Interrelationship between the Concentration of Heavy Metals in Normal Korean Tissues

YC Yoo,SK Lee,JY Yang,SW In,KW Kim,SC Kim,KH Chung 대한약학회 1999 大韓藥學會 總會 및 學術大會 Vol.48 No.-

무뇌증을 동반한 양막대증후군 1 예

강순범,김정훈,유영철 대한산부인과학회 1991 Obstetrics & Gynecology Science Vol.34 No.5

저자들은 본원에서 1988년 4월, 임신 18주의 태아에서 무뇌증을 동반한 양막대증후군 1예를 경험하였기에 문헌적 고찰과 함께 보고하는 바이다. The entity named the amniotic band syndrome has been known for at least 300 years, but the paper by Torpin in 1965 has provoked renewed interest. This syndrome is a collection of fetal malformations associated with fibrous bands that appear to entangle or entrap various fetal parts in utero, leading to deformation, malformation, or disruption. A case of amniotic band syndrome with anencephaly in 1988 was experienced and presented with a brief review of the literature.

폐쇄성 두류

박병준,고영초,유 헌,이채혁,박효일 대한신경외과학회 2002 Journal of Korean neurosurgical society Vol.31 No.4

광범위 안면부 반흔 성형술에 피부 신장기를 이용한 연속 절제술

김도형,양원용,유영천,고법민 대한미용성형외과학회 2002 Archives of Aesthetic Plastic Surgery Vol.8 No.1

The hepatoprotective and antioxidative effects of methanol extract and its fractions of Phellinus linteus in Hep G2 cells

Sgng EK,Kim JH,Jeon JY,Yoo SM,Sohn DH,Kim YC 大韓藥學會 2000 大韓藥學會 總會 및 學術大會 Vol.2000 No.1

자궁탈 임신 1예

이강보(KB Lee),유석권(SK Yoo),김영철(YC Kim),박인수(IS Park) 대한산부인과학회 1981 Obstetrics & Gynecology Science Vol.24 No.6

저자는 임신자궁탈 1예를 경험하였기에 간략한 문헌고찰과 아울러 증례를 보고하였다. Authors experience a case of full term pregnancy in association with the total uterine prolapse which was performed vacumm extraction following pitocin induction. A review of literature on the prolapse of uterus complicating pregnancy was made briefly.

난소암 환자에 대한 복합 화학요법 ( PAC Regimen ) 의 독성에 관한 연구

김두상(DS Kim),김문신(MS Kim),김용철(YC Kim),박형무(HM Park),유명숙(MS Yoo),신호문(HM Shin),김동명(DM Kim),조수현(SH Cho),조태승(TS Cho),환윤영(YY Hwang),심재철(JC Sim) 대한산부인과학회 1984 Obstetrics & Gynecology Science Vol.27 No.2

한양의대 산부인과학교실에서 1978년 10월부터 1982년 9월까지 PAC regimen(제1일에 adriamycin 50mg/㎡, 제2일에 cis-platinum 50mg/㎡, 제3~7일에 cyclophosphamide 150mg/ ㎡)으 로 화학치료를 받은 상피성난소암환자 16예를 대상으로 그 독성을 조사 분석하여 타 보고 자들의 성적과 비교 관찰한 바 다음과 같은 결론을 얻었다. 1. 혈액학적 독성은 총 16예중 10예(62.5%)에서 발생하였으며 혈소판 감소증은 3예 (18.8%), 백 혈구감소증 6예(37.5%), 빈혈 6예(37.5%)로 나타났으며 수혈은 1예(6.3%)에 실시하였다. 2. 신장에 대한 독성은 총 16예중 7예(43.8%)에서 각각 BUN증가 4예(25%) 혈청 creatinine 증 가 3예(18.8%)로 나타났으나, 전예가 경증이었다. 3. 가장 빈발하고 고통스러운 독성은 오심 구토로 전예에서 발생하였으며 perphenazine과 diazepam으로 어느정도 극복할 수 있었다. 4. 기타 말초신경독성은 5예(31.3%), 청력장애 1예(25%), 주관적인 시력장애 3예(18/8%), 간장 독성 1예(6.3%)였고 탈모증은 전예(100%)에서 발생하였다. The toxicity of PAC regimen was evaluated in 17 patients of ovarian epithelial carcinoma at the Edpartmane of Obstet. Nad Gynecol., Hanyang University Hospiatal from October, 1978 through september 1982. The PAC regimen consists of adriamycin 50mg/㎡ on the first day, cis-platinum 50mg/㎡ on the second day, and cyclophos-phanide 150mg/㎡ on the third to seventh day. It was repeated every 4 weeks. The results were as follow: 1. The hematologic toxicity occurred in 62.5%(10/16) of the patients, including thrombocytenia 18.8%(3/16), leukipenia 37.5%(6/16), and anemia 37.5%(6/16). For only one case, transfusion was require. 2. Nephrotoxicity occurred in 43.8%(7/160), including an elevation of BUN 25.0%(4/16) and an elevation of serum creatinine 18.8%(3/16). But all were in mild degree. 3. For the symptoms of gastrointestinal tract were nausea and vomiting which occurred in all cases and most distressing problems. All patients, however, were well tolerated with perphenazine and diazepam. 4. Peripheral neurotoxicity occurred in 31.3%(5/16), ototoxicity in 25.0%(1/4), blurred vision in 18.8%(3/16), hepatotoxicity in 6.3%(1/16) and alopecia in 100%.

