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필라델피아 염색체 양성 급성골수성백혈병에서 Imatinib Mesylate로 분자학적 관해를 유도한 후 성공적인 자가 말초혈액 조혈모세포이식이 시행되었던 1예
김여경,이제중,이병환,변정래,조덕,이일권,정익주,양동욱,김형준 대한조혈모세포이식학회 2003 대한조혈모세포이식학회지 Vol.8 No.1
저자들은 필라델피아 염색체 양성 급성골수성백혈병 환자에서 복합항암화학요법으로 혈액학적 완전관해를 유도하고, imatinib mesylate를 이용하여 분자학적 관해를 유도한 후, 성공적으로 자가 말초혈액조혈모세포이식을 시행하였던 1예를 경험하였기에 이를 보고하는 바이다. Philadelphia chromosome (Ph¹)-positive acute myeloid leukemia (AML) is very rare disease, comprising 3~4% of the AML, and is a clinically distinct entity with poor clinical outcome with conventional chemotherapy. We report a case of Ph¹-positive AML who underwent successful autologous peripheral blood stem cell transplantation after achieving a molecular remission with imatinib mesylate.
진행성 비호지킨 림프종 환자에서 ICE 구제 요법에 의한 조혈모세포 가동화 후 자가 말초혈액 조혈모세포이식
이제중,이병환,김여경,변정래,이일권,박무림,정익주,김형준 대한조혈모세포이식학회 2003 대한조혈모세포이식학회지 Vol.8 No.1
연구배경: 비호지킨 림프종에서 자가 말초혈액 조혈모세포이식술이 폭넓게 이용됨으로 인해서, 높은 치료효과뿐만 아니라 조혈모세포의 가동화 효율이 높은 구제 요법이 요구되었다. 방법: 본 연구에서는 진행성 비호지킨 림프종에서 ICE 요법을 이용하여 조혈모세포를 가동화시킨 후 자가 말초혈액 조혈모세포이식이 시행하였던 환자를 후향적으로 분석하였다. 결과: 대상 환자의 중앙 연령은 38세(범위, 16~61)였으며, ICE 요법은 환자당 4주기(범위, 1~6주기)가 투여되었고, 투여 간격은 중앙값이 24일(범위, 16~36일)이었다. 고위험도 관해군을 제외한 13예의 환자 중 완전반응은 7예(53.8%), 부분반응은 4예(30.8%), 진행성질환은 2예(15.4%)를 보였다. 치료에 따른 3~4등급의 혈액학적 독성은 중성구감소증이 13예(81.3%), 혈소판감소증이 7예(42.8%)에서 관찰되었다. 조혈모세포 채집은 ICE 요법 후 중앙값이 12일(범위, 6~20일)에 시행되었고, 각 ICE 요법당 채집한 단핵구치는 중앙값이 5.75× 10^(8)/체중, CD34^(+) 세포는 중앙값이 1.25× 10^(6)/체중, CFU-GM치는 중앙값이 1.19× 10^(5)/체중이었다. 조혈모세포이식은 11예에서 시행되었고, 중앙 추적기간 401일에 평가한 2년 전체생존율은 70.1±14.7%, 1년 및 2년 무사건생존율은 각각 60.7±15.4%와 32.3±17.1%를 보였다. 결론: ICE 요법은 재발성/불응성 비호지킨 림프종 환자에서 높은 치료 반응률과 만족할 만한 조혈모세포 가동화를 보여 주었지만, 치료에 대한 순응도가 낮아서 투여 간격이 연장되는 문제점을 안고 있어서, 우리나라 환자의 실정에 적합한 구제요법에 대한 연구가 필요할 것으로 생각된다. Background: Due to the extensive application of high-dose chemotherapy with autologous peripheral blood stem cell transplantation (PBSCT), a salvage chemotherapeutic regimen with high response rate as well as effective capacity of PBSC mobilization is needed in non-Hodgkin's lymphoma (NHL). Methods: We analyzed the applicability of ICE (ifosphamide, carboplatin, and etoposide) regimen in NHL patients who underewent autologous PBSCT. Results: The median age was 38 years (range, 16~61 years), the patients received median 4 cycles (range, 1~6 cycles) of ICE regimen, and the median interval between each chemotherapeutic cycle was 24 days (range, 16~36 days). There were 7 (53.8%) complete responses, 4 (30.8%) partial responses, and 2 (15.4%) progressive diseases after ICE regimen. Toxicity included grade 3/4 neutropenia and throm bocytopenia in 13 (81.3%) and 7 (42.8%) patients, respectively. PBSC collection began on median day 12 (range, 6~20 days) after ICE therapy. The median number of mononuclear cells, CD34+ cells, and CFU-GM was 5.75× 10^(8)/kg, 1.25× 10^(6)/kg, and 1.19× 10^(5)/kg, respectively. With a median follow- up of 401 days, the patients who underwent autologous PBSCT had overall survival with 70.1±14.7% at 2 year and event free survival with 60.7±15.4% and 32.3±17.1% at 1 year and 2 years, respectively. Conclusion: ICE chemotherapy is an effective cytoreduction and mobilization regimen in patients with NHL, but profound myelosuppression with delayed recovery might pose difficulties in applying for Korean patients. Further evaluation for appropriate salvage regimens in Korean patients should be needed.
