ILBA: An Improved Bat Algorithm with Inertia Weight Factor and Lévy Flight

Ma weifeng,Shi Hao,Sun Xiaoyong 보안공학연구지원센터 2016 International Journal of Multimedia and Ubiquitous Vol.11 No.10

Aiming at such shortcomings of traditional Bat algorithm as low precision convergence, premature convergence, slow convergence, an improved BA based on inertia weight factor and Lévy flight (ILBA) has been proposed, which has made two modifications on update equations of bat flying position in BA, using inertia weight factor to keep the flight inertia of bat individual, adaptively adjust the exploitation mechanism of the algorithm in different iteration periods, make the algorithm achieve better convergence precision and altering the strategy about position update of bats from Brownian random walks into Lévy flights strategy to effectively avoid local optimism of the algorithm and guarantee its exploration mechanism while taking advantage of heavy-tailed effect of Lévy flight to speed up the convergence. By means of 4 typical test functions simulation, the results show that ILBA boasts faster convergence and superior optimal performance compared to traditional BA and LBA.

An Intelligent Framework of Oral Examination System under Network Environment and Its Application

Weifeng MA,Xiaoyong SUN 보안공학연구지원센터 2014 International Journal of Multimedia and Ubiquitous Vol.9 No.12

As a crucial step in the process of teaching and training, examination, especially oral examination, is characterized with such defects as excessive subjectivity, difficult organization, low efficiency and heavy pressure. Thus, network technology and computer technology are employed to further promote the informationization of traditional oral examination. Through analyzing the existing problems of traditional oral examination and the feasibility of oral examination under network environment, this paper puts forward a universal framework and management model for oral examination under network environment and designed an oral examination system based on digital voice technology, artificial intelligence and software engineering. The research findings have been applied to mandarin Chinese test. So far Over 10 organization users have adopted the system and more than 300,000 examinees have been tested. Viewed from the practice, expected effects have been achieved.

An Optimal ODAM-Based Broadcast Algorithm for Vehicular Ad-Hoc Networks

( Weifeng Sun ),( Feng Xia ),( Jianhua Ma ),( Tong Fu ),( Yu Sun ) 한국인터넷정보학회 2012 KSII Transactions on Internet and Information Syst Vol.6 No.12

Broadcast routing has become an important research field for vehicular ad-hoc networks (VANETs) recently. However, the packet delivery rate is generally low in existing VANET broadcast routing protocols. Therefore, the design of an appropriate broadcast protocol based on the features of VANET has become a crucial part of the development of VANET. This paper analyzes the disadvantage of existing broadcast routing protocols in VANETs, and proposes an improved algorithm (namely ODAM-C) based on the ODAM (Optimized Dissemination of Alarm Messages) protocol. The ODAM-C algorithm improves the packet delivery rate by two mechanisms based on the forwarding features of ODAM. The first distance-based mechanism reduces the possibility of packet loss by considering the angles between source nodes, forwarding nodes and receiving nodes. The second mechanism increases the redundancy of forwarding nodes to guarantee the packet success delivery ratio. We show by analysis and simulations that the proposed algorithm can improve packet delivery rate for vehicular networks compared against two widely-used existing protocols.

Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis

Zhang Weifeng,Li Gaocai,Luo Rongjin,Lei Jie,Song Yu,Wang Bingjin,Ma Liang,Liao Zhiwei,Ke Wencan,Liu Hui,Hua Wenbin,Zhao Kangcheng,Feng Xiaobo,Wu Xinghuo,Zhang Yukun,Wang Kun,Yang Cao 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-

Low back pain (LBP) is a major musculoskeletal disorder and the socioeconomic problem with a high prevalence that mainly involves intervertebral disc (IVD) degeneration, characterized by progressive nucleus pulposus (NP) cell death and the development of an inflammatory microenvironment in NP tissue. Excessively accumulated cytosolic DNA acts as a damage-associated molecular pattern (DAMP) that is monitored by the cGAS-STING axis to trigger the immune response in many degenerative diseases. NLRP3 inflammasome-dependent pyroptosis is a type of inflammatory programmed death that promotes a chronic inflammatory response and tissue degeneration. However, the relationship between the cGAS-STING axis and NLRP3 inflammasome-induced pyroptosis in the pathogenesis of IVD degeneration remains unclear. Here, we used magnetic resonance imaging (MRI) and histopathology to demonstrate that cGAS, STING, and NLRP3 are associated with the degree of IVD degeneration. Oxidative stress induced cGAS-STING axis activation and NLRP3 inflammasome-mediated pyroptosis in a STING-dependent manner in human NP cells. Interestingly, the canonical morphological and functional characteristics of mitochondrial permeability transition pore (mPTP) opening with the cytosolic escape of mitochondrial DNA (mtDNA) were observed in human NP cells under oxidative stress. Furthermore, the administration of a specific pharmacological inhibitor of mPTP and self-mtDNA cytosolic leakage effectively reduced NLRP3 inflammasome-mediated pyroptotic NP cell death and microenvironmental inflammation in vitro and degenerative progression in a rat disc needle puncture model. Collectively, these data highlight the critical roles of the cGAS-STING-NLRP3 axis and pyroptosis in the progression of IVD degeneration and provide promising therapeutic approaches for discogenic LBP.

