한식과 비만 관련 대사질환에 관한 연구

허양임(Yang-Im Hur) 한국식품영양과학회 2011 식품산업과 영양 Vol.16 No.2

Guidelines for Cardiovascular Magnetic Resonance Imaging from the Korean Society of Cardiovascular Imaging (KOSCI) - Part 3: Perfusion, Delayed Enhancement, and T1- and T2 Mapping

Im, Dong Jin,Hong, Su Jin,Park, Eun-Ah,Kim, Eun Young,Jo, Yeseul,Kim, Jeong Jae,Park, Chul Hwan,Yong, Hwan Seok,Lee, Jae Wook,Hur, Jee Hye,Yang, Dong Hyun,Lee, Bae-Young Korean Society of Magnetic Resonance in Medicine 2020 Investigative Magnetic Resonance Imaging Vol.24 No.1

This document is the third part of the guidelines for the interpretation and post-processing of cardiac magnetic resonance (CMR) studies. These consensus recommendations have been developed by a Consensus Committee of the Korean Society of Cardiovascular Imaging (KOSCI) to standardize the requirements for image interpretation and post-processing of CMR. This third part of the recommendations describes tissue characterization modules, including perfusion, late gadolinium enhancement, and T1- and T2 mapping. Additionally, this document provides guidance for visual and quantitative assessment, consisting of "What-to-See," "How-To," and common pitfalls for the analysis of each module. The Consensus Committee hopes that this document will contribute to the standardization of image interpretation and post-processing of CMR studies.

Development of LasI and LasR Binding Aptamer to Inhibit Biofilm Formation of Pseudomonas aeruginosa

Jin-Young HUR,Cho-Im OH,Woo-Ri SHIN,Do-Young KIM,Sang Yong KIM,Ji-Young AHN,Yang-Hoon KIM 한국생물공학회 2023 한국생물공학회 학술대회 Vol.2023 No.4

Guidelines for Cardiovascular Magnetic Resonance Imaging from the Korean Society of Cardiovascular Imaging (KOSCI) - Part 3: Perfusion, Delayed Enhancement, and T1- and T2 Mappin

Dong Jin Im,Su Jin Hong,박은아,Eun Young Kim,Yeseul Jo,JeongJae Kim,Chul Hwan Park,Hwan Seok Yong,Jae Wook Lee,Jee Hye Hur,Dong Hyun Yang,Bae Young Lee 대한자기공명의과학회 2020 Investigative Magnetic Resonance Imaging Vol.24 No.1

This document is the third part of the guidelines for the interpretation and post-processing of cardiac magnetic resonance (CMR) studies. These consensus recommendations have been developed by a Consensus Committee of the Korean Society of Cardiovascular Imaging (KOSCI) to standardize the requirements for image interpretation and post-processing of CMR. This third part of the recommendations describes tissue characterization modules, including perfusion, late gadolinium enhancement, and T1- and T2 mapping. Additionally, this document provides guidance for visual and quantitative assessment, consisting of “What-to-See,” “How-To,” and common pitfalls for the analysis of each module. The Consensus Committee hopes that this document will contribute to the standardization of image interpretation and post-processing of CMR studies.

Guidelines for Cardiovascular Magnetic Resonance Imaging from the Korean Society of Cardiovascular Imaging—Part 2: Interpretation of Cine, Flow, and Angiography Data

Lee Jae Wook,Hur Jee Hye,Yang Dong Hyun,Lee Bae Young,Im Dong Jin,Hong Su Jin,Kim Eun Young,Park Eun-Ah,Jo Yeseul,Kim Jeong Jae,Park Chul Hwan,Yong Hwan Seok 아시아심장혈관영상의학회 2019 Cardiovascular Imaging Asia Vol.3 No.4

Cardiovascular magnetic resonance imaging (CMR) is expected to be increasingly used in Korea due to technological advances and the expanded national insurance coverage of CMR assessments. For improved patient care, proper acquisition of CMR images as well as their accurate interpretation by well-trained personnel are equally important. In response to the increased demand for CMR, the Korean Society of Cardiovascular Imaging (KOSCI) has issued interpretation guidelines in conjunction with the Korean Society of Radiology. KOSCI has also created a formal Committee on CMR guidelines to create updated practices. The members of this committee review previously published interpretation guidelines and discuss the patterns of CMR use in Korea.

