Potential roles of D-serine and serine racemase in experimental temporal lobe epilepsy

Ryu, H.J.,Kim, J.-E.,Yeo, S.-I.,Kim, D.-S.,Kwon, O.-S.,Choi, S.Y.,Kang, T.-C. Wiley Subscription Services, Inc., A Wiley Company 2010 Journal of neuroscience research Vol.88 No.11

<P>To confirm the roles of D-serinergic gliotransmission in epilepsy, we investigated the relationship between spatiotemporally specific glial responses and the D-serine/serine racemase system in mesial temporal structures following status epilepticus (SE). In control animals, D-serine and serine racemase immunoreactivities were detected mainly in astrocytes. After SE, D-serine and serine racemase immunoreactivities were increased in astrocytes. Double-immunofluorescence study revealed that up-regulation of serine racemase immunoreactivity was relevant not to D-serine immunoreactivity but to nestin or vimentin immunoreactivity. Neither D-serine nor serine racemase was found in naïve or reactive microglia. In addition, phosphorylated N-methyl-D-aspartate (NMDA) receptor subunit 1 (pNR1-Ser896) immunoreactivity in the hippocampus was increased compared with controls. Increased D-serine immunoreactivity showed direct correlation with the phosphorylation of Ser896 of NR1. Given the findings of our previous study, these findings suggest that D-serine and serine racemase in astrocytes may play roles in neuronal hyperexcitability via a cooperative activation of NMDA receptors. Furthermore, serine racemase may be involved in migration and differentiation of immature astrocytes, which is relevant to reactive astrogliosis. © 2010 Wiley-Liss, Inc.</P>

Comparative Efficacy of Different Soy Protein Sources on Growth Performance, Nutrient Digestibility and Intestinal Morphology in Weaned Pigs

Yang, Y.X.,Kim, Y.G.,Lohakare, J.D.,Yun, J.H.,Lee, J.K.,Kwon, M.S.,Park, J.I.,Choi, J.Y.,Chae, B.J. Asian Australasian Association of Animal Productio 2007 Animal Bioscience Vol.20 No.5

To elucidate the efficacy of different soy protein sources on piglet's performance, a total of 280 weaned piglets ($Duroc{\times}Yorkshire{\times}Landrace$, $23{\pm}3$ d of age, $5.86{\pm}0.45$ kg initial BW) were allotted to 5 treatment diets comprising soybean meal (SBM), soy protein concentrate (SPC), Hamlet protein (HP300), fungal (Aspergillus oryzae) fermented soy protein (FSP-A), and fungal plus bacterial (A. oryzae+Bacillus subtilis) fermented soy protein (FSP-B), respectively. Experimental diets for feeding trial were formulated to contain each soy protein sources at 8% level to corn-whey powder basal diet. There were 14 pigs per pen and 4 pens per treatment. Experimental diets were fed from 0 to 14 d after weaning and then a common commercial diet was fed from 15 to 35 d. Also for ileal digestibility studies, 18 pigs were assigned to 6 dietary treatments as N-free, SBM, SPC, HP300, FSP-A and FSP-B with T-canulation at distal ileum for 6 days. At $14^{th}$ d of experimental feeding, the ADG was significantly higher (p<0.05) in SPC fed diet as compared with others. Similar trend was noticed during the 15-35 d and overall study (0-35 d). All the processed soy protein sources tested in this experiment improved (p<0.05) growth than SBM during overall study. The nutrient digestibility of GE, DM, CP and Ca showed lower (p<0.05) values in SBM and FSP-A fed groups than SPC and FSP-B treatments. The apparent ileal digestibility of TEAA, non-TEAA and TAA showed lower (p<0.05) in SBM treatments compared with other soy protein sources. The true ileal digestibility of TEAA, non-TEAA and TAA were lower (p<0.05) in SBM fed group than SPC and HP300 treatments, and lower than FSP treatments though they didn't achieve significant difference (p>0.05). Villous height and crypt depth was not affected by dietary treatments. In conclusion, the growth and digestibility of nutrients in weaned pigs fed SPC was superior to others. Also FSP-A and FSP-B showed improved performance than those fed SBM.

