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The Improvement of China’s Nuclear Safety Supervision Technical Support Ability
Han Wu,Guoxin Yu,Xiangyang Zheng,Keyan Teng 한국방사성폐기물학회 2022 방사성폐기물학회지 Vol.20 No.4
The International Atomic Energy Agency (IAEA) entails independent decision-making for the safety supervision of civil nuclear facilities. To evaluate and review the safety of nuclear facilities, the national regulatory body usually consults independent institutions or external committees. Technical Support Organizations (TSOs) include national laboratories, research institutions, and consulting organizations. Support from professional organizations in other countries may also be required occasionally. Most of the world’s major nuclear power countries adopt an independent nuclear safety supervision model. Accordingly, China has continuously improved upon the construction of such a system by establishing the National Nuclear Safety Administration (NNSA) as the decision-making department for nuclear and radiation safety supervision, six regional safety supervision stations, the Nuclear and Radiation Safety Center (NSC), a nuclear safety expert committee, and the National Nuclear and Radiation Safety Supervision Technology R&D Base, which serves as the test, verification, and R&D platform for providing consultation and technical support. An R&D system, however, remains to be formed. Future endeavors must focus on improving the technical support capacity of these systems. As an enhancement from institutional independence to capability independence is necessary for ensuring the independence of China’s nuclear safety regulatory institution, its regulatory capacity must be improved in the future.
Tianyan Liu,Xiangyang Xu,Minghui Zhang,Runbo Zhang,Yue Wu,Hongzhi Ji,Yanfang Liu 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.7
Under the engaging process, excessive temperature of clutch plates may lead to thermal failure. Existing research has failed to find the hot spot and the radial temperature difference real-timely. They also neglected the influence of dynamic sliding process and hydraulic characteristics. Thus, a multi-domain dynamic model of the whole clutch was proposed, involving the mechanical dynamics, the hydraulic dynamics and thermics. With the thermal resistance network method, the real-time axial and radial temperature prediction of clutch plates was realized. The highest temperature occurs on the friction pairs of axial middle and the maximum value occurs on the radial 5th mass. Compared with the results by FEM, the deviation is about 6.5 %, but the time duration is reduced significantly. Furthermore, the influence of the outer hub vibration (160 Hz, 0.2 Hz) on the dynamic characteristics was discussed. This work was tested to be an effective and good basis for the health prediction of wet clutches.
Mandi Cai,Yifeng Wu,Rencai Ma,Junlin Chen,Zexing Chen,Chenfu Deng,Xinzhao Huang,Xiangyang Ma,Xiaobao Zou 대한척추신경외과학회 2024 Neurospine Vol.21 No.2
Objective: To compare the clinical outcomes of transoral anterior Jefferson-fracture reduction plate (JeRP) and posterior screw rod (PSR) surgery for unstable atlas fractures via C1-ring osteosynthesis. Methods: From June 2009 to June 2022, 49 consecutive patients with unstable atlas fractures were treated by transoral anterior JeRP fixation (JeRP group) or PSR fixation (PSR group) and followed up at General Hospital of Southern Theatre Command of PLA; 30 males and 19 females were included. The visual analogue scale (VAS) score, Neck Disability Index (NDI), distance to anterior arch fracture (DAAF), distance to posterior arch fracture (DPAF), lateral mass displacement (LMD), Redlund-Johnell value, postoperative complications, and fracture healing rate were retrospectively collected and statistically analyzed. Results: Compared with that in the PSR group, the bleeding volume in the JeRP group was lower, and the length of hospital stay was longer. The VAS scores and NDIs of both groups were significantly improved after surgery. The postoperative DAAF and DPAF were significantly smaller after surgery in both groups. Compared with the significantly shorter DPAF in the PSR group, the JeRP group had a smaller DAAF, shorter LMDs and larger RedlundJohnell value postoperatively and at the final follow-up. The fracture healing rate at 3 months after surgery was significantly greater in the JeRP group (p < 0.05). Conclusion: Both C1-ring osteosynthesis procedures for treating unstable atlas fractures yield satisfactory clinical outcomes. Transoral anterior JeRP fixation is more effective than PSR fixation for holistic fracture reduction and short-term fracture healing, but the hospital stay is longer.
