A Multi-objective DCP Model for Bi-Level Resource-Constrained Project Scheduling Problems in Grounding Grid System Project under Hybrid Uncertainty

Zhe Zhang,Ming Liu,Xiaoyang Zhou,Lu Chen 대한토목학회 2016 KSCE JOURNAL OF CIVIL ENGINEERING Vol.20 No.5

Since more elements are involved in the construction projects, the decision making process of Resource-constrained Project Scheduling Problems (RCPSP) cannot be determined by a manager, but multiple level decision makers. This study focuses on the RCPSP in a practical grounding grid system project in Jin’ An Qiao hydropower station, which consider the hierarchical organization structure and hybrid uncertainty environment simultaneously. In this practical RCPSP, the construction contractor is the Upper Level Decision Maker (ULDM), while the outsourcing partner is the Lower Level Decision Maker (LLDM). Considering the operations difficulties and practical decision making process in the RCPSP, a bi-level multi-objective RCPSP model with bi-random coefficients is developed. To deal with the bi-random variables in the model, the Dependent-Chance Programming (DCP) method is introduced and the equivalent crisp model is derived. Subsequently, motivated by the particular nature of model, Bi-level Global-local-neighbor Particle Swarm Optimization Algorithm (BGLN-PSO) is designed to obtain the optimal schedule for grounding grid system project. A practical application is presented to verify the efficiency of proposed bi-level multi-objective RCPSP model and algorithm.

Hybrid Gradient Vector Fields Based on Maneuver Space for Path-following Guidance

Yiyang Zhao,Deyun Zhou,Zhen Yang,Xiaoyang Li,Jichuan Huang,Xiaofeng Lv 제어로봇시스템학회 2022 제어로봇시스템학회 국제학술대회 논문집 Vol.2022 No.11

Guidance path-planning and following are two important functionalities of unmanned aerial vehicles (UAVs), but only a few approaches deal with both. In this study, an innovative hybrid gradient vector fields algorithm based on maneuver space (HGVFs-MS) for path-following guidance is proposed to control fixed-wing UAVs to follow a generated guidance path and oriented target curves in three-dimensional space, which can be any combination of straight lines, arcs, and helixes as motion primitives. The strategies designed in earlier studies have flaws that prevent the UAV from following arcs that make its turning angle too large. The switching strategy proposed in this study solves this problem by introducing the concept of the virtual waypoints. Finally, the performance of the HGVFs-MS algorithm is verified by three representative simulation scenarios. The simulation considers the constraints of the aircraft, and its results indicate that the algorithm performs well in following both lateral and longitudinal control, particularly for curved paths.

Study on Cooperative Air-to-Ground Surveillance Planning and Controlling for Unmanned Aerial Vehicles

Shiyuan Chai,Zhen Yang,Jichuan Huang,Xiaoyang Li,Yiyang Zhao,Deyun Zhou 제어로봇시스템학회 2022 제어로봇시스템학회 국제학술대회 논문집 Vol.2022 No.11

The use of unmanned aerial vehicles (UAVs) for air-to-ground mission in complex environments has increased considerably in recent years. The numerous studies on UAVs cooperative air-to-ground mission controlling have been reported, but few have considered the impact of the communication instability due to electromagnetic interference (EMI) which is common in many air-to-ground applications. Under the influence of EMI, the air-to-ground mission stages are represented as a dynamic combination of several communication-available and communication-unavailable stages. Traditional cooperative surveillance algorithms cannot handle such situations well. In this study, we presented a method which based on Voronoi diagrams to solve the impact of communication outages, and an attention mechanism ant-colony optimization (AACO) algorithm was proposed for UAV path-planning control in air-to-ground surveillance missions. The controlling strategy is adaptively updated by introducing an attention mechanism for regular instruction information, a priori information, and emergent information of the mission to satisfy the mission target. Simulation results show that the proposed algorithm achieves better search performance than traditional algorithms in scenarios which include communication-available and communication-unavailable situations.