Guidelines for Cardiovascular Magnetic Resonance Imaging from the Korean Society of Cardiovascular Imaging (KOSCI) - Part 2: Interpretation of Cine, Flow, and Angiography Data

Lee, Jae Wook,Hur, Jee Hye,Yang, Dong Hyun,Lee, Bae Young,Im, Dong Jin,Hong, Su Jin,Kim, Eun Young,Park, Eun-Ah,Jo, Yeseul,Kim, Jeong Jae,Park, Chul Hwan,Yong, Hwan Seok Korean Society of Magnetic Resonance in Medicine 2019 Investigative Magnetic Resonance Imaging Vol.23 No.4

Cardiovascular magnetic resonance imaging (CMR) is expected to be increasingly used in Korea due to technology advances and the expanded national insurance coverage of these tests. For improved patient care, it is crucial not only that CMR images are properly acquired but that they are accurately interpreted by well-trained personnel. In response to the increased demand for CMR, the Korean Society of Cardiovascular Imaging (KOSCI) has issued interpretation guidelines in conjunction with the Korean Society of Radiology (KSR). KOSCI has also created a formal Committee on CMR Guidelines to write updated practices. The members of this Committee review previously published interpretation guidelines and discuss the patterns of CMR use in Korea.

Prevalence of Dietary Supplement Use in Korean Children and Adolescents: Insights from Korea National Health and Nutrition Examination Survey 2007-2009

윤지예,박현아,강재헌,김경우,Yang Im Hur,Jin Joo Park,Ran Lee,Hyun Hye Lee 대한의학회 2012 Journal of Korean medical science Vol.27 No.5

The purpose of this study was to estimate the prevalence of dietary supplement (DS) use in Korean children and adolescents and to examine the related factors associated with DS use from the 4th Korea National Health and Nutrition Examination Survey. Total 6,131participants aged between 2 and 18 yr were included in the analysis. We estimated the prevalence of DS use mainly from the DS questionnaire data of the Nutrition Survey. Reported supplements were classified according to the Health Functional Food Code. We also assessed the relationship between DS use and anthropometry, socioeconomic factors,health behaviors, and chronic diseases. Approximately 34% of Korean children and adolescent was taking DS. Younger age (P = 0.003), higher household income (P < 0.001),presence of chronic diseases (P = 0.05), regular meal consumption (P = 0.002), frequent snack consumption (P = 0.001), and normal body mass index rather than overweight (P = 0.10) or obesity (P = 0.03) were associated with the DS use after adjustment for related factors. Vitamin/mineral supplements (343.5/103 persons) were the most commonly taken DS in Korean children and adolescents, followed by Omega-3 (28.8), ginseng (18.3),colostrums (14.1) and chlorella/spirulina (10.0). In conclusion, DS use is common as much as in 34% of Korean children and adolescents and is associated with age, household income level, chronic diseases, meal regularity, and obesity status.

