Political and Economic Situations of the Commonwealth of Independent States and Confronting Tasks of Koreans

Yoon,In-Jin/Jang,Won-Chang/Lee,Kwang-Kyu/Rhee,Jong-Hoon/Sim,Heon-Yong 고려대학교 아세아문제연구소 2001 亞細亞硏究 Vol.44 No.2

Growth Inhibition of Colon Cancer through Inactivation of STAT3 Pathway by IL-10 and IL-1ra Released from Murine Macrophage

Jin Tae Hong, Dohee Won1, Mi Hee Park, Sun Mi Kown, Miran Jo, Sang-Yoon Nam, Beom Jun Lee, Young Won Yun, Ki-Wan Oh, Sang Bae Han 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.4

The objective of this study was to determine the effect of macrophages on growth of human colon cancer cells. The results showed that co-culture of colon cancer cells with macrophages inhibited the growth of colon cancer cells (HCT116 and SW620) depending on the number of macrophages, RAW 264.7 cells, and activated THP-1 cells accompanied by down regulation of pSTAT3 in cancer cells. We also found that expression and release of cancer cell growth inhibitory cytokines, IL-1 receptor antagonist (IL-1ra) and IL-10, was increased in macrophages. Blocking of the STAT3 pathway with specific inhibitor and siRNA of STAT3 abolished the growth of colon cancer cells and expression of IL-1ra and IL-10. In addition, neutralization of IL-1ra and IL-10 with antibodies resulted in reversal of macrophage-induced inhibition of cancer cell growth. These data showed that IL-1ra and IL-10 released from macrophages inhibit growth of colon cancer cells through inhibition of the STAT3 pathway

국내 정형외과 의료소송 현황 파악

이원(Won Lee),이미진(Mi Jin Lee),김용민(Yong Min Kim),우찬명(Chan Myung Woo),김소윤(So Yoon Kim),김양수(Yang-Soo Kim) 대한정형외과학회 2016 대한정형외과학회지 Vol.51 No.3

목적: 국내 정형외과 관련 의료소송 판결문의 분석을 통하여 정형외과 의료소송의 현황과 원인이 된 과정을 파악하고자 함이다. 대상 및 방법: 소송시작이 2005년부터 2010년인 정형외과 의료소송 판결문 341건을 대상으로 하여 빈도분석을 실시하였다. 결과: 사건 발생 시점에서 소송 종결 시점까지의 평균 소요기간은 4.22년이었다. 의료소송의 원인이 된 과정은 수술이 46.3%였고, 수술의 종류는 척추 수술이 가장 많았다. 사고의 결과는 장애가 가장 많았고, 최종심 결과는 원고일부승이 40.5%, 원고패(기각)가 34.3%였다. 감염은 전체 중 26.1%에서 발생하였고, 손해배상 청구금액은 평균 181,998,036원이었으며 인용금액은 평균 58,897,161원이었다. 결론: 정형외과 의료소송으로 이어진 의료사고의 주요 원인 과정은 수술이 가장 많았고, 그 중에서도 척추 수술이 가장 많았다. 추후 의료사고의 근본 원인분석을 통해 의료사고를 줄이고 재발을 방지하기 위한 후속 연구가 이루어져야 할 것이다. Purpose: Through the analysis of orthopedics lawsuit rulings, the purpose of this study is to understand the current trends of medical lawsuits in orthopedics in Korea. Materials and Methods: An analysis of medical lawsuits in orthopedics was conducted. As the study method, a quantitative analysis was performed on 341 cases. Results: The average period of lawsuits, from the occurrence of the medical accident to end of the ruling, took an average of 4.22 years. The most frequent procedure that was the main cause of the medical accidents was surgery, at 46.3%. When surgery is the main procedure that caused the medical accidents, the result of examining the types of surgeries showed that spine surgery had the highest percentage. For the outcome of the accident, the highest number of cases resulted in disability and for the final court outcome, 40.5% ruled partially in favor of the plaintiff (the patient) with acknowledgement of only the damage incurred due to medical error of the total sum claimed, and dismissal of the claim made by the plaintiff (patient) accounted for 34.3%; 26.1% of cases develop infection. For the amount of claim for damage, the average amount of claim was 181,998,036 won; in the judgement amount, the average amount of judgement was 58,897,161 won. Conclusion: The most frequent procedure in orthopedics was surgery and spine surgery comprised a large proportion of these surgeries. Future studies to determine root causes of medical accidents should be conducted to reduce medical lawsuits and to plan against the repeating of medical accidents.