Exosomes Derived from Human Adipose Mesenchymal Stem Cells Inhibits Fibrosis and Treats Oral Submucous Fibrosis via the miR-181a-5p/Smad2 Axis

Shao Zifei,Xu Jinhao,Xu Xiaoyang,Wang Xiang,Zhou Yuxi,Li Yiyang,Li Kun 한국조직공학과 재생의학회 2024 조직공학과 재생의학 Vol.21 No.1

BACKGROUND: Oral submucous fibrosis (OSF) is a chronic disease with carcinogenic tendency that poses a non-negligible threat to human health. Exosomes derived from human adipose mesenchymal stem cells (ADSC-Exo) reduces visceral and cutaneous fibroses, but their role in OSF has received little attention. The aim of this study was to investigate the effects of ADSC-Exo on OSF and elucidate the mechanism. METHODS: In brief, ADSCs were extracted from adipose tissues and subjected to flow cytometry and induction culture. Fibroblasts were isolated from human buccal mucosa and subjected to immunofluorescence. Myofibroblasts were obtained from fibroblasts induced by arecoline and identified. Immunofluorescence assay confirmed that myofibroblasts could take up ADSC-Exo. The effects of ADSC-Exo on the proliferative and migratory capacities of myofibroblasts were examined using the Cell Counting Kit-8 and scratch assay. Real-time quantitative polymerase chain reaction (qPCR) was performed to evaluate mothers against decapentaplegic homolog 2 (Smad2), Smad3, Smad7, collagen type 1 (Col1), Col3, alpha smooth muscle actin (α-SMA), fibronectin, and vimentin. Western blotting was performed to detect phospho (p)-Smad2, Smad2, p-Smad2/3, Smad2/3, Smad7, Col1, Col3, α-SMA, fibronectin, and vimentin. Furthermore, the dual-luciferase reporter assay was performed to prove that miR-181a-5p in ADSC-Exo directly inhibited the expression of Smad2 mRNA to regulate the transforming growth factor beta (TGF-β) pathway. We also performed qPCR and western blotting to verify the results. RESULTS: ADSC-Exo could promote the proliferation and migration of myofibroblasts, reduce the expressions of p-smad2, Smad2, p-smad2/3, Smad2/3, Col1, αSMA, fibronectin, and vimentin and elevated the levels of Smad7 and Col3. In addition, miR-181a-5p was highly expressed in ADSC-Exo and bound to the 3'-untranslated region of Smad2. ADSC-Exo enriched with miR-181a-5p reduced collagen production in myofibroblasts and modulated the TGF-β pathway. CONCLUSIONS: ADSC-Exo promoted the proliferative and migratory capacities of myofibroblasts and inhibited collagen deposition and trans-differentiation of myofibroblasts in vitro. miR-181a-5p in exosomes targets Smad2 to regulate the TGF-β pathway in myofibroblasts. ADSC-Exo perform antifibrotic actions through the miR-181a-5p/Smad2 axis and may be a promising clinical treatment for OSF. BACKGROUND: Oral submucous fibrosis (OSF) is a chronic disease with carcinogenic tendency that poses a non-negligible threat to human health. Exosomes derived from human adipose mesenchymal stem cells (ADSC-Exo) reduces visceral and cutaneous fibroses, but their role in OSF has received little attention. The aim of this study was to investigate the effects of ADSC-Exo on OSF and elucidate the mechanism. METHODS: In brief, ADSCs were extracted from adipose tissues and subjected to flow cytometry and induction culture. Fibroblasts were isolated from human buccal mucosa and subjected to immunofluorescence. Myofibroblasts were obtained from fibroblasts induced by arecoline and identified. Immunofluorescence assay confirmed that myofibroblasts could take up ADSC-Exo. The effects of ADSC-Exo on the proliferative and migratory capacities of myofibroblasts were examined using the Cell Counting Kit-8 and scratch assay. Real-time quantitative polymerase chain reaction (qPCR) was performed to evaluate mothers against decapentaplegic homolog 2 (Smad2), Smad3, Smad7, collagen type 1 (Col1), Col3, alpha smooth muscle actin (α-SMA), fibronectin, and vimentin. Western blotting was performed to detect phospho (p)-Smad2, Smad2, p-Smad2/3, Smad2/3, Smad7, Col1, Col3, α-SMA, fibronectin, and vimentin. Furthermore, the dual-luciferase reporter assay was performed to prove that miR-181a-5p in ADSC-Exo directly inhibited the expression of Smad2 mRNA to regulate the transforming growth factor beta (TGF-β) pathway. We also performed qPCR and western blotting to verify the results. RESULTS: ADSC-Exo could promote the proliferation and migration of myofibroblasts, reduce the expressions of p-smad2, Smad2, p-smad2/3, Smad2/3, Col1, αSMA, fibronectin, and vimentin and elevated the levels of Smad7 and Col3. In addition, miR-181a-5p was highly expressed in ADSC-Exo and bound to the 3'-untranslated region of Smad2. ADSC-Exo enriched with miR-181a-5p reduced collagen production in myofibroblasts and modulated the TGF-β pathway. CONCLUSIONS: ADSC-Exo promoted the proliferative and migratory capacities of myofibroblasts and inhibited collagen deposition and trans-differentiation of myofibroblasts in vitro. miR-181a-5p in exosomes targets Smad2 to regulate the TGF-β pathway in myofibroblasts. ADSC-Exo perform antifibrotic actions through the miR-181a-5p/Smad2 axis and may be a promising clinical treatment for OSF.

