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IGF-1 from Adipose-Derived Mesenchymal Stem Cells Promotes Radioresistance of Breast Cancer Cells
Yang, Hui-Ying,Qu, Rong-Mei,Lin, Xiao-Shan,Liu, Tong-Xin,Sun, Quan-Quan,Yang, Chun,Li, Xiao-Hong,Lu, Wei,Hu, Xiao-Fang,Dai, Jing-Xing,Yuan, Lin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23
Purpose: The aim of this study was to investigate effects of adipose-derived mesenchymal stem cells (AMSCs) on radioresistance of breast cancer cells. Materials and Methods: MTT assays were used to detect any influence of AMSC supernatants on proliferation of breast cancer cells; cell migration assays were used to determine the effect of breast cancer cells on the recruitment of AMSCs; the cell survival fraction post-irradiation was assessed by clonogenic survival assay; ${\gamma}$-H2AX foci number post-irradiation was determined via fluorescence microscopy; and expression of IGF-1R was detected by Western blotting. Results: AMSC supernatants promoted proliferation and radioresistance of breast cancer cells. Breast cancer cells could recruit AMSCs, especially after irradiation. IGF-1 derived from AMSCs might be responsible for the radioresistance of breast cancer cells. Conclusions: Our results suggest that AMSCs in the tumor microenvironment may affect the outcome of radiotherapy for breast cancer in vitro.
Xiao-Lin Luo,Ya-Shao Chen,Min-Juan Wang,De-Suo Yang,Jie Yang 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.32 No.-
Cu2O micro-crystals with different morphologies (including three branching structures) weresynthesized through hydrothermal method by using sodium tartrate as chelating reagent. Branchinggrowth patterns of Cu2O microcrystals have a strong dependence on the amount of sodium tartrate. These different Cu2O microcrystals were used as catalysts to promote the thermal decomposition ofammonium perchlorate (AP). The thermal decomposition of AP in the presence or absence of Cu2Omicro-crystals was investigated non-isothermally through thermogravimetry and differential scanningcalorimetry (DSC). The data obtained from DSC were applied for the calculation and comparison of thekinetic parameters of AP decomposition process through a model-free approach.
EFFECTIVE SYNTHESIS AND APPLICATION OF ZAO NANOPARTICLES WITH GOOD DISPERSION
LIN-LIN ZHANG,HONG-ZHEN XIE,MIN ZHANG,JIN-KU LIU,XIAO-HONG YANG 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2012 NANO Vol.7 No.3
The well dispersed ZAO nanoparticle with 25?30 nm in diameter was prepared by an ultrasonictemplate method. The morphologies, structures, and photoelectricity of the ZAO nanoparticles were analyzed by TEM, XRD, UV-Vis, etc. The thermochemistry behaviors of the precursor were studied by TG-DSC. The composite ¯lm with semipermeable structure made from ZAO nanoparticles and collodion can be explored ¯rstly. The photocatalytic properties of the ZAO nanoparticles and composite ¯lm were investigated. The composite ¯lm can be applied in the sewage treatment ¯eld.
rs10505474 and rs7837328 at 8q24 Cumulatively Confer Risk of Prostate Cancer in Northern Han Chinese
Zhang, Lin-Lin,Sun, Liang,Zhu, Xiao-Quan,Xu, Yong,Yang, Kuo,Yang, Fan,Yang, Yi-Ge,Chen, Guo-Qiang,Fu, Ji-Cheng,Zheng, Chen-Guang,Li, Ying,Mu, Xiao-Qiu,Shi, Xiao-Hong,Zhao, Fan,Wang, Fei,Yang, Ze,Wang, Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7
Aims: Genome-wide association studies (GWAS) have identified several risk variants for prostate cancer (pCa) mainly in Europeans, which need to be further verified in other racial groups. We selected six previously identified variants as candidates and to define the association with PCa in Northern Han Chinese. Methods: 749 subjects from Beijing and Tianjin in Northern China were included. Six variants (rs10505474, rs7837328, rs4242384, rs7813, rs486907 and rs1058205) were genotyped by high resolution melting (HRM) assays. The individual and cumulative contribution for of the risk of PCa and clinical covariates were analyzed. Results: Among the six candidate variants, onlyrs10505474, and rs7837328, both locating at 8q24 region, were associated with PCa in our population.rs10505474 (A) was associated with PCa ($OR_{recessive}=1.56$, p=0.006); and rs7837328 (A) was associated with PCa ($OR_{dominant}=1.38$, p=0.042/$OR_{recessive}=1.99$, p=0.003). Moreover, we observed a cumulative effects between them ($p_{trend}=2.58{\times}10^{-5}$). The joint population attributable risk showed the two variants might account for 71.85% of PCa risk. In addition, we found the homozygotes of rs10505474 (A) and rs7837328 (A) were associated with PCa clinical covariants (age at onset, tumor stage, respectively) ($p_{age}=0.046$, $P_{tumorstage}=0.048$). Conclusion: rs10505474 (A) and rs7387328 (A) at 8q24 are associated with PCa and cumulatively confer risk, suggesting the two variations could determine susceptibility to PCa in the Northern Chinese Han population.