온수배관을 이용한 온실의 난방성능

윤용철(Yong Cheol Yoon),신익수(Yik Soo Shin),김현태(Hyeon Tae Kim),배승범(Seoung Beom Bae),최진식(Jin Sik Choi),서원명(Won Myung Suh) (사)한국생물환경조절학회 2012 생물환경조절학회지 Vol.21 No.2

본 연구는 온실의 난방 에너지 절감을 목적으로 온실 내부에 알루미늄 온수배관을 설치하여 난방효과에 대한 기초자료를 구축하고자 수행되었다. 그 연구결과를 요약하면 다음과 같다. 전체 실험을 포함하여 온실내의 높이별 온도편차는 4.0~7.0℃ 정도의 범위로서 그 차이가 크게 나타났다. 팬코일유니트(FCU)를 작동시킨 경우가 작동시키지 않은 경우에 비해 유출입수의 온도차가 3.3℃ 정도 크고, 소비전력량은 36.2~40.1% 정도 증가하였으며, 시간당 방열량은 44.6~52.0% 정도 증가하는 것으로 나타났다. 실험기간동안 순환유량은 0.48~0.49L · s<SUP>?1</SUP> 정도의 범위에 있었고, 평균유속은 1.53~1.56m · s<SUP>?1</SUP> 정도였다. 유출입수의 평균 온도차는 6.24~11.50℃이었다. 최저 외기온 ?14.0~?0.6℃ 범위에서 설정온도별 방열량은 135,930~307,150㎉ 정도의 범위로서 시간당 9,610~19,630㎉ · h<SUP>?1</SUP> 정도의 범위에 있었다. 이것은 최대난방부하의 약 23~53% 정도의 난방에너지를 공급할 수 있을 것으로 나타났다. 전체 방열량과 소비전력량은 각각 2,548,306㎉ 및 3,075.7㎾h이다. 화석연료인 경유로 난방할 경우, 소요되는 경유의 총 소비량은 281.6L 정도이고 비용은 321,000won인 것으로 나타났다. 농가용 전력요금을 적용하면 전력사용에 대한 총비용은 110,730won 정도로서 경유 소비 비용의 33.5% 정도로 나타났다. 실험구의 온도가 대조구보다 약 8.3~14.6℃ 정도 높게 나타났다. This research was conducted to obtain basic data with regard to the heating performance that would be produced by installing an aluminum hot water pipe inside the greenhouse with the goal of reducing the heating energy in greenhouse. The research results are summarized as follows. The degree of difference in relation to the temperature by height within the greenhouse during the entire experiment was significant - within the range of 4.0~7.0℃. The temperature difference between incoming and outgoing water was about 3.3℃ greater when FCU was activated compared to when it was not activated. Meanwhile, the amount of energy consumed increased about 36.2~40.1%. The amount of pyrexia per hour also increased by 44.6~52.0%. During the experiment period, circulated flux was within the range of 0.48~0.49 L · s<SUP>?1</SUP> while average fluid speed was 1.53~1.56 m · s<SUP>?1</SUP>. The average temperature difference between incoming and outgoing water was 6.24~11.50℃. The amount of heating value by each set temperature within the minimum outdoor temperature range of ?14.0~?0.6℃ was 135,930~307,150 ㎉, and the range was within the 9,610~19,630 ㎉ · h<SUP>?1</SUP> per hour. This demonstrated that about 23~53% heating energy of the maximum heating load could be supplied. Total radiating value and amount of energy consumed were 2,548,306 ㎉ and 3,075.7 ㎾h, respectively. When heating takes place using oil, which is a fossil fuel, the total amount of light oil consumed was 281.6 L while the cost was 321,000 won. When the electricity cost for farms is applied, the total cost was about 110,730 won, which is about 33.5% of the cost required compared to oil consumption. The temperature at in the experiment area was about 8.3~14.6℃ higher compared to that of the control area.

