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( Sang-Cheol Bae ),( Jin-Hye Cha ),( Jung-Yoon Choe ),( Sung Jae Choi ),( Soo-Kyung Cho ),( Won-Tae Chung ),( Chung-Il Joung ),( Young-Ok Jung ),( Young Mo Kang ),( Dong-Wook Kim ),( Jinseok Kim ),( Y 대한류마티스학회 2018 대한류마티스학회지 Vol.25 No.2
Objective. Productivity loss was compared by 3-stage of disease activity and associations between higher disease activity and high productivity loss were identified. Methods. Data were extracted from Rheumatoid Arthritis (RA) Patient-reported Outcomes Research, which enrolled 2,000 RA patients (>20-year) on disease-modifying-antirheumatic-drugs (DMARDs) (≥ 6-month) from December 2012 to June 2013. This included 1,457 RA patients with the disease activity score (DAS-28-ESR) in their medical charts. Productivity loss in time and indirect cost was estimated using The World Health Organization Health and Work Performance Questionnaire (HPQ). Baseline characteristics and productivity loss outcomes were compared according to DAS-28-ESR groups. Results. 84.4% were females, 54.2% had low DAS-28-ESR (<3.2), and 38.2% and 7.6% had moderate (3.2∼5.1) and high DAS-28-ESR (>5.1). Patients with moderate to high DAS-28-ESR had higher lost productivity time (LPT) and monthly costs of LPT than those with low DAS-28-ESR (time in hours: 110.0±58.4 vs. 132.4±57.2 vs. 71.5±52.0, p<0.0001; monthly costs of LPT in 1,000 Korean won: 1,097±607 vs. 1,302±554 vs. 741±531, p<0.0001). Multiple regression analyses revealed significant associations with high LPT in high (adjusted odds ratio [OR]=3.87, 95% confidence interval [CI]: 2.18∼6.87) and moderate DAS-28-ESR (adjusted OR=1.88, 95% CI: 1.41∼2.52) compared to low DAS-28-ESR. In addition, positive associations with high monthly costs of LPT were observed in high (adjusted OR=3.45, 95% CI: 1.98∼5.99) and moderate DAS-28-ESR (adjusted OR=1.93, 95% CI: 1.43∼2.54) compared to low DAS-28-ESR. Conclusion. Timely therapeutic strategies should be taken into consideration given that the RA patients with moderate to high DAS-28-ESR showed strong associations with high productivity loss for effective management of RA. (J Rheum Dis 2018;25:122-130)
Yoon, Hyun Jung,Chung, Myung Jin,Lee, Kyung Soo,Kim, Jung Soo,Park, Hye Yun,Koh, Won-Jung The Korean Society of Radiology 2016 KOREAN JOURNAL OF RADIOLOGY Vol.17 No.2
<P><B>Objective</B></P><P>To determine the patho-mechanism of pleural effusion or hydropneumothorax in <I>Mycobacterium avium</I> complex (MAC) lung disease through the computed tomographic (CT) findings.</P><P><B>Materials and Methods</B></P><P>We retrospectively collected data from 5 patients who had pleural fluid samples that were culture-positive for MAC between January 2001 and December 2013. The clinical findings were investigated and the radiological findings on chest CT were reviewed by 2 radiologists.</P><P><B>Results</B></P><P>The 5 patients were all male with a median age of 77 and all had underlying comorbid conditions. Pleural fluid analysis revealed a wide range of white blood cell counts (410–100690/µL). The causative microorganisms were determined as <I>Mycobacterium avium</I> and <I>Mycobacterium intracellulare</I> in 1 and 4 patients, respectively. Radiologically, the peripheral portion of the involved lung demonstrated fibro-bullous changes or cavitary lesions causing lung destruction, reflecting the chronic, insidious nature of MAC lung disease. All patients had broncho-pleural fistulas (BPFs) and pneumothorax was accompanied with pleural effusion.</P><P><B>Conclusion</B></P><P>In patients with underlying MAC lung disease who present with pleural effusion, the presence of BPFs and pleural air on CT imaging are indicative that spread of MAC infection is the cause of the effusion.</P>
