Intragranular and Intergranular Crack Propagation in Nanocrystalline Ni Under Single-Cycle Mode I Loading

Yan Feng,Jie Li,Xinhua Yang 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.7

As the first step to study the fatigue crack propagation, the molecular simulations were performed to investigate theopening, propagation and closure behaviors of intragranular and intergranular cracks in nanocrystalline Ni under single-cyclemode I loading. The atomic crack angle was proposed to characterize the crack-tip blunting and sharpening quantitatively. There are obvious different mechanisms between intragranular and intergranular crack propagation. Intragranular crack propagationcould be induced by stacking faults and can change its direction very easily, but the intergranular crack perpendicularto the loading direction would propagate along the grain boundary and encounter strong resistance at the triple junction. New cracks could form in the grain boundaries ahead of the original crack. Different from the traditional understanding forintragranular and intergranular cracks, however, the dislocation density increases even in the unloading process and the cracktip is possibly sharpened temporarily during loading.

京未話劇是認識北京的一面鏡子

馮燕慶 한국중국문화학회 2001 中國學論叢 Vol.12 No.-

在國際文化交流日益頻繁的新世紀, 中國散已經開了對外開放的大門. 在文學藝術領域, 各式各樣的著名文學作品源源不斷地被譯介到國家外, 使世人遷漸認識和了解了有着懲久歷史的古老文明的國度他的昨天, 前天和今天的文化.然而, 作爲話劇,這一西洋泊來的文化藝衛品種, 在中國的歷史狼不太長, 特別是京味話劇的誕生和發展, 還未更多的被世人關注, 和了解. 筆者旨在介紹京味話劇初次走出國門從來曾創造過的輝煌, 竝分析. 探討京味話劇在新的歷史時期發展的前景和走向, 鐵世界深入了解中國, 認識北京, 提供一介審美的感性的舞臺,進一步促進中國和世界的文化交流活動.

A novel M2e-multiple antigenic peptide providing heterologous protection in mice

Feng Wen,Ji-Hong Ma,Hai Yu,Fu-Ru Yang,Meng Huang,Yan-Jun Zhou,Ze-Jun Li,Xiu-Hui Wang,Guo-Xin Li,Yi-Feng Jiang,Wu Tong,Guangzhi Tong 대한수의학회 2016 Journal of Veterinary Science Vol.17 No.1

Swine influenza viruses (SwIVs) cause considerable morbidity and mortality in domestic pigs, resulting in a significant economic burden. Moreover, pigs have been considered to be a possible mixing vessel in which novel strains loom. Here, we developed and evaluated a novel M2e-multiple antigenic peptide (M2e-MAP) as a supplemental antigen for inactivated H3N2 vaccine to provide cross-protection against two main subtypes of SwIVs, H1N1 and H3N2. The novel tetra-branched MAP was constructed by fusing four copies of M2e to one copy of foreign T helper cell epitopes. A high-yield reassortant H3N2 virus was generated by plasmid based reverse genetics. The efficacy of the novel H3N2 inactivated vaccines with or without M2e-MAP supplementation was evaluated in a mouse model. M2e-MAP conjugated vaccine induced strong antibody responses in mice. Complete protection against the heterologous swine H1N1 virus was observed in mice vaccinated with M2e-MAP combined vaccine. Moreover, this novel peptide confers protection against lethal challenge of A/Puerto Rico/8/34 (H1N1). Taken together, our results suggest the combined immunization of reassortant inactivated H3N2 vaccine and the novel M2e-MAP provided cross-protection against swine and human viruses and may serve as a promising approach for influenza vaccine development.