Ai Kexin,Chen Mu,Liang Zhao,Ding Xiangyang,Gao Yang,Zhang Honghao,Wu Suwan,He Yanjie,Li Yuhua 한국응용약물학회 2024 Biomolecules & Therapeutics(구 응용약물학회지) Vol.32 No.5
Tyrosine kinase inhibitors (TKIs) have revolutionized the treatment landscape for chronic myeloid leukemia (CML). However, TKI resistance poses a significant challenge, leading to treatment failure and disease progression. Resistance mechanisms include both BCR::ABL1-dependent and BCR::ABL1-independent pathways. The mechanisms underlying BCR::ABL1 independence remain incompletely understood, with CML cells potentially activating alternative signaling pathways, including the AKT/mTOR and JAK2/STAT5 pathways, to compensate for the loss of BCR::ABL1 kinase activity. This study explored tumoral VISTA (encoded by VSIR) as a contributing factor to TKI resistance in CML patients and identified elevated tumoral VISTA levels as a marker of resistance and poor survival. Through in vitro and in vivo analyses, we demonstrated that VSIR knockdown and the application of NSC-622608, a novel VISTA inhibitor, significantly impeded CML cell proliferation and induced apoptosis by attenuating the AKT/ mTOR and JAK2/STAT5 pathways, which are crucial for CML cell survival independent of BCR::ABL1 kinase activity. Moreover, VSIR overexpression promoted TKI resistance in CML cells. Importantly, the synergistic effect of NSC-622608 with TKIs offers a potent therapeutic avenue against both imatinib-sensitive and imatinib-resistant CML cells, including those harboring the challenging T315I mutation. Our findings highlight the role of tumoral VISTA in mediating TKI resistance in CML, suggesting that inhibition of VISTA, particularly in combination with TKIs, is an innovative approach to enhancing treatment outcomes in CML patients, irrespective of BCR::ABL1 mutation status. This study not only identified a new pathway contributing to TKI resistance but also revealed the possibility of targeting tumoral VISTA as a means of overcoming this significant clinical challenge.
Qiang Liu,Zhaohui Meng,Ronghui Wu,Liyun Ma,Wu Qiu,Honghao Zhang,Shuihong Zhu,Lingqing Kong,Zijjie Xu,Aniruddha Patil,Xiangyang Liu 한국섬유공학회 2019 Fibers and polymers Vol.20 No.10
In this work, regenerated silk fibroin (RSF) and silicon dioxide (SiO2) composite fiber was successfully extrudedby wet spinning method. The effect of SiO2 addition on structure of the composite fiber at microscopic level is studied, whichsubsequently correlated to the mechanical performance. The best concentration ratio for composite fiber is identified byscreening SiO2 concentration from 0.025 w/w% to 0.5 w/w%. The experimental results revealed that the SiO2 at a lowconcentration of 0.1 w/w% was well distributed. The breaking stress, breaking strain and Young’s modulus at 0.1 w/w% SiO2addition of the RSF fibers increased considerably compared to the neat RSF fibers from 243±3 to 458±21 MPa, 51±4 % to54±7 % and 6.34±0.55 to 11.69±1.12 GPa, respectively. To the best of our knowledge, this is the first report for RSF/SiO2composite fiber. We believed the insight provided in this report which looks into the structural evolution should be beneficialto the future design and building of other advanced functional fibers.
Linxiao Chen,Wei Xia,Jinxing Song,Mengqi Wu,Zhizhen Xu,Xiangyang Hu,Wenqing Zhang 한국식물학회 2020 Journal of Plant Biology Vol.63 No.4
Due to global warming, high temperature has become the main abiotic stress affecting plant growth worldwide. LysM-containing receptor-like kinase 4 (LYK4) is the receptor for chitin, and ERECTA(ER) is a key factor in plant tolerance to high temperature. In this study, we constructed a chitin-induced chimeric LYK4-ER gene, in which the extracellular region and transmembrane domain of the LYK4 gene are fused with the intracellular region of the ER gene. Colony PCR, RT-PCR and western blot analyses of LYK4-ER transcription in plants, confirmed that the LYK4-ER gene was successfully constructed and transferred into Arabidopsis. The LYK4-ER gene localized to the cytomembrane and cytoplasm in vivo because of the binding properties of the transmembrane domain of the LYK4-ER gene to the cell membrane. The transgenic plants showed a higher germination rate and germination index as well as a shorter mean germination time than the wild-type plants, indicating that the LYK4-ER gene increases the heat tolerance of Arabidopsis. The lower H2O2 content and relative electrolytic leakage of the transgenic plants showed that the status of these plants under heat stress was improved. UPLC-MS/MS was used to analyze the phytohormones content, which suggested that the transgenic plants exhibited improved heat tolerance through jasmonic acid signal transduction pathways.
Yanmin Zou,Zhen Zhang,Xiaoling Shao,Yao Chen,Xiangyang Wu,Liuqing Yang,Jingjing Zhu,Dongmei Zhang 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.2
A novel three-phase hollow fiber liquid phase microextraction was developed for the determination of malachite green (MG) in environmental waters, which selected [BMIM][PF6] mixed with 1% trioctylphosphine oxide (TOPO) as supported phase. Several parameters (accepter phase pH, sample pH, supported phase membrane, volume of accepter phase, salinity, extraction time) that could affect extraction performance were investigated. Under the optimal extraction conditions, the established approach showed excellent characters as: high enrichment factor (212), wide linear range (0.20-100 μg L-1), low detection limit (0.01 μg L-1), good reproducibility (RSD, 8.9%, n=5) and satisfactory recovery (84.0-106.2%). The method was applied to detect MG at Yangtze River and pond waters in Zhenjiang, Jiangsu province, and 4 sites among 15 sampling sites were found MG with the concentration of 1.73-11.06 μg L-1, which confirmed that the proposed environmentally friendly method was simple and effective for monitoring MG in aquatic system.