Mechanical Thrombectomy for Refractory Cerebral Venous Sinus Thrombosis in a Child with Nephrotic Syndrome : A Case Report

Jing Ye,Yuan Yang,Weifeng Wan,Xuntai Ma,Lei Liu,Yong Liu,Zhongchun He,Zhengzhou Yuan 대한신경외과학회 2023 Journal of Korean neurosurgical society Vol.66 No.6

Nephrotic syndrome (NS) is associated with cerebral venous sinus thrombosis (CVST), which is a rare cerebrovascular disorder in children. Systemic anticoagulation with heparin is the standard therapy for CVST, and mechanical thrombectomy (MT) has been described as a salvage treatment for adult anticoagulant refractory CVST, However, it has never been reported in children. We describe a case of MT for refractory CVST in a child with NS. A 13-year-old boy with newly diagnosed NS presented to an emergency department with acute headache. A head computed tomography showed acute thrombus in the superior sagittal sinus, straight sinus and transverse sinus. The child was started on heparin therapy, but clinically deteriorated and became unresponsive. In view of the rapid deterioration of the condition after anticoagulation treatment, the patient received intravascular treatment. Several endovascular technologies, such as stent retriever and large bore suction catheter have been adopted. After endovascular treatment, the patient’s neurological condition was improved within 24 hours, and magnetic resonance venography of the head demonstrated that the CVST was reduced. The child recovered with normal neurological function at discharge. This case highlights the importance of considering MT for refractory CVST, and we suggest that MT may be considered for refractory CVST with NS in children.

Imbalance of Innate and Adaptive Immunity in Esophageal Achalasia

Lu Yao,Zuqiang Liu,Weifeng Chen,Jiaqi Xu,Xiaoyue Xu,Jiaxin Xu,Liyun Ma,Xiaoqing Li,Quanlin Li,Pinghong Zhou 대한소화기 기능성질환∙운동학회 2023 Journal of Neurogastroenterology and Motility (JNM Vol.29 No.4

Background/AimsPrevious studies reveal that immune-mediated neuroinflammation plays a key role in the etiology of esophageal achalasia. However, the understanding of leucocyte phenotype and proportion is limited. This study aim to evaluate the phenotypes of leukocytes and peripheral blood mononuclear cells transcriptomes in esophageal achalasia. MethodsWe performed high-dimensional flow cytometry to identified subsets of peripheral leukocytes, and further validated in lower esophageal sphincter histologically. RNA sequencing was applied to investigate the transcriptional changes in peripheral blood mononuclear cells of patients with achalasia. Cell-type Identification by Estimating Relative Subsets of RNA Transcripts (CIBERSORT) was used for estimating the immune cell types. A differential gene expression analysis was performed and the differential expressed genes were subjected to gene ontology, Kyoto Encyclopedia of Genes and Genomes network, protein-protein interaction network construction. ResultsAn imbalance between innate and adaptive immune cells occurred in achalasia. Specifically, neutrophils and CD8+ T cells increased both in peripheral blood and lower esophageal sphincter in achalasia. Eosinophils decreased in peripheral blood but massively infiltrated in lower esophageal sphincter. CIBERSORT analysis of peripheral blood mononuclear cells RNA sequencing displayed an increased prevalence of CD8+ T cells. 170 dysregulated genes were identified in achalasia, which were enriched in immune cells migration, immune response, etc. Proton pump inhibitor analysis revealed the intersections and gained 7 hub genes in achalasia, which were IL-6, Toll-like receptor 2, IL-1β, tumor necrosis factor, complement C3, and complement C1q A chain. ConclusionPatients with achalasia exhibited an imbalance of systematic innate and adaptive immunity, which may play an important role in the development of achalasia.