Productivity Loss of Rheumatoid Arthritis Patients according to the Their Stages of the Disease Activity Score

( Sang-Cheol Bae ),( Jin-Hye Cha ),( Jung-Yoon Choe ),( Sung Jae Choi ),( Soo-Kyung Cho ),( Won-Tae Chung ),( Chung-Il Joung ),( Young-Ok Jung ),( Young Mo Kang ),( Dong-Wook Kim ),( Jinseok Kim ),( Y 대한류마티스학회 2018 대한류마티스학회지 Vol.25 No.2

Objective. Productivity loss was compared by 3-stage of disease activity and associations between higher disease activity and high productivity loss were identified. Methods. Data were extracted from Rheumatoid Arthritis (RA) Patient-reported Outcomes Research, which enrolled 2,000 RA patients (>20-year) on disease-modifying-antirheumatic-drugs (DMARDs) (≥ 6-month) from December 2012 to June 2013. This included 1,457 RA patients with the disease activity score (DAS-28-ESR) in their medical charts. Productivity loss in time and indirect cost was estimated using The World Health Organization Health and Work Performance Questionnaire (HPQ). Baseline characteristics and productivity loss outcomes were compared according to DAS-28-ESR groups. Results. 84.4% were females, 54.2% had low DAS-28-ESR (<3.2), and 38.2% and 7.6% had moderate (3.2∼5.1) and high DAS-28-ESR (>5.1). Patients with moderate to high DAS-28-ESR had higher lost productivity time (LPT) and monthly costs of LPT than those with low DAS-28-ESR (time in hours: 110.0±58.4 vs. 132.4±57.2 vs. 71.5±52.0, p<0.0001; monthly costs of LPT in 1,000 Korean won: 1,097±607 vs. 1,302±554 vs. 741±531, p<0.0001). Multiple regression analyses revealed significant associations with high LPT in high (adjusted odds ratio [OR]=3.87, 95% confidence interval [CI]: 2.18∼6.87) and moderate DAS-28-ESR (adjusted OR=1.88, 95% CI: 1.41∼2.52) compared to low DAS-28-ESR. In addition, positive associations with high monthly costs of LPT were observed in high (adjusted OR=3.45, 95% CI: 1.98∼5.99) and moderate DAS-28-ESR (adjusted OR=1.93, 95% CI: 1.43∼2.54) compared to low DAS-28-ESR. Conclusion. Timely therapeutic strategies should be taken into consideration given that the RA patients with moderate to high DAS-28-ESR showed strong associations with high productivity loss for effective management of RA. (J Rheum Dis 2018;25:122-130)

Epidemiological Aspects and Trends of the Extensive Eradication Programs for Bovine Brucellosis Outbreaks-Associated Human Brucellosis in Korea, 2002~2013

Won-Chang Lee,Hachung Yoon,Myeong-Jin Lee,Young Hwan Kwon 한국항공우주의학협회 2019 항공우주의학회지 Vol.29 No.2

Fever, Skin Eruptions, Leukocytosis-and Sudden Visual Loss

( Yoon Jin Choi ),( Sang Ho Oh ),( Won Kyung Song ),( Sung Chul Lee ),( Dong Sik Bang ) 대한피부과학회 2008 초록집 Vol.46 No.10

Telomerase Reverse Transcriptase Gene Alterations and Disease-Promoting Properties of Hepatocellular Carcinoma

