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- 저자 : Xuemei Hu (검색결과 15 건)
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Hu, Lin,Bai, Zhigang,Ma, Xuemei,Bai, Nan,Zhang, Zhongtao The Korean Gastric Cancer Association 2020 Journal of gastric cancer Vol. No.
Purpose: Gastric cancer is a highly metastatic malignant tumor, often characterized by chemoresistance and high mortality. In the present study, we aimed to investigate the role of B-cell lymphoma 3 (Bcl-3) protein on cell migration and chemosensitivity of gastric cancer. Materials and Methods: The gastric cancer cell lines, AGS and NCI-N87, were used for the in vitro studies and the in vivo studies were performed using BALB/c nude mice. Western blotting, wound healing assay, Cell Counting Kit-8 assay, immunohistochemistry, and terminal deoxynucleotidyl transferase dUTP nick end labeling assay were used to evaluate the role of Bcl-3 in gastric cancer. Results: We found that the protein expression of hypoxia (HYP)-inducible factor-1α and Bcl-3 were markedly upregulated under hypoxic conditions in both AGS and NCI-N87 cells in a time-dependent manner. Interestingly, small interfering RNA-mediated knockdown of Bcl-3 expression affected the migration and chemosensitivity of the gastric cancer cells. AGS and NCI-N87 cells transfected with si-RNA-Bcl-3 (si-Bcl-3) showed significantly reduced migratory ability and increased chemosensitivity to oxaliplatin, 5-fluorouracil, and irinotecan. In addition, si-Bcl-3 restored the autophagy induced by HYP. Further, the protective role of si-Bcl-3 on the gastric cancer cells could be reversed by the autophagy inducer, rapamycin. Importantly, the in vivo xenograft tumor experiments showed similar results. Conclusions: Our present study reveals that Bcl-3 knockdown inhibits cell migration and chemoresistance of gastric cancer cells through restoring HYP-induced autophagy.
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Hu Boran,Gao Jin,Xu Shaochen,Zhu Jiangyu,Fan Xuemei,Zhou Xiaoyan 한국응용생명화학회 2020 Applied Biological Chemistry (Appl Biol Chem) Vol.63 No.3
The metabolites that provide the aroma and flavor to wine are the products of several influences, such as grape cultivar, geographic location and associated environmental features, viticultural practices, and vinification techniques, which are central to production protocols, quality evaluation and development of wine regions. Accordingly, we initiated the requisite studies to investigate the differences in the dry red wine metabolites of different grape varieties. The proton-nuclear magnetic resonance technique (1H-NMR) combined with multivariate statistical analysis was used to investigate the changes of metabolite levels in Cabernet Sauvignon, Merlot and Cabernet Gernischt dry red wines vinified in Changli, Hebei province, China, in 2017. The results showed that the types of metabolites in different varieties of dry red wines were similar, but the content was significantly different. The main contributors to the differences in Cabernet Sauvignon, Merlot and Cabernet Gernischt dry red wines were ethyl acetate, lactic acid, alanine, succinic acid, proline, malic acid, and gallic acid, indicating 1H-NMR method combined with multivariate statistical analysis can distinguish these three types of dry red wines from each other. It provides a benchmark for further comparative study on wine quality and the verification of wine authenticity.
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Shuangyi Hu,Xuemei Ren,Dongdong Zheng 제어·로봇·시스템학회 2024 International Journal of Control, Automation, and Vol.22 No.1
In this paper, a disturbance observer-based finite-time optimal synchronization control strategy is proposed with an adaptive bias torque for multi-motor driving servo systems. Finite time disturbance observers are designed to estimate the system nonlinearity and external disturbance, which ensure the finite time convergence of observation errors. Meanwhile a virtual tracking control input is designed to guarantee the output tracking of the load subsystem and a generalized synchronization error is obtained for the motor subsystem. Based on the synchronization error system, an auxiliary exponential function with finite-time convergence property is introduced to obtain the sufficient conditions for optimal synchronization control, which avoids solving the complex HamiltonJacobi-Bellman function. Simulation and experimental results reveal the flexibility of the proposed control scheme.
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Lin Hu,Zhigang Bai,Xuemei Ma,Nan Bai,Zhongtao Zhang 대한위암학회 2020 Journal of gastric cancer Vol. No.
Purpose: Gastric cancer is a highly metastatic malignant tumor, often characterized by chemoresistance and high mortality. In the present study, we aimed to investigate the role of B-cell lymphoma 3 (Bcl-3) protein on cell migration and chemosensitivity of gastric cancer. Materials and Methods: The gastric cancer cell lines, AGS and NCI-N87, were used for the in vitro studies and the in vivo studies were performed using BALB/c nude mice. Western blotting, wound healing assay, Cell Counting Kit-8 assay, immunohistochemistry, and terminal deoxynucleotidyl transferase dUTP nick end labeling assay were used to evaluate the role of Bcl-3 in gastric cancer. Results: We found that the protein expression of hypoxia (HYP)-inducible factor-1α and Bcl-3 were markedly upregulated under hypoxic conditions in both AGS and NCI-N87 cells in a time-dependent manner. Interestingly, small interfering RNA-mediated knockdown of Bcl-3 expression affected the migration and chemosensitivity of the gastric cancer cells. AGS and NCI-N87 cells transfected with si-RNA-Bcl-3 (si-Bcl-3) showed significantly reduced migratory ability and increased chemosensitivity to oxaliplatin, 5-fluorouracil, and irinotecan. In addition, si-Bcl-3 restored the autophagy induced by HYP. Further, the protective role of si-Bcl-3 on the gastric cancer cells could be reversed by the autophagy inducer, rapamycin. Importantly, the in vivo xenograft tumor experiments showed similar results. Conclusions: Our present study reveals that Bcl-3 knockdown inhibits cell migration and chemoresistance of gastric cancer cells through restoring HYP-induced autophagy.