간호대학생의 이론・실습 성적과 임상수행능력의 관련성 : 성인간호학 교과목을 중심으로

권현진,김다영,김민정,김소현,박예담,박지원,왕서현,유영주,이재현,주가은,신수진 이화여자대학교간호학회 2020 이화간호학회지 Vol.- No.54

Purpose: This study aimed to explore the relationship among score of theory course, score of practicum course and clinical practice ability by the course, Adult Health Nursing. Methods: A descriptive research was conducted using questionaries. Data were collected from September 25 to October 2, 2019. Participants were 67 nursing students at one university in Seoul on their junior year who have experienced clinical settings. The collected data were analyzed by t-test, ANOVA, Cohen’s Kappa, and Scheffe’s test using SPSS 25.0 version program. Results: Participants were given a quartile number from 1 to 4 respectively according to their scores of theory course those of practicum course. The total mean score of clinical practice ability was 3.61, with a perfect score of 5. The scores of theory course and practicum course showed slight correlation(Cohen’s Kappa=.168). However, significant correlation did not existed among score of theory course, score of practicum course and clinical practice ability. Conclusion: The result showed that score of theory course, score of practicum course and clinical practice ability have no significant correlation. However, its finding suggests the necessity of further research about various approach and new evaluation methods needed in order to improve nursing students’ competency.

갱년기 남성의 체험

권인영・김채연・김하정・신유정・이도경・장환희・정예은,김채연,김하정,신유정,이도경,장환희,정예은,양숙자,손지희 이화여자대학교 간호학회 2018 이화간호학회지 Vol.- No.52

Purpose: The purpose of this study is to obtain comprehensive understanding of Korean middle-age men's experience in their andropause. The findings of this study will provide supportive data for development of nursing interventions. Methods: This study is explored by hermeneutic phenomenological analytic method suggested by van Manen. Data was collected through in-depth interviews with 7 middle aged men between July and September, 2017. Before the interviews, preliminary questionnaire was preformed for all participants. Results: The analysis produced five themes: 'My body is getting weaker than before', 'A sense of despondency with current life', 'Regarding andropause not as much important as menopause', 'The obscurity of one's life about andropause', 'Cut off andropause from life'. Conclusion: This study explored Korean middle-age men's experience in their andropause. Although most participants experienced physical and psychological symptoms, they denied that they are andropause. Moreover, they lacked knowledge and showed attitude of indifference. In addition, Andropause is not as commonly recognized in the society of Korea. Even if they perceive it, they cannot reveal the fact and respond poorly. It brings up the necessity to provide proper information and education. A variety of nursing interventions are also required for the men for their physical or mental recovery and health care. Therefore, this study offers the deep understanding of the significance and nature of the experience in andropause. Furthermore, this study may put foundation for development in nursing care of studies of this subject.

Sintering temperature dependent piezoelectric properties of (Bi,Na)TiO₃-(Ba,Sr)TiO₃ ceramics

Kwon, Y.H.,Shin, D.J.,Lee, G.H.,Koh, J.H. Ceramurgica ; Elsevier Science Ltd 2016 CERAMICS INTERNATIONAL Vol.42 No.8

In this paper, the strain and piezoelectric properties of lead-free piezoelectric (100-x)(Bi<SUB>0.5</SUB>Na<SUB>0.5</SUB>)TiO<SUB>3</SUB>-x(Ba<SUB>0.5</SUB>Sr<SUB>0.5</SUB>)TiO<SUB>3</SUB> (x=0, 3, 6, 8, 12, 15, 18wt%) ceramics were investigated for sintering temperatures ranging from 1125 to 1225<SUP>o</SUP>C to determine the optimized processing conditions. The optimized (100-x)(Bi<SUB>0.5</SUB>Na<SUB>0.5</SUB>)TiO<SUB>3</SUB>-x(Ba<SUB>0.5</SUB>Sr<SUB>0.5</SUB>)TiO<SUB>3</SUB> ceramics exhibited a high relative dielectric permittivity ε<SUB>r</SUB> of 1608, piezoelectric charge coefficient d<SUB>33</SUB> of 155pC/N, electromechanical coupling factor k<SUB>p</SUB> of 38.5%, and the generated electric power of 25.7nW/cm<SUP>2</SUP>, respectively. Especially, the electric field dependent strains of (100-x)(Bi<SUB>0.5</SUB>Na<SUB>0.5</SUB>)TiO<SUB>3</SUB>-(Ba<SUB>0.5</SUB>Sr<SUB>0.5</SUB>)TiO<SUB>3</SUB> ceramics were also measured and analyzed, and various types of strain effects were observed and analyzed. Our studies suggest that optimized sintering temperature and optimized barium strontium titanate content can enhance the piezoelectric properties of lead-free (100-x)(Bi<SUB>0.5</SUB>Na<SUB>0.5</SUB>)TiO<SUB>3</SUB>-x(Ba<SUB>0.5</SUB>Sr<SUB>0.5</SUB>)TiO<SUB>3</SUB> ceramics. As a result, the optimized composition was 88(Bi<SUB>0.5</SUB>Na<SUB>0.5</SUB>)TiO<SUB>3</SUB>-12(Ba<SUB>0.5</SUB>Sr<SUB>0.5</SUB>)TiO<SUB>3</SUB>, which sintered at 1200<SUP>o</SUP>C.

