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우리나라의 건강보험 약가 사후관리제도 고찰 및 발전 방안
강예림(Ye Rim Kang),고소희(So Hee Ko),이종혁(Jong Hyuk Lee) 대한약학회 2017 약학회지 Vol.61 No.1
This study examines post-listing control systems for pharmaceutical pricing and suggests a reasonable improvement policy in Korea. There are four post-listing control systems for pharmaceutical pricing in Korean national health insurance. When each scheme was introduced, they had their own background and goals. But it is very difficult to understand and predict the timing and extent of the price cuts due to complex system by introducing or revising some schemes without clear policy objectives. At the same time, the social costs are often caused by various confusions, including distribution sites, due to frequent price cuts. For this reason, the current post-listing control system needs to be improved. We investigated the latest trends of the post-listing control system of the major countries that operate a similar system through literatures, website, reports of relevant institutions. From a mid- to long-term point of view, the system should be that can enhance the health of the population by comprehensively reflecting drug prescribing behavior and use status under clear target for drug expenditure management. It should also be developed as a system that can create a healthy industrial ecosystem for the development of the pharmaceutical industry.
지방질다당류로 자극한 마우스 대식세포에 있어서 zaluzanin C의 항염증 효과
강예림(Ye Rim Kang),이희원(Hee Won Lee),김윤희(Yoon Hee Kim) 한국식품과학회 2016 한국식품과학회지 Vol.48 No.4
천연물 유래 단일 성분의 항염증 효과에 대한 잠재성을 평가하는 스크리닝의 일환으로 11종의 단일 물질을 대상으로 항염증 효과를 탐색한 결과, 단풍취에서 분리정제한 zaluzanin C의 산화질소(II) 생성 억제능이 뛰어난 것을 확인하였다. 따라서 본 연구에서는 단풍취에서 분리정제한 zaluzanin C가 지질다당류로 자극한 마우스 대식세포인 RAW264.7 세포에서 염증반응에 미치는 영향에 대해 평가하고, 관련 메커니즘에 대해 검토하였다. Zaluzanin C는 LPS 자극에 의해 유도된 iNOS 단백질 발현양을 감소시킴으로써 산화질소(II) 생성을 억제할 뿐만 아니라 IL-6와 같은 염증 유발 사이토카인의 분비를 억제하였다. 이러한 효과는 전사인자인 NF-kB의 세포질에서 핵으로의 이동을 억제함으로써 나타나는 것으로 판단된다. 이러한 결과로부터, zaluzanin C가 염증 반응을 저해하는 효과가 있는 것으로 나타나, 향후 염증성 질환을 예방, 개선 및 치료하는데 유용한 물질로 사용될 가능성이 있을 것으로 생각된다. 하지만 이를 위해서는 zaluzanin C의 생체 내 이용률 및 생리적 활성 농도 등에 대한 추가 연구가 필요한 것으로 생각된다. Zaluzanin C is a sesquiterpene lactone isolated from Ainsliaea acerifolia, a Korean medicinal plant. In the present study, the anti-inflammatory effects of zaluzanin C were demonstrated in lipopolysaccharide (LPS)-stimulated murine macrophages (RAW264.7 cells). Zaluzanin C inhibited the release of nitric oxide (NO) by alleviating the protein expression of inducible NO synthase in LPS-treated RAW264.7 cells. Furthermore, it suppressed the release of interleukin-6 induced by LPS. Zaluzanin C was also found to block the translocation of the p65 subunit of nuclear factor-kB from the cytosol to the nucleus, which is one of the underlying mechanisms of the anti-inflammatory action of zaluzanin C. These data suggest the potential of zaluzanin C in the treatment of inflammatory diseases.