( Chung Hyun Tae ),( Hey In Kim ),( Min Sun Rye ),( Kwang Jin Woo ),( Jeong Mi Lee ),( Hey Won Yoon ),( Chage Mo Moon ),( Seong Eun Kim ),( Hye Kyung Jung ),( Sung Ae Jung ),( Min Sun Cho ),( Ki Nam S 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Extracellular Ca2+ have previously been shown to regulate the growth of colon cancer and act as chemopreventive agents. Furthermore, Ca2+ signaling is presumed to be involved in various tumorigenic pathways. This study was performed to determine CaSR expression levels in gastric cancer and to examine the related clinicopathological factors. Methods: Forty-eight paired samples comprising gastric cancer tissues and the matched normal tissues were obtained from surgical specimens after gastrectomy. The CaSR mRNA and protein expression levels were measured using real-time polymerase chain reaction and Western blotting, respectively. Immunohistochemistry was used to evaluate the expression of CaSR in both tissues. The results obtained were classifi ed into 3 groups according to the following expression grades: 0 (lower CaSR expression in the cancer tissue), 1 (similar levels of CaSR expression in both tissues), and 2 (greater CaSR expression in the cancer tissue). Results: In 67.5% and 60.0% of gastric cancers, the CaSR mRNA and protein expression levels were lower than that in normal tissues. Immunohistochemical staining demonstrated that the expression levels of CaSR in gastric cancer tissues were similarly (grade 1; 50.0%) or lower (grade 0; 29.2%) than that in normal tissues. The CaSR mRNA levels was signifi cantly lower in gastric cancer tissues with a higher T stage (p = 0.035) and perineural invasion (p = 0.044). However, there was no signifi cant relationship between CaSR expression and other clinicopathological factors, i.e., age, sex, serum Ca2+ concentration, differentiation, Lauren`s classifi cation, size, LN involvement, distant metastasis, and venous and lymphatic invasion. Conclusions: The low CaSR expression is associated with the depth invasion and perineural invasion of gastric cancer. Although further studies are needed to clarify the role of CaSR, the present study provides new insights into the pathogenesis and progression of gastric cancers.
Yoon, Jin Sun,Hwang, Deok Won,Kim, Eun Shil,Kim, Jung Soon,Kim, Sujong,Chung, Hwa Jin,Lee, Sang Kook,Yi, Jun Ho,Uhm, Jieun,Won, Young Woong,Park, Byeong Bae,Choi, Jung Hye,Lee, Young Yiul Springer-Verlag 2016 Investigational new drugs Vol.34 No.1
<P>Arsenic compounds have been used in traditional medicine for several centuries. KML001 (sodium metaarsenite; NaAsO2) is an orally bio-available arsenic compound with potential anti-cancer activity. However, the effect of KML001 has not been studied in lymphoid neoplasms. The aim of this study is to evaluate the anti-proliferative effect of KML001 in non-Hodgkin's lymphoma and to compare its efficacy with As2O3. KML001 inhibited cellular proliferation in all tested lymphoma cell lines as well as JurkatR cells (adriamycin-resistant Jurkat cells) in a dose-dependent manner, while As2O3 was not effective. Cell cycle regulatory protein studies have suggested that KML001 induces G1 arrest via p27-induced inhibition of the kinase activities of CDK2, 4, and 6. Treatment of KML001 induced apoptosis in Jurkat and JurkatR cells. The apoptotic process was associated with down-regulation of Bcl-2 (antiapoptotic molecule), up-regulation of Bax (proapoptotic molecule), and inhibition of caspase-3, -8, and -9. In addition, cell signaling including the STAT, PI3K/Akt, MAPK, and NF-kappa B signal pathways were inhibited in KML001-treated Jurkat and JurkatR cells. Furthermore, targeting the telomere by KML001 was observed in the Jurkat and JurkatR cells. The In vivo anti-tumoral activity of KML001 was confirmed in a xenograft murine model. Interestingly, partial responses were seen in two lymphoma patients treated with 10 mg/day (follicular lymphoma for 16 weeks and mantle cell lymphoma for 24 weeks) without severe toxicities. These findings suggest that KML001 may be a candidate agent for the treatment of de novo, refractory, and relapsed non-Hodgkin's lymphoma patients.</P>
Circadian Rhythm of Surfactant Protein A, B and C mRNA in Rats
( Chung Mi Kim ),( Jang Won Sohn ),( Ho Joo Yoon ),( Dong Ho Shin ),( Sung Soo Park ) 대한내과학회 2003 The Korean Journal of Internal Medicine Vol.18 No.2
Background: All organisms have developed an internal timing system capable of reacting to and anticipating environmental stimuli with a program of appropriately timed metabolic, physiologic and behavioral events. The alveolar epithelial type II cell of th