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- 저자 : Xiaonan Zhong (검색결과 3 건)
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Genetic Detection of Clubroot Resistance Loci in a New Population of Brassica rapa
Wenxing Pang,Shan Liang,Xiaonan Li,Pengpeng Li,Sha Yu,임용표,Zhong Yun Piao 한국원예학회 2014 Horticulture, Environment, and Biotechnology Vol.55 No.6
Clubroot is one of the most serious diseases affecting Brassica crop production worldwide. In order toidentify the location of clubroot resistance genes in Chinese cabbage, we constructed a linkage map for an F2 populationderived from a cross between a resistant turnip inbred line, ‘Siloga’ (B. rapa ssp. rapifera), and a susceptible Chinesecabbage inbred line, ‘BJN3’ (B. rapa ssp. pekinensis). The newly developed genetic map included 207 markers andcovered 1151.7 cM. In combination with clubroot resistance tests from the field, the data allowed us to identify threequantitative trait loci of clubroot resistance, using a composite interval mapping method. Clubroot resistance genesQS_B1.1, QS_B3.1, and QS_B8.1 were located on chromosomes A1, A3, and A8, respectively, of B. rapa. Theircontribution rates were 8.18%, 70.55%, and 7.28%, respectively. QS_B1.1 was a novel locus of clubroot resistance,independent of any published clubroot-resistance loci. QS_B3.1 was first detected in ‘Siloga,’ mapped to the previousCRb and CRa region, whereas QS_B8.1 was closely linked to Crr1b. Epistatic interactions with additive effects weredetected between QS_B3.1 and QS_B8.1.
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Ramchiary, Nirala,Nguyen, Van Dan,Li, Xiaonan,Hong, Chang Pyo,Dhandapani, Vignesh,Choi, Su Ryun,Yu, Ge,Piao, Zhong Yun,Lim, Yong Pyo Oxford University Press 2011 DNA research Vol.18 No.5
<P>Genic microsatellite markers, also known as functional markers, are preferred over anonymous markers as they reveal the variation in transcribed genes among individuals. In this study, we developed a total of 707 expressed sequence tag-derived simple sequence repeat markers (EST-SSRs) and used for development of a high-density integrated map using four individual mapping populations of <I>B. rapa</I>. This map contains a total of 1426 markers, consisting of 306 EST-SSRs, 153 intron polymorphic markers, 395 bacterial artificial chromosome-derived SSRs (BAC-SSRs), and 572 public SSRs and other markers covering a total distance of 1245.9 cM of the <I>B. rapa</I> genome. Analysis of allelic diversity in 24 <I>B. rapa</I> germplasm using 234 mapped EST-SSR markers showed amplification of 2 alleles by majority of EST-SSRs, although amplification of alleles ranging from 2 to 8 was found. Transferability analysis of 167 EST-SSRs in 35 species belonging to cultivated and wild <I>brassica</I> relatives showed 42.51% (<I>Sysimprium leteum</I>) to 100% (<I>B. carinata, B. juncea</I>, and <I>B. napus</I>) amplification. Our newly developed EST-SSRs and high-density linkage map based on highly transferable genic markers would facilitate the molecular mapping of quantitative trait loci and the positional cloning of specific genes, in addition to marker-assisted selection and comparative genomic studies of <I>B. rapa</I> with other related species.</P>
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Xiao-Dong Li,Jing Zhou,Rui Li,Bingjun Zhang,Yuge Wang,Xiaonan Zhong,Yaqing Shu,Yanyu Chang,Wei Qiu 대한신경과학회 2022 Journal of Clinical Neurology Vol.18 No.4
Background and Purpose Patients presenting with clinical characteristics that are strongly suggestive of neuromyelitis optica spectrum disorders (NMOSD) have a high risk of developing definite NMOSD in the future. Little is known about the clinical course, treatment, and prognosis of these patients with likely NMOSD at disease onset. Methods This study prospectively recruited and visited 24 patients with the limited form of NMOSD (LF-NMOSD) at disease onset from November 2012 to June 2021. Their demographics, clinical course, longitudinal aquaporin-4 immunoglobulin G (AQP4-IgG) serology, MRI, therapeutic management, and outcome data were collected and analyzed. Results The onset age of the cohort was 38.1±12.0 years (mean±standard deviation). The median disease duration was 73.5 months (interquartile range=44.3–117.0 months), and the follow-up period was 54.2±23.8 months. At the end of the last visit, the final diagnosis was categorized into AQP4-IgG-seronegative NMOSD (n=16, 66.7%), AQP4-IgG-seropositive NMOSD (n=7, 29.2%), or multiple sclerosis (n=1, 4.2%). Seven of the 24 patients (29.2%) experienced conversion to AQP4-IgG seropositivity, and the interval from onset to this serological conversion was 37.9±21.9 months. Isolated/mixed area postrema syndrome (APS) was the predominant onset phenotype (37.5%). The patients with isolated/mixed APS onset showed a predilection for conversion to AQP4-IgG seropositivity. All patients experienced a multiphasic disease course, with immunosuppressive therapy reducing the incidence rates of clinical relapse and residual functional disability. Conclusions Definite NMOSD may be preceded by LF-NMOSD, particularly isolated/ mixed APS. Intensive long-term follow-up and attack-prevention immunotherapeutic management is recommended in patients with LF-NMOSD.
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