2001년부터 2006년까지 지역사회 획득 급성 신우신장염 여성환자의 임상상 및 원인균의 내성 양상

위성헌,장우임,김형욱,김영식,김수영,허지안,김상일,김양리,강문원 대한감염학회 2007 감염과 화학요법 Vol.39 No.1

목적 : 급성 신우신장염은 지역사회에서 발생하는 가장 흔한 감염질환 중의 하나이며 균혈증이나 신장농양과 동반될 수 있다. 원인균은 대부분 E. coli이고 여러 항균제에 대한 내성이 효율적인 항균제의 선택에서 중요하며 최근 항균제 내성 양상의 변화는 효율적인 항균제의 선택을 위해 확인해야할 매우 중요한 요소이다. 재료 및 방법 : 2001년 1월부터 2006년 12월까지 가톨릭대학교 수원 성빈센트병원에 급성 신우신장염으로 입원한 16세 이상의 여성 중에서 요 배양에서 요로 감염균이 10^(5)CFU/mL 이상의 집락을 형성한 577명을 대상으로 임상적 특성 및 치료 결과를 조사하였고 검출된 원인균의 각 항균제에 대한 감수성 양상을 확인하고 연도별 변화를 분석하였다. 결과 : 환자들의 평균 연령은 51세였고 신우신장염 환자군 382명, 균혈 증 환자군 161명, 신장농양 환자군 34명으로 구분되었다. 균혈 증 환자군이 신우신장염 환자군에 비해 연령, 초기 체온 및 혈액 C-반응 단백 수치가 더 높았다. 항균제 투여 후 체온이 정상화되는데 걸린 시간은 균혈증 환자군과 신장농양 환자군이 각각 76.4시간과 91.2시간으로 신우신장염 환자군의 44.6시간 보다 길었다. 분리된 554개의 E. coli 균주는 ampicillin, gentamicin, ciprofloxacin, cefuroxime, amikacin에 대해 각각 38.3%, 81.3%, 86.3%, 97.3%, 98.7%의 감수성을 보였으며 2001년부터 2006년까지의 연도별 ciprofloxacin에 대한 감수성이 감소하는 추세를 보였다. 결론 : 급성 신우신장염으로 입원한 환자군에서 광범위 β-lactam 항균제나 fluoroquinolone의 사용을 최소화하면서 aminoglycoside 단독요법이나 정주용 2세대 cephalosporin을 초기 경험적 항균제로 사용하고 감수성 결과에 따라 적절한 경구용 전환 항균제를 사용할 수 있었다. 신우신장염, 균혈증 및 신장농양 환자군의 임상적 차이점을 분석하고 원인균의 감수성 결과를 기초로 적절한 항균제를 선택해야하며 분리된 E. coli에서 ciprofloxacin 내성율이 증가하고 있어 지역사회 전체에서 fluoroquinolone계열의 항균제를 더욱 아껴서 사용하는 노력이 요구되고 있다. Background : Acute pyelonephritis in women is one of the most common infections within the community; some patients also suffer from related bacteremia and renal abscess. The predominant pathogen in acute pyelonephritis is Escherichia coli and the changes in antimicrobial resistance over time is a very important factor in the choice of effective and economic antibiotics. Materials and Methods:We investigated clinical features and antibiotic sensitivities of 577 organisms isolated from the urine cultures of 577 patients, admitted to Catholic University St Vincent's Hospital for community-acquired acute pyelonephritis from January 2001 to December 2006. We analyzed the patterns of antimicrobial resistance of urinary isolates and the clinical courses of the patients. Results : Patients demographics revealed a mean age of 51, (age:16 to 91), with bacteremic patients representing 30.8% of patients and renal abscess patients representing 5.9% of the group. Sixteen (4.2%) of 382 in the pyelonephritis group and five (3.1%) of 161 in the bacteremia group revealed clinical manifestations of therapeutic failure such as persistent fever and pyuria. The mean time to defervescence was 44.6 h for the pyelonephritis group, 76.4 h for the bacteremia group and 91.2 h for the renal abscess group. Among the 577 isolates, 554 isolates were E. coli, 10 were K. pneumoniae, three were S. saprophyticus, three were Proteus mirabilis. two were K. oxytoca, and two were Enterobacter aerogenes. Among 554 E. coli, the rates of susceptibility to ampicillin was 38.3%; to sulfamethoxazole 62.1%; to gentamicin 81.3%; to ciprofloxacin 86.3%; to cefuroxime 97.3%; to amikacin 98.7%; to cefotaxime 99.5%. Conclusion : In hospitalized patients, initial intravenous treatment with an aminoglycoside or a second -generation cephalosporin, and then switch to oral first, second-cephalosporin, amoxicillin and sulfamethoxazole is recommended. In vitro resistance to fluoroquinolones appears to be increasing, and therefore close monitoring of antibiotic susceptibility patterns in isolates of urinary tract infections and the use of fluoroquinolone-sparing agents are required.