( Jin Seoub Kim ),( Hye Seon Kim ),( Hee Chul Nam ),( Pil Soo Sung ),( Si Hyun Bae ),( Jong Young Choi ),( Seung Kew Yoon ),( Jeong Won Jang ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: Telomerase reverse transcriptase (TERT) was recently identified as a gatekeeper driver gene with a fundamental role in multi-step hepatocarcinogenesis. This study aimed to investigate the tumor-promoting effects of TERT interaction gene set and genomic alterations in hepatocellular carcinoma (HCC). Methods: A total of 239 biopsy-proven HCC samples were analyzed for the study. Protein-protein interaction (PPI) networks through the STRING database were performed to establish a set of interacting genes with TERT. The expression of the selected gene set, TERT, and telomere length were examined by qRT-PCR. TERT promoter mutations were assessed using Sanger sequencing. Integration of hepatitis B virus (HBV) was examined using the NGS-based probe capture assay. The data were correlated with outcomes of HCC patients. Results: The PPI networks identified eight key TERT-interaction gene sets, such as CCT5, TUBA1B, mTOR, RPS6KB1, AKT1, WHAZ, YWHAQ, and TERT. Among these, TERT was the most significant differentially expressed gene, with its significantly higher expression in the tumor than non-tumor tissues. The high expression of TERT was correlated with tumor size and HCC stage progression. TERT expression and telomere lengths were positively correlated in patients with HBV-HCC invading portal vein. Together with telomere length, the presence of C228T, the hot spot mutation in the TERT promoter, as well as HBV integration resulted in a higher expression of TERT, with enhanced expression with the presence of both TERT promoter mutation and HBV integration. Patients with high TERT expression had significantly higher rates of recurrence and worse progression- free survival than those with low TERT expression. Conclusions: TERT gene alterations and expression are involved in hepatocarcinogenesis and the clinical outcomes of HCC, in terms of the development, recurrence, and disease progression. TERT pathway might serve as a potential therapeutic target for HCC.

The Effect of the Class Stress on Help-Seeking Behaviors and Class Effort by Basic Instructional Dance Participants

( Won Ho Cho ),( Yong Jin Yoon ) 한국체육학회 2015 국제스포츠과학 학술대회 Vol.2015 No.1

Purpose: The purpose of this paper is to investigate the effect of the class stress on help-seeking behavior and class efforts by Basic Instructional Dance Participants. he main cause of stress for most college students is a direct result of psychological and physical factors. In this study we will focus specifically on "Basic Instructional Dance," which is a dance class that can include practical assessments, practical skills, injury, etc and thus cause a high degree of stress. Such stress can have a negative impact on that need for help-seeking behaviors, such as factors in efforts to involve student teaching. These elements of stress can also inhibit learning. Through this study, we propose a lesson plan for stress relief to improve learning and students` help-seeking behaviors. Method: As a measurement tool, a questionnaire study was used. There were 34 questions and they were about demographic characteristics, class stress, help-seeking behavior, and class effort. The participants in this study were those who attended the basic instructional dance classes at Y, E, H, S, D universities in Seoul. A total of 350 copies of the questionnaire were distributed to university dance participants during the period of time from March 5, 2015 to May 20, 2015. Out of 350 questionnaires, 315 questionnaires were used for the actual analysis. The data were analyzed using SPSS for frequency analysis, correlation analysis and reliability analysis. Through AMOS program, confirmatory factor analysis and structural equation modeling were conducted. Result: First, course content, teaching methods, classroom environment in the classroom stress had negative effect on help-seeking behaviors Second, course content, teaching methods, classroom environment in the classroom stress had negative effect on class effort. Third, help-seeking behaviors had significant effect on class effort. Conclusion: Firstly, course content, teaching methods, classroom environment as well as the classroom stress has negative effect on help-seeking behaviors and class effort. In other words, the problem of classroom cleanliness, class content and lessons that does not meet the student`s learning level can hinder student participation in class. Because dance professors understand the intent and direction of students they can adjust the lessons based on their learning level. Thus, we conclude there is a need to conduct lessons using a variety of organizational skills as well as a need for cleanliness in the class location. Secondly, help-seeking behaviors had significant effect on class effort. It can be said that the cause pay more efforts to participate in the lessons and solve problems that occur during school students with the help seeking behaviors. Accordingly dance professors should strive to make students more involved in the lesson by enhancing the understanding and focusing on teaching through practical and easy explanations and repetitive behavior for help-seeking students.

UV-induced Accumulation of Ceramide Mediates Matrix Metalloproteinase-1 Expression in Human Dermal Fibroblasts

( Yoon Kyung Kim ),( Sang Min Kim ),( Dong Hun Lee ),( Chong Won Choi ),( Jin Ho Chung ) 대한피부과학회 2007 대한피부과학회 학술발표대회집 Vol.59 No.2