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Xiaoqing Hu,Xuemei Xu,Cheng Hao LI 한국식물생명공학회 2018 Plant biotechnology reports Vol.12 No.2
Dehydration-responsive element binding (DREB) transcription factors (TFs) play a significant role in the response to many abiotic stresses, and they can regulate the downstream expression of some defense genes. In this study, a novel DREB TF gene, designated as LoERF017, was identified from Larix olgensis. The ORF of the LoERF017 gene is 624 bp and it contains an AP2/EREBP domain belonging to a typical DREB TF. Sub-cellular location analysis showed that LoERF017 was located in the nucleus. QRT-PCR analysis indicated that LoERF017 could be induced by NaCl, PEG6000, sodium nitroprusside (SNP), and ABA treatment. Moreover, an analysis of the survival rate and the development of transgenic plants under mannitol and NaCl revealed that the overexpression of LoERF017 in Arabidopsis could improve tolerance to osmotic and salt stress. Compared with wild-type (WT) plants, the overexpression of LoERF017 resulted in higher superoxide dismutase (SOD) and peroxidase (POD) activities and lower malondialdehyde (MDA) and reactive oxygen species (ROS) levels under osmotic stress. Downstream stress-responsive genes, including COR, rd29A, and ERD10, were also activated in transgenic plants overexpressing LoERF017. In brief, the overexpression of the LoERF017 gene may directly or indirectly induce antioxidant enzyme systems and downstream stress-response genes to enhance osmotic resistance capacity in plants.
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Angle-sensitive Pixels Based on Subwavelength Compound Gratings
Yunlong Meng,Xuemei Hu,Cheng Yang,Xinyu Shen,Xueyun Cao,Lankun Lin,Feng Yan,Tao Yue 한국광학회 2022 Current Optics and Photonics Vol.6 No.4
In this paper, we present a new design for angle-sensitive pixels (ASPs). The proposed ASPs take advantage of subwavelength compound gratings to capture the light angle, which enables pixel size to reach the wavelength scale of 0.7 μm × 0.7 μm. The subwavelength compound gratings are implement-ed by the wires of the readout circuit inherent to the standard complementary metal–oxide–semiconductor manufacturing process, thus avoiding additional off-chip optics or post-processing. This technique allows the use of two pixels for horizontal or vertical angle detection, and can determine the light’s angle in the range from −45° to +45°. The proposed sensor enables surface-profile reconstruction of mi-croscale samples using a lensless imaging system.
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Approximate Optimal Stabilization Control of Servo Mechanisms based on Reinforcement Learning Scheme
Yongfeng Lv,Xuemei Ren,Shuangyi Hu,Hao Xu 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.10
A reinforcement learning (RL) based adaptive dynamic programming (ADP) is developed to learn the approximate optimal stabilization input of the servo mechanisms, where the unknown system dynamics are approximated with a three-ayer neural network (NN) identifier. First, the servo mechanism model is constructed and a three-layer NN identifier is used to approximate the unknown servo system. The NN weights of both the hidden layer and output layer are synchronously tuned with an adaptive gradient law. An RL-based critic three-layer NN is then used to learn the optimal cost function, where NN weights of the first layer are set as constants, NN weights of the second layer are updated by minimizing the squared Hamilton-Jacobi-Bellman (HJB) error. The optimal stabilization input of the servomechanism is obtained based on the three-layer NN identifier and RL-based critic NN scheme, which can stabilize the motor speed from its initial value to the given value. Moreover, the convergence analysis of the identifier and RL-based critic NN is proved, the stability of the cost function with the proposed optimal input is analyzed. Finally, a servo mechanism model and a complex system are provided to verify the correctness of the proposed methods.
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Yu Guan,Tao Hu,Jiang Wu,Lili Zhao,Fengguo Tian,Wei-Guo Pan,Ping He,Xuemei Qi,Fangqin Li,Kai Xu 한국화학공학회 2019 Korean Journal of Chemical Engineering Vol.36 No.1
We used a simple method of graphene oxide (GO) preparation with different oxidation levels, and control the properties of the TiO2 nanocrystals by tuning the content and oxidation degree of GO to enhance the photocatalytic performance. During the hydrothermal reaction, reduction of GO, formation of TiO2 and chemical bonds between TiO2 and reduced graphene oxide (RGO) was achieved simultaneously. Characterization results showed that TiO2 properties such as crystalline grain and particle size could be tailored by the amount of functional groups, and that crystallinity was also controlled by GO degrees of oxidation. TiO2/RGO photocatalysts showed great efficiency of mercury oxidation, which reached 83.7% and 43.6% under UV and LED light irradiation, respectively. The effects of crystalline grain size and surface chemical properties on Hg0 removal under LED and UV light irradiation were analyzed. In addition, the properties of the photocatalysts before and after UV illumination were investigated, finding that part of Ti-OH on TiO2 surface transformed to Ti-O-Ti. In a nutshell, this work could provide a new insight into enhancing activity of photocatalysts and understanding the photocatalytic mechanism.
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