여동준(Dong Jun YEO),최명수(Myung Soo CHOI),변정환(Jung Hoan BYUN),서정주(Jung Joo SUH),양정규(Jung Kyu YANG) 전남대학교 수산과학연구소 2006 수산과학연구소논문집 Vol.14 No.2
This paper deals with the free vibrations of truncated conical shell with elastic supports by the transfer matrix method. The classical thin shell theory based upon the Flügge theory is assumed and the governing equations of a conical shell are written as a coupled set of first order differential equations using the transfer matrix. The Runge-Kutta-Gill integration method are used to solve the governing differential equations. The natural frequencies and corresponding mode shapes are calculated numerically for the truncated conical shell with elastic supports and various boundary conditions at the edges. And all boundary conditions and elastic supports between conical shell and foundation could be treated only by adequately varying the values of the spring constants. Numerical results show that the transfer matrix method can accurately obtain natural vibration characteristics of the conical shells with elastic supports.
여동준(Dong Jun YEO),최명수(Myung Soo CHOI),변정환(Jung Hwan BYUN),서정주(Jung Joo SUH),양정규(Jung Kyu YANG) 전남대학교 수산과학연구소 2006 수산과학연구소논문집 Vol.15 No.1
This paper deals with the free vibrations of folded plates by the transfer influence coefficient method. The governing equations of a non-circular cylindrical shell including a plate as special case are written in a coupled set of first order matrix differential equations. The Runge-Kutta-Gill integration method is used to solve the governing differential equations. The natural frequencies and corresponding mode shapes are calculated numerically for the folded plate of various crank angles. All boundary conditions and the intermediate supports between folded plate and foundation could be treated only by adequately varying the values of the spring constants.
여동준(Dong Jun YEO),최명수(Myung Soo CHOI),변정환(Jung Hwan BYUN),서정주(Jung Joo SUH),양정규(Jung Kyu YANG) 전남대학교 수산과학연구소 2006 수산과학연구소논문집 Vol.15 No.2
In this paper, the authors formulated analytical algorithm for the in-plane free vibration of a annular plate with intermediate support part by the transfer influence coefficient method (TICM) which is based on the successive transmission of influence coefficients on nodal circumferences. To confirm the effectiveness of the suggested algorithm, we analyzed the free vibration of a annular plate with three typical intermediate support parts by the TICM and the Transfer matrix method (TMM) on a personal computer. The computational result was that the TICM was superior to the TMM in the in-plane free vibration analysis of a annular plate with rigid intermediate supports.
변정환(Jung Hwan BYUN),최명수(Myung Soo CHOI),여동준(Dong Jun YEO),양정규(Jung Kyu YANG),서정주(Jung Joo SUH) 전남대학교 수산과학연구소 2006 수산과학연구소논문집 Vol.14 No.1
A delivery ship is used to handle the cargo with the crane to/from the ships. The ship is inclined in the direction of a cargo which is hung on a crane. In this case, a arc shaped rail should be in the equilibrium state to get good anti-rolling performance. In this study, a device and control algorithm are developed to take accurate and quick equilibrium of the rail. The device is composed of a hinged immovable support and two screw jacks. And the control algorithm demands two controllers. One controller is designed such that the screw jack 1 and 2 follow the position reference signal generated by a tilt sensor. The other controller of is designed to remove the synchronous error occurred between jack 1 and jack 2. The simulation results show that the desirable control performance is achieved.