미국 의학드라마에 나타난 간호이미지와 역할수행 연구

권영애,길민지,김정현,박옥경,서민정,유현정,이민경,정지혜,조양현,천기윤,이자형,정덕유,김성남 이화여자대학교 간호과학대학 2009 이화간호학회지 Vol.- No.43

We tried to inquire the people's views on nursing or nurses, correct the image of nurse and take it as a basis to be applied on nursing education examining the image of nursing on Television drama playing a important role of mass media. 523 nurses of the characters in drama is applied to the analysis object of this study by selecting 3 American medical dramas, Grey's Anatomy, House M.D, E.R from 2005 to 2007. Contents analysis method was used in Data Analysis, which was used in Lim Mi-lim ?Research on contents analysis on image of nursing on television drama?, 7 Items was used after Coders previously modify and compensate it based on research documents of Kalish & Kalisch(1986), Yoon Young(1983), Lee Hye-Ok(1982), Lee Young-Bok, etc in analysis items. Before making the coding, we did pre-test. 6 Coders made of 3teams, 2 Coders are in each team, made the Codings the article on each person by Item seeing the recorded Film. An each team makes coding about 50episodes, total 147episodes for 2weeks. We used double coding and when the results are different between two coders, we decided just one result through mutual agreement. The average of reliability degree was 97.4% which measured the reliability degree by the method of Holsti. The statistic method of Frequency, Percentage was used using EXCEL Program in data processing. The result of research is as follows. 1. The general feature of nurses on the drama is that they are women(92.7%) which is 20 or 30-aged(70.5%). 2. Relative importance of 65.2% nurses in drama is depicted as surrounding characters and most of them was expressed as the character plating surrounding role. 3. The affair attitude of nurses shown on drama is revealed as active(24.5%), autonomous(32%), kind(16.8%), mechanical(23.2%) and adept(28.4%). However, unknown category is the highest in all affairs. 4. The professional activity of nurses was classified with professional/simple affair, The professional activity of nurses was 80% and simple activity of nurses was 22.9%. The professional activity of nurses was classified with personal/assistant affair. The personal activity of nurses was 61.9% and assistant activity of nurses was 15.1%. 5. The place nurses of the drama appears are hospital(97.7%). 6. The appearance feature of nurses is shown on common physique (55.0%), common stature(79.3%), common appearance(76.1%), common dignity(97.5%) and decent (51.1%). 7. The feature of character of nurses depicted on Television drama is neutral in all 11 affairs. We want the following epigraph based on above conclusion. 1. The continuos research intended for mass people is required about how their image of nurse is changed after watching medical drama. 2. The research to construct monitoring mass media system and make plans for developing is required for nurse image being in a triangular position as a professional job.

중년여성의 자기효능감과 우울과 건강증진행위의 관계

권서진,김덕운,박소라,박혜영,신소영,심재영,손지희,이수연,정다회,홍지혜 이화여자대학교 간호과학대학 2010 이화간호학회지 Vol.- No.44

The purpose of this study was to investigate health promotion behaviors and its influencing factors, self-efficacy and depression among middle-aged women. Data on 204 women between the ages of 45 and 59 were collected from June 8th, 2009 to July 10th, 2009. Structured questionnaires were used to collect data. The following instruments were used in the study after some adaption. Health promotion Lifestyle Profile which was developed by Park(1995), Kim(1996), Jung(1996), revised by Choi(2004) was used. It consisted of 6 sub-categories likewise self actualization, exercise and stress management, hygine, rest, nutrition and health responsibility. Self-efficacy which was developed by Becker, Stuifbergen & Hall(1993), The Self-Rated Abilities for Health Practices Scale revised by Choi(2004) was used. Depression which was developed by Radloff(1977), revised by Jun(1992) CES-D scale(Center for Epidemiologic Studies Depression scale) was used. The data were analyzed using SPSS 16.0 for Windows to t-test, ANOVA and Pearson's correlation. The results of this study are as follows: 1.The ones who thought they were healthy had a statically higher score than those who thought they were unhealthy in a health promoting behavior score(p=.004). 2.The ones who had higher monthly income had a statically higher score than those who had lower monthly income in a self-efficacy score(p=.019). 3.The score of depression was statically high when the ones had lower education level, lower monthly income or lower health level estimated by themselves(p=.002). 4.There was a weak correlation between health promoting behavior and depression(r=-.320, p=.000), and between depression and self-efficacy(r=-.313, p=.000). There was a strong correlation between self-efficacy and health promoting behavior(r=.766, p=.000). In conclusion, the results of this study show that the degree of self-efficacy and depression effects health promotion behavior, and suggest that self-efficacy and depression should be considered significantly to develop efficient health promoting programs.

