.59, 95% CI = 0.43-0.82; Dominant model: OR = 0.60, 95% CI = 0.44-0.83). In summary, this meta-analysis suggests that TNF-${\alpha}$-238A allele significantly decreased the cervical cancer risk, and the TNF-${\alpha}$-308G>A polymorphism is associated with the susceptibility to cervical cancer in Caucasian and African population.