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A case of pressure blister after using air mesh cool mat
( Won-oh Kim ),( Jin-woong Jung ),( Jae-we Cho ),( Young-wook Ryoo ),( Sung-ae Kim ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Air mesh cool mat is consisted of holes in grid structure that allows the wind passes through and cools the user. 54-year-old man presented with asymptomatic erythematous regular and circular grouped vesicles on right trunk. The lesions were found when he woke up at morning after sleeping on the air mesh cool mat for the first time. He didn’t drink alcohol or take any medicine before sleep. Skin biopsy showed separated epidermis and no specific finding on dermis. Eosinophilic fluid and erythrocytes were found in the vesicle. Aspiration of blister, normal saline wet dressing and antibiotic ointment improved the lesions in a week. In this case, it is very likely that the pressure of body weight applied during sleep push the skin into the holes of mesh and caused the lesion. Long-term pressure on the soft tissue can cause blistering of the skin. Therefore, caution should be taken when using the air mesh cool mat for a long time while touching the skin directly in the summer, and it is considered necessary to insert a warning phrase in the product manual.
( Won Oh Kim ),( Han Byul Kim ),( Eu Gene Han ),( Nan Hee Cho ),( Mi Sun Choi ),( Ho Chan Cho ),( Sung Ae Kim ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2
Background: With the increase in the prevalence of diabetic foot ulcer (DFU), the demand for optimal treatment and management strategies has risen too. Objectives: Our study investigated the wound-healing effect of platelet-rich plasma (PRP) on DFU and the correlations between the various factors affecting DFU treatment. Methods: 10 diabetes patients with grade 1 DFU were treated using PRP prepared from the patients’ blood (collected using a commercial kit, MyCells Autologous Preparation kit<sup>®</sup>, Holon, Israel). The ulcer margins were biopsied before and after PRP treatment. Hematoxylin and Eosin staining and immunohistochemical staining for HIF-1α and CD31 were performed to confirm angiogenesis. Spearman’s correlation tests were performed to determine the correlations between the treatment period and various clinical factors. Results: The mean PRP treatment period was 29.4 days. PRP was administered a mean of 3 (1-6) times. The time taken for a 50% reduction in the wound area was 16 days. Among the clinical factors, the presence of calluses in the lesion prolonged the pretreatment period, and significantly reduced the duration of PRP treatment. After PRP treatment, on CD31 staining, the number of endothelial cells was significantly increased. However, on HIF-1α, there was no significant difference. Conclusion: We found that PRP can contribute to wound regeneration through neovascularization. PRP therapy, with various growth factors, is expected to be another treatment option for DFUs.
Cho, Min-Chul,Kim, Jin Hyun,Jung, Myeong Hee,Cho, In Ae,Jo, Hyen Chul,Shin, Jeong Kyu,Lee, Soon Ae,Choi, Won Jun,Lee, Jong Hak The Korean Society for Reproductive Medicine 2019 Clinical and Experimental Reproductive Medicine Vol.46 No.3
Objective: Vitamin D-binding protein (VDBP) mediates various biological processes in humans. The goal of this study was to investigate whether VDBP gene polymorphisms could predispose Korean women to endometriosis. Methods: We prospectively enrolled women with endometriosis (n = 16) and healthy controls (n = 16). Total serum 25-hydroxyl vitamin D (25(OH)D) concentrations were measured using an Elecsys vitamin D total kit. Levels of bioavailable and free 25(OH)D were calculated. Concentrations of VDBP were measured using a vitamin D BP Quantikine ELISA kit. DNA was extracted using a DNeasy blood & tissue kit. Two single-nucleotide polymorphisms (SNPs; rs4588 and rs7041) in GC, the gene that codes for VDBP, were analyzed using a TaqMan SNP genotyping assay kit. The functional variant of VDBP was determined based on the results of the two SNPs. Results: Gravidity and parity were significantly lower in the endometriosis patients than in the control group, but serum CA-125 levels and the erythrocyte sedimentation rate were significantly higher. Total serum 25(OH)D levels in the endometriosis patients were significantly lower than in the control group. However, serum bioavailable 25(OH)D, free 25(OH)D, and VDBP levels did not differ significantly between the endometriosis and control groups. The genotypes and allele frequencies of GC were similar in both groups. Conclusion: Korean women with endometriosis had lower total serum 25(OH)D concentrations than controls. Neither serum VDBP concentrations nor polymorphisms in the gene coding for VDBP were associated with endometriosis. Further studies are needed to investigate the pathophysiology and clinical implications of 25(OH)D and VDBP in endometriosis.
Cho, In Ae,Lee, Yeon Jee,Lee, Hee Jung,Choi, In Young,Shin, Jeong Kyu,Lee, Soon Ae,Lee, Jong Hak,Choi, Won Jun The Korean Society for Reproductive Medicine 2018 Clinical and Experimental Reproductive Medicine Vol.45 No.3
Objective: The favored method of preserving fertility in young female cancer survivors is cryopreservation and autotransplantation of ovarian tissue. Reducing hypoxia until angiogenesis takes place is essential for the survival of transplanted ovarian tissue. The aim of this study was to investigate the role of angiopoietin-1 (Angpt-1), angiopoietin-2 (Angpt-2), and vascular endothelial growth factor (VEGF) in ovarian tissue grafts that were cryopreserved using two methods. Methods: Ovarian tissues harvested from ICR mice were divided into three groups: group I (control), no cryopreservation; group II, vitrification in EFS (ethylene-glycol, ficoll, and sucrose solution)-40; and group III, slow freezing in dimethyl sulfoxide. We extracted mRNA for VEGF, Angpt-1, and Angpt-2 from ovarian tissue 1 week following cryopreservation and again 2 weeks after autotransplantation. We used reverse transcriptase-polymerase chain reaction to quantify the levels of VEGF, Angpt-1, and Angpt-2 in the tissue. Results: Angpt-1 and Angpt-2 expression decreased after cryopreservation in groups II and III. After autotransplantation, Angpt-1 and Angpt-2 expression in ovarian tissue showed different trends. Angpt-1 expression in groups II and III was lower than in group I, but Angpt-2 in groups II and III showed no significant difference from group I. The vitrified ovarian tissues had higher expression of VEGF and Angpt-2 than the slow-frozen ovarian tissues, but the difference was not statistically significant. Conclusion: Our results indicate that Angpt-2 may play an important role in ovarian tissue transplantation after cryopreservation although further studies are needed to understand its exact function.
Cho, In Ae,Park, Ji Kwon,Baek, Jong Chul,Ha, A Na,Kang, Min Young,Lee, Jae Ik,Park, Ji Eun,Shin, Jeong Kyu,Choi, Won Jun,Lee, Soon Ae,Lee, Jong Hak,Paik, Won Young Korean Society of Medical Genetics and Genomics 2015 대한의학유전학회지 Vol.12 No.2
Distal limb deformities are congenital malformations with phenotypic variability and high genetic heterogeneity. Split hand/foot malformation, also known as ectrodactyly, is a congenital limb malformation characterized by a defect of the central rays of the hands and/or feet. Split hand/foot malformation with long-bone deficiency (SHFLD) is a rare condition related to a 17p13.3 duplication. Recently, genomic duplications encompassing BHLHA9 have been associated with SHFLD. We report a case of SHFLD presenting with campomelia of the right femur, bilateral agenesis of fibulae, bilateral club feet, and oligosyndactyly of the hands and feet, that was associated with a 17p13.3 duplication, as determined prenatally using array comparative genomic hybridization.