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Influence of Different Inlet Conditions on Micromixer
Wei Xu,Xiuhua He,Lingfeng Gao,Tian Xia,Zhengying Yu 한국유체기계학회 2018 International journal of fluid machinery and syste Vol.11 No.2
This paper presents the influence of different inlet conditions on the performance of micromixer. On the purpose of obtaining the internal flow fields and mixing characteristics, there are 28 micromixers with different structural parameters have been studied by numerical simulations. The influence of different inlet conditions on the mixing performance of micromixers with periodic triangle baffles and rectangle baffles was examined by experiments. The results of experiment and numerical simulation were completely discussed and analyzed. The consistency between results of experiment and numerical simulation proves the reliability of research method and the accuracy of numerical simulation. It also indicates that different numbers of inlets have significant effects on the mixing performance of micromixers. The optimum inclination angles of inlets for each kind of micromixer were obtained under different conditions. For optimizing or designing passive micromixers, it is an effective way to improve the performance of micromixers by increasing the number of inlets or changing the angle of the inlets.
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Yan Cui,Qing Ye,Heya Wang,Yingchao Li,Xiuhua Xia,Weirong Yao,He Qian 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.12
The present study was designed to investigatethe protective effect of aloin against alcoholic liver disease ina chronic alcohol feeding mouse model. Mice were givenalcohol twice a day by intragastric administration for11 weeks (4.0, 4.7, 5.5 g/kg bw/day for the first 3 weeksrespectively, 6.3 g/kg bw/day for the following 8 weeks). Aloin (10, 30 mg/kg bw) or vehicle was given by gavage tomice after each alcohol administration. Alcohol elevated theserum transaminases alanine aminotransferase, aspartateaminotransferase, total cholesterol and triglyceride levelswhich were significantly attenuated by the co-administrationof aloin (p\0.05). Histopathological observations wereconsistent with these indices. Co-administration of aloinsignificantly suppressed the alcohol-dependent induction ofsterol regulatory element-binding protein-1c expression(p\0.01) and remarkably up-regulated themRNA levels ofAMP-activated protein kinase-a2 (p\0.001). Furthermore,aloin supplementation significantly inhibited the alcoholdependentelevation of malondialdehyde and cytochromeP4502E1 expression (p\0.05), and significantly elevatedsuperoxide dismutase activity (p\0.01). The up-regulationof serum lipopolysaccharide (LPS), hepatic nitric oxide,tumor necrosis factor a, toll-like receptor-4, and myeloiddifferentiation primary response gene 88 were also markedlysuppressed by the co-administration of aloin (p\0.05) inalcohol-treated mice. These results suggest that aloin mayrepresent a novel, protective strategy against chronic alcoholicliver injury by attenuating lipid accumulation, oxidativestress and LPS-induced inflammatory response.
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