임부에 병발된 전이성 융모암 1 예

이부순(BS Lee),박영주(YJ Park),주영철(YC Joo),유태숙(TS Yoo) 대한산부인과학회 1974 Obstetrics & Gynecology Science Vol.17 No.10

임신 32주에 병발된 전이성융모암 1예를 경험하였기에 간단한 문헌적 고찰과 아울러 이에 보고하는 바이다. The case to be reported is unusual intersting patient becauses of coexisting metastatic choriocarcinoma and pregnancy. A 32 year old multigravida had genital bleeding from vulvar metastatic lesion of choriocarcinoma at 32 gestational week. During the 1st admission cesarean section and tubal ligation were performed and a living female baby weighing 1,700 gm was delevered. Two courses of methotrexate(12.5mg/day, 72.5mg/course) treatment were cone without notable side effect and patient was discharged with complete remission of trophoblastic tumor. During the 2nd admission total abdominal hysterectomy, left salpingo-oophorectomy and right salpingectomy were performed and possible primary lesion of choriocarcinoma was found at the mid-posterior aspect of uterine cavity. After total 4 courses of methotrexate(72.5mg/day- 100mg/course) treatment without remarkable side effect, patient was discharged with partial remission of trophoblastic tumor. Chest lesions still remained but vulvar metastatic lesion disappeared completely. The patient was readmitted due to severe headache and limitation of extension of the right elbow and knee. Skull x-ray showed several small bean sized metastatic lesions in the skull vault. Left carotid angiography revealed possible brain metastasis from choriocarcinoma, which was disclosed by autopsy later on. In spite of additional 7th & 8th course of methotrexate (37.5mg-75mg/each course) and 6 mercaptopurine (40mg x 3 for 3 days) treatment the patient`s had getting worse and finally, the patient expired on Feb. 19, 1973. Literatures are briefly reviewed.

초음파 진단장치를 이용한 임신 전반기의 자궁 및 태아의 발육측정

배석천(SC Bae),유태건(TK Yoo),김창이(CY Kim),노영철(YC Roh) 대한산부인과학회 1978 Obstetrics & Gynecology Science Vol.21 No.6