경기도 남부 지역에서 발생한 쯔쯔가무시병 212예의 임상적 특성 및 초기 단순 흉부 엑스선 사진의 의의

위성헌,장우임,김형욱,허지안,김상일,김양리,강문원 대한감염학회 2008 감염과 화학요법 Vol.40 No.1

목적 : 쯔쯔가무시병의 임상 양상은 적절한 항균제 투여에 의해 쉽게 치료될 수 있는 경미한 경우에서 생명을 위협하는 합병증을 동반하는 중증 질환까지 다양하다. 발열, 발진, 가피 등 특징적인 임상 증상을 통해 조기에 진단하는 것이 예후에 중요하며 중증도를 예측할 수 있는 임상적인 지표를 조기에 확인하는 것도 효과적인 치료를 위해 매우 중요하다. 재료 및 방법 : 2000년 1월부터 2004년 12월까지 가톨릭대학교 성빈센트병원에 쯔쯔가무시병으로 입원한 18세 이상의 환자 212명에 대한 의무 기록을 후향적으로 검토하여 임상 양상, 실힘실, 소견 및 단순 흥부 엑스선 사진의 판독 소견을 분석하였다. 결과 : 환자들의 평균 연령은 59.7세였고, 여성이 145명, 남성이 67명이었다. 총 212명의 쯔쯔가무시병 환자들에게 7일간 독시사이클린을 투여하였고, 사망한 1명을 제외한 211명(99.5%)에서 후유증이나 재발 없이 치료에 성공하였다. 총 212명 중 59명(27.8%)에서 단순 흉부 엑스선상 흉막 삼출, 간질성 폐렴 및 폐침윤 등의 비정상 소견이 관찰되었는데, 정상 소견을 보인 환자군에 비해 혈청 C-반응 단백이나 ADA 수치가 더 높았고, 혈색소 수치나 혈청 알부민 수치는 더 낮았다. 그러나 항균제 투여 후 체온이 정상화되는데 걸린 시간이나 치료 실패율에서는 통계적으로 의미 있는 차이를 보이지 않았다. 결론 : 쯔쯔가무시병 환자들에게 독시사이클린을 하루 200 mg씩 7일간 투여하여 효과적으로 치료할 수 있었다. 향후 내원 초기 환자들의 실험실적 결과를 예측하는 지표로서 단순 흥부 엑스선 소견이 이용될 수 있을 것이다. Background : Scrub typhus may cause complications such as pneumonia, meningoencephalitis, liver failure, and renal failure, although most of patients with scrub typhus are treated with appropriate antibiotics. scrub typhus has varying degree of disease severity, from mild to fatal, therefore, early recognition of the clinical parameters representing the severity of the disease is a very important factor for effective treatment. Materials and Methods : We investigated clinical, laboratory results and simple chest X-ray images retrospectively by reviewing the medical records of 212 scrub typhus patients, admitted to Catholic University St. Vincent's Hospital from September 2000 to November 2004. Results : Patients demographics revealed a mean age of 59.7, (age: 18 to 90), and 145 of the 212 patients were female (68.4%). Cure was achieved in 211 (99.5%) of the 212 patients with the 1-week course of daily 200 mg doses of doxycycline. Fifty-nine (27.8%) of the patients revealed the abnormal findings, such as interstitial, pneumonic infiltrations, or pleural effusions, in the results of simple chest X-ray images, and cure was achieved in 58 (98.3%) of 59 patients. The median time to defervescence was 27.1 h for the group showing abnormal simple chest X-ray findings, 23.3 h for the group showing normal chest X-ray findings. The titers of serum C-reactive protein and adenine deaminase were significantly higher, and initial hemoglobin and serum albumin levels were lower, in the group with abnormal simple chest X-ray findings, compared to the group with normal simple chest X-ray findings. Conclusion : The 1-week course of daily 200-mg doses of doxycycline was effective for the treatment of scrub typhus. Initial simple chest X-ray findings may be useful in the selection of patients, who might show more favorable laboratory findings.

Application of Machine Learning Algorithms to Predict Osteoporotic Fractures in Women

Su Jeong Kang,Moon Jong Kim,Yang-Im Hur,Ji-Hee Haam,Young-Sang Kim 대한가정의학회 2024 Korean Journal of Family Medicine Vol.45 No.3

Background: Predicting the risk of osteoporotic fractures is vital for prevention. Traditional methods such as the Fracture Risk Assessment Tool (FRAX) model use clinical factors. This study examined the predictive power of the FRAX score and machine-learning algorithms trained on FRAX parameters. Methods: We analyzed the data of 2,147 female participants from the Ansan cohort study. The FRAX parameters employed in this study included age, sex (female), height and weight, current smoking status, excessive alcohol consumption (>3 units/d of alcohol), and diagnosis of rheumatoid arthritis. Osteoporotic fracture was defined as one or more fractures of the hip, spine, or wrist during a 10-year observation period. Machine-learning algorithms, such as gradient boosting, random forest, decision tree, and logistic regression, were employed to predict osteoporotic fractures with a 70:30 training-to-test set ratio. We evaluated the area under the receiver operating characteristic curve (AUROC) scores to assess and compare the performance of these algorithms with the FRAX score. Results: Of the 2,147 participants, 3.5% experienced osteoporotic fractures. Those with fractures were older, shorter in height, and had a higher prevalence of rheumatoid arthritis, as well as higher FRAX scores. The AUROC for the FRAX was 0.617. The machine-learning algorithms showed AUROC values of 0.662, 0.652, 0.648, and 0.637 for gradient boosting, logistic regression, decision tree, and random forest, respectively. Conclusion: This study highlighted the immense potential of machine-learning algorithms to improve osteoporotic fracture risk prediction in women when complete FRAX parameter information is unavailable.