Kang, Mee Joo,Lee, Kyoung Bun,Jang, Jin-Young,Kwon, Wooil,Park, Jae Woo,Chang, Ye Rim,Kim, Sun-Whe by Lippincott Williams Wilkins. 2013 PANCREAS Vol.42 No.8
OBJECTIVES: Current version of World Health Organization classification introduced the concept of “intraductal papillary mucinous neoplasm (IPMN) with an associated invasive carcinoma.” The authors investigated the clinicopathologic characteristics and prognosis of this disease category according to tumor morphology and percentage of invasive component. METHODS: Fifty-nine patients who underwent surgical resection of IPMN with an associated invasive carcinoma at Seoul National University Hospital were subgrouped according to the invasive component of less than 5% (minimally invasive [MI] intraductal papillary mucinous carcinoma [IPMC] [MI-IPMC]), 5%–50% (invasive IPMC [IPMC-I]), and 50% or greater (pancreatic ductal adenocarcinoma [PDAC]-associated IPMN [PDAC-IPMN]). Prognosis was compared with 219 curatively resected conventional PDAC. RESULTS: Eleven MI-IPMCs (18.6%), 24 IPMC-Is (40.7%), and 24 PDAC-IPMNs (40.7%) were identified. With the transition from MI-IPMC to IPMC-I and PDAC-IPMN, percentage of advanced T (P < 0.001) or N stage (P = 0.001), expression of S100A4 (P = 0.004), p53 (P = 0.028), and CD24 (P = 0.009) increased; and SMAD4 expression decreased (P < 0.001). The overall 5-year survival rates for MI-IPMC, IPMC-I, and PDAC-IPMN were 80.8%, 59.0%, and 29.3%, respectively (P < 0.001). Pancreatic ductal adenocarcinoma-associated IPMN had poor prognosis compared with MI-IPMC (P = 0.011) or IPMC-I (P = 0.026) but had comparable prognosis with conventional PDAC (P = 0.138). CONCLUSIONS: Pancreatic ductal adenocarcinoma-associated IPMN has different clinicopathological characteristics compared with the IPMC-I. Intraductal papillary mucinous neoplasm with an associated invasive carcinoma is composed of a wide spectrum of disease.
Kang, Mee Joo,Jang, Jin-Young,Lee, Kyoung Bun,Chang, Ye Rim,Kwon, Wooil,Kim, Sun-Whe J.B. Lippincott [etc.] 2014 Annals of surgery Vol.260 No.2
<P>To evaluate long-term follow-up results after surgical treatment of intraductal papillary mucinous neoplasm (IPMN) to optimize postoperative surveillance strategies.</P>
The natural course of pancreatic fistula and fluid collection after distal pancreatectomy
Ye Rim Chang,Mee Joo Kang,Hongbeom Kim,Jin-Young Jang,Sun-Whe Kim 대한외과학회 2016 Annals of Surgical Treatment and Research(ASRT) Vol.91 No.5
Purpose: Postoperative pancreatic fistula (POPF) is one of the most common and clinically relevant complications after distal pancreatectomy. Some aspects of POPF management remain controversial. Therefore, the aim of this study was to determine the natural course of POPF and fluid collection after distal pancreatectomy and to reappraise the necessity of intraoperative abdominal drainage insertion. Methods: For recent 10 years, 264 distal pancreatectomies were performed at Seoul National University Hospital. Clinicopathologic data including POPF and postoperative fluid collection (POFC), and its treatment modality were reviewed retrospectively. During follow-up, the location, size, and clinical impact of the POFC were determined on the basis of CT images. Results: Clinically relevant POPFs were identified in 72 patients (27.3%). Therapeutic interventions were performed in 40 patients (55.6%), and conservative management was successful in 32 patients (44.4%). POFC was detected in 191 cases (72.3%) on the first postoperative CT. During follow-up, spontaneous regressions were observed in 119 cases (93.0%). Only thick pancreatic stump increased the risk of clinically relevant POPF (≥17.3 mm, P = 0.002) and the occurrence of POFC (≥16.0 mm, P < 0.001) in multivariate analysis. Conclusion: Intraoperative abdominal drainage insertion could be selectively indwelled in patients with a thickness of pancreas ≥17.3 mm. Since radiologically-proven POFC after distal pancreatecomy showed a 93.0 rate of spontaneous regression, POFC without signs of infection can be safely monitored.