A Maneuver Control Method for Stealthy Engagement in Beyond-visual-range Air Combat Based on Sliding Mode Control

Yue Liu,Zhen Yang,Jichuan Huang,Guang Zhan,Xiaoyang Li,Deyun Zhou 제어로봇시스템학회 2022 제어로봇시스템학회 국제학술대회 논문집 Vol.2022 No.11

A S-type engagement of beyond-visual-range (BVR) air combat tactical method based on sliding mode control is proposed, which is aiming at the problem of Doppler pulse (PD) radar blind zone. By introducing the Electronic Support Measures (ESM), the whole tactical process is divided into two sub-processes: quick engagement and stealthy engagement. This paper designs a stealthy engagement process controller based on the double power sliding mode control, and a quick engagement process controller based on the back-stepping second order sliding mode. The simulation experiment shows that our aircraft can use EMS to judge the enemy radar detection information and switch the strategy. And it can successfully enter the enemy radar blind zone through S-type maneuver, occupy the dominant area, which can effectively complete the stealthy engagement.

A Clinical Study on Juheli (Recombinant Human Interleukin - 11) in the Second Prevention of Chemotherapy Induced Thrombocytopenia

Xiao, Yang,Liu, Jun,Huang, Xin-En,Guo, Jian-Xiong,Fu, Peng-Chao,Huang, Xiao-Hong,Zhou, Juan,Ye, Ai-Qin Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.2

Objective: to investigate the effect and side effects of recombinant human interleukin - 11 (rhIL - 11, in Chinese Juheli, produced by Qi Lu Biotechnology CO., LTD) in the second prevention of chemotherapy induced thrombocytopenia (CIT). Methods: Cancer patients with CIT were recruited and were treated with rhIL - 11 (treatment phase, TP), and in the following cycle, all these patients administered with rhIL - 11 24 hours immediately after chemotherapy (preventive treatment phase, PTP). Duration and severity of thrombocytopenia between two phases were compared. Results: for patients in TP or PTP, nadir values of platelet were ($29.28{\pm}20.08){\times}10^9/L$ and ($45.24{\pm}19.66){\times}10^9/L$, duration of thrombocytopenia in TP and PTP was ($11.52{\pm}4.33$) and ($8.20{\pm}+2.77$)days, recovery time was ($19.40{\pm}3.89$)and ($13.44{\pm}3.02$)days, duration of rhIL - 11 administration was ($10.68{\pm}2.46$)and ($6.28{\pm}1.77$)days, number of patients needing platelet infusion was 16and4 respectively, all differences were statistically significant (p value were 0.007, 0.002, 0.000, 0.000, 0.034 respectively). For TP and PTP, number of patients with hemorrhage was 8 and 4, duration of bleeding was ($5.00{\pm}0.82$) and ($4.50{\pm}0.71$) days respectively, with no statistically significant difference. Adverse reactions mainly included fever, edema, arrhythmia, joint pain, fatigue, skin rash, headache, dizziness, etc., all were not statistically significant between TP and PTP. Conclusion: rhIL - 11 could be well tolerated and is effective that could reduce the duration, severity of CIT, platelet transfusion, and incidence of bleeding, as well as shorten the recovery time, duration of rhIL - 11 administration. Thus, rhIL - 11 could be commended in the second prevention of CIT for patients with cancer.