Salivary Pepsin as an Intrinsic Marker for Diagnosis of Sub-types of Gastroesophageal Reflux Disease and Gastroesophageal Reflux Disease-related Disorders

( Yan-jun Wang ),( Xiu-qiong Lang ),( Dan Wu ),( Yu-qin He ),( Chun-hui Lan ),( Xiao-xiao ),( Bin Wang ),( Duo-wu Zou ),( Ji-min Wu ),( Yong-bin Zhao ),( Peter W Dettmar ),( Dong-feng Chen ),( Min Yan 대한소화기 기능성질환·운동학회 2020 Journal of Neurogastroenterology and Motility (JNM Vol.26 No.1

Background/Aims To determine the value of salivary pepsin in discriminating sub-types of gastroesophageal reflux disease (GERD) and GERD-related disorders. Methods Overall, 322 patients with different sub-types of GERD and 45 healthy controls (HC) were studied. All patients took Gastroesophageal Reflux Disease Questionnaire (GerdQ) and underwent endoscopy and 24-hour esophageal pH monitoring and manometry. Salivary pepsin concentration (SPC) was detected by using colloidal gold double-antibody immunological sandwich assay. Oral esomeprazole treatment was administrated in the patients with non-erosive reflux disease (NERD) and extra-esophageal symptoms (EES). Results Compared to HC, patients with erosive esophagitis, NERD, EES, EES plus typical GERD symptoms, or Barrett’s esophagus had a higher prevalence of saliva and SPC (all P < 0.001). There was no significant difference in the positive rate for pepsin in patients with functional heartburn or GERD with anxiety and depression, compared to HC. After esomeprazole treatment, the positive rate and SPC were significantly reduced in NERD (both P < 0.001) and in EES (P = 0.001 and P = 0.002, respectively). Of the 64 NERD patients, 71.9% (n = 46) were positive for salivary pepsin, which was significantly higher than the rate (43.8%, n = 28) of pathological acid reflux as detected by 24-hour esophageal pH monitoring (P = 0.002). Conclusions Salivary pepsin has an important significance for the diagnosis of GERD and GERD-related disorders. Salivary pepsin and 24-hour esophageal pH monitoring may complement with each other to improve the diagnostic efficiency.

GRID-BASED METHODS FOR LINEARLY EQUALITY CONSTRAINED OPTIMIZATION PROBLEMS

Feng, Yan,Zhang, Xuesheng,Liu, Liying 한국전산응용수학회 2007 Journal of applied mathematics & informatics Vol.23 No.1

This paper describes a direct search method for a class of linearly constrained optimization problem. Through research we find it can be treated as an unconstrained optimization problem. And with the decrease of dimension of the variables need to be computed in the algorithms, the implementation of convergence to KKT points will be simplified to some extent. Convergence is shown under mild conditions which allow successive frames to be rotated, translated, and scaled relative to one another.

Enhanced hierarchical model of object recognition based on a novel patch selection method in salient regions

Yan-Feng Lu,Tae-Koo Kang,Hua-Zhen Zhang,Myo-Taeg Lim IET 2015 IET computer vision Vol.9 No.5

<P>The biologically inspired hierarchical model for object recognition, Hierarchical Model and X (HMAX), has attracted considerable attention in recent years. HMAX is robust (i.e. shift- and scale-invariant), but its use of random-patch-selection makes it sensitive to rotational deformation, which heavily limits its performance in object recognition. The main reason is that numerous randomly chosen patches are often orientation selective, thereby leading to mismatch. To address this issue, the authors propose a novel patch selection method for HMAX called saliency and keypoint-based patch selection (SKPS), which is based on a saliency (attention) mechanism and multi-scale keypoints. In contrast to the conventional random-patch-selection-based HMAX model that involves huge amounts of redundant information in feature extraction, the SKPS-based HMAX model (S-HMAX) extracts a very few features while offering promising distinctiveness. To show the effectiveness of S-HMAX, the authors apply it to object categorisation and conduct experiments on the CalTech101, TU Darmstadt, ImageNet and GRAZ01 databases. The experimental results demonstrate that S-HMAX outperforms conventional HMAX and is very comparable with existing architectures that have a similar framework.</P>

Rice Bran Application under Deep Flooding can Control Weed and Increase Grain Yield in Organic Rice Culture

Yan, Yong-Feng,Fu, Jin-Dong,Lee, Byun-Woo The Korean Society of Crop Science 2007 Journal of crop science and biotechnology Vol.10 No.2