Characterization of quercetin and its glycoside derivatives in Malus germplasm

Lei Zhang,Qipeng Xu,Yaohua You,Weifeng Chen,Zhengcao Xiao,Pengmin Li,Fengwang Ma 한국원예학회 2018 Horticulture, Environment, and Biotechnology Vol.59 No.6

Quercetin and its glycoside derivatives were identifi ed and quantifi ed using high-performance liquid chromatograph (HPLC)and liquid chromatograph/mass spectrometer/mass spectrometer (LC/MS/MS) in the leaves, flowers, and fruits of 22 Malusgenotypes. In all genotypes, small amounts of quercetin aglycone were present, with water-soluble glycoside forms were themost abundant in diff erent Malus plant tissues, including quercetin-3-galactoside, quercetin-3-rutinoside, quercetin-3-glucoside,quercetin-3-xyloside, quercetin-3-arabinoside, and quercetin-3-rhamnoside. Among these six quercetin glycosides,quercetin-3-galactoside was the common form in Malus plants, except in the leaves and flowers of M. ceracifolia and M. magdeburgensis , and in the fruits of M. micromalus ‘Haihong Fruit’, where there was a higher concentration of quercetin-3-glucoside. Among the diff erent tissues tested, leaves contained the highest concentration of quercetin and its glycosides,while fruits contained the lowest concentrations of these compounds. Among the genotypes we analyzed, no specifi c genotypeconsistently contained the highest concentration of quercetin and its glycoside derivatives. M. domestica ‘Honeycrisp’had the highest total compound concentration (approximately 1600 mg kg −1 ), whereas M. hupehensis contained the lowestin its fruits. In contrast, the concentration of total quercetin and its glycosides was more than 5000 mg kg −1 in the leaves ofeight genotypes and greater than 2500 mg kg −1 in the flowers of seven species. In general, the concentration of quercetinand its glycoside derivatives depended on the species and tissue type. These results may provide useful information for theevaluation and selection of edible Malus fruits and the materials for quercetin glycoside extraction.

Novel reassortant 2.3.4.4B H5N6 highly pathogenic avian influenza viruses circulating among wild, domestic birds in Xinjiang, Northwest China

Qian Zhang,Xindi Mei,Cheng Zhang,Juan Li,Nana Chang,Dilihuma Aji,Weifeng Shi,Yuhai Bi,Zhenghai Ma 대한수의학회 2021 Journal of Veterinary Science Vol.22 No.4

Background: The H5 avian influenza viruses (AIVs) of clade 2.3.4.4 circulate in wild and domestic birds worldwide. In 2017, nine strains of H5N6 AIVs were isolated from aquatic poultry in Xinjiang, Northwest China. Objectives: This study aimed to analyze the origin, reassortment, and mutations of the AIV isolates. Methods: AIVs were isolated from oropharyngeal and cloacal swabs of poultry. Identification was accomplished by inoculating isolates into embryonated chicken eggs and performing hemagglutination tests and reverse transcription polymerase chain reaction (RT-PCR). The viral genomes were amplified with RT-PCR and then sequenced. The sequence alignment, phylogenetic, and molecular characteristic analyses were performed by using bioinformatic software. Results: Nine isolates originated from the same ancestor. The viral HA gene belonged to clade 2.3.4.4B, while the NA gene had a close phylogenetic relationship with the 2.3.4.4C H5N6 highly pathogenic avian influenza viruses (HPAIVs) isolated from shoveler ducks in Ningxia in 2015. The NP gene was grouped into an independent subcluster within the 2.3.4.4B H5N8 AIVs, and the remaining six genes all had close phylogenetic relationships with the 2.3.4.4B H5N8 HPAIVs isolated from the wild birds in China, Egypt, Uganda, Cameroon, and India in 2016–2017, Multiple basic amino acid residues associated with HPAIVs were located adjacent to the cleavage site of the HA protein. The nine isolates comprised reassortant 2.3.4.4B HPAIVs originating from 2.3.4.4B H5N8 and 2.3.4.4C H5N6 viruses in wild birds. Conclusions: These results suggest that the Northern Tianshan Mountain wetlands in Xinjiang may have a key role in AIVs disseminating from Central China to the Eurasian continent and East African.

Renewable biomass derived hierarchically porous carbonaceous sponges and their magnetic nanocomposites for removal of organic molecules from water

Hongwei Zhou,Bo Yan,Jialiang Lai,Hanbin Liu,Aijie Ma,Weixing Chen,Xilang Jin,Weifeng Zhao,Gai Zhanga 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.58 No.-

This work describes the preparation, characterization and removal capability of a novel biomass derived carbonaceous sponges (CS) and their nanocomposites. The CS has hierarchically porous structure which is composed of lamellar structures and secondary porous structures. The pore size is on a scale from 1 nm to 200 μm. Utilizing the CS as adsorbents, rapid removal of model organic molecules, including methylene blue (MB), methyl orange (MO) and crystal violet (CV), from their aqueous solutions can be completed within 1 min with the assistance of pressure and the removal efficiency reaches up to 100%, 81% and 98%, respectively. The removal capabilities for CS towards MB, MO and CV are 0.0769 g/g, 0.2218 g/g and 1.0384 g/g, respectively and 0.0635 g/g, 0.0977 g/g and 0.8634 g/g, respectively for CS nanocomposites.