서울지역 4년제 간호대학생들의 임상실습 유,무에 따른 진로태도성숙

권혜진,김보람,김소연,김수임,성정아,신영미,윤서진,이경진,홍영선,이자형,정덕유,신혜원 이화여자대학교 간호과학대학 2009 이화간호학회지 Vol.- No.43

This study was conducted to investigate the differences in the degrees of career attitude maturity according to the clinical practice experience of the college of nursing students. The convenience sample was 275 students attending the college of nursing in Seoul. Data was obtained through a questionnaire from December 1st to 12th, 2008. The instrument used to measure the career attitude maturity in this study was "A barometer of maturity in career attitudes" developed by Ki-hak, Lee(1997). The collected data were analyzed by descriptive statistics, Chronbach's alpha, t-test and ANOVA with the SPSS 16.0 program. Below is the result of this study. 1. The average score for career attitude maturity of nursing students who experienced clinical practices was 135.56(±12.17): higher than the average score of inexperienced students, 134.37(±12.44). However it could not show meaningful differences in the statistics(F=-.805, p=.422). 2. Determinacy, one of five subordinate concepts of career attitude maturity, was statistically significative. On average, the group comprised of students with clinical practices scored 27.60(±3.81): higher than that of unpracticed students, 26.63(±4.26)(F=-1.976, p=.049). 3. The more academic years they have, except for junior year students, the points of career attitude maturity relative to general characteristics were increasingly higher. The points were 132.60(±11.99) for freshmen, 135.93(±12.72) for sophomores, 133.50(±12.57) for juniors and 138.11(±11.24) for seniors(F=2.714, p=.045). 4. According to the age of the group, the grade of career attitude maturity became higher. The scores were 133.21(±12.34) for 18-19yrs., 134.05(±12.16) for 20-22yrs., 138.43(±10.96) for 23-26yrs. and 148.71(±12.76) for 27-32yrs. (F=5.118, p=.002). 5. The average total score for career attitude maturity of nursing students was 135.00(±12.30). Of the five subdivisions―readiness, conviction, determinacy, independence and finality― readiness demonstrated the highest result with 32.33(±4.46) followed by conviction, determinacy, independence and finality respectively. Based on the results, there are some proposals for further researches. As this research was only for college of nursing in Seoul, it is necessary to compare career attitude maturity with 3-year colleges and other departments. In addition, alongside clinical practices there is a growing need to develop programs that will not only provide guidelines but also prepare students for the maturity of their career attitude.

영구자석 동기전동기의 토크 리플 저감 운전

이동희(D. H. Lee),이종희(J. H. Lee),김영삼(Y. S. Kim),김지현(J. H. Kim),권영안(Y. A. Kwon) 대한전기학회 2001 대한전기학회 학술대회 논문집 Vol.2001 No.7

Forebrain-specific ablation of phospholipase Cγ1 causes manic-like behavior

Yang, Y R,Jung, J H,Kim, S-J,Hamada, K,Suzuki, A,Kim, H J,Lee, J H,Kwon, O-B,Lee, Y K,Kim, J,Kim, E-K,Jang, H-J,Kang, D-S,Choi, J-S,Lee, C J,Marshall, J,Koh, H-Y,Kim, C-J,Seok, H,Kim, S H,Choi, J H,Ch Macmillan Publishers Limited, part of Springer Nat 2017 Molecular psychiatry Vol.22 No.10

<P>Manic episodes are one of the major diagnostic symptoms in a spectrum of neuropsychiatric disorders that include schizophrenia, obsessive-compulsive disorder and bipolar disorder (BD). Despite a possible association between BD and the gene encoding phospholipase C gamma 1 (PLCG1), its etiological basis remains unclear. Here, we report that mice lacking phospholipase C gamma 1 (PLC gamma 1) in the forebrain (Plcg1(f/f); CaMKII) exhibit hyperactivity, decreased anxiety-like behavior, reduced depressive-related behavior, hyperhedonia, hyperphagia, impaired learning and memory and exaggerated startle responses. Inhibitory transmission in hippocampal pyramidal neurons and striatal dopamine receptor D1-expressing neurons of Plcg1-deficient mice was significantly reduced. The decrease in inhibitory transmission is likely due to a reduced number of gamma-aminobutyric acid (GABA)-ergic boutons, which may result from impaired localization and/or stabilization of postsynaptic CaMKII (Ca2+/calmodulin-dependent protein kinase II) at inhibitory synapses. Moreover, mutant mice display impaired brain-derived neurotrophic factor-tropomyosin receptor kinase B-dependent synaptic plasticity in the hippocampus, which could account for deficits of spatial memory. Lithium and valproate, the drugs presently used to treat mania associated with BD, rescued the hyperactive phenotypes of Plcg1(f/f); CaMKII mice. These findings provide evidence that PLC gamma 1 is critical for synaptic function and plasticity and that the loss of PLC gamma 1 from the forebrain results in manic-like behavior.</P>