Investigation on seismic behavior of combined retaining structure with different rock shapes
Yu-liang Lin,Lianheng Zhao,T.Y. Yang,Guo-lin Yang,Xiao-bin Chen 국제구조공학회 2020 Structural Engineering and Mechanics, An Int'l Jou Vol.73 No.5
A combination of a gravity wall and an anchor beam is widely used to support the high soil deposit on rock mass. In this study, two groups of shaking table test were performed to investigate the responses of such combined retaining structure, where the rock masses were shaped with a flat surface and a curved surface, respectively. Meanwhile, the dynamic numerical analysis was carried out for a comparison or an extensive study. The results were studied and compared between the combined retaining structures with different shaped rock masses with regard to the acceleration response, the earth pressure response, and the axial anchor force. The acceleration response is not significantly influenced by the surface shape of rock mass. The earth pressure response on the combined retaining structure with a flat rock surface is more intensive than the one with a curved rock surface. The anchor force is significantly enlarged by seismic excitation with a main earthquake-induced increment at the first intensive pulse of Wenchuan motion. The value of anchor force in the combined retaining structure with a flat rock surface is generally larger than the one with a curved rock surface. Generally, the combined retaining structure with a curved rock surface presents a better seismic performance.
Lin Xiong,Ya-Qin Gao,Wei-Hong Li,Tian-Feng Guo,Xiao-Lin Yang 한국식품과학회 2015 Food Science and Biotechnology Vol.24 No.5
An LC-MS/MS method was established for simultaneous identification of levels of bilpaterol, cimbuterol, clenproperol, and bambuterol in goat and beef muscle. Meat samples were subjected to extraction using an aqueous acidic solution and cleansed using MCX solid phase extraction. β2-Agonists residues were extracted using an aqueous acidic solution. Proteins in extraction liquids was removed based on adjusting pH using perchloric acid and a sodium hydroxide solution, followed by SPE for clean-up. Linearity values of the method based on R2 values were 0.9976-0.9997 with 70.1-108.8% recovery and relative standard deviation values of 3.5-13.3%. Low limits of detection (LOD) and quantitation (LOQ) of 0.01-0.02 and 0.02-0.08 μg/kg, respectively, were achieved for spiked goat and spiked beef muscle. The method was sensitive and specific and is an improvement over other currently available technologies.
Human Intersectin 2 (ITSN2) binds to Eps8 protein and enhances its degradation
( Xiao Feng Ding ),( Zijian Yang ),( Fang Liang Zhou ),( Xiang Huchang ),( Zhou Chang Luo ),( Zhi Cheng He ),( Qian Liu ),( Hong Li ),( Feng Yan ),( Fang Mei Wang ),( Shuang Lin Xiang ),( Jian Zhang ) 생화학분자생물학회 (구 한국생화학분자생물학회) 2012 BMB Reports Vol.45 No.3
Participates in actin remodeling through Rac and receptor endocytosis via Rab5. Here, we used yeast two-hybrid system with Eps8 as bait to screen a human brain cDNA library. ITSN2 was identified as the novel binding factor of Eps8. The interaction between ITSN2 and Eps8 was demonstrated by the in vivo co-immunoprecipitation and colocalization assays and the in vitro GST pull-down assays. Furthermore, we mapped the interaction domains to the region between amino acids 260-306 of Eps8 and the coiled-coil domain of ITSN2. In addition, protein stability assays and immunofluorescence analysis showed ITSN2 overexpression induced the degradation of Eps8 proteins, which was markedly alleviated with the lysosome inhibitor NH4Cl treatment. Taken together, our results suggested ITSN2 interacts with Eps8 and stimulates the degradation of Eps8 proteins. [BMB reports 2012; 45(3): 183-188]
Lin Yue,Jianbo Guo,Jingliang Yang,Jing Lian,Xiao Luo,Xiangning Wang,Kaihong Wang,Li Wang 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.3
The electrochemical oxidation of dye wastewater with the cathode modified by quinones has beeninvestigated. Under the optimal conditions, the decolorization efficiency can reach 96.0% after 120 min. The addition of tert-butanol significantly decreased the decolorization efficiency, suggesting theinvolvement of -OH radicals in the decomposition of H2O2. A potential difference may result in a quinoneradical on the cathode which can catalyze the reduction of O2 to H2O2. UV–vis spectrum and GC/MSanalysis revealed that the dye molecule was firstly initiated by the cleavage of –N55N–, and decomposedto aromatic intermediates, further degraded to ring opening products and finally mineralized.