저자들은 1976년 1월부터 만 6개월 동안 가톨릭의과대학 부속 성모병원 산부인과에 내원한 환자중 임신 5주에서 21주까지의 산모 67명에 대하여 81회의 초음파 단층촬영을 시행하여 다음과 같은 결론을 얻었다. 1) 태아상은 임신 6주의 9예중 3예(33.3%), 7주의 8예중 5예(62.5%), 그리고 8주 이후에는 모든 예(100.0%)에서 관찰되었다. 2) 자궁의 종경은 임신 5주부터 21주까지 7.3cm에서 18.9cm으로 증가하여 희귀직선은 0.71 wks+3.14 (r=0.96, P<0.01)이었고, 최대전후경은 동일기간 동안 4.2cm에서 10.0cm으로 증가하였으며 희귀직선은 0.27 wks+3.53 (r=0.83, P<0.01)이었다. 3) 태낭은 임신 5주부터 12주까지 1.4cm에서 5.3cm으로 증가하였으며 희귀직선은 0.53 wks-1.41 (r=0.92, P<0.01)이었다. 4) 아두대횡경치는 임신 11주부터 21주까지 1.8cm에서 4.6cm으로 증가하였고 희귀직선은 0.30 wks-1.80 (r=0.53, P<0.01)이었다. 임신 전반기에 시행한 초음파 단층촬영의 측정치들이 이 희귀직선들과 일치하면 정상적으로 진행되는 임신으로 간주할 수 있다. Gestational assessment in early stage has always been a challenge to the obstetricans. It is not always possible to draw definitive conclusions of the basis of uterine size, and positive immunological pregnancy tests are not always indicative of a normally progressing pregnancy because of hCG excretion continues as long as there is even a little trophoblast tissue left in the uterus. Roentgenological studies are reliable only around the 20th week of gestation with limited diagnostic and prognostic potential. Ultrasound have, in contrast, been shown to be capable of distinguishing the normally progressing pregnancies from abnormal cases after 5th week of pregnancy. This study consisted of sixty seven presumably normal gravidas whose last menstrual period was known precisely and who were subjected to sonographic analysis at varying intervals from the fifth to the twenty first week of amenorrhea at the Dept. of Obst. & Gynecol., Catholic Medical College from 1st of Jan. 1976 to 31st of July 1976. Some were examined serially at various intervals during early pregnancy. Others had only one set of observations. The B-scan was employed for all examinations. The results were as follows; 1. In the 5 weeks and 3 days of pregnancy a small "white ring" can visualized as the earliest sign of detection for gestation sac, and by the 6 weeks fetal echoes were clearly visible within the gestation sac. Between the 11th-12th week the gestation sac and the fetal head were appeared. There was disappeared the gestation sac from the 13th weeks. 2. Fetal echoes were visible in the 6th week of pregnancy in 33.3% of normal pregnancies (n=9), in the 7th week in 62.5% (n=8) and from the 8th week onward in 100% of cases. 3. Although the number of observations in each instance is not great, the growth of the uterus, the gestational sac, and the fetal head all appear to bear a linear correlation to the duration of pregnancy. a) From the 5th to the 21st week, the regression equation obtained for longitudinal growth of the uterus was y=0.71 wk

자궁벽내임신 2 례

문화숙,김상갑,백영철,권혁영,박양희,안병언,이기욱,이가영,유준희 대한산부인과학회 1993 Obstetrics & Gynecology Science Vol.36 No.12

자궁벽내임신이란 매우 희귀하며 조기진단이 어려운 반면, 진단이 늦어져서 임신이 진행된후 중증 실혈 및 쇼크상태에 빠져서 진단될 경우에는 환자에게 무척 치명적이며 자궁보존은 어렵게 될 것으로 사료된다. 사실 자궁벽내임신은 초기에는 증세가 전혀 없으므로 다른 자궁외임신과는 달리 복벽촉진 및 질식내진으로 조기진단은 불가능하며, 최근에는 혈청 beta-HCG 정량측정, 복식 및 질식초음파기기의 사용과 병행하여 진단적 및 수술적 골반경(pelviscopic operation)사용을 부합하면 진단 및 치료가 아주 용이해질 것으로 사료된다. 한편, MTX와 folinic acid사용도 고려해볼 수 있으나, 본 저자의 소견으로는 MTX사용은 수술시 출혈을 감소시키는 효과는 있겠지만 확정적인 치료효과는 없을 것으로 사료된다. 의료기기의 발달로 인해 과거에는 조기진단이 어려웠던 자궁벽내임신 진단이 조기에 가능하므로 조기진단의 중요성을 인식하고 진찰 및 치료에 임하는 것이 중요하다고 사료되는 바이다. Intramural implantation is among the rarest sites for ectopic gestation. Intramural pregnancy was first reported in 1924 by Perli and since then has been rarely found in literatures. The pathologic diagnosis of an intramural ectopic pregnancy requires that the myometrium surround the products of conception separate from the endometrial cavity or fallopian tubes. Recent improvement in the sonography and radioimmunoassay of the beta-subunit of human chorionic gonadotropin have markedly enhanced the ability to diagnose of intramural pregnancy. So, diagnosis of intramural pregnancy is possible during very early gestation. We have recently experienced two cases of intramural pregnancy and report with a brief review of the literatures.