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- 저자 : Xingyu Gu (검색결과 4 건)
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Dynamic Response of Pavement under FWD using Spectral Element Method
Xingyu Gu,Lin-Bing Wang,Sheng Cheng,Fujian Ni 대한토목학회 2014 KSCE JOURNAL OF CIVIL ENGINEERING Vol.18 No.4
This paper presents the development of Spectral Element Method (SEM) for simulating pavement response under FWD pulseloads. Based on Fourier-Bessel function and Fast Fourier Transform, the algorithms and procedures of SEM are introduced,including the formation of layered stiffness matrix and system stiffness matrix with different bond conditions between twointerfaces. Deflections calculated from the SEM under different pulse durations are compared and verified with staticdeflections calculated from BISAR3 and measured dynamic deflections separately. Research results indicate that pavementdeflections are sensitive to load pulse duration. The SEM can also be used to solve viscoelastic problems by choosing properrheological models.
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Zhiqi Huang,Xingyu Li,Tian Xie,Changjiang Gu,Kan Ni,Qingqing Yin,Xiaolei Cao,Chunhui Zhang 대한암학회 2020 Cancer Research and Treatment Vol.52 No.4
Purpose RIOK1 has been proved to play an important role in cancer cell proliferation and migration in various types of cancers—such as colorectal and gastric cancers. However, the expression of RIOK1 in breast cancer (BC) and the relationship between RIOK1 expression and the development of BC are not well characterized. In this study, we assessed the expression of RIOK1 in BC and evaluated the mechanisms underlying its biological function in this disease context. Materials and Methods We used immunohistochemistry, western blot and quantitative real-time polymerase chain reaction to evaluate the expression of RIOK1 in BC patients. Then, knockdown or overexpression of RIOK1 were used to evaluate the effect on BC cells in vitro and in vivo. Finally, we predicted miR-204-5p could be a potential regulator of RIOK1. Results We found that the expression levels of RIOK1 were significantly higher in hormone receptor (HR)–negative BC patients and was associated with tumor grades (p=0.010) and p53 expression (p=0.008) and survival duration (p=0.011). Kaplan-Meier analysis suggested a tendency for the poor prognosis. In vitro, knockdown of RIOK1 could inhibit proliferation, invasion, and induced apoptosis in HR-negative BC cells and inhibited tumorigenesis in vivo, while overexpression of RIOK1 promoted HR-positive tumor progression. MiR-204-5p could regulate RIOK1 expression and be involved in BC progression. Conclusion These findings indicate that RIOK1 expression could be a biomarker of HR-negative BC, and it may serve as an effective prognostic indicator and promote BC progression.
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Xiaowei Wang,Jiaxing Ren,Xinyu Hu,Xingyu Gu,Ning Li 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.6
The compaction characteristics of porous asphalt (PA) mixtures are significantly different from those of traditional dense-graded asphalt mixtures. Compaction efforts are critical for PA mixtures to exhibit good performance in terms of strength, functionality, and durability. The objective of this study was to determine the optimum number of gyrations for typical PA mixtures compacted using a Superpave gyratory compactor. The compaction characteristics and the influence of seven gyration levels on the indicators of air voids (AV) content, Marshall Stability (MS), multi-directional permeability, stone-on-stone contact, and durability of PA mixture were investigated through laboratory experiments. A multi-directional permeameter was designed to evaluate the multi-directional permeability of PA mixtures, including vertical, horizontal, and combined horizontal-vertical permeability. The AV content, multi-directional permeability decreases with the increasing gyrations. Based on the requirements of each indicator, the minimum and maximum gyrations for each indicator were determined. Balancing the performance of strength, functionality, and durability, the optimum number of gyrations for the PA mixtures was determined to be between 45 and 75 gyrations, which allows for different gyrations depending on the application of the PA mixture. Finally, the requirements of MS, horizontal permeability, and combined horizontal-vertical permeability are recommended for improving the performance of PA mixture.
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Yuexuan Xu,Xin Guo,Bokai Xuan,Hao Sun,Gaowei Zhang,Jian Li,Xingyu Huo,Zhifeng Gu 제어·로봇·시스템학회 2024 International Journal of Control, Automation, and Vol.22 No.3
This paper investigates an impedance-based iterative learning sliding mode control scheme for robotassisted bathing, taking into consideration scenarios with unknown model parameters. Initially, the utilization ofimpedance control is not confined to merely adjusting the desired trajectory but is also instrumental in ensuringactive compliance control during the robot-assisted bathing procedure. Furthermore, an iterative learning control(ILC) is devised to estimate the iteration-invariant dynamic parameters, which are intricate and challenging to precisely ascertain in practical applications. To mitigate the effect of divergent initial conditions in ILC, a trajectoryreconstruction method is introduced, thus ensuring the convergence of tracking errors even when starting from random initial states. Moreover, an adaptive sliding mode control mechanism is proposed to counteract non-parametricexternal disturbances and the torque generated through human-machine interaction during the bathing process. Theconvergence of the double closed-loop system in both the time and iterative domains is demonstrated through theapplication of the composite energy function method. Eventually, the efficacy and superiority of the control strategyoutlined in this paper are jointly verified through co-simulation employing MATLAB and ADAMS.
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