Rice bran application just after transplanting has been increasingly practiced as an herbicide-substitute for organic rice production in Korea. However, this practice is frequently reported to be unsatisfactory in weed suppression. An experiment with five treatments that combines flooding depth, rice bran application dose, and herbicide treatment was done in the paddy field to evaluate whether rice bran application under deep flooding can lead to a successful weed control in compensation for the single practice of rice bran application. Rice bran was broadcasted on the flood water surface just after deep flooding of 8 to 10cm that was started at seven days after transplanting. In the shallow flooding plot without herbicide six weed species were recorded: Monochoria vaginalis, Echinochloa crus-galli, Ludvigia prostrate, Cyperus amuricus, Aneima keisak, and Bidens tripartite. Among the first four dominant weed species, deep flooding significantly suppressed the occurrence of Echinochloa crus-galli and Cyperus amuricus while did not suppress the occurrence of Monochoria vaginalis and Ludwigia prostrate. On the contrary, rice bran application under deep flooding suppressed significantly Monochoria vaginalis and Ludwigia prostrate while didn't exert an additional suppression of Echinochloa crus-galli and Cyperus amuricus compared to deep flooding alone. Rice bran application and deep flooding suppressed complimentarily all the six weed species to a satisfactory extent except for Monochoria vaginalis of which suppression efficacy was 31.9%. Deep flooding reduced the panicle number substantially by inhibiting the tiller production, increased the spikelet number per panicle slightly, and leaded to a lower rice grain yield compared to shallow flooding with herbicide. Rice bran application under deep flooding mitigated the panicle reduction due to deep flooding, increased the spikelets per panicle significantly, and thus produced even higher grain yield in the rice bran application of 2000kg $ha^{-1}$ as compared to the shallow flooding treatment with herbicide. In conclusion, this practice applying rice bran under deep flooding would be promising to be incorporated as an integral practice for an organic rice farming system.

Roles of Immunohistochemical Staining in Diagnosing Pulmonary Squamous Cell Carcinoma

Yan, Yue,Zhang, Ya-Xiong,Fang, Wen-Feng,Kang, Shi-Yang,Zhan, Jian-Hua,Chen, Nan,Hong, Shao-Dong,Liang, Wen-Hua,Tang, Yan-Na,He, Da-Cheng,Wu, Xuan,Zhang, Li Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2

Background: Differentiating morphologic features based on hematoxylin-eosin (HE) staining is the most common method to classify pathological subtypes of non-small-cell lung cancer (NSCLC). However, its accuracy and inter-observer reproducibility in pathological diagnosis of poorly differentiated NSCLC remained to be improved. Materials and Methods: We attempted to explore the role of immunohistochemistry (IHC) staining in diagnosing pulmonary squamous cell carcinoma (SQCC) with poorly differentiated features by HE staining or with elevated serum adenocarcinoma-specific tumor markers (AD-TMs). We also compared the difference of epidermal growth factor receptor (EGFR) mutation rate between patients with confirmed SQCC and those with revised pathological subtype. Logistic regression analyses were used to test the association between different factors and diagnostic accuracy. Results: A total of 132 patients who met the eligible criteria and had adequate specimens for IHC confirmation were included. Pathological revised cases in poor differentiated subgroup, biopsy samples and high-level AD-TMs cases were more than those with high/moderate differentiation, surgical specimens and normal-level AD-TMs. Moreover, biopsy sample was a significant factor decreasing diagnostic accuracy of pathological subtype (OR, 4.037; 95% CI 1.446-11.267, p=0.008). Additionally, EGFR mutation rate was higher in patients with pathological diagnostic changes than those with confirmed SQCC (16.7% vs 4.4%, p=0.157). Conclusions: Diagnosis based on HE staining only might cause pathological misinterpretation in NSCLC patients with poor differentiation or high-level AD-TMs, especially those with biopsy samples. HE staining and IHC should be combined as pathological diagnostic standard. The occurrence of EGFR mutations in pulmonary SQCC might be overestimated.

Genotypic Variation of Cadmium Accumulation and Distribution in Rice

Yan, Yong-Feng,Choi, Doug-Hwan,Kim, Do-Soon,Lee, Byun-Woo 한국작물학회 2010 Journal of crop science and biotechnology Vol.13 No.2

An effective way to reduce the risk of cadmium (Cd) entering the food chain is to use low Cd-accumulation rice cultivars, particularly in Asia. The fundamental requirement for breeding low grain Cd-accumulation cultivars is to know the genotypic variation in Cd accumulation and the physiological processes and genetic basis governing the Cd accumulation in rice grain. In this experiment, genotypic variation in Cd accumulation and distribution among rice organs was studied using thirty-five rice varieties. They were grown with irrigation water containing 2 ppm Cd throughout rice growing season under field condition in 2007. At harvest, plants were sampled and analyzed for Cd concentration and accumulation in each rice organ. Significant variation of Cd concentration and accumulation in rice organs were found among thirty-five rice cultivars, revealing more than 8-fold varietal differences in grain Cd concentration and shoot Cd accumulation. Cd concentration and accumulation in grain were significantly different among cultivar groups, showing the highest in indica and the lowest in temperate japonica. Tongil-type and tropical japonica rice showed a Cd concentration intermediate to that of temperate japonica and indica rice. The higher Cd accumulation in grain of indica rice was attributable to the greater ability of Cd uptake. The greater ability of root-shoot translocation in tropical japonica and shoot-grain redistribution in tongil-type resulted in the significantly higher grain Cd concentration in these cultivar groups than in temperate japonica. For over 35 cultivars tested, grain Cd concentration revealed a significant positive correlation with root Cd concentration and shoot Cd concentration and accumulation while no significant correlation with root-shoot translocation factor and shoot-grain redistribution ratio. However, correlation analyses within each cultivar group showed that grain Cd concentration was significantly correlated with root-shoot translocation factor in indica, with root Cd concentration in tongil-type, with shoot Cd concentration and accumulation in tropical japonica, and with shoot Cd accumulation and shoot-grain redistribution ratio in temperate japonica. These results indicate that genotypic variation in grain Cd accumulation, in general, is controlled by all the three physiological processes but the major physiological process governing its genotypic variation within cultivar group is different depending on cultivar groups.

Efficacy and Safety of the Safe Triangular Working Zone Approach in Percutaneous Vertebroplasty for Spinal Metastasis

Yan Bi Cong,Fan Yan Feng,Tian Qing Hua,Wang Tao,Huang Zhi Long,Song Hong Mei,Li Ying,Jiao Lei,Wu Chun Gen 대한영상의학회 2022 Korean Journal of Radiology Vol.23 No.9

Objective: This study aimed to assess the technical feasibility, efficacy, and safety of the safe triangular working zone (STWZ) approach applied in percutaneous vertebroplasty (PV) for spinal metastases involving the posterior part of the vertebral body. Materials and Methods: We prospectively enrolled 87 patients who underwent PV for spinal metastasis involving the posterior part of the vertebral body, with or without the STWZ approach, from January 2019 to April 2022. Forty-nine patients (27 females and 22 males; mean age ± standard deviation [SD], 57.2 ± 11.6 years; age range, 31–76 years) were included in group A (with STWZ approach), accounting for 54 vertebrae. Thirty-eight patients (18 females and 20 males; 59.1 ± 10.9 years; 29–81 years) were included in group B (without STWZ approach), accounting for 57 vertebrae. Patient demographics, procedure-related variables, and pain relief as assessed using the visual analog scale (VAS) were collected at different time points. Tumor recurrence in the vertebrae after PV was analyzed using Kaplan–Meier curves. Results: The STWZ approach was successful from T1 to L5 without severe complications. Cement filling was satisfactory in 47/54 (87.0%) and 25/57 (43.9%) vertebrae in groups A and B, respectively (p < 0.001). Cement leakage was not significantly different between groups A and B (p = 1.000). Mean VAS score ± SD before and 1 week and 1, 3, 6, 9, and 12 months after PV were 7.6 ± 1.8, 4.2 ± 2.0, 2.7 ± 1.9, 1.9 ± 1.5, 1.7 ± 1.4, 1.7 ± 1.1, and 1.6 ± 1.3, respectively, in group A and 7.2 ± 1.7, 4.0 ± 1.3, 3.4 ± 1.6, 2.4 ± 1.2, 1.8 ± 1.0, 1.4 ± 0.5, and 1.7 ± 0.9, respectively, in group B. Kaplan–Meier analysis showed a lower tumor recurrence rate in group A than in group B (p = 0.001). Conclusion: The STWZ approach may represent a new, safe, alternative/auxiliary approach to target the posterior part of the vertebral